CN114660310B - Automatic calibration method of sample analysis system - Google Patents
Automatic calibration method of sample analysis system Download PDFInfo
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- CN114660310B CN114660310B CN202210570516.4A CN202210570516A CN114660310B CN 114660310 B CN114660310 B CN 114660310B CN 202210570516 A CN202210570516 A CN 202210570516A CN 114660310 B CN114660310 B CN 114660310B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Abstract
The application provides an automatic calibration method of a sample analysis system. The sample analysis system comprises control equipment, sample distribution equipment and sample analysis equipment, and the method comprises the steps of obtaining identification information of a sample to be detected through the control equipment; determining whether the sample to be detected is a calibration sample or not based on the identification information; if the sample to be measured is a calibration sample, determining whether sample analysis equipment which provides an automatic calibration request exists; if the sample analysis equipment which provides the automatic calibration request exists, indicating the sample distribution equipment to distribute the sample to be measured which is determined as the calibration sample to the sample analysis equipment which provides the automatic calibration request; the sample analysis device that instructed the automatic calibration request performs an automatic calibration procedure based on the sample to be measured that is determined to be the calibration sample. The method can avoid the problem of calibration error caused by manual arrangement of wrong calibration sample positions, and a user does not need to manually perform repeated tests on each calibration sample for many times, so that the labor cost is effectively saved, and the calibration process is more intelligent.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an automatic calibration method of a sample analysis system.
Background
Multi-point calibration requires that multiple concentrations of calibration samples be taken and the instrument repeated n times. At present, calibration samples are generally selected manually, and the calibration samples are manually placed into corresponding sample analyzers according to the set sequence of the calibration samples in front of the analyzer to complete multi-point calibration. However, the multi-point calibration process is tedious and time-consuming, and once calibration is performed, a user needs to stand in front of the instrument for a long time until the calibration process is finished, which is not user-friendly.
Disclosure of Invention
The application provides an automatic calibration method of a sample analysis system, and aims to solve the problem that a user needs to stand in front of an instrument for a long time due to the fact that n times of calibration detection which is repeatedly executed on a calibration sample is manually completed by the existing multi-point calibration method according to the established sequence of the calibration sample.
In order to solve the technical problem, the application adopts a technical scheme that: an automatic calibration method for a sample analysis system is provided. The method comprises the following steps performed automatically by the sample analysis device: acquiring identification information of a sample to be detected; determining whether the sample to be detected is a calibration sample or not based on the identification information; if the sample to be measured is a calibration sample, determining whether an automatic calibration request exists; and if the automatic calibration request exists, executing an automatic calibration process by using the sample to be tested.
In one embodiment, prior to the sample analysis device making an auto-targeting request, the method comprises performing, by the sample analysis device, the steps of: receiving a quantity of a sample to be tested configured in an interface of the sample analysis device to be subjected to an auto-calibration procedure; judging whether the number of samples to be measured configured to be subjected to the automatic calibration process meets the number requirement of automatic calibration; if the number of the samples to be tested which are configured to be subjected to the automatic calibration process meets the number requirement of automatic calibration, judging whether the concentration value of the samples to be tested which are configured to be subjected to the automatic calibration process is a preset calibration concentration value; if the number of the samples to be tested which are configured to execute the automatic calibration process does not meet the number requirement of the automatic calibration, generating first prompt information; and if the concentration value of the sample to be measured configured to perform the automatic calibration process is the preset calibration concentration value, making an automatic calibration request to the control equipment.
In one embodiment, the method further comprises performing, by the control device, the steps of: if the sample to be detected is a common sample, determining whether sample analysis equipment which does not provide the automatic calibration request exists; if the sample analysis device which does not make the automatic calibration request exists, instructing the sample distribution device to distribute the sample to be tested which is determined to be the common sample to the sample analysis device which does not make the automatic calibration request based on a preset distribution rule; instructing the sample analysis device not making an automatic calibration request to perform a normal detection procedure based on the sample to be tested determined to be a normal sample.
In one embodiment, the method further comprises performing, by the control device, the steps of: if no sample analysis device which provides the automatic calibration request exists, instructing the sample distribution device to distribute the sample to be tested which is determined to be the calibration sample to the sample analysis device based on a preset distribution rule; instructing the sample analyzing apparatus to perform a general detection procedure based on the sample to be measured determined as the calibration sample.
