CN111229576A - Biological micro-cutting device based on flexible vibration reduction ultrasonic amplitude transformer - Google Patents
Biological micro-cutting device based on flexible vibration reduction ultrasonic amplitude transformer Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
- B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
- B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
- B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
- B06B1/06—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
- B06B1/0644—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element
- B06B1/0655—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element of cylindrical shape
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
- B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
- B06B3/00—Methods or apparatus specially adapted for transmitting mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
- B06B3/02—Methods or apparatus specially adapted for transmitting mechanical vibrations of infrasonic, sonic, or ultrasonic frequency involving a change of amplitude
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D1/00—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor
- B26D1/0006—Cutting members therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D5/00—Arrangements for operating and controlling machines or devices for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D5/08—Means for actuating the cutting member to effect the cut
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
- B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
- B06B2201/00—Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
- B06B2201/50—Application to a particular transducer type
- B06B2201/55—Piezoelectric transducer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
- B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
- B06B2201/00—Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
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Abstract
The invention discloses a biological microdissection device based on a flexible vibration-reduction ultrasonic amplitude transformer, which comprises an energy converter, the amplitude transformer, a connecting ring, a flexible mechanism and a cutting needle, wherein one shaft end of the amplitude transformer is connected with the energy converter, the other shaft end of the amplitude transformer penetrates through the connecting ring to be connected with the flexible mechanism, the amplitude transformer and the flexible mechanism are both connected with the connecting ring, and the cutting needle is connected with the flexible mechanism. The invention enables the whole device to work under longitudinal vibration frequency, avoids the disturbance of the needle point caused by other vibration modes, enables the vibration of the needle point to be more stable, and improves the cutting precision; by combining the flexible mechanism with the amplitude transformer, the transverse vibration can be inhibited in a smaller range, and the axial vibration can be amplified, so that the cutting precision and performance are improved; each group of flexible parts in the flexible mechanism adopts a circumferential array arrangement mode of four flexible hinges, so that stress is more uniformly distributed in four directions, and the inhibition effect on transverse vibration is further improved.
Description
Technical Field
The invention relates to the technical field of biomedicine, in particular to a biological microdissection device based on a flexible vibration reduction ultrasonic amplitude transformer.
Background
With the rapid development of modern biomedicine, the bio-piezoelectric ultrasonic cutting technology is more and more widely applied, and the cutting object of the biological tissue gradually evolves to more microscopic tumor tissue slices, single cells and the like from bone tissue in clinical medicine and pathological soft tissue in surgical operation, which puts high requirements on tools for cutting the biological tissue. In the process of micro-cutting of microscopic biological tissues, the key points and difficulties are mainly focused on how to precisely separate target tissues and reduce the damage to the tissues. The researchers have proposed a micro-cutting method by ultrasonic vibration, which utilizes piezoelectric ceramics to drive the cutting needle to do high-frequency axial vibration, and transmits the vibration energy to the part of the tissue contacted with the cutting needle, thereby causing the tissue mass points to be compressed and stretched alternately, and causing the pressure in the tissue to change rapidly. When this pressure change reaches a certain threshold, the structures inside the tissue are destroyed. When tissue cutting is performed, the high-frequency vibration of the needle tip can break the molecular bonds of the internal tissues of the microorganism, so that the cut target area is separated from the surrounding tissues. The method for cutting the target tissue by utilizing the ultrasonic vibration has the advantages of high precision, no radiation, low cost and the like, and is widely applied to cell membrane puncture and cutting of a pathological section target area at present.
