CN111228331A - Skin burn and scald wound repairing preparation and preparation method thereof - Google Patents
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Abstract
The invention belongs to the technical field of medical products and preparation processes thereof, and discloses a skin burn and scald wound repairing preparation and a preparation method thereof. The repairing preparation is prepared by mixing various materials with anti-inflammatory and analgesic effects and abundant sources for repairing skin wound. The repair preparation for the skin burn and scald wound surface is an external preparation, can quickly freeze surface nerves when contacting the skin wound surface so as to achieve the effect of relieving pain, is matched with other raw materials with bacteriostasis and disinfection effects, and has the functions of repairing, rebuilding, relieving and quickly healing the skin wound surface under the synergistic effect of the raw materials with extremely strong repair capacity. The external application method is high-efficiency and safe, ensures no scab and no scar. The preparation method has the advantages of simple operation process, less operation equipment, low requirement on operators, moderate cost, safety and reliability.
Description
Technical Field
The invention belongs to the technical field of medical products and preparation processes thereof, and particularly relates to a skin burn and scald wound repairing preparation and a preparation method thereof.
Background
Burns and scalds are injuries caused by external factors such as boiling water (oil), fire, light, radiation or chemical substances, including skin mucosa injuries, serious injuries to subcutaneous tissues can occur, and the burns and scalds are one of the most common and extremely complex trauma diseases which occur in battlefields, fire fighting, mines, factories and various natural disasters and daily work and life. If not properly handled, adverse consequences can result.
The severity of burn and scald is mainly judged according to the position, area and depth of the burn and scald, and generally divided into three degrees according to the depth of the burn and scald:
first-degree burn and scald: only the epidermis layer is injured, and the injured skin is reddened and swollen, has strong pain feeling and does not have blisters;
second degree burn and scald: damage to the dermis, local red swelling, fever, severe pain and obvious blisters;
three-degree burn and scald: the whole skin including subcutaneous fat, bone and muscle are damaged, the skin is scorched and necrotic, and the pain is not severe because nerves are damaged.
At present, a lot of medicines for treating burns and scalds exist, and a lot of patents and documents exist, namely, medicines and treatment measures for treating burns and scalds mainly based on western medicine, wherein the western medicine treatment is to clean (namely debridement) wound surfaces, treat and disinfect necrotic muscle tissues of the wounds and then wrap the wounds. Western medicine does not advocate the application of drugs on the wound surface, mainly takes internal drugs (such as anti-inflammatory and analgesic drugs), and the method looks scientific, has not ideal actual effect and is expensive. While the theoretical literatures and patents of traditional Chinese medicine for external treatment of burns and scalds in China are disclosed and published in large quantities, new dosage forms are continuously appeared, such as: "Longhu Shaoshangshang oil"; concentrated suspension and liquid agent, such as Jinyusan solvent, Huzhang scald liquid, etc., ointment, Huanglian ointment; tincture named FUQIPING tincture; powder, ulcer powder; the film agent is a compound rhubarb burn medicine film. (Guoshi, et al, the progress of burn treatment with external traditional Chinese medicine preparation, vol. 13, 4, in 2004, 8 months in traditional Chinese medicine J for external treatment). The medicines have long healing time and high price in different degrees, and scars can be left after healing. For example, the Chinese patent application No. 95110884.0 discloses a Chinese medicine for treating burns and scalds, which is powder prepared from more than ten Chinese herbal medicines such as centipede, raw scorpion, sky-blueness, angelica dahurica, coptis root and the like, but the using procedure is complex, the best effect is difficult to achieve if the Chinese patent application No. 95110884.0 is not properly prepared for patients, the use is troublesome, the treatment effect is poor, and the treatment time is long, so that a preparation which can quickly relieve pain of the burn and scald wound surface, can diminish inflammation and inhibit bacteria, quickly and effectively repairs the skin of the wound surface, can heal the wound surface in a short time, does not leave scars after healing and has high.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide a skin burn and scald wound repair preparation and a preparation method thereof.
The technical scheme adopted by the invention is as follows: the skin burn and scald wound repair preparation is prepared from the following raw materials in parts by mass:
1-10 parts of surface dry cell activating factor, 1-6 parts of peppermint oil, 1400 parts of diluent 300 and 10-50 parts of solvent;
preferably, the wound repair preparation is prepared from the following raw materials in parts by mass:
3-8 parts of surface dry cell activating factor, 2-5 parts of peppermint oil, 1100 parts of diluent 500-.