In one embodiment, the method further comprises performing, by the control device, the steps of: if the sample to be tested is a quality control sample, instructing the sample distribution equipment to distribute the sample to be tested determined as the quality control sample to the sample analysis equipment specified by the distribution rule or making a quality control request based on a preset distribution rule or in response to the quality control request made by the sample analysis equipment; and instructing the sample analysis equipment specified by the distribution rule or making a quality control request to execute a quality control detection process based on the sample to be detected determined as a quality control sample.
In one embodiment, the identification information includes name information and reference information, the name information is used for characterizing whether the sample to be tested is a calibration sample, and the reference information is used for characterizing a standard attribute of the sample to be tested, the method further includes: sequentially carrying out calibration detection on the samples to be detected which are determined as the calibration samples by the sample analysis equipment which provides the automatic calibration request; and automatically calibrating the target to be calibrated based on the calibration detection result of the sample to be calibrated and the reference information.
In one embodiment, the step of sequentially performing calibration detection on the samples to be tested determined as the calibration samples by the sample analysis device making the automatic calibration request comprises: judging whether the detection result of the currently detected sample to be detected is abnormal or not by the sample analysis equipment which provides the automatic calibration request; if the detection result of the currently detected sample to be detected is abnormal, the detection process of the currently detected sample to be detected is stopped, second prompt information is generated, and the next sample to be detected which is determined as a calibration sample is subjected to calibration detection.
In one embodiment, the step of sequentially performing calibration detection on the samples to be tested determined as the calibration samples by the sample analysis device which makes the automatic calibration request comprises: judging whether the number of the samples to be detected with abnormal detection results is larger than a preset threshold value or not by the sample analysis equipment which provides the automatic calibration request; if the number of the samples to be detected with abnormal detection results is larger than the preset threshold value, ending the automatic calibration process and generating third prompt information.
In one embodiment, the sample analysis system is provided with three different files for storing the detection results corresponding to the automatic calibration process, the normal detection process and the quality control detection process, respectively; the step of sequentially performing calibration testing on the samples to be tested determined as the calibration samples by the sample analysis device making the automatic calibration request comprises: and storing the corresponding calibration detection result to different positions in a file for storing the detection result of the automatic calibration process by the sample analysis equipment which provides the automatic calibration request according to the reference information of different samples to be detected.
In one embodiment, the step of automatically calibrating the target to be calibrated based on the calibration detection result of the sample to be calibrated and the reference information includes: judging whether the calibration detection results of different samples to be detected are abnormal or not by the sample analysis equipment which provides the automatic calibration request; if the calibration detection results of different samples to be detected are abnormal, the automatic calibration process is ended, and fourth prompt information is generated.
The beneficial effect of this application compares in prior art: the method comprises the steps of obtaining identification information of a sample to be detected through the control equipment, and determining whether the sample to be detected is a calibration sample or not based on the identification information; when the sample to be measured is the calibration sample and the sample analysis device which makes the automatic calibration request exists, the sample distribution device is instructed to distribute the sample to be measured which is determined to be the calibration sample to the sample analysis device which makes the automatic calibration request, and the sample analysis device which makes the automatic calibration request is instructed to execute the automatic calibration process based on the sample to be measured which is determined to be the calibration sample. The method is based on the steps of obtaining the identification information of each sample to be measured and then executing an automatic calibration process on the samples to be measured, and has no requirement on the placing sequence of the samples to be measured, so that a plurality of samples to be measured can be placed randomly in the multi-point calibration process; compare in accomplishing the scheme of calibration according to the order that the calibration sample set through manual mode, not only can avoid leading to the problem of calibration mistake to take place because of the position of artifical pendulum wrong calibration sample, and need not the user and stand for a long time before sample analytical equipment through manual mode in order to carry out repeated test many times to every calibration sample, effectively saved the human cost for the calibration process is more intelligent.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a flow chart illustrating steps performed by a sample analysis device in an automatic calibration method for a sample analysis system according to an embodiment of the present application;
FIG. 2 is a schematic view of an interface of a sample analysis device provided in an embodiment of the present application;
FIG. 3 is a flowchart illustrating steps performed by the control device in an automatic calibration method for a sample analysis system according to an embodiment of the present application;
FIG. 4 is a flowchart illustrating steps performed by a sample analysis device in an automatic calibration method for a sample analysis system according to another embodiment of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.