The first research on the microdissection mechanism based on ultrasonic vibration in japan celebrity-ancient house university proposed a microdissection device vibrating in the Z direction, as shown in fig. 1(a), which consists of piezoelectric ceramics and a bent cutting needle, wherein the piezoelectric ceramics generates Z-direction high-frequency vibration, and the vibration energy is transmitted to a needle point through mechanical connection, so as to achieve the purpose of tissue cutting. The haerbin industry university and suzhou university also propose a piezoelectric ceramic advanced microdissection apparatus, as shown in fig. 1(b), which directly connects a piezoelectric ceramic to a cutting needle, effectively reducing loss during energy transfer, but the piezoelectric ceramic inevitably accompanies certain transverse vibration while generating axial vibration for cutting, the transverse vibration is amplified through the transmission of the cutting needle, the transverse vibration should be avoided to the utmost in cutting a micro tissue, the excessive transverse vibration causes reduction of cutting precision, the separation effect is deteriorated, and cell damage and even death can be caused in the cutting process of a living cell. At the same time, the axial vibration of the needle tip is the key to the cutting action, and when the axial vibration is increased, the transverse vibration is also increased.
Therefore, in view of the above technical problems, there is a need for a biological microdissection device capable of suppressing lateral vibration to a smaller extent without reducing axial vibration.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a biological microdissection device based on a flexible vibration reduction ultrasonic amplitude transformer.
In order to achieve the above object, an embodiment of the present invention provides the following technical solutions:
a biological micro-cutting device based on a flexible vibration reduction ultrasonic amplitude transformer comprises an energy converter, the amplitude transformer, a connecting ring, a flexible mechanism and a cutting needle, wherein one shaft end of the amplitude transformer is connected with the energy converter, the other shaft end of the amplitude transformer penetrates through the connecting ring to be connected with the flexible mechanism, the amplitude transformer and the flexible mechanism are connected with the connecting ring, and the cutting needle is connected with the flexible mechanism.
As a further improvement of the present invention, the flexible mechanism includes a hollow support seat, and a support rod partially extending into the support seat, the support seat is connected to the connection ring, at least one set of flexible members is connected between the outer circumferential surface of the support rod and the inner wall of the support seat, and each set of flexible members includes a plurality of flexible members.
As a further improvement of the invention, each group of flexible parts comprises four flexible parts which are uniformly arranged at intervals along the circumference of the supporting rod.
As a further improvement of the invention, the support seat is connected with a connecting plate, the connecting plate is annular, a plurality of first mounting holes are arranged on the connecting plate, and a plurality of first threaded holes are arranged at one axial end of the connecting ring.
As a further improvement of the invention, at least one through hole is arranged on the side wall of the supporting seat.
As a further improvement of the invention, the cutting needle partially extends into the supporting rod, at least one locking hole is arranged on the circumferential surface of the supporting rod, and the cutting needle is tightly propped against the at least one locking hole by screwing at least one set screw into the locking hole.
As a further improvement of the invention, the horn is a stepped horn.
As a further improvement of the invention, the horn comprises a first horn body and a second horn body which are connected, the outer diameter of the first horn body is smaller than that of the second horn body, the first horn body is in threaded connection with the flexible mechanism, and the second horn body is in threaded connection with the transducer.
As a further improvement of the invention, a transition fillet is arranged at the joint of the first luffing jib body and the second luffing jib body.
As a further improvement of the invention, a first cylinder is arranged at the free shaft end of the first amplitude variation rod body, a second cylinder is arranged at the free shaft end of the second amplitude variation rod body, the first cylinder is in threaded connection with the flexible mechanism, and the second cylinder is in threaded connection with the transducer.
The invention has the beneficial effects that:
(1) the invention enables the whole device to work under the longitudinal vibration frequency, avoids the needle point disturbance caused by other vibration modes, enables the needle point vibration to be more stable, and improves the cutting precision.
(2) Through the mode that combines together flexible mechanism and amplitude transformer, further restrained transverse vibration, can restrain transverse vibration in a less scope, can also amplify axial vibration simultaneously, improved biological microdissection precision, efficiency and performance.
(3) Each group of flexible components in the flexible mechanism adopts a circumferential array arrangement mode of four flexible hinges, so that stress is more uniformly distributed in four directions, and the inhibition effect on transverse vibration is further improved.
