CN109988702A - A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design - Google Patents

A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design Download PDF

Info

Publication number
CN109988702A
CN109988702A CN201910391617.3A CN201910391617A CN109988702A CN 109988702 A CN109988702 A CN 109988702A CN 201910391617 A CN201910391617 A CN 201910391617A CN 109988702 A CN109988702 A CN 109988702A
Authority
CN
China
Prior art keywords
needle
injection
injection head
adaptation
modularized design
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910391617.3A
Other languages
Chinese (zh)
Inventor
黄海波
潘一帆
朱易辰
阎肃
陈立国
戴辞海
刘文齐
王亚飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou University
Original Assignee
Suzhou University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou University filed Critical Suzhou University
Priority to CN201910391617.3A priority Critical patent/CN109988702A/en
Publication of CN109988702A publication Critical patent/CN109988702A/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses a kind of piezoelectric supersonic microinjection devices of many types of syringe needle of adaptation of modularized design.The injection device includes the connecting rod for playing connection function, for providing the piezoelectric driving module of movement, it is connect with connecting rod and for providing the shell of accommodating space, the compliant mechanism of the movement of piezoelectric driving module generation is connect and is used to transmit with piezoelectric driving module, it is alternatively connect with compliant mechanism and multiple base modules for fixing injection needle, different base modules adapts to different types of injection needle.A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design provided by the embodiment of the present invention is using the design of replaceable base module, so that microinjection device can not only inhibit harmful oscillation crosswise in injection process, while compatible different types of injection needle.