The terms "first", "second" and "third" in this application are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or as implying a number of indicated technical features. Thus, a feature defined as "first," "second," or "third" may explicitly or implicitly include at least one of the feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless explicitly specified otherwise. In the embodiment of the present application, all directional indicators (such as up, down, left, right, front, rear \8230;) are used only to explain the relative positional relationship between the components, the motion situation, etc. at a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indicator is changed accordingly. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein may be combined with other embodiments.
The present application will be described in detail with reference to the accompanying drawings and examples.
In this embodiment, an automatic calibration method for a sample analysis system is provided. The sample analysis apparatus includes a control apparatus (CMS), a sample distribution apparatus, and a sample analysis apparatus. Wherein the sample dispensing device may be an injector. The sample analysis device may be operable to issue an automatic calibration request to test a calibration sample. In a specific embodiment, the sample analysis system is provided with three different files for storing the detection results corresponding to the automatic calibration process, the normal detection process, and the quality control detection process, respectively.
Referring to fig. 1 and 2, fig. 1 is a flowchart illustrating steps performed by a sample analysis device according to an automatic calibration method of a sample analysis system provided in an embodiment of the present application; fig. 2 is a schematic diagram of an interface of a sample analysis device according to an embodiment of the present disclosure. The automatic calibration method of the sample analysis system comprises the following steps executed by the sample analysis device:
step S11: a quantity of a sample to be tested configured in an interface of a sample analysis device to be subjected to an automated calibration procedure is received.
Step S12: and judging whether the number of the samples to be detected configured to execute the automatic calibration process meets the number requirement of automatic calibration.
In the automatic calibration process, each item detection has certain requirements on the number of the calibration samples, and the detection and calibration can be carried out only when the number of the calibration samples is not less than the number of the calibration samples required by the automatic calibration. For example, in this embodiment, the number of autoscales for the CRP calibration sample is 6 and the number of autoscales for the SAA calibration sample is 5; of course, it will be understood by those skilled in the art that the number of autocalibrations of the CRP calibration sample and the number of autocalibrations of the SAA calibration sample may be specifically set according to the actual situation when the calibration is performed using other reagents, and the present application is not limited thereto. In other embodiments, the number of automatic calibration for different types of calibration samples can be set according to the actual requirements of the test, and is not particularly limited herein.
Specifically, if the number of the samples to be measured configured to perform the automatic calibration process satisfies the number requirement for automatic calibration (i.e. the preset number value), step S13 is performed. If the number of samples to be measured configured to perform the automatic calibration process does not satisfy the number requirement for automatic calibration, step S14 is performed.
Step S13: and judging whether the concentration value of the sample to be tested configured to execute the automatic calibration process is a preset calibration concentration value.
Wherein, if the concentration value of the sample to be measured configured to perform the automatic calibration process is a preset calibration concentration value, the sample analyzing apparatus performs step S15. If the concentration value of the sample to be measured configured to perform the automatic calibration process is not the preset calibration concentration value, step S16 is performed.
Step S14: and generating first prompt information.
The first prompt message may be a text message, such as "error" or "exception," displayed in an interface of the sample analysis device. Or the first prompt message is the voice broadcast message of the sample analysis device, such as "number error" or "number shortage" and the like.
Step S15: an auto-targeting request is made to the control device.
Step S16: and generating prompt information.
The prompt message can be text message such as 'error' or 'abnormal' displayed on a pop-up window of an interface of the sample analysis equipment, or corresponding voice prompt message generated by the sample analysis equipment.