Preferably, the wound repair preparation is prepared from the following raw materials in parts by mass:
5 parts of surface dry cell activating factor, 3 parts of peppermint oil, 700 parts of diluent and 28 parts of solvent.
The surface stem cell activating factor (Phycoscharide AI) can promote EGF to be combined with an EGFR receptor, thereby enhancing the activity of epidermal adult stem cells, improving the continuous aging mobilization ability of aged epidermal adult stem cells, activating the epidermal stem cells, and having the effects of repairing and reconstructing skin wound surfaces, resisting inflammation, relieving and rapidly healing skin wound surfaces.
Peppermint oil (Mentha arbensis oil), a clear liquid that is colorless or pale yellow. Has special cool fragrance, pungent taste and cool aftertaste. Has effects of refreshing, relieving pain, diminishing inflammation, and sterilizing, especially has special effects of relieving inflammation and relieving pain on skin wound, and can promote pain of body when used due to effect of menthol on central nervous system.
The repair preparation for the skin burn and scald wound surface is prepared by mixing various materials with anti-inflammation and analgesic effects and rich sources for repairing the skin wound surface. The repair preparation for the skin burn and scald wound surface is an external preparation, can quickly freeze surface nerves when contacting the skin wound surface so as to achieve the effect of relieving pain, is matched with other raw materials with bacteriostasis and disinfection effects, and has the functions of repairing, rebuilding, relieving and quickly healing the skin wound surface under the synergistic effect of the raw materials with extremely strong repair capacity.
Preferably, the diluent comprises pure water,
preferably, the pure water comprises distilled water,
further preferably, the distilled water comprises redistilled water and/or triple distilled water.
The reason why the primary distilled water and the multiple distilled water are selected as the diluents in the provided skin burn and scald wound repairing preparation is that the distilled water has the function of hypotonic effect in the pharmaceutical industry. The distilled water is used for washing the wound, so that cells such as tumor and the like possibly remaining on the wound surface can absorb water to swell, crack, necrose and lose activity, and further the cells such as tumor and the like are prevented from continuously growing on the wound surface.
Preferably, the solvent comprises a water-soluble solvent,
preferably, the water-soluble solvent comprises ethanol,
further preferably, the ethanol concentration is 70-95% by volume, preferably 75-90%.
The ethanol with a certain concentration is selected as a solvent in the provided repair preparation for the skin burn and scald wound surface, and 70-75% of alcohol in volume ratio is commonly used for disinfection, wherein the alcohol with too high concentration can form a protective film on the surface of bacteria to prevent the bacteria from entering the bacteria body, so that the bacteria are difficult to kill thoroughly. If the alcohol concentration is too low, the bacteria can enter, but the protein in the body can not be coagulated, and the bacteria can not be killed completely.
Preferably, the wound repair preparation is an external preparation.
Preferably, the external preparation comprises one or more of a gel, a spray and an aerosol.
The skin burn and scald wound repair preparation is used for treating the skin wound in an external mode, the repair preparation is directly contacted with the wound, the treatment duration is reduced, the healing efficiency is improved, the preparation is efficient and safe, and therefore the skin wound is prevented from scabbing and scars after healing are prevented.
A preparation method of a skin burn and scald wound repairing preparation comprises the steps of selecting peppermint oil and a solvent according to a corresponding proportion, stirring, adding a diluent according to a corresponding proportion, stirring uniformly, adding a epidermal stem cell activating factor according to a corresponding proportion, and stirring uniformly to obtain a finished product.
The preparation method of the skin burn and scald wound repair preparation has the advantages that the preparation method is simple and convenient in operation process, few in operation equipment, low in requirement on operators, moderate in cost, safe and reliable on the basis of maximally fusing and well storing the active ingredients of the raw materials after finely selecting the raw materials.
Preferably, the mixing is performed in a sterile environment while the peppermint oil and the solvent are selected for stirring;
preferably, the stirring time is 8 to 25 minutes, preferably 10 to 22 minutes, and further preferably 15 minutes;
preferably, the stirring temperature is 20 to 35 degrees celsius, preferably 22 to 30 degrees celsius, and more preferably 25 degrees celsius.