(4) The setting of go-between can improve the steadiness between flexible mechanism and the amplitude transformer for the axial vibration of amplitude transformer can be fast and accurate transmit to the flexible mechanism on, avoid the loss of axial vibration energy, and simultaneously, the go-between can be connected with the manipulator and drive the cutting needle and remove to waiting to cut biological tissue department, avoid being connected with the manipulator through flexible mechanism or amplitude transformer, avoid causing the destruction to the structure of flexible mechanism or amplitude transformer, further improve axial vibration and restrain transverse vibration, improve cutting accuracy and cutting efficiency.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1(a) is a schematic structural view of a prior art Z-direction vibrating microdissection device;
FIG. 1(b) is a schematic structural diagram of a prior art piezoelectric ceramic pre-stage microdissection device;
FIG. 2 is a schematic structural diagram of a preferred embodiment of the present invention;
FIG. 3 is a cross-sectional view of a preferred embodiment of the present invention;
FIG. 4 is a schematic structural view of the cutting needle, the flexible mechanism, the attachment ring and the horn connection of the preferred embodiment of the present invention;
FIG. 5 is a cross-sectional view of the cutting needle, the compliance mechanism, the attachment ring and the horn connection of the preferred embodiment of the present invention;
FIG. 6 is a schematic structural view of a compliant mechanism according to a preferred embodiment of the present invention;
FIG. 7 is a front view of the compliant mechanism of the preferred embodiment of the present invention;
FIG. 8 is a side view of a flexible mechanism of a preferred embodiment of the present invention;
FIG. 9 is a top view of the flexible mechanism of the preferred embodiment of the present invention;
FIG. 10 is a schematic view of the attachment ring of the preferred embodiment of the present invention;
FIG. 11 is a schematic structural diagram of a transducer in accordance with a preferred embodiment of the present invention;
FIG. 12 is a schematic view of the cutting apparatus of the preferred embodiment of the present invention;
in the figure: 1. transducer, 2, horn, 3, connecting ring, 4, flexible mechanism, 5, cutting pin, 6, first screw, 7, set screw, 8, second screw, 9, pre-stressed bolt, 101, first piezoelectric ceramic, 102, second piezoelectric ceramic, 103, first electrode plate, 104, second electrode plate, 105, front cover plate, 106, back cover plate, 107, insulating sleeve, 108, fourth threaded hole, 201, first horn body, 202, second horn body, 203, transition fillet, 204, support plate, 206, first cylinder, 207, second cylinder, 301, first threaded hole, 302, second threaded hole, 401, supporting seat, 402, strut, 403, flexible piece, 404, connecting plate, 405, first mounting hole, 406, reinforcing plate, 407, through hole, 408, locking hole, 409, receiving hole, 410, third threaded hole.
Detailed Description
In order to make those skilled in the art better understand the technical solution of the present invention, the technical solution in the embodiment of the present invention will be clearly and completely described below with reference to the drawings in the embodiment of the present invention, and it is obvious that the described embodiment is only a part of the embodiment of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in figure 2, the biological microdissection device based on the flexible vibration reduction ultrasonic amplitude transformer comprises a transducer 1, an amplitude transformer 2, a connecting ring 3, a flexible mechanism 4 and a cutting needle 5, wherein one shaft end of the amplitude transformer 2 is connected with the transducer 1, the other shaft end of the amplitude transformer 2 penetrates through the connecting ring 3 to be connected with the flexible mechanism 4, the amplitude transformer 2 and the flexible mechanism 4 are both connected with the connecting ring 3, and the cutting needle 5 is connected with the flexible mechanism 4.
As shown in fig. 6-9, the preferred flexible mechanism 4 of the present invention comprises a hollow support seat 401, a strut 402 partially extending into the support seat 401, the support seat 401 is connected to the connecting ring 3, at least one set of flexible members is connected between the outer circumferential surface of the strut 402 and the inner wall of the support seat 401, and each set of flexible members comprises a plurality of flexible members 403.