In a specific implementation process, before the sample analysis device issues the automatic calibration request, the method further includes: detecting whether an automatic calibration instruction is received, wherein the automatic calibration instruction can be an instruction generated by clicking an 'automatic calibration button' of the sample analysis equipment by a user; if an automatic calibration instruction is received, judging whether the sample analysis equipment is in an automatic sampling mode; if the sample analysis equipment is not in the automatic sampling mode, prompting to switch to the automatic sampling mode through an interface pop-up window of the sample analysis equipment, and if the sample analysis equipment is in the automatic sampling mode, judging whether a control equipment (CMS) is connected or not; if the CMS is not connected, the interface of the sample analysis device pops up to prompt 'please connect CMS first'; if the CMS is connected, judging whether the batch number is valid; wherein, the batch number is the production batch number of the calibration sample, so as to be used for tracing the calibration sample. Specifically, if the batch number is invalid, the interface popup window of the sample analysis device prompts "error"; if the lot number is valid, step S12 is performed.
Specifically, if the concentration value of the sample to be measured configured to perform the automatic calibration process is a preset calibration concentration value, the sample analysis device further determines whether the gain calibration reference value is valid; if the gain calibration reference value is invalid, the interface of the sample analysis device pops up to prompt an error; and if the gain calibration reference value is valid, judging whether the sample to be tested which meets the quantity requirement of automatic calibration and is configured to be subjected to the automatic calibration process is tested and finished. For example, there are 6 samples to be tested that satisfy the number requirement of the automatic calibration and are configured to be executed with the automatic calibration process, and it is determined whether all the tests of the 6 samples to be tested that are configured to be executed with the automatic calibration process are completed. If yes, prompting that' multi-point calibration is completed, if the data needs to be cleared again, firstly: if not, prompting 'please place the test tube rack with the sample to be tested determined as the calibration sample in the sample distribution equipment'. And then judging whether the gain calibration is executed or not, if not, automatically executing the gain calibration, and after the gain calibration is passed, sending an automatic calibration request to the control equipment. Specifically, the above steps are the same as or similar to the related steps in the existing calibration process, and the same or similar technical effects can be achieved, which are not described herein again.
Of course, the sample analysis apparatus also includes a sample section, a reagent section, and a measurement section, etc. in the existing sample analysis apparatus. The sample part is used for bearing a sample to be tested in the test solution, and the sample to be tested is sucked and then provided for the measuring part. The reagent unit is used for carrying a reagent in a test solution, and sucking the reagent and supplying the reagent to the measurement unit. The measuring component is used for carrying out project test on a sample to be tested so as to obtain test data of a project. The specific structures and functions of these components can be referred to the specific structures and functions of the related components in the existing sample analysis device, and the same or similar technical effects can be achieved, which are not described herein again.
Referring to fig. 3, fig. 3 is a flowchart illustrating steps performed by a control device in an automatic calibration method of a sample analysis system according to an embodiment of the present application; the method for automatic calibration of a sample analysis system further comprises the following steps performed by the control device:
step S21: and acquiring identification information of the sample to be detected.
Wherein, the sample to be detected comprises one or more of a common sample, a quality control sample or a calibration sample. The quality control sample is used for detecting the state of the sample analysis device to determine whether the state of the sample analysis device is controllable, generally speaking, the quality control test is for testing the sample analysis device and the test items, and when the state of the sample analysis device is out of control, the state may be the cause of testing the sample analysis device itself or the cause of the quality control sample itself. The calibration sample is a standardized sample of known concentration values for use in correcting the condition of the sample analyzing apparatus. In general, calibration samples are also used for the test sample analyzer and the test items, and when the same test sample analyzer is performing different test items, the requirements on the state of the sample analyzer are different, so that different calibrations can be performed on the test sample analyzers in different test items according to the calibration samples.
In the specific implementation process, when a sample to be detected is provided, a bar code corresponding to the sample to be detected is generated according to a defined rule, and the bar code is printed and adhered to a test tube of the corresponding sample to be detected. The bar code of the common sample has no any rule and is generated by a user according to industry habits.
In the specific implementation process, the bar code on the sample to be detected is read through the sample distribution equipment, and then the bar code read by the sample distribution equipment is analyzed through the control equipment to obtain the identification information. The identification information comprises name information and reference information. And the name information is used for representing whether the sample to be detected is the calibration sample. The name information can be a common sample, a quality control sample or a calibration sample. The reference information is used to characterize the standard properties of the sample to be tested. The reference information may include the concentration of the calibration sample.
Step S22: and determining whether the sample to be detected is the calibration sample or not based on the identification information.
