CN111234108A - 一种可用于面膜的水凝胶材料制备方法 - Google Patents
一种可用于面膜的水凝胶材料制备方法 Download PDFInfo
- Publication number
- CN111234108A CN111234108A CN202010099833.3A CN202010099833A CN111234108A CN 111234108 A CN111234108 A CN 111234108A CN 202010099833 A CN202010099833 A CN 202010099833A CN 111234108 A CN111234108 A CN 111234108A
- Authority
- CN
- China
- Prior art keywords
- hydrogel material
- zinc oxide
- preparation
- facial mask
- mask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 44
- 239000000017 hydrogel Substances 0.000 title claims abstract description 42
- 230000001815 facial effect Effects 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc oxide Inorganic materials [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 53
- 239000011787 zinc oxide Substances 0.000 claims abstract description 37
- -1 zinc oxide compound Chemical class 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 9
- ZQAFTOCXRSCXFR-UHFFFAOYSA-N ethane-1,2-diol;3-oxobutanoic acid Chemical compound OCCO.CC(=O)CC(O)=O ZQAFTOCXRSCXFR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000008239 natural water Substances 0.000 claims abstract description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 29
- 238000003756 stirring Methods 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 10
- 230000005855 radiation Effects 0.000 claims description 10
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 7
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 7
- 239000000661 sodium alginate Substances 0.000 claims description 7
- 235000010413 sodium alginate Nutrition 0.000 claims description 7
- 229940005550 sodium alginate Drugs 0.000 claims description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 6
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 6
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 6
- 150000005690 diesters Chemical class 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229920002674 hyaluronan Polymers 0.000 claims description 6
- 229960003160 hyaluronic acid Drugs 0.000 claims description 6
- 239000004246 zinc acetate Substances 0.000 claims description 6
- WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 claims description 5
- 229960000271 arbutin Drugs 0.000 claims description 5
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- 125000004386 diacrylate group Chemical group 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- WOWBFOBYOAGEEA-UHFFFAOYSA-N diafenthiuron Chemical compound CC(C)C1=C(NC(=S)NC(C)(C)C)C(C(C)C)=CC(OC=2C=CC=CC=2)=C1 WOWBFOBYOAGEEA-UHFFFAOYSA-N 0.000 claims description 3