In this embodiment, each group of flexible parts includes four flexible parts 403, and the four flexible parts 403 are arranged at equal intervals along the circumference of the supporting rod 402, so that the stress is more uniformly distributed in four directions, and the suppression effect on the transverse vibration is further improved. In this embodiment, the flexible members 403 are arranged in three sets, and the three sets of flexible members are spaced apart along the axial direction of the strut 402. Further preferably, the flexible member 403 is a flexible hinge, which is a special kinematic pair that moves by means of elastic deformation of itself, and has the advantages of no gap, no friction, small volume, light weight, integrated design and processing, no assembly, high precision, and the like, and can further suppress transverse vibration.
As shown in fig. 3, 4, 5, and 10, in order to facilitate connection between the support base 401 and the connection ring 3, it is preferable that the support base 401 is connected with a connection plate 404, the connection plate 404 is annular, a plurality of first mounting holes 405 are formed in the connection plate 404, a plurality of first threaded holes 301 are formed in one axial end of the connection ring 3, and the connection plate 404 and the connection ring 3 are fixedly connected by screwing first screws 6 into the first threaded holes 301 through the first mounting holes 405. Further preferably, the number of the first mounting holes 405 and the number of the first threaded holes 301 are four, so as to improve the stability between the connecting plate 404 and the connecting ring 3.
In order to improve the stability between the support base 401 and the connection plate 404, it is preferable that a plurality of reinforcing plates 406 are connected between the support base 401 and the connection plate 404. It is further preferred that the number of reinforcing plates 406 is four.
In the present invention, at least one through hole 407 is preferably formed in the sidewall of the supporting seat 401, and the weight of the supporting seat 401 is reduced by the through hole 407, thereby facilitating axial vibration.
According to the invention, the cutting needle 5 partially extends into the supporting rod 402, the circumference of the supporting rod 402 is provided with at least one locking hole 408, and the cutting needle 5 is tightly pressed by screwing at least one set screw 7 into the at least one locking hole 408. In this embodiment, the number of the locking holes 408 and the number of the set screws 7 are two. In order to facilitate the insertion of the cutting needle 5 into the bar 402, it is preferred that the bar 402 be provided with a receiving hole 409, the receiving hole 409 being in communication with the locking hole 408. Further preferably, the cutting needle 5 is made of tungsten material, the diameter of the needle point of the cutting needle 5 is 1 μm, and the cutting precision is improved.
According to the invention, the amplitude transformer 2 is preferably a step-type amplitude transformer, so that the axial amplification factor is larger.
In this embodiment, the horn 2 includes a first horn body 201 and a second horn body 202 connected to each other, the outer diameter of the first horn body 201 is smaller than the outer diameter of the second horn body 202, the first horn body 201 is in threaded connection with the flexible mechanism 4, and the second horn body 202 is in threaded connection with the transducer 1.
In the invention, the transition fillet 203 is preferably arranged at the joint of the first amplitude transformer body 201 and the second amplitude transformer body 202, so that the amplitude transformer 2 is prevented from being broken due to stress concentration, and the service life of the amplitude transformer 2 is prolonged.
In order to facilitate the connection between the horn 2 and the connecting ring 3, it is preferable that the second horn 202 is provided with a support plate 204, the support plate 204 is annular, and the support plate 204 is connected with the connecting ring 3. Specifically, a plurality of second mounting holes (not shown in the figure) are formed in the support plate 204, a plurality of second threaded holes 302 are formed in the other shaft end of the connecting ring 3, and the support plate 204 and the connecting ring 3 are fixedly connected by screwing second screws 8 into the second threaded holes 302 through the second mounting holes.
According to the invention, the free axial end of the first luffing jib body 201 is preferably provided with a first cylinder 206, the free axial end of the second luffing jib body 202 is preferably provided with a second cylinder 207, the first cylinder 206 is in threaded connection with the flexible mechanism 4, and the second cylinder 207 is in threaded connection with the transducer 1.