Description

A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design
Technical field
The present invention relates to the technical fields of biomedical relevant surgical device, more particularly to a kind of modularized design It is adapted to the piezoelectric supersonic microinjection device of many types of syringe needle.
Background technique
With the fast development of modern biomedical, the application of biological cell microinjection is also more burning hot, such as transgenosis Biology, human assistance reproduction, bio-pharmaceuticals and clone technology etc..Microinjection is divided into three processes: rupture of membranes is injected and is moved back Needle.During rupture of membranes, since the object to be operated (eg. egg cell) is a fragile viscoelastic body, injection needle is inserted directly into Method can make cell that huge deformation occur, be easy to cause the damage of cytoskeleton and internal structure, cause to be injected cell Survival rate is low.Scientific research circle is directed to when microinjection how to reduce injury of the rupture of membranes in the process to cell, reduces injection vibration to thin Born of the same parents' bring influences, and makes a large amount of research.Scientists introduce ultrasonic piezo technology, during rupture of membranes, injection needle needle Point generate ultrasonic vibration, cell only need a very little deformation can smooth rupture of membranes, reduce in needle point insertion process to thin It is damaged caused by born of the same parents.Oscillation crosswise of the vibration of needle point comprising axial vibration and other directions along vibration axis direction, it is excessive Oscillation crosswise can increase the damage to cell.Therefore, how to inhibit oscillation crosswise is to further increase injection success rate and injection The key of cell survival rate afterwards.As shown in Fig. 1 (a), ultrasonic vibration generator designed by Connecticut, USA university, the device By piezoelectric ceramics, injection mironeedle and micropin fixed structure composition;The scheme of this piezoelectric ceramics postposition, so that energy is transmitted to Injection needle distance is longer, and the vibration transmission of long range can generate harmful oscillation crosswise, be easy to cause to damage to cell.Such as figure Shown in 1 (b), for the problems of ultrasonic vibration generator designed by University of Connecticut, University Of Suzhou Huang Haibo religion The design scheme for proposing that piezoelectric ceramics is preposition is awarded, the program improves energy by reducing the distance between piezoelectric ceramics and injection needle Transmission efficiency is measured, the unnecessary oscillation crosswise generated in vibration long range transmittance process is eliminated, reduces the damage to cell. Nowadays, the preposition scheme of piezoelectric ceramics is widely used, the commercial PiezoXpert pressure produced such as Eppendorf company Piezoelectric ceramics is directly connected with the metallic rod of fixed micropin by electric rupture of membranes instrument, and capacity usage ratio is high, can effectively carry out to cell Film drilling.
At the same time, in microinjection field, common injection needle includes staight needle and looper two types.In microinjection In the process, it is necessary first to fill the solution that DNA, sperm etc. are injected to injection needle.Since injection needle bore is superfine, It is very time-consuming that enough substances are drawn using direct absorption method.In order to accelerate experiment process, it will usually be injected solution and load on Injection needle tail end, by siphonage, solution slowly reaches injection needle tip, and siphonage compares direct completion method, greatly Reduce the loading time greatly.Staight needle can use siphonage quick load and largely inject solution, therefore be suitable for transgenosis work Journey, and staight needle is cheap, it is easy to make, it can be prepared in general laboratory, but staight needle is unfavorable under the microscope Focusing, it is cumbersome.Looper is not available siphonage and is loaded tank solution due to special construction, therefore looper is only applicable to only The scene of micro-injection solution, such as ICSI need to be drawn, and looper makes relative difficulty, needs special equipment, price is slightly expensive; But looper is convenient to focus under micro-vision, in rupture of membranes, injection is in same focal plane with cell always during the withdraw of the needle, It is easy to operate.
Although the prior art has been directed to microinjection device and has done many improvement, microscope equipment in the prior art Be designed just for a kind of injection needle (staight needle or looper), and the field that different injection needle (staight needle or looper) is applicable in Range is different, therefore, if needing to replace in entire microinjection device when carrying out different experiments Microinjections, increases Add cost and increases the difficulty used.Further, microinjection device design in the prior art excessively complexity and one Body, not only processing and assembly difficulty are big, processing cost is high, and since the service life of piezoelectric ceramics is limited, after being also unfavorable for Phase maintenance.
Therefore, in view of the above technical problems, it is necessary to which different injection needles and design can be selected according to application scenarios by providing Simply, be conducive to a kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design of later maintenance.
Summary of the invention
In view of this, being designed to provide for the embodiment of the present invention a kind of select different injection needles according to application scenarios and sets Count a kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design that is simple, being conducive to later maintenance.This Microinjection device provided by inventive embodiments based on modularized design is using replaceable injection pedestal design, so that micro- The compatible different types of injection needle of injection device can select the injection needle of suitable type according to scene.Further, of the invention Piezoelectric driving module and corresponding shell of the microinjection device using encapsulation provided by embodiment based on modularized design Module effectively improves the anti-interference ability of microscope equipment and the overall weight of alleviator and is conducive to dissipating for piezoelectric ceramics Heat.
To achieve the goals above, the technical solution that one embodiment of the invention provides is as follows: a kind of modularized design is fitted Piezoelectric supersonic microinjection device with many types of syringe needle, comprising: connecting rod, for playing the extension rod of connection function;Piezoelectric Driving Module is fixedly connected with the connecting rod, for providing the driving source of movement;Shell is connect with the connecting rod, is used for institute It states piezoelectric driving module and accommodating space is provided;Compliant mechanism is connect with the piezoelectric driving module, is driven for transmitting the piezoelectricity The movement that dynamic model block generates;Multiple base modules are alternatively connect with the compliant mechanism, and different pedestals is adapted to inhomogeneity The injection needle of type and for fixing and seal the injection needle.
As a further improvement of the present invention, the multiple base module includes staight needle pedestal and looper pedestal.
As a further improvement of the present invention, the staight needle pedestal includes: staight needle injection needle, the needle section of the injection needle It is linear;First injection head, including the interconnecting piece being connect with the compliant mechanism and for sealing the staight needle injection needle First sealing ring;Second injection head is connect with first injection head, close including second for sealing the staight needle injection needle Seal;Third injection head is connect with second injection head, for covering the staight needle pedestal;The staight needle injection needle passes through The injection needle passageway formed by first injection head, the second injection head and third injection head.