- FZGFBJMPSHGTRQ-UHFFFAOYSA-M trimethyl(2-prop-2-enoyloxyethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCOC(=O)C=C FZGFBJMPSHGTRQ-UHFFFAOYSA-M 0.000 claims description 3
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 108010022355 Fibroins Proteins 0.000 claims description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 229940045110 chitosan Drugs 0.000 claims description 2
- 235000014103 egg white Nutrition 0.000 claims description 2
- 210000000969 egg white Anatomy 0.000 claims description 2
- 239000013538 functional additive Substances 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 229940014259 gelatin Drugs 0.000 claims description 2
- 229960003966 nicotinamide Drugs 0.000 claims description 2
- 235000005152 nicotinamide Nutrition 0.000 claims description 2
- 239000011570 nicotinamide Substances 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 239000000341 volatile oil Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003999 initiator Substances 0.000 abstract description 4
- 230000005012 migration Effects 0.000 abstract description 4
- 238000013508 migration Methods 0.000 abstract description 4
- 239000012752 auxiliary agent Substances 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 14
- 239000000126 substance Substances 0.000 description 6
- AJIGHJRZJOUETA-UHFFFAOYSA-N ethane-1,2-diol;2-methylprop-2-enoic acid;3-oxobutanoic acid Chemical compound OCCO.CC(=C)C(O)=O.CC(=O)CC(O)=O AJIGHJRZJOUETA-UHFFFAOYSA-N 0.000 description 5
- 239000002105 nanoparticle Substances 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- YEQBHMVRNHTCPJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;3-oxobutanoic acid Chemical compound CC(=C)C(O)=O.CC(=O)CC(O)=O YEQBHMVRNHTCPJ-UHFFFAOYSA-N 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 125000004989 dicarbonyl group Chemical group 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000008062 acetophenones Chemical class 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000007674 genetic toxicity Effects 0.000 description 1
- 231100000025 genetic toxicology Toxicity 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000001027 hydrothermal synthesis Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000001782 photodegradation Methods 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/46—Polymerisation initiated by wave energy or particle radiation
- C08F2/48—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/246—Intercrosslinking of at least two polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/28—Treatment by wave energy or particle radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2351/00—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