As shown in fig. 11, the preferred transducer 1 of the present invention includes a first piezoelectric ceramic 101, a second piezoelectric ceramic 102, a first electrode piece 103, a second electrode piece 104, a front cover plate 105, and a rear cover plate 106, wherein the first electrode piece 103 is disposed between one axial end of the first piezoelectric ceramic 101 and one axial end of the second piezoelectric ceramic 102, the front cover plate 105 is disposed at the other axial end of the first piezoelectric ceramic 101, and the second electrode piece 104 is disposed between the other axial end of the second piezoelectric ceramic 102 and the rear cover plate 106. Preferably, the front cover plate 105 and the first piezoelectric ceramic 101, the first electrode pad 103 and the first piezoelectric ceramic, the first electrode pad 103 and the second piezoelectric ceramic 102, the second electrode pad 104 and the second piezoelectric ceramic 102, and the second electrode pad and the rear cover plate 106 are bonded to each other by epoxy resin.
Further preferably, a third threaded hole 410 is formed in the strut 402 of the flexible mechanism 4, a fourth threaded hole 108 is formed in the front cover plate 105 of the transducer 1, the first cylinder 206 is screwed in the third threaded hole 410, and the second cylinder 207 is screwed in the fourth threaded hole 108, so that the amplitude transformer 2 and the flexible mechanism 4, and the amplitude transformer 2 and the transducer 1 are stably connected.
It is further preferable that an insulating sleeve 107 is arranged in the first piezoelectric ceramic 101, the first electrode plate 103, the second piezoelectric ceramic 102 and the second electrode plate 104 in a penetrating manner, a prestressed bolt 9 penetrates through the rear cover plate 106 and the insulating sleeve 107 and is screwed into the front cover plate 105, and the front cover plate 105, the first piezoelectric ceramic 101, the first electrode plate 103, the second piezoelectric ceramic 102, the second electrode plate 104 and the rear cover plate 106 are fixed together through the prestressed bolt 9, so that the first piezoelectric ceramic 101 and the second piezoelectric ceramic 102 are prevented from being brittle. A fixed pretension can be applied to the prestressing bolt 9 by means of a side torque wrench.
In order to obtain a high front-rear vibration speed ratio and simultaneously consider the processing difficulty and cost, it is preferable that the front cover plate 105 is made of an aluminum alloy material and the rear cover plate 106 is made of a No. 45 steel material. Since micro-cutting is often a relatively rapid process, the cutting device works in a discontinuous state, and it is preferable that the first piezoelectric ceramic 101 and the second piezoelectric ceramic 102 both use PZT-4 type piezoelectric ceramics with higher piezoelectric constants and electromechanical coupling coefficients to obtain higher electromechanical conversion efficiency. Preferably, brass is used for the first electrode plate 103 and the second electrode plate 104.
According to the invention, the amplitude transformer 2, the connecting ring 3 and the flexible mechanism 4 are preferably processed from 316L stainless steel materials, so that the service lives of the amplitude transformer 2, the connecting ring 3 and the flexible mechanism 4 are prolonged.
As shown in fig. 12, a sample 11 to be cut is placed in the culture dish 10, a microscope 12 is disposed above the sample, the first electrode plate 103 and the second electrode plate 104 are connected to the driving source 13, and the connection ring 3 is connected to a manipulator, which can move the connection ring 3 without limiting the axial movement of the connection ring 3. The driving source 13 is turned on, the transducer 1 is started, the transducer 1 drives the amplitude transformer 2 to axially vibrate, the amplitude transformer is axially amplified and then transmitted to the flexible mechanism 4, and the flexible mechanism 4 drives the cutting needle 5 to cut the sample 11 to be cut.
The invention completes the validity verification of the device through simulation, and the specific realization is as follows:
the cutting device is designed according to 30Khz, and the amplitude transformer 2 is subjected to simulation analysis.
Modal analysis is carried out by using ansys workbench, the cutting device reaches longitudinal resonance frequency at 29.5Khz, and compared with 30Khz at design, the error is only 1.6%, and the experimental condition is met.
At this frequency, harmonic response analysis was performed on the compliant, damped horn cutting apparatus of the present invention.