Preferably, the time length of uniformly mixing by adding the diluent in a corresponding proportion is 5-20 minutes, preferably 8-16 minutes, and further preferably 10 minutes;
preferably, the temperature for adding the diluent in the corresponding proportion and stirring uniformly is 20-35 ℃, preferably 22-30 ℃, and further preferably 25 ℃.
Preferably, the period of uniformly stirring the epidermal stem cell activating factors in a corresponding proportion is 7-25 minutes, preferably 9-18 minutes, and further preferably 12 minutes;
preferably, the temperature for uniformly mixing the epidermal stem cell activating factors in corresponding proportion is 20-35 ℃, preferably 22-30 ℃, and further preferably 25 ℃.
The preparation method of the skin burn and scald wound repair preparation is characterized in that the stirring time and temperature are set, so that the solvent and medicinal ingredients in the medicinal materials are maximally saturated in limited time of various raw materials, and the solvent and the selected Chinese medicinal materials can be fully acted under the condition of the ratio of the solvent to the total mass of all the medicinal materials, so that the efficient fusion of the effective ingredients is promoted.
The invention has the beneficial effects that:
the invention provides a repair preparation for skin burn and scald wound surfaces, which is prepared by mixing various materials with anti-inflammation and analgesic effects and rich sources for repairing skin wound surfaces. The repair preparation for the skin burn and scald wound surface is an external preparation, can quickly freeze surface nerves when contacting the skin wound surface so as to achieve the effect of relieving pain, is matched with other raw materials with bacteriostasis and disinfection effects, and has the functions of repairing, rebuilding, relieving and quickly healing the skin wound surface under the synergistic effect of the raw materials with extremely strong repair capacity. The repair preparation treats the skin wound surface in an external mode, is directly contacted with the wound surface, reduces the treatment duration, improves the healing efficiency, is efficient and safe, and further ensures that the skin wound surface does not scab and leaves no scar after healing. The preparation method of the repairing preparation has the advantages of simple and direct operation process, less operation equipment, low requirement on operators, moderate cost, safety and reliability on the basis of maximally fusing and well storing the effective components of the raw materials after finely selecting the materials.
Detailed Description
The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples were carried out under the conventional conditions, unless otherwise specified. The reagents used are all conventional products which are commercially available.
Example 1:
selecting 10 g of peppermint oil and 200 g of 70% ethanol according to corresponding proportion, stirring for 8 minutes in a sterile environment at 20-22 ℃, adding 3000 g of distilled water according to corresponding proportion, stirring for 5 minutes at 20-22 ℃ until the mixture is uniform, adding 10 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 7 minutes at 20-22 ℃ until the mixture is uniform to obtain a finished product.
Example 2:
selecting 10 g of peppermint oil and 200 g of 70% ethanol according to corresponding proportion, stirring for 25 minutes in a sterile environment at the temperature of 33-35 ℃, adding 3000 g of distilled water according to corresponding proportion, stirring for 20 minutes to be uniform at the temperature of 33-35 ℃, adding 10 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 25 minutes to be uniform at the temperature of 33-35 ℃ to obtain a finished product.
Example 3:
selecting 60 g of peppermint oil and 500 g of 70% ethanol according to corresponding proportion, stirring for 8 minutes in an aseptic environment at 20-22 ℃, adding 14000 g of redistilled water according to corresponding proportion, stirring for 5 minutes at 20-22 ℃ until the mixture is uniform, adding 100 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 7 minutes at 20-22 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 4:
selecting 60 g of peppermint oil and 500 g of 70% ethanol according to corresponding proportion, stirring for 25 minutes in a sterile environment at the temperature of 33-35 ℃, adding 14000 g of redistilled water according to corresponding proportion, stirring for 20 minutes to be uniform at the temperature of 33-35 ℃, adding 100 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 25 minutes to be uniform at the temperature of 33-35 ℃ to obtain a finished product.
Example 5:
selecting 20g of peppermint oil and 200 g of 75% ethanol according to corresponding proportion, stirring for 10 minutes in a sterile environment at the temperature of 22-25 ℃, adding 5000 g of triple-distilled water according to corresponding proportion, stirring for 8 minutes at the temperature of 22-25 ℃ until the mixture is uniform, adding 30 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 9 minutes at the temperature of 22-25 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 6:
selecting 20g of peppermint oil and 200 g of 75% ethanol according to corresponding proportion, stirring for 22 minutes in a sterile environment at 28-30 ℃, adding 5000 g of triple-distilled water according to corresponding proportion, stirring for 16 minutes at 28-30 ℃ until the mixture is uniform, adding 30 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 18 minutes at 28-30 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 7:
selecting 50 g of peppermint oil and 350 g of 75% ethanol according to corresponding proportion, stirring for 10 minutes in a sterile environment at 22-25 ℃, adding 11000 g of triple distilled water according to corresponding proportion, stirring for 8 minutes at 22-25 ℃ until the mixture is uniform, adding 80 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 9 minutes at 22-25 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 8:
selecting 50 g of peppermint oil and 350 g of 75% ethanol according to corresponding proportion, stirring for 22 minutes in a sterile environment at 28-30 ℃, adding 11000 g of triple distilled water according to corresponding proportion, stirring for 16 minutes at 28-30 ℃ until the mixture is uniform, adding 80 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 18 minutes at 28-30 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 9:
selecting 50 g of peppermint oil and 350 g of 90% ethanol according to corresponding proportion, stirring for 10 minutes in a sterile environment at 22-25 ℃, adding 11000 g of redistilled water according to corresponding proportion, stirring for 8 minutes at 22-25 ℃ until the mixture is uniform, adding 80 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 9 minutes at 22-25 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 10:
selecting 50 g of peppermint oil and 350 g of 90% ethanol according to corresponding proportion, stirring for 22 minutes in a sterile environment at 28-30 ℃, adding 11000 g of redistilled water according to corresponding proportion, stirring for 16 minutes at 28-30 ℃ until the mixture is uniform, adding 80 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 18 minutes at 28-30 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 11:
selecting 50 g of peppermint oil and 350 g of 95% ethanol according to corresponding proportion, stirring for 10 minutes in an aseptic environment at 22-25 ℃, adding 11000 g of ultrapure water according to corresponding proportion, stirring for 8 minutes at 22-25 ℃ until the mixture is uniform, adding 80 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 9 minutes at 22-25 ℃ until the mixture is uniform, thus obtaining the finished product.
Example 12:
selecting 50 g of peppermint oil and 350 g of 95% ethanol according to corresponding proportion, stirring for 22 minutes in a sterile environment at 28-30 ℃, adding 11000 g of ultrapure water according to corresponding proportion, stirring for 16 minutes at 28-30 ℃ until the mixture is uniform, adding 80 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 18 minutes at 28-30 ℃ until the mixture is uniform, thus obtaining the finished product.
Example 13:
selecting 30 g of peppermint oil and 280 g of 95% ethanol according to corresponding proportion, stirring for 15 minutes in a sterile environment at 25-26 ℃, adding 7000 g of redistilled water according to corresponding proportion, stirring for 10 minutes at 25-26 ℃ until the mixture is uniform, adding 50 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 12 minutes at 25-26 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 14:
selecting 30 g of peppermint oil and 280 g of 90% ethanol according to corresponding proportion, stirring for 15 minutes in a sterile environment at 25-26 ℃, adding 7000 g of redistilled water according to corresponding proportion, stirring for 10 minutes at 25-26 ℃ until the mixture is uniform, adding 50 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 12 minutes at 25-26 ℃ until the mixture is uniform, thus obtaining a finished product.
Example 15:
selecting 30 g of peppermint oil and 280 g of 70% ethanol according to corresponding proportion, stirring for 15 minutes in a sterile environment at 25-26 ℃, adding 7000 g of triple distilled water according to corresponding proportion, stirring for 10 minutes at 25-26 ℃ until the mixture is uniform, adding 50 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 12 minutes at 25-26 ℃ until the mixture is uniform, thus obtaining the finished product.
Example 16:
selecting 30 g of peppermint oil and 280 g of 75% ethanol according to corresponding proportion, stirring for 15 minutes in a sterile environment at 25-26 ℃, adding 7000 g of ultrapure water according to corresponding proportion, stirring for 10 minutes at 25-26 ℃ until the mixture is uniform, adding 50 g of epidermal stem cell activating factor according to corresponding proportion, and stirring for 12 minutes at 25-26 ℃ until the mixture is uniform, thus obtaining the finished product.
The above mint oil is selected from preparations produced by Jiangxi Cedar natural medicinal oil company.
The ethanol is selected from preparations produced by Stbada chemical Co., Ltd, Dongguan, Guangdong, and then various suitable ethanol with different ethanol contents are obtained by chemical proportioning.