- C08J2351/02—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers grafted on to polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2371/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2489/00—Characterised by the use of proteins; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明公开了一种可用于面膜的水凝胶材料制备方法；其具体步骤为：将0.1～3％质量分数的天然水性框架材料预溶或分散于50～100℃的84～99.3％质量分数的水中形成溶液，溶液中加入0.5～10％质量分数的互穿交联剂和0.1～3％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯‑纳米氧化锌复合物进行光引发反应，得到一种可用于面膜的水凝胶材料。步骤中可以加入0.1～5％质量分数的功能助剂。水凝胶材料拉伸强度不低于30MPa。与现有技术相比，本发明具有如下优势：材料选择范围宽、力学性能调节余地大、引发剂安全无迁移和制备工艺简单温和。
Description
技术领域
本发明属于日用化学品与生物医学工程领域,具体涉及一种可用于面膜的水凝胶材料制备方法。
背景技术
面膜(Facemask)，是美容护肤品中的一个类别，涂敷于面部具有美容功能，如补水保湿、美白、抗衰老、平衡油脂等等。面膜的原理，就是利用覆盖在脸部的短暂时间，暂时隔离外界的空气与污染，提高肌肤温度，皮肤的毛孔扩张，促进汗腺分泌与新陈代谢，使肌肤的含氧量上升，有利于肌肤排除表皮细胞新陈代谢的产物和累积的油脂类物质，面膜中的水分渗入表皮的角质层，皮肤变得柔软，肌肤自然光亮有弹性。传统面膜的形式主要有泥膏型、撕拉型、冻胶型、湿纸巾型四种。泥膏型、撕拉型和冻胶型存在着手工涂敷、易沾污家居环境的缺点。湿纸巾型依赖于惰性织物，存在着面部匹配不好、功能成分易流失等缺点。
水凝胶型面膜是以具保湿作用的水凝胶材料为基材制成的面膜。水凝胶(Hydrogel)，它是由高分子网络和水溶剂两种组分构成，兼具固体和液体两方面的性质。当把凝胶贴到皮肤上时，受到体温的影响，凝胶内部的物理结构从聚集态变成自由态，并渗透到皮肤里。因此，水凝胶面膜具有亲和皮肤、蓄水量高和缓释补水三大特质。另外，在以水凝胶为核心的面膜内加入胶原蛋白、透明质酸、熊果苷、烟酰胺等有效成分，可制成多种功能的面膜。水溶性水凝胶内的果冻状精华成分不易蒸发、干燥，其退热舒缓的效果对急性皮肤损伤(如过敏、长痘、擦伤)有良好效果
CN108685791A提出了一种无载体混合成型补水凝胶面膜及其制备方法，以海藻酸钠为高分子网络主体，以碳酸钙、氯化钙或氯化镁等无机盐作为力学性能调节。CN106821772A提出了一种网络互穿面膜基材的制备方法，是通过溶液共混方式制备互穿网络膜。采用海藻酸钠和明胶作为原料，选用儿茶素和氯化钙作为交联剂，以增强其力学强度。无机盐存在着与皮肤的渗透生理作用问题；有机小分子交联剂与天然高分子通过氢键实现，属于较弱的相互作用、且具有可逆性，在配方多组分体系中并不稳定。
CN201910952885提出了一种抗菌型琼脂丙烯酰胺水凝胶的制备方法，原料为双键功能化抗菌材料(G-ε-PL)、琼脂和丙烯酰胺，在紫外光(340～360nm)辐射引发下，得到抗菌型琼脂丙烯酰胺水凝胶。但是，紫外光辐射会对很多生物活性物质产生破坏作用，包括对化妆品里常用的熊果苷[日用化学工业,2014,44(10):580-583]、维生素[刘艳玲，安徽农业大学硕士学位论文，2015]、磷脂[王宁，郑州大学硕士学位论文,2007]、植物精油[洪鹏,中国食品科学技术学会第十三届年会.2016]和蛋白[国际皮肤性病学杂志,2015,41(1):54-57]等功能活性组分的光降解。
CN 108467464A提出了一种化妆品含壬二酸可见光固化水凝胶，配方包括水溶性单体、多官能团交联单体、可见光引发剂、壬二酸等。但是，配方中并没有水的成分，并使用了多达40～80％的有机单体，既不经济、脱离了水凝胶的初衷，又有潜在的皮肤不适应性。
CN106986967A提出了一种具有双交联网络结构海藻酸钠复合水凝胶的方法，配方包括海藻酸钠、活性单体、光引发剂、交联剂、鎓盐、纳米钙和去离子水等。但是，配方中使用了一些合成小分子，如光引发剂和鎓盐，固化反应后会留在凝胶体系中，极具迁移的可能性。如用于食品或化妆品，则有潜在的生理安全问题[食品安全质量检测学报2015,(9):23-30.]，尤其是鎓盐，更有遗传毒性的可能[中国药理学与毒理学杂志,2006,20(6):500-503.]。
CN106146689A提出了丙烯基甲基化β-环糊精和苯乙酮类光引发剂分子形成包合物的，相对于传统的的光引发剂具有更高的聚合速率和更好的聚合效率。但由于环糊精类包合作用具有可逆性[Angewandte Chemie International Edition,19(5):344-362.]，因此亦无法避免小分子引发剂(苯乙酮类)的迁移。
发明内容
为解决上述技术问题，本发明提出一种可用于面膜的水凝胶材料制备方法。
本发明的目的是通过以下技术方案来实现的：
本发明涉及一种可用于面膜的水凝胶材料制备方法；其步骤为：将0.1～3％质量分数的天然水性框架材料预溶或分散于50～100℃的84～99.3％质量分数的水中形成溶液，溶液中加入0.5～10％质量分数的互穿交联剂和0.5～10％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物进行光引发反应，得到所述可用于面膜的水凝胶材料。
进一步的，所述天然水性框架材料可以包括透明质酸、壳聚糖、明胶、海藻酸钠、纤维素、蚕丝蛋白和蛋清中的一种或几种。