As a further improvement of the present invention, the looper pedestal includes: looper injection needle, the needle section of the injection needle For bending-like;First injection head, including the interconnecting piece being connect with the compliant mechanism and for sealing the looper injection needle First sealing ring;Second injection head is connect with first injection head, close including second for sealing the looper injection needle Seal;Third injection head is connect with second injection head, for covering the looper pedestal;The looper injection needle passes through The injection needle passageway formed by first injection head, the second injection head and third injection head.
As a further improvement of the present invention, the connection type of the interconnecting piece of the compliant mechanism and first injection head To be threadedly coupled.
As a further improvement of the present invention, the junction of the compliant mechanism and the base module is equipped with the second elasticity Part.
As a further improvement of the present invention, the junction of the compliant mechanism and the piezoelectric driving module is provided with the One elastic component.
As a further improvement of the present invention, the compliant mechanism uses one group of four columnar combined type triangle flexible hinge Chain mechanism.
As a further improvement of the present invention, each of described Composite Triangular shape flexure hinge mechanism triangle is flexible Linkage includes the first reed, the second reed and moving mass.
As a further improvement of the present invention, the angle of first reed and second reed is 90 degree.
The invention has the following advantages that
Microinjection device based on modularized design provided by the embodiment of the present invention uses packaged Piezoelectric Driving Module, exposed piezoelectric ceramics compared with prior art, has better anti-interference ability and stability is higher.Further, Microinjection device based on modularized design provided by the embodiment of the present invention uses one group of four columnar combined type triangle Flexure hinge mechanism can not only inhibit the oscillation crosswise in injection process well, also reduce the processing of multiple groups flexible hinge Difficulty and processing cost.Further, the microinjection device provided by the embodiment of the present invention based on modularized design uses Interchangeable base module, so that the same microinjection device can select the base of different type injection needle according to use occasion Seat module, has effectively widened the application range of microinjection device and has reduced experimentation cost, improves microinjection device Later maintenance.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this The some embodiments recorded in invention, for those of ordinary skill in the art, without creative efforts, It is also possible to obtain other drawings based on these drawings.
Fig. 1 (a) is the injection device structural schematic diagram of prior art piezoelectric ceramics postposition scheme;
Fig. 1 (b) is the injection device structural schematic diagram of the preposition scheme of prior art piezoelectric ceramics;
Fig. 2 is the structural schematic diagram (partially transparent figure and partial sectional view) of the microinjection device equipped with looper pedestal;
Fig. 3 is the schematic perspective view of compliant mechanism in Fig. 2;
Fig. 4 (a) is the main view of compliant mechanism in embodiment illustrated in fig. 3;
Fig. 4 (b) is the left view of compliant mechanism in embodiment illustrated in fig. 3;
Fig. 4 (c) is the top view of compliant mechanism in embodiment illustrated in fig. 3;
Fig. 4 (d) is the 3 dimensional drawing of compliant mechanism in embodiment illustrated in fig. 3;
Fig. 5 is the structural schematic diagram of the microinjection device equipped with staight needle pedestal;
Fig. 6 is the structural schematic diagram of the microinjection device equipped with looper pedestal;
Fig. 7 is the unassembled state that the microinjection device based on modularized design includes staight needle pedestal and looper pedestal Decomposition diagram.
Description of symbols in attached drawing:
100, injection device 1, connecting rod 2, shell
3, piezoelectric driving module 4, compliant mechanism 5, base module
6, the first injection head 7, the second injection head 8, third injection head
10, injection needle 101 ', staight needle needle section 101, looper needle section
21, the first elastic component 23, the second elastic component 51, the first sealing ring
53, the second sealing ring 41, the first reed 42, the second reed
43, moving mass 61, interconnecting piece
Specific embodiment
Technical solution in order to enable those skilled in the art to better understand the present invention, below in conjunction with of the invention real The attached drawing in example is applied, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common Technical staff's every other embodiment obtained without making creative work, all should belong to protection of the present invention Range.
Join shown in Fig. 2, first embodiment of the invention provides a kind of piezoelectric supersonic of many types of syringe needle of adaptation of modularized design Microinjection device 100.For the ease of showing the internal structure of microinjection device 100, microinjection device in Fig. 2 100 are shown in relation to base module 5 using transparent view, except the other parts of base module 5 are shown using cross-sectional view.A kind of module Changing the piezoelectric supersonic microinjection device 100 for being adapted to many types of syringe needle designed includes: the connecting rod 1 for playing connection function, with Connecting rod 1 is fixedly connected and the piezoelectric driving module 3 of the driving source for providing movement, connect and is used for pressure with connecting rod 1 Electric drive module 3 provides the shell 2 of accommodating space, connect with piezoelectric driving module and produces for transmitting the piezoelectric driving module The compliant mechanism 4 of raw movement, the multiple base modules 5 alternatively being connect with the compliant mechanism 4.Different base modules 5 are adapted to different types of injection needle 10 and for fixing injection needle 10.
Referring to shown in Fig. 3 and Fig. 4 (a) to 4 (d), compliant mechanism 4 is columnar compound using one group four in the embodiment of the present invention Formula triangle flexure hinge mechanism.Flexible hinge is a kind of peculair motion pair that displacement is generated using the flexible deformation of material, tool Whether there is or not friction, gapless, easy to maintain, high resolution and can integration processing the advantages that.The classification of the flexible hinge on basis is main There are four types of: straight beam type, straight round, ellipse and delta-type.Triangle (reed-type) flexible hinge makes up to a certain extent Common gap formula hinge stroke short defect, and the hunt effect that this flexible hinge generates can lead in entire mechanism Crossing reasonable structure design makes global error be reduced to minimum, the running precision for the flexible hinge that increased.Triangular hinge tool Have that stroke is big, Static positioning accuracy is high, axis floats the excellent static characteristic such as small.It includes two triangles that the embodiment of the present invention, which uses, The combined type triangular hinge that hinge is spliced.This combined type triangle not only has stroke big, Static positioning accuracy High, axis floats the excellent static characteristic such as small, while increasing the stability of mechanism again, plays and leads to the axial vibration of injection needle To effect, the precision of injection is improved.
In this embodiment, using one group of four columnar combined type triangle flexure hinge mechanism.It is compound in compliant mechanism 4 Each of triangle flexure hinge mechanism triangle flexure hinge mechanism includes the first reed 401, the second reed 402 and fortune Motion block 403.Angle between first reed 401 and the second reed 402 is preferably 90 degree.The material of triangle compliant mechanism is not Become rusty steel and elasticity modulus is more than or equal to 200Gpa.The embodiment of the present invention is only with one group of four columnar combined type triangle flexible hinge Chain mechanism can not only inhibit the oscillation crosswise in injection process well, also reduce multiple groups flexible hinge processing difficulty and Processing cost.
Referring to figure 5 and figure 6, the respectively structural schematic diagram and looper pedestal of the microinjection device equipped with staight needle pedestal The structural schematic diagram of microinjection device.In this embodiment, multiple base modules include staight needle pedestal and looper pedestal.Staight needle Pedestal and looper pedestal are alternatively connect with compliant mechanism 4 respectively, and microinjection device 100 can select straight according to application Needle pedestal or looper pedestal.
As shown in figure 5, staight needle pedestal includes staight needle injection needle 10, the first injection head 6, the second injection head 7 and third injection First 8, the first injection head 6, the second injection head 7 and third injection head 8 form an injection needle passageway so that staight needle injection needle 10 is worn It crosses.As shown in fig. 6, the needle section 101 ' of staight needle injection needle 10 is linear.First injection head 6 includes connecting with compliant mechanism 4 Interconnecting piece (not shown in Fig. 5) and the first sealing ring 51 for sealing staight needle injection needle 10.Second injection head 7 and the first note First 6 connection is penetrated, the second injection head 7 includes the second sealing ring 53 for sealing staight needle injection needle 10.Third injection head 8 and second Injection head 7 connects, and third injection head 8 is the capping with central through hole, for covering staight needle pedestal 5.First sealing ring, 51 He Second sealing ring 53 is specially 0 type sealing ring, and material can be using rubber, silica gel, elastic metallic etc..First sealing ring 51 and On the one hand two sealing rings 53 play fixed function, on the other hand seal.
In the invention, the number of similar functions component in Fig. 6 is unified with Fig. 5 phase.As shown in fig. 6, looper pedestal packet Include looper injection needle 10, the first injection head 6, the second injection head 7 and third injection head 8, the first injection head 6, the second injection head 7 and Third injection head 8 forms an injection needle passageway so that looper injection needle 10 passes through.As shown in fig. 6, the needle of looper injection needle 10 Head 101 is bending-like.The range of the bending angle of needle section 101 is 25 degree to 30 degree.In this embodiment, bending angle is adopted With 30 degree.First injection head 6 includes the interconnecting piece 61 (as shown in Figure 2) connecting with compliant mechanism 4 and injects for sealing looper First sealing ring 51 of needle 10.Second injection head 7 is connect with the first injection head 6, and the second injection head 7 includes for sealing looper note Penetrate the second sealing ring 53 of needle 10.Third injection head 8 is connect with the second injection head 7, and third injection head 8 is with central through hole Capping, for covering staight needle pedestal 5.First sealing ring 51 and the second sealing ring 53 are specially O-ring seal, and material can use Rubber, silica gel, elastic metallic etc..On the one hand first sealing ring 51 and the second sealing ring 53 play fixed function, on the other hand rise close Envelope effect.
As shown in fig. 7, the microinjection device 100 based on modularized design include multiple and different base modules 5 without Decomposition diagram with state.Multiple and different base modules 5 is respectively staight needle pedestal shown in fig. 5 and looper shown in fig. 6 Pedestal.Microinjection device 100 based on modularized design uses interchangeable base module 5, so that the same microinjection Device can select the base module 5 of different type injection needle according to use occasion, effectively widen microinjection device Application range and the later maintenance for reducing experimentation cost, improving microinjection device.When selecting different base modules, The other parts of microinjection device 100 can share, and be effectively reduced cost.
In this embodiment, compliant mechanism 4 is to be threadedly coupled with the connection type of the interconnecting piece 61 of the first injection head 6.For The junction of elimination thread pitch and increased unstability, compliant mechanism 4 and base module 5 is equipped with the second elastic component 23. Second elastic component 23 can specifically use spring washer.Elastic washer is not solved only effectively by flexible deformation and locking effect The instability problem certainly introduced due to thread pitch is also improved the effect for inhibiting oscillation crosswise, can preferably fastened Microinjection device 100.
In this embodiment, piezoelectric driving module 3 is packaged piezoelectric ceramics, compared to the prior art exposed piezoelectricity Ceramics, have better anti-interference ability and stability is higher.Connection type between piezoelectric driving module 3 and compliant mechanism 4 To be threadedly coupled.In order to eliminate thread pitch and increased unstability, the junction of compliant mechanism 4 and piezoelectric driving module 3 It is provided with the first elastic component 21.First elastic component 21 can specifically use spring washer.Elastic washer passes through flexible deformation and lock It is set for using, not only efficiently solves the instability problem introduced due to thread pitch, also improve and inhibit oscillation crosswise Effect can preferably fasten microinjection device 100.
Shell 2 is formed with accommodating space, and piezoelectric driving module 3 is placed in the accommodating space.In this embodiment, shell 2 It is not direct to be connected with piezoelectric driving module 3.Shown in referring to figure 5 and figure 6, shell 2 rejects part unnecessary portion (i.e. cylinder The part of upper hollow out), to mitigate the overall weight of microinjection device 100, and be conducive to piezoelectric driving module 3 heat dissipation and Increase the service life of piezoelectric driving module 3.
Injection device 100 provided by the embodiment of the present invention is ined succession a piezoelectric driving module 3 on connecting rod 1;Pressure Electric drive module 3 is connected directly with compliant mechanism 4, passes motion to compliant mechanism 4;Movement by the filtering of compliant mechanism 4, Balance passes to the base module 5 of front;For the ease of being applicable in different scenes, base module 5 has multiple and alternatively It is connected with compliant mechanism 4.
Microinjection device based on modularized design provided by the embodiment of the present invention uses packaged Piezoelectric Driving Module, exposed piezoelectric ceramics compared with prior art, has better anti-interference ability and stability is higher.
Microinjection device based on modularized design provided by the embodiment of the present invention is columnar compound using one group four Formula triangle flexure hinge mechanism can not only inhibit the oscillation crosswise in injection process well, also reduce multiple groups flexible hinge The difficulty and processing cost of chain processing.
Microinjection device based on modularized design provided by the embodiment of the present invention uses interchangeable base module, So that the same microinjection device can select the base module of different type injection needle according to use occasion, effectively widen The application range of microinjection device and the later maintenance for reducing experimentation cost, improving microinjection device
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiments being understood that.

Claims (10)

1. a kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design, which is characterized in that described micro- Injection device includes:
Connecting rod, for playing the extension rod of connection function;
Piezoelectric driving module is fixedly connected with the connecting rod, for providing the driving source of movement;
Shell is connect with the connecting rod, for providing accommodating space to the piezoelectric driving module;
Compliant mechanism is connect with the piezoelectric driving module, the movement generated for transmitting the piezoelectric driving module;
Multiple base modules are alternatively connect with the compliant mechanism, different pedestal be adapted to different types of injection needle and For fixing the injection needle.
2. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 1, special Sign is that the multiple base module includes staight needle pedestal and looper pedestal.
3. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 2, special Sign is that the staight needle pedestal includes:
Staight needle injection needle, the needle section of the injection needle are linear;
First injection head, first including the interconnecting piece connecting with the compliant mechanism and for sealing the staight needle injection needle are close Seal;
Second injection head is connect with first injection head, including the second sealing ring for sealing the staight needle injection needle;
Third injection head is connect with second injection head, for covering the staight needle pedestal;
The staight needle injection needle is passed through to be led to by the injection needle that first injection head, the second injection head and third injection head are formed Road.
4. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 2, special Sign is that the looper pedestal includes:
Looper injection needle, the needle section of the injection needle are bending-like;
First injection head, first including the interconnecting piece connecting with the compliant mechanism and for sealing the looper injection needle are close Seal;
Second injection head is connect with first injection head, including the second sealing ring for sealing the looper injection needle;
Third injection head is connect with second injection head, for covering the looper pedestal;
The looper injection needle is passed through to be led to by the injection needle that first injection head, the second injection head and third injection head are formed Road.
5. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 3 or 4, It is characterized in that, the compliant mechanism is to be threadedly coupled with the connection type of the interconnecting piece of first injection head.
6. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 3 or 4, It is characterized in that, the junction of the compliant mechanism and the base module is equipped with the second elastic component.
7. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 1, special Sign is that the junction of the compliant mechanism and the piezoelectric driving module is provided with the first elastic component.
8. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 1, special Sign is that the compliant mechanism uses one group of four columnar combined type triangle flexure hinge mechanism.
9. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 8, special Sign is, each of described Composite Triangular shape flexure hinge mechanism triangle flexure hinge mechanism includes the first reed, the Two reeds and moving mass.
10. the piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design according to claim 6, special Sign is that the angle of first reed and second reed is 90 degree.
CN201910391617.3A 2019-05-10 2019-05-10 A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design Pending CN109988702A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910391617.3A CN109988702A (en) 2019-05-10 2019-05-10 A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910391617.3A CN109988702A (en) 2019-05-10 2019-05-10 A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design

Publications (1)

Publication Number Publication Date
CN109988702A true CN109988702A (en) 2019-07-09

Family

ID=67136406

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910391617.3A Pending CN109988702A (en) 2019-05-10 2019-05-10 A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design

Country Status (1)

Country Link
CN (1) CN109988702A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111229576A (en) * 2020-01-19 2020-06-05 苏州大学 Biological micro-cutting device based on flexible vibration reduction ultrasonic amplitude transformer
CN113107959A (en) * 2021-04-12 2021-07-13 齐鲁工业大学 Spiral flexible hinge
CN114369516A (en) * 2021-12-27 2022-04-19 华南理工大学 Membrane puncturing device based on piezoelectric superstructure strong-modal damping compliant guide mechanism

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104109629A (en) * 2014-07-30 2014-10-22 苏州大学 Piezoelectric ultrasonic microinjector and piezoelectric ultrasonic microinjection system
CN108330061A (en) * 2018-05-14 2018-07-27 苏州大学张家港工业技术研究院 Piezoelectric supersonic microinjection device based on flexure hinge mechanism
CN208003194U (en) * 2017-08-28 2018-10-26 黄扬富 A kind of medical fixed-quantity injector
CN108893248A (en) * 2018-06-12 2018-11-27 苏州大学张家港工业技术研究院 Piezoelectric supersonic microinjector
CN109207343A (en) * 2018-08-24 2019-01-15 苏州大学 A kind of cell microinjection device based on triangle compliant mechanism
CN210736725U (en) * 2019-05-10 2020-06-12 苏州大学 Piezoelectric ultrasonic microinjection device adaptive to multiple needles and designed in modular mode

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104109629A (en) * 2014-07-30 2014-10-22 苏州大学 Piezoelectric ultrasonic microinjector and piezoelectric ultrasonic microinjection system
CN208003194U (en) * 2017-08-28 2018-10-26 黄扬富 A kind of medical fixed-quantity injector
CN108330061A (en) * 2018-05-14 2018-07-27 苏州大学张家港工业技术研究院 Piezoelectric supersonic microinjection device based on flexure hinge mechanism
CN108893248A (en) * 2018-06-12 2018-11-27 苏州大学张家港工业技术研究院 Piezoelectric supersonic microinjector
CN109207343A (en) * 2018-08-24 2019-01-15 苏州大学 A kind of cell microinjection device based on triangle compliant mechanism
CN210736725U (en) * 2019-05-10 2020-06-12 苏州大学 Piezoelectric ultrasonic microinjection device adaptive to multiple needles and designed in modular mode

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111229576A (en) * 2020-01-19 2020-06-05 苏州大学 Biological micro-cutting device based on flexible vibration reduction ultrasonic amplitude transformer
CN113107959A (en) * 2021-04-12 2021-07-13 齐鲁工业大学 Spiral flexible hinge
CN114369516A (en) * 2021-12-27 2022-04-19 华南理工大学 Membrane puncturing device based on piezoelectric superstructure strong-modal damping compliant guide mechanism
CN114369516B (en) * 2021-12-27 2023-12-22 华南理工大学 Film puncturing device based on piezoelectric superstructure strong modal damping compliant guide mechanism

Similar Documents

Publication Publication Date Title
CN109988702A (en) A kind of piezoelectric supersonic microinjection device of many types of syringe needle of adaptation of modularized design
US20190353507A1 (en) Two-dimensional three-degree-of-freedom micro-motion platform structure for high-precision positioning and measurement
CN108330061B (en) Piezoelectric ultrasonic microinjection device based on flexible hinge mechanism
CN102642611A (en) Actively deformed stressed-skin structure based on pneumatic muscles
CN109909990A (en) Insertion type software mechanical arm for internal medicine operation
CN109639088A (en) A kind of compound source energy collector that declines of electromagnetism-piezoelectricity-magnetostriction
CN210736725U (en) Piezoelectric ultrasonic microinjection device adaptive to multiple needles and designed in modular mode
CN109207343A (en) A kind of cell microinjection device based on triangle compliant mechanism
Shih et al. Design and ballistic performance of hybrid plates manufactured from aramid composites for developing multilayered armor systems
CN105515441A (en) Vibration active control platform based on piezoelectric crude fiber composite material and method thereof
CN108893248A (en) Piezoelectric supersonic microinjector
CN209113862U (en) A kind of cell microinjection device based on triangle compliant mechanism
CN201059506Y (en) LED lamp with current-limiting resistance
Yan et al. Cell microinjection device suitable for curved needle based on triangular flexible mechanism
Morara et al. Solving XCSP problems by using Gecode
CN201478685U (en) Array microchip laser structure
CN109307932A (en) A kind of fibre-optic scanner
Qiao et al. Beam collimation and focusing and error analysis of LD and fiber coupling system based on ZEMAX
CN205112082U (en) Optic fibre ceramic bushing mould
CN111229576A (en) Biological micro-cutting device based on flexible vibration reduction ultrasonic amplitude transformer
CN202119983U (en) Large power semiconductor laser array light beam aligning apparatus
Dong et al. Effects of Different Surface Treatment Processes on Bonding Properties of Aluminum Alloys under Full Temperature Field Environment
CN102076173B (en) Clamp for printed circuit board
CN206369836U (en) A kind of high-power 450nm LASER Excited Fluorescences light source of fiber coupling
CN201297575Y (en) Multi-source and multi-point displaying light guide structure

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information
CB03 Change of inventor or designer information

Inventor after: Liu Wenqi

Inventor after: Pan Yifan

Inventor after: Huang Haibo

Inventor after: Wang Yafei

Inventor after: Zhu Yichen

Inventor after: Yan Su

Inventor after: Chen Liguo

Inventor after: Dai Cihai

Inventor before: Huang Haibo

Inventor before: Pan Yifan

Inventor before: Zhu Yichen

Inventor before: Yan Su

Inventor before: Chen Liguo

Inventor before: Dai Cihai

Inventor before: Liu Wenqi

Inventor before: Wang Yafei