First, the axial magnification of the cutting device is determined. The Full method is selected in an ansys workbench Harmonic Response module for solving, an axial sinusoidal displacement with the amplitude of 1 mu m is applied to the second amplitude transformer body 202 of the amplitude transformer 2, and after the amplitude transformer 2 amplifies the axial sinusoidal displacement, the axial output displacement amplitude of the needle tip of the cutting needle 5 is about 7.24 mu m. The axial magnification of the horn 2 is about 7.24.
Next, the flexible, shock absorbing horn cutting apparatus of the present invention was subjected to transverse vibration analysis. And observing the condition of transverse vibration when a certain needle point is axially output.
The simulation is based on this assumption: the drive source 13 generates 1 μm of axial vibration accompanied by 0.1 μm of lateral disturbance, which are in a 10-fold relationship.
Under this assumption, the following simulation results were obtained with constant parameter adjustment, as shown in table 1.
TABLE 1 transverse vibration of the cutting device at 29.5Khz with a certain axial displacement output
From the data in table 1, it can be seen that the cutting device of the present invention can obtain larger axial output energy with smaller input energy, and at the same time, the lateral vibration is suppressed in a smaller range, further improving the cutting precision.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. A biological micro-cutting device based on a flexible vibration reduction ultrasonic amplitude transformer is characterized by comprising an energy converter, the amplitude transformer, a connecting ring, a flexible mechanism and a cutting needle, wherein one shaft end of the amplitude transformer is connected with the energy converter, the other shaft end of the amplitude transformer penetrates through the connecting ring to be connected with the flexible mechanism, the amplitude transformer and the flexible mechanism are both connected with the connecting ring, and the cutting needle is connected with the flexible mechanism.
2. The flexible vibration-damping ultrasonic horn-based biological microdissection device as recited in claim 1, wherein the flexible mechanism comprises a hollow support seat, a support rod partially extending into the support seat, the support seat is connected with the connection ring, at least one set of flexible members is connected between the outer circumferential surface of the support rod and the inner wall of the support seat, and each set of flexible members comprises a plurality of flexible members.
3. The flexible vibration-damped ultrasonic horn-based biological microdissection device of claim 2 wherein each set of flexures includes four of said flexures spaced evenly along the circumference of said strut.
4. The flexible vibration-damping ultrasonic horn-based biological microdissection device as recited in claim 2, wherein the support base is connected with a connecting plate, the connecting plate is annular, a plurality of first mounting holes are formed in the connecting plate, and a plurality of first threaded holes are formed in one axial end of the connecting ring.
5. The flexible vibration-damping ultrasonic horn-based biological microdissection device as recited in claim 2, wherein at least one through hole is formed in a side wall of the support base.
6. The biological microdissection device based on the flexible vibration-damping ultrasonic horn as claimed in claim 2, wherein the cutting needle partially extends into the supporting rod, at least one locking hole is arranged on the circumferential surface of the supporting rod, and the cutting needle is tightly pressed against the at least one locking hole by screwing at least one set screw into the at least one locking hole.
7. The flexible vibration dampened ultrasonic horn-based biological microdissection device of any of claims 1-6, wherein said horn is a stepped horn.
8. The flexible vibration dampened ultrasonic horn-based biological microdissection device of claim 7, wherein said horn comprises a first horn body and a second horn body connected, the outer diameter of said first horn body being less than the outer diameter of said second horn body, said first horn body being threadably connected to said compliance mechanism, said second horn body being threadably connected to said transducer.
9. The flexible vibration damped ultrasonic horn-based biological microdissection device of claim 8, wherein the junction of said first horn body and said second horn body is provided with a transition fillet.
10. The flexible vibration damping ultrasonic horn-based biological microdissection device as recited in claim 8, wherein a first post is disposed at the free axial end of the first horn body, a second post is disposed at the free axial end of the second horn body, the first post is in threaded connection with the compliance mechanism, and the second post is in threaded connection with the transducer.
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