进一步的，所述互穿交联剂可以包括聚乙二醇二丙烯酸酯、丙烯酸-2-羟乙酯、甲基丙烯酸-2-羟乙酯、丙烯酰胺和丙烯酰氧乙基三甲基氯化铵中的一种或几种。
进一步的，所述甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物的制备步骤为：
取0.5～3％质量分数的乙酸锌溶于82～97.5％质量分数的乙醇，均匀搅拌，逐滴加入1～10％质量分数的2～10％浓度的氨水至pH＝8，常温搅拌0.5～3小时，加入1～5％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯，加热至50～75℃搅拌0.5～4小时，得甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物。
进一步的，所述甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物中纳米氧化锌的粒径为1～900nm。
进一步的，所述光引发反应的条件为0～40℃、400～500nm光波长、10～500J/m2辐射剂量。
在甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物中，存在着双羰基与氧化锌纳米粒子表面的锌的配位作用(图2)，既可以稳定氧化锌纳米粒子，又可以形成大π共轭结构，使其吸收波长红移至400～500nm。复合物在与其波长匹配的光源辐射下，可形成自由基或空穴-电子对，引发含双键的化合物聚合，甲基丙烯酸乙酰乙酸乙二醇双酯即与互穿交联剂共聚成网络，而氧化锌纳米粒子在光照和反应水热作用下进一步晶化、粒径长大至微米以上晶体颗粒。由于复合物生成的产物皆为难以迁移之物质。而氧化锌本身是安全无毒，皮肤亲和性较高，能舒缓镇静敏感肌肤，有收敛性和一定的杀菌能力，在许多护肤品都有使用。
进一步的，步骤中可以加入0.1～5％质量分数的功能助剂。
进一步的，所述功能助剂包括熊果苷、玻尿酸、维生素E、烟酰胺、尼泊金酯、尿囊素、植物精油和胶原蛋白中的一种或几种。
进一步的，所述水凝胶材料拉伸强度不低于30MPa。
本发明通过互穿交联天然水性框架材料方法获得的可用于面膜的水凝胶材料，是一种较有前途的面膜基材制备方法。
与现有技术相比，本发明具有如下优势：材料选择范围宽、力学性能调节余地大、引发剂安全无迁移和制备工艺简单温和。
附图说明
通过阅读参照以下附图对非限制性实施例所作的详细描述，本发明的其它特征、目的和优点将会变得更明显：
图1为实施例1的甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物的电镜图；
图2为在甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物中存在的双羰基与氧化锌纳米粒子表面的锌的配位作用之示意图。
具体实施方式
下面结合具体实施例对本发明进行详细说明。以下实施例将有助于本领域的技术人员进一步理解本发明，但不以任何形式限制本发明。应当指出的是，对本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变化和改进,包括各实例间的任意组合。
实施例1
将0.5％质量分数的明胶预溶于90℃的97％质量分数的水中形成溶液，溶液中加入2％质量分数的聚乙二醇二丙烯酸酯和0.5％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，在20℃、405nm光波长、200J/m2辐射剂量下进行光引发反应，得到一种可用于面膜的水凝胶材料，其拉伸强度为82MPa(GB/T 1040.2-2006)。
其中，甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物的制备步骤为：取1％质量分数的乙酸锌溶于95％质量分数的乙醇，均匀搅拌，逐滴加入2％质量分数的氨水(5％浓度)至pH＝8，常温搅拌1小时，加入2％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯，加热至60℃搅拌2小时，得甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，电镜图显示纳米氧化锌的平均粒径为100nm；具体见附图1。
实施例2
将0.1％质量分数的透明质酸预溶于50℃的89.8％质量分数的水中形成溶液，溶液中加入10％质量分数的丙烯酸-2-羟乙酯和0.1％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，在20℃、420nm光波长、100J/m2辐射剂量下进行光引发反应，得到一种可用于面膜的水凝胶材料，其拉伸强度为125MPa(GB/T 1040.2-2006)。
其中，甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物的制备步骤为：取0.5％质量分数的乙酸锌溶于93.5％质量分数的乙醇，均匀搅拌，逐滴加入1％质量分数的氨水(2％浓度)至pH＝8，常温搅拌0.5小时，加入5％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯，加热至50℃搅拌0.5小时，得甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，电镜图显示纳米氧化锌的平均粒径为1nm。
实施例3
将3％质量分数的海藻酸钠预溶于99℃的93.4％质量分数的水中形成溶液，溶液中加入0.1％质量分数的熊果苷、0.5％质量分数的丙烯酰氧乙基三甲基氯化铵和3％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，在40℃、450nm光波长、10J/m2辐射剂量下进行光引发反应，得到一种可用于面膜的水凝胶材料，其拉伸强度为43MPa(GB/T 1040.2-2006)。