The distilled water, the redistilled water, the triple distilled water, and the ultrapure water are selected from preparations produced by Sichuan Chengdu Technology Co.
The epidermal stem cell activating factor provided above is selected from preparations produced by Guangdong Kesuo chemical Co.
The product prepared by the embodiments is used as a basic product, a gel is obtained by the basic product through gelation, and the gel can be directly used after being smeared on a skin wound; the basic product can be put into mechanical equipment which can promote the contents in the basic product to be sprayed in the form of mist; putting the basic product into a spray bottle for application.
A storage mode: storing in dry and ventilated place.
The use method comprises the following steps: cleaning wound surface with the repairing preparation, relieving pain and diminishing inflammation, applying medical antiseptic gauze on the wound surface of burn and scald, spraying the repairing preparation on the gauze, covering with a layer of medical film, and finishing the bandaging. Removing the gauze after the wound is healed. The gauze must be kept wet during the treatment process using the repair preparation to avoid dryness.
Examples of the experiments
Selecting mice as experimental objects, and grouping the experimental objects, wherein each group of mice is half male and half female, 10 mice (5 female mice and 5 male mice) in each group are guaranteed, and 18 groups are provided, wherein 1-16 groups are experimental groups, 17 th group is a control group, and 18 th group is a control group.
Experimental reagent: the spray product obtained by the repair preparation prepared in each embodiment is selected, and the product obtained in the corresponding embodiment is used for the grouped coding number of the experimental group. The control group used the conditioning solution prepared in CN108403450A in example III, and the control group used only the surface stem cell activating factor.
Treating burns and scalds: each mouse was coated with 8% sodium sulfide depilatory, gently scraped off after several minutes, and wiped clean with clear water. Observing for several hours, and determining that the depilated part has no abnormal conditions such as red swelling, inflammation and damage. Adopts chloral hydrate for shallow anesthesia and is arranged on a healing operation table. The pot with water was placed on an electric furnace and a 20g weight was placed in the pot and heated to boiling for 10 min. Then the upper end of the weight is clamped by a signature, the weight is quickly placed on the skin of the mouse for 5s, and slight pressure is applied, so that the scald area is 2cm multiplied by 2 cm.
Administration treatment: spraying the test components with the sprays obtained in the corresponding examples 5-8 times per day, 3-5mL each time; spraying the repairing liquid obtained in the third embodiment to a control group, and spraying three times every day, wherein three times are sprayed each time; the control group was applied with surface stem cell activating factor 3-5 times daily, 1-2mL each time.
Wound surface observation: after the daily application of the medicine is finished, the skin wound of the mouse is observed, data are directly measured by adopting a ruler, and the area of the wound is calculated. The total observation period was 5 days.
The results of observation and calculation are as follows:
TABLE 1 treatment Change in scald wounds (/ cm) in subject mice2)
According to the data in the table, the prepared skin burn and scald wound spray preparation has obvious treatment effect on experimental subjects in each example, wherein the overall repair and healing effects of the examples 13, 15 and 16 are more effective, and the overall healing effect of the other examples tends to increase. The repair liquid of the control group has a certain repair effect, but the final observed effect is obviously better than the healing effect of the repair preparation spray. Therefore, the skin burn and scald wound repair preparation has an obvious healing effect, can achieve a high healing rate in a short time, and does not have any side effect. Meanwhile, the effect of wound surface repair by only using the surface stem cell activation factor is obviously weaker than that of the whole scheme.
Clinical data
Patient 1: for male, age 10, the first degree of burn and scald is confirmed.
The treatment mode comprises the following steps: the spray prepared in example 16 is used for 5-8 times a day, and 2-3mL of the spray is used each time.
The treatment results are as follows: after 3-4 days, the burn and scald wound of the patient is recovered as early as possible.
Patient 2: male, 27 years old, is diagnosed with extensive second degree burn and scald.
The treatment mode comprises the following steps: the spray prepared in example 16 is used for 5-8 times a day, and each time is 3-5 mL.
The treatment results are as follows: after 7-8 days, the burn and scald wound of the patient is recovered as early as possible.
The invention provides a repair preparation for skin burn and scald wound surfaces, which is prepared by mixing various materials with anti-inflammation and analgesic effects and rich sources for repairing skin wound surfaces. The repair preparation for the skin burn and scald wound surface is an external preparation, can quickly freeze surface nerves when contacting the skin wound surface so as to achieve the effect of relieving pain, is matched with other raw materials with bacteriostasis and disinfection effects, and has the functions of repairing, rebuilding, relieving and quickly healing the skin wound surface under the synergistic effect of the raw materials with extremely strong repair capacity. The repair preparation treats the skin wound surface in an external mode, is directly contacted with the wound surface, reduces the treatment duration, improves the healing efficiency, is efficient and safe, and further ensures that the skin wound surface does not scab and leaves no scar after healing. The preparation method of the repairing preparation has the advantages of simple and direct operation process, less operation equipment, low requirement on operators, moderate cost, safety and reliability on the basis of maximally fusing and well storing the effective components of the raw materials after finely selecting the materials.
While particular embodiments of the present invention have been illustrated and described, it will be appreciated that the present invention is not limited to the above-described alternative embodiments, and that various other forms of product may be devised by anyone in light of the present invention. The foregoing detailed description should not be construed as limiting the scope of the invention, and those skilled in the art will understand that various modifications can be made to the technical solutions described in the foregoing embodiments, or some or all of the technical features can be equivalently replaced, without departing from the spirit and scope of the invention, and at the same time, such modifications or replacements do not cause the essence of the corresponding technical solutions to depart from the scope of the technical solutions of the embodiments of the invention; the scope of the invention should be determined with reference to the appended claims, and the description should be construed to interpret the claims.
Claims (10)
1. The skin burn and scald wound repair preparation is characterized by being prepared from the following raw materials in parts by mass:
1-10 parts of surface dry cell activating factor, 1-6 parts of peppermint oil, 1400 parts of diluent 300 and 10-50 parts of solvent;
preferably, the wound repair preparation is prepared from the following raw materials in parts by mass:
3-8 parts of surface dry cell activating factor, 2-5 parts of peppermint oil, 1100 parts of diluent 500-.
2. The skin burn and scald wound repair preparation according to claim 1, which is prepared from the following raw materials in parts by mass:
5 parts of surface dry cell activating factor, 3 parts of peppermint oil, 700 parts of diluent and 28 parts of solvent.
3. The skin burn and scald wound repair preparation according to any one of claims 1 to 2, wherein the diluent comprises pure water,
preferably, the pure water comprises distilled water,
further preferably, the distilled water comprises redistilled water and/or triple distilled water.
4. The skin burn and scald wound repair preparation according to any one of claims 1 to 2, wherein the solvent comprises a water-soluble solvent,
preferably, the water-soluble solvent comprises ethanol,
further preferably, the ethanol volume concentration is 70% -95%, preferably 75% -90%.
5. The skin burn and scald wound repair preparation according to any one of claims 1 to 2, wherein the wound repair preparation is an external preparation.
6. The skin burn and scald wound repair preparation according to claim 5, wherein the external preparation comprises one or more of a gel, a spray and an aerosol.
7. The preparation method of the skin burn and scald wound repair preparation according to any one of claims 1 to 2, wherein the preparation method comprises selecting peppermint oil and a solvent according to a corresponding proportion, stirring, adding a diluent according to a corresponding proportion, stirring uniformly, adding an epidermal stem cell activating factor according to a corresponding proportion, stirring uniformly, and obtaining a finished product.
8. The method for preparing a skin burn and scald wound healing preparation according to claim 7, wherein the mixing of the peppermint oil and the solvent is performed in a sterile environment;
preferably, the stirring time is 8 to 25 minutes, preferably 10 to 22 minutes, and further preferably 15 minutes;
preferably, the stirring temperature is 20-35 ℃, preferably 22-30 ℃, and further preferably 25 ℃.
9. The preparation method of the skin burn and scald wound repair preparation according to claim 7, wherein the time period for uniformly mixing with the diluent in a corresponding proportion is 5-20 minutes, preferably 8-16 minutes, and further preferably 10 minutes;
preferably, the temperature for adding the diluent in the corresponding proportion and uniformly stirring is 20-35 ℃, preferably 22-30 ℃, and further preferably 25 ℃.
10. The preparation method of the skin burn and scald wound repair preparation according to claim 7, wherein the period of uniform mixing of the epidermal stem cell activating factors in the corresponding proportion is 7-25 minutes, preferably 9-18 minutes, and further preferably 12 minutes;
preferably, the temperature for uniformly mixing the epidermal stem cell activating factors in the corresponding proportion is 20-35 ℃, preferably 22-30 ℃, and further preferably 25 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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