Specifically, whether the sample to be measured is a calibration sample is determined based on the name information of the identification information. And if the identified name information is the calibration sample, determining the sample to be measured as the calibration sample. In a specific implementation process, as shown in fig. 2, after determining that the sample to be measured is the calibration sample, the name of the current calibration sample may be defined according to the identified concentration information of each calibration sample to distinguish a plurality of different calibration samples, so that in the process of performing step S25, the detection result of each calibration sample is displayed and stored in different positions in the file for storing the detection result of the automatic calibration process. For example, if the identified concentration information of one of the calibration samples is a, the calibration sample is defined as calibration sample 1, a is displayed in the information frame of the concentration corresponding to the calibration sample 1, and the detection result of the calibration sample 1 detected in each channel is correspondingly displayed in the list where the calibration sample 1 is located; and if the identified concentration information of the other calibration sample is B, the calibration sample is defined as a calibration sample 2, B is displayed in an information frame of the concentration corresponding to the calibration sample 2, and the detection result of the calibration sample 2 detected in each channel is correspondingly displayed in a list where the calibration sample 2 is located. The detection results of the calibration sample 1 and the calibration sample 2 in each channel can be displayed on the same display interface of the sample analysis apparatus.
Further, corresponding calibration may be performed in the subsequent step S25 according to the name information of the identified calibration sample. For example, if the identified name information is a C calibration sample, the sample represents a C-reactive protein (CRP) calibration solution, and an item displayed in an interface of the sample analysis apparatus is "CRP"; in subsequent step S25 a CRP scaling operation is performed. Wherein performing the CRP scaling operation requires that the number of scaled samples is not less than six. If the identified sample name information is S calibration sample, representing Serum Amyloid A (SAA) calibration solution; the item displayed in the interface of the sample analysis device is "SAA"; in subsequent step S25, an SAA scaling operation is performed. Wherein performing the SAA calibration operation requires that the number of calibration samples be no less than five.
Specifically, if the identified name information is a common sample, determining that the sample to be detected is the common sample; at this time, the control device further determines whether there is a sample analysis device for which no automatic calibration request is made, and if there is a sample analysis device for which no automatic calibration request is made, the control device instructs the sample distribution device to distribute the sample to be measured, which is determined as a normal sample, to the sample analysis device for which no automatic calibration request is made based on a predetermined distribution rule; and instructs the sample analyzing apparatus which has not made the automatic calibration request to execute the ordinary testing procedure based on the sample to be tested which is determined to be the ordinary sample.
If the identified name information is a quality control sample, determining the sample to be detected as the quality control sample; at this time, the control device instructs the sample distribution device to distribute the sample to be tested determined as the quality control sample to the sample analysis device specified by the distribution rule or making the quality control request based on a predetermined distribution rule or in response to the quality control request made by the sample analysis device; and instructs the quality control request sample analyzing apparatus designated or proposed by the assignment rule to execute a quality control testing process based on the sample to be tested determined as the quality control sample. Specifically, corresponding quality control is executed according to the identified name information; for example, if the identified name information is a CD quality control product, the CD quality control product is distributed to a blood globe to perform quality control; if the CRP quality control product is identified as the product name information, the CRP quality control product is distributed to a special egg instrument for quality control.
In the specific implementation process, the detection process can be respectively executed once on the common sample and/or the quality control sample, and the corresponding sample analysis equipment stores the detection result of the common detection process executed on the common sample to the corresponding position in the file for storing the detection result of the common detection process; and storing the detection result of the quality control detection process executed on the quality control sample to a corresponding position in a file for storing the detection result of the quality control detection process. And simultaneously, the corresponding detection result can be displayed in a corresponding list of an interface of the sample analysis equipment according to the bar code number.
Of course, in other embodiments, when it is determined that the sample to be detected is neither a calibration sample nor a quality control sample, the sample to be detected is determined as a normal sample by default, and the control device directly instructs the sample analysis device to perform a normal detection procedure on the sample to be detected, so as to improve the detection efficiency.
Step S23: and if the sample to be detected is the calibration sample, determining whether the sample analysis equipment which provides the automatic calibration request exists.
Specifically, if there is a sample analysis device that has made an automatic calibration request, step S24 is executed; if there is no sample analysis apparatus that has made the automatic calibration request, the control apparatus instructs the sample distribution apparatus to distribute the sample to be measured determined as the calibration sample to the sample analysis apparatus based on a predetermined distribution rule, and instructs the sample analysis apparatus to perform the ordinary detection procedure based on the sample to be measured determined as the calibration sample. The specific process of performing the common detection on the sample to be detected can refer to the existing detection process of the common sample, and can achieve the same or similar technical effects, which is not described herein again.
Step S24: and if the sample analysis device which gives the automatic calibration request exists, instructing the sample distribution device to distribute the sample to be tested which is determined to be the calibration sample to the sample analysis device which gives the automatic calibration request.
Step S25: the sample analysis device that instructed the automatic calibration request performs an automatic calibration procedure based on the sample to be measured that is determined to be the calibration sample.
In specific implementation, referring to fig. 4, fig. 4 is a flowchart illustrating steps performed by a sample analysis device according to an automatic calibration method of a sample analysis system provided in another embodiment of the present application; the automatic calibration method of the sample analysis system further comprises the following steps:
step S31: and sequentially carrying out calibration detection on the samples to be detected determined as calibration samples by the sample analysis equipment which provides the automatic calibration request.
Specifically, a sample analyzer such as a biochemical analyzer or an immunoassay analyzer may sequentially perform a calibration test on a sample to be measured determined as a calibration sample. In a specific detection process, a sample to be detected, which is determined as a calibration sample, can be reacted with a reagent to obtain reaction data of a calibration test, and the reaction data is used as a detection result of the current sample to be detected. For example, when the CRP item detection is performed on a sample to be detected determined as a calibration sample, the specific detection flow is the same as or similar to the detection flow of the existing CRP item, and the same or similar technical effects can be achieved, which is not described herein again.
In practice, the test can be repeated 2-3 times for each calibration sample in each channel of the sample analysis device. For example, as shown in fig. 2, the test can be repeated three times in channel 1 and three times in channel 2 of the sample analysis device to improve the test accuracy.
In a specific implementation process, the sample analysis device that provides the automatic calibration request further stores the corresponding calibration detection result to different positions in a file for storing the detection result of the automatic calibration process according to the reference information of different samples to be detected.
In a specific implementation process, after step S31, the method further includes:
step S32: and judging whether the detection result of the currently detected sample to be detected is abnormal or not by the sample analysis equipment which provides the automatic calibration request.
Specifically, if the detection result of the currently detected sample to be detected is abnormal, step S33 is executed; if the detection result of the currently detected sample to be detected is not abnormal, step S34 is executed. Specifically, the specific implementation manner for determining whether the detection result is abnormal is the same as or similar to the specific implementation manner for determining whether the detection result is abnormal in the existing calibration process, and the same or similar technical effects can be achieved, which is not described herein again.
Step S33: and terminating the detection flow of the currently detected sample to be detected, and generating second prompt information. After which step S35 is performed.
The second prompt message may be an alarm signal, such as flashing of a flashing light, voice broadcast, and the like.
Step S34: and judging whether the calibration process of the current calibration sample is finished or not by the sample analysis equipment which provides the automatic calibration request.
If the calibration process of the current calibration sample is completed, executing step S37; if the calibration process of the current calibration sample is not completed, the method returns to step S31 to perform calibration detection on the next sample to be detected determined as the calibration sample.
Step S35: and judging whether the number of the samples to be detected with abnormal detection results is greater than a preset threshold value or not by the sample analysis equipment which provides the automatic calibration request.
The preset threshold may be two, three, or five, and may be specifically set according to an actual situation, which is not limited in this application. Specifically, if the number of the samples to be detected with abnormal detection results is greater than the preset threshold value, the step S36 is executed; if the number of the samples to be tested with abnormal detection results is not greater than the preset threshold, step S37 is executed.
Step S36: and ending the whole automatic calibration process and generating third prompt information.
Wherein the third prompt message is different from the second prompt message. For example, the second prompt message is flashing of a flashing light, and the third prompt message is similar voice messages such as voice broadcast 'calibration end' and the like; of course, the third prompt message and the second prompt message may be the same, but the prompt time, frequency or color is different; for example, the third prompt message and the second prompt message are both flashing lights, but the second prompt message is flashing yellow lights, and the third prompt message is flashing red lights; or the second prompt information is a yellow light flashing flickering which is performed at a frequency of flashing once every 10 seconds, and the third prompt information is a yellow light flashing which is performed at a frequency of flashing once every 5 seconds.
Step S37: and judging whether the whole calibration process is finished or not by the sample analysis equipment which provides the automatic calibration request.
Specifically, if the whole calibration process is not completed, step S38 is performed to detect the next batch of samples to be detected, which are determined as calibration samples. If the entire calibration process is completed, step S39 is executed.
Step S38: the auto-scaling request is resent by the sample analysis device that presented the auto-scaling request.
Step S39: and automatically calibrating the target to be calibrated based on the calibration detection result and the reference information of the sample to be calibrated.
The target to be calibrated is a calibration curve or a calibration function. Illustratively, a calibration curve corresponding to each channel is generated based on the average value of detection results obtained by detecting the calibration sample n for multiple times in each channel, namely a calibration sample 1, a calibration sample 2, \8230; the calibration curves of the channels can be displayed on the same display interface.
Specifically, step S39 specifically includes: and judging whether the calibration detection results of different samples to be detected are abnormal or not by the sample analysis equipment which provides the automatic calibration request.
Specifically, if there is an abnormality between the calibration detection results of different samples to be detected, the automatic calibration process is ended, and fourth prompt information is generated. The fourth prompt message may be a text prompt or a voice prompt for "automatically scaling the structural abnormality". If no abnormity exists between the calibration detection results of different samples to be detected, automatically calculating and storing the calibration curve, and generating fifth prompt information. The fifth prompting message can be a text prompt or a voice prompt of 'automatic calibration completion'. The text prompt may be displayed on an interface of the sample analysis device.
The automatic calibration method of the sample analysis system provided by the embodiment includes the steps that the control device obtains identification information of a sample to be detected, and whether the sample to be detected is a calibration sample is determined based on the identification information; when the sample to be measured is a calibration sample and the sample analysis device for the automatic calibration request exists, the sample distribution device is instructed to distribute the sample to be measured determined as the calibration sample to the sample analysis device for which the automatic calibration request is made, and the sample analysis device for which the automatic calibration request is made is instructed to execute the automatic calibration process based on the sample to be measured determined as the calibration sample. The method is based on the steps of obtaining the identification information of each sample to be measured and then executing an automatic calibration process on the samples to be measured, and has no requirement on the placing sequence of the samples to be measured, so that a plurality of samples to be measured can be placed randomly in the multi-point calibration process; compare in accomplishing the scheme of calibration according to the order that the calibration sample set through manual mode, not only can avoid causing the problem of calibration mistake to take place because of the position of artifical pendulum wrong calibration sample, and need not the user and stand for a long time before sample analytical equipment through manual mode in order to carry out repeated test many times to every calibration sample, effectively saved the human cost for the calibration process is more intelligent. Meanwhile, by means of bar code identification, a user can perform testing according to an expected flow by placing a common sample/quality control sample/calibration sample with a bar code in an instrument, so that the operation cost of the user is greatly reduced, and the time of the user is saved.
The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure or those directly or indirectly applied to other related technical fields are intended to be included in the scope of the present disclosure.
Claims (8)
1. A method for automatic calibration of a sample analysis system, wherein the sample analysis system comprises a control device, a sample distribution device and a sample analysis device, the method comprising performing by the control device the steps of:
acquiring identification information of a sample to be detected;
determining whether the sample to be detected is a calibration sample or not based on the identification information;
if the sample to be detected is a calibration sample, determining whether a sample analysis device which provides an automatic calibration request exists;
if the sample analysis device which provides the automatic calibration request exists, the sample distribution device is instructed to distribute the sample to be tested which is determined as the calibration sample to the sample analysis device which provides the automatic calibration request;
instructing the sample analysis device that made the auto-calibration request to perform an auto-calibration procedure based on the sample to be measured that is determined to be a calibration sample;
before the sample analysis device makes an auto-targeting request, the method comprises performing, by the sample analysis device, the steps of:
receiving a quantity of a sample to be tested configured in an interface of the sample analysis device to be subjected to an auto-calibration procedure;
judging whether the number of samples to be measured configured to be subjected to the automatic calibration process meets the number requirement of automatic calibration;
if the number of the samples to be detected which are configured to execute the automatic calibration process meets the number requirement of the automatic calibration, judging whether the concentration value of the samples to be detected which are configured to execute the automatic calibration process is a preset calibration concentration value; if the number of the samples to be detected which are configured to execute the automatic calibration process does not meet the requirement of the number of the automatic calibration, generating first prompt information;
if the concentration value of the sample to be measured configured to execute the automatic calibration process is the preset calibration concentration value, an automatic calibration request is made to the control equipment;
the method further comprises performing, by the control device, the steps of:
if the sample analysis device which provides the automatic calibration request does not exist, instructing the sample distribution device to distribute the sample to be tested which is determined as the calibration sample to the sample analysis device based on a preset distribution rule;
instructing the sample analyzing apparatus to perform a general detection procedure based on the sample to be measured determined as the calibration sample.
2. The method according to claim 1, characterized in that the method further comprises performing by the control device the steps of:
if the sample to be detected is a common sample, determining whether sample analysis equipment which does not provide the automatic calibration request exists;
if the sample analysis device which does not make the automatic calibration request exists, indicating the sample distribution device to distribute the sample to be tested which is determined to be the common sample to the sample analysis device which does not make the automatic calibration request based on a preset distribution rule;
instructing the sample analysis device not proposing the automatic calibration request to perform a normal detection procedure based on the sample to be detected determined to be a normal sample.
3. The method according to claim 1, characterized in that the method further comprises performing, by the control device, the steps of:
if the sample to be tested is a quality control sample, instructing the sample distribution equipment to distribute the sample to be tested determined as the quality control sample to the sample analysis equipment specified by the distribution rule or making a quality control request based on a preset distribution rule or in response to the quality control request made by the sample analysis equipment;
and instructing the sample analysis equipment specified by the distribution rule or making a quality control request to execute a quality control detection process based on the sample to be detected determined as a quality control sample.
4. The method of claim 1, wherein the identification information includes name information for characterizing whether the sample to be tested is a calibration sample and reference information for characterizing a standard attribute of the sample to be tested, and the method further comprises:
sequentially carrying out calibration detection on the samples to be detected which are determined as the calibration samples by the sample analysis equipment which provides the automatic calibration request;
and automatically calibrating the target to be calibrated based on the calibration detection result of the sample to be calibrated and the reference information.
5. The method of claim 4, wherein the step of sequentially performing calibration testing on the samples to be tested determined to be the calibration samples by the sample analysis device making the automatic calibration request comprises:
judging whether the detection result of the currently detected sample to be detected is abnormal or not by the sample analysis equipment which provides the automatic calibration request;
if the detection result of the currently detected sample to be detected is abnormal, the detection process of the currently detected sample to be detected is stopped, second prompt information is generated, and the next sample to be detected which is determined as a calibration sample is subjected to calibration detection.
6. The method of claim 5, wherein the step of sequentially performing calibration testing on the samples to be tested determined to be the calibration samples by the sample analysis device making the automatic calibration request comprises:
judging whether the number of the samples to be detected with abnormal detection results is larger than a preset threshold value or not by the sample analysis equipment which provides the automatic calibration request;
if the number of the samples to be detected with abnormal detection results is larger than the preset threshold value, ending the automatic calibration process and generating third prompt information.
7. The method of claim 4, wherein the sample analysis system is provided with three different files for storing the detection results corresponding to the automatic calibration process, the normal detection process, and the quality control detection process, respectively;
the step of sequentially performing calibration detection on the samples to be tested determined as the calibration samples by the sample analysis device which makes the automatic calibration request comprises the following steps:
and storing the corresponding calibration detection result to different positions in a file for storing the detection result of the automatic calibration process by the sample analysis equipment which provides the automatic calibration request according to the reference information of different samples to be detected.
8. The method of claim 4, wherein the step of automatically calibrating the target to be calibrated based on the calibration test result of the sample to be calibrated and the reference information comprises:
judging whether the calibration detection results of different samples to be detected are abnormal or not by the sample analysis equipment which provides the automatic calibration request;
if the calibration detection results of different samples to be detected are abnormal, the automatic calibration process is ended, and fourth prompt information is generated.
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