其中，甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物的制备步骤为：取3％质量分数的乙酸锌溶于86％质量分数的乙醇，均匀搅拌，逐滴加入10％质量分数的氨水(10％浓度)至pH＝8，常温搅拌3小时，加入1％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯，加热至75℃搅拌3小时，得甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，电镜图显示纳米氧化锌的平均粒径为900nm。
实施例4
将1％质量分数的壳聚糖预溶于80℃的93.5％质量分数的水中形成溶液，溶液中加入5％质量分数的丙烯酰胺和甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，在1℃、500nm光波长、500J/m2辐射剂量下进行光引发反应，得到一种可用于面膜的水凝胶材料，其拉伸强度为98MPa(GB/T 1040.2-2006)。
甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物的制备步骤为：取2％质量分数的乙酸锌溶于94％质量分数的乙醇，均匀搅拌，逐滴加入2％质量分数的氨水(5％浓度)至pH＝8，常温搅拌1小时，加入2％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯，加热至60℃搅拌2小时，得甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物，电镜图显示纳米氧化锌的平均粒径为300nm。
对比例1
将0.5％质量分数的琼脂预溶于90℃的97％质量分数的水中形成溶液，溶液中加入2％质量分数的聚乙二醇二丙烯酸酯，得到的材料拉伸强度仅为2MPa(GB/T 1040.2-2006)，不耐扯动，不适合作为面膜材料使用。
对比例2
将1％质量分数的壳聚糖预溶于80℃的93.5％质量分数的水中形成溶液，溶液中加入5％质量分数的丙烯酰胺和0.5％质量分数的硫杂蒽酮，在1℃、500nm光波长、500J/m2辐射剂量下进行光引发反应，得到一种可用于面膜的水凝胶材料，其拉伸强度为102MPa(GB/T 1040.2-2006)，但表面有硫杂蒽酮迁移析出。
以上对本发明的具体实施例进行了描述。需要理解的是，本发明并不局限于上述特定实施方式，本领域技术人员可以在权利要求的范围内做出各种变化或修改，这并不影响本发明的实质内容。在不冲突的情况下，本申请的实施例和实施例中的特征可以任意相互组合。
Claims (8)
1.一种可用于面膜的水凝胶材料制备方法，其特征在于，具体步骤为：
将0.1～3％质量分数的天然水性框架材料预溶或分散于50～100℃的84～99.3％质量分数的水中形成溶液，溶液中加入0.5～10％质量分数的互穿交联剂和0.5～10％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物进行光引发反应，得到所述可用于面膜的水凝胶材料。
2.根据权利要求1所述的可用于面膜的水凝胶材料制备方法，其特征在于，所述天然水性框架材料包括透明质酸、壳聚糖、明胶、海藻酸钠、纤维素、蚕丝蛋白和蛋清中的一种或几种。
3.根据权利要求1所述的可用于面膜的水凝胶材料制备方法，其特征在于，所述互穿交联剂包括聚乙二醇二丙烯酸酯、丙烯酸-2-羟乙酯、甲基丙烯酸-2-羟乙酯、丙烯酰胺和丙烯酰氧乙基三甲基氯化铵中的一种或几种。
4.根据权利要求1所述的可用于面膜的水凝胶材料制备方法，其特征在于，所述甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物的制备步骤为：
取0.5～3％质量分数的乙酸锌溶于82～97.5％质量分数的乙醇，均匀搅拌，逐滴加入1～10％质量分数的2～10％浓度的氨水至pH＝8，常温搅拌0.5～3小时，加入1～5％质量分数的甲基丙烯酸乙酰乙酸乙二醇双酯，加热至50～75℃搅拌0.5～4小时，得甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物。
5.根据权利要求1所述的可用于面膜的水凝胶材料制备方法，其特征在于，所述甲基丙烯酸乙酰乙酸乙二醇双酯-纳米氧化锌复合物中纳米氧化锌的粒径为1～900nm。
6.根据权利要求1所述的可用于面膜的水凝胶材料制备方法，其特征在于，所述光引发反应的条件为0～40℃、400～500nm光波长、10～500J/m2辐射剂量。
7.根据权利要求1所述的可用于面膜的水凝胶材料制备方法，其特征在于，步骤中可以加入0.1～5％质量分数的功能助剂。
8.根据权利要求7所述的可用于面膜的水凝胶材料制备方法，其特征在于，所述功能助剂包括熊果苷、玻尿酸、维生素E、烟酰胺、尼泊金酯、尿囊素、植物精油和胶原蛋白中的一种或几种。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010099833.3A CN111234108B (zh) | 2020-02-18 | 2020-02-18 | 一种可用于面膜的水凝胶材料制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010099833.3A CN111234108B (zh) | 2020-02-18 | 2020-02-18 | 一种可用于面膜的水凝胶材料制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111234108A true CN111234108A (zh) | 2020-06-05 |
| CN111234108B CN111234108B (zh) | 2021-05-25 |
Family
ID=70880007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010099833.3A Active CN111234108B (zh) | 2020-02-18 | 2020-02-18 | 一种可用于面膜的水凝胶材料制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111234108B (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113774658A (zh) * | 2021-08-20 | 2021-12-10 | 南通帝沙纺织有限公司 | 一种含氨基酸烟酰胺保湿锁水美肤香薰面料及其制备方法 |
| CN114438775A (zh) * | 2021-12-21 | 2022-05-06 | 广东美凡芮科技有限公司 | 一种功能性面膜基体制备方法及面膜 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3721555A (en) * | 1971-08-24 | 1973-03-20 | Eastman Kodak Co | Diffusion transfer reception elements,film units and processes therefor |
| JP2002173647A (ja) * | 2000-12-05 | 2002-06-21 | Kansai Paint Co Ltd | 防汚塗料組成物 |
| CN105026505A (zh) * | 2013-03-11 | 2015-11-04 | 陶氏环球技术有限责任公司 | 粘合剂组合物和其在抗结露涂料组合物中的应用 |
| CN105541611A (zh) * | 2015-12-25 | 2016-05-04 | 潍坊科麦化工有限公司 | 一种制备甲基丙烯酸乙酰乙酸乙二醇双酯的方法 |
| CN105693907A (zh) * | 2016-01-27 | 2016-06-22 | 上海交通大学 | 粒径和不对称程度可控的含二氧化硅的Janus粒子的制备方法 |
| DE202017104712U1 (de) * | 2017-08-07 | 2017-11-14 | Kusum Sachin Joshi | Feuerbeständige, vor Korrosion schützende, wasserdichte, energiesparende, wärmeisolierende Beschichtungszusammensetzung auf Wasserbasis |
-
2020
- 2020-02-18 CN CN202010099833.3A patent/CN111234108B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3721555A (en) * | 1971-08-24 | 1973-03-20 | Eastman Kodak Co | Diffusion transfer reception elements,film units and processes therefor |
| JP2002173647A (ja) * | 2000-12-05 | 2002-06-21 | Kansai Paint Co Ltd | 防汚塗料組成物 |
| CN105026505A (zh) * | 2013-03-11 | 2015-11-04 | 陶氏环球技术有限责任公司 | 粘合剂组合物和其在抗结露涂料组合物中的应用 |
| CN105541611A (zh) * | 2015-12-25 | 2016-05-04 | 潍坊科麦化工有限公司 | 一种制备甲基丙烯酸乙酰乙酸乙二醇双酯的方法 |
| CN105693907A (zh) * | 2016-01-27 | 2016-06-22 | 上海交通大学 | 粒径和不对称程度可控的含二氧化硅的Janus粒子的制备方法 |
| DE202017104712U1 (de) * | 2017-08-07 | 2017-11-14 | Kusum Sachin Joshi | Feuerbeständige, vor Korrosion schützende, wasserdichte, energiesparende, wärmeisolierende Beschichtungszusammensetzung auf Wasserbasis |
Non-Patent Citations (2)
| Title |
|---|
| TINGTING REN,等: "Raspberry-like morphology of polyvinyl chloride/zinc oxide nanoparticles induced by surface interaction and formation of nanoporous foam", 《RSC ADVANCES》 * |
| 焦书科，等: "丙烯酸酯系水乳漆的螯合固化", 《应用化学》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113774658A (zh) * | 2021-08-20 | 2021-12-10 | 南通帝沙纺织有限公司 | 一种含氨基酸烟酰胺保湿锁水美肤香薰面料及其制备方法 |
| CN114438775A (zh) * | 2021-12-21 | 2022-05-06 | 广东美凡芮科技有限公司 | 一种功能性面膜基体制备方法及面膜 |
| CN114438775B (zh) * | 2021-12-21 | 2023-11-10 | 广东美凡芮科技有限公司 | 一种功能性面膜基体制备方法及面膜 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111234108B (zh) | 2021-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Liu et al. | A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing | |
| Gan et al. | Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry | |
| CN110551299B (zh) | 一种自粘附性聚丙烯酰胺复合水凝胶及其制备方法与应用 | |
| Tang et al. | Mussel-inspired biocompatible polydopamine/carboxymethyl cellulose/polyacrylic acid adhesive hydrogels with UV-shielding capacity | |
| Deng et al. | Cellulose nanofibril as a crosslinker to reinforce the sodium alginate/chitosan hydrogels | |
| Qiao et al. | Preparation of printable double-network hydrogels with rapid self-healing and high elasticity based on hyaluronic acid for controlled drug release | |
| US8696975B2 (en) | Methods of making shaped polymeric materials | |
| Yeo et al. | Dual-crosslinked, self-healing and thermo-responsive methylcellulose/chitosan oligomer copolymer hydrogels | |
| CN111234108B (zh) | 一种可用于面膜的水凝胶材料制备方法 | |
| Liu et al. | A review on preparations, properties, and applications of cis-ortho-hydroxyl polysaccharides hydrogels crosslinked with borax | |
| Liu et al. | Preparation of gelatin/poly (γ-glutamic acid) hydrogels with stimulated response by hot-pressing preassembly and radiation crosslinking | |
| Wang et al. | Facile fabrication of self-healing, injectable and antimicrobial cationic guar gum hydrogel dressings driven by hydrogen bonds | |
| KR101816792B1 (ko) | 바이오셀룰로오스 미세섬유 수분산체 네트워크 조성물 | |
| KR20180058641A (ko) | 보습력이 우수한 하이드로겔 조성물 및 이를 이용한 시트 | |
| EP4019056A1 (en) | Method to produce in situ self-assembled multifunctional nanocomposite hydrogel and its uses thereof | |
| Tyliszczak et al. | Novel hydrogels containing nanosilver for biomedical applications-synthesis and characterization | |
| Guo et al. | Sulfonated, quaternized, and chlorogenic acid composited sodium alginate hydrogels/Eucommia ulmoides rubber films as in vitro antibacterial wound dressings for accelerating wound healing | |
| KR20170103628A (ko) | 셀룰로오스 나노섬유 수분산체 조성물 | |
| CN112121032A (zh) | 一种皮肤护理用水凝胶贴及其制备方法 | |
| Graça et al. | Reduced graphene oxide-enriched chitosan hydrogel/cellulose acetate-based nanofibers application in mild hyperthermia and skin regeneration | |
| Yi et al. | Bioinspired adhesive and self-healing bacterial cellulose hydrogels formed by a multiple dynamic crosslinking strategy for sealing hemostasis | |
| JP2009024274A (ja) | 含浸用シート及びそれを用いたウェットシート製品 | |
| Liu et al. | Research progress on antimicrobial hydrogel dressing for wound repair | |
| Shahriari et al. | Advances in self-healing hydrogels to repair tissue defects | |
| Yu et al. | Mussel-inspired chemistry in producing mechanically robust and bioactive hydrogels as skin dressings |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |