CN116832087A - Pharmaceutical composition for repairing skin surface wound and preparation method and application thereof - Google Patents
Pharmaceutical composition for repairing skin surface wound and preparation method and application thereof Download PDFInfo
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- CN116832087A CN116832087A CN202311120939.7A CN202311120939A CN116832087A CN 116832087 A CN116832087 A CN 116832087A CN 202311120939 A CN202311120939 A CN 202311120939A CN 116832087 A CN116832087 A CN 116832087A
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 235000013871 bee wax Nutrition 0.000 claims abstract description 29
- 239000012166 beeswax Substances 0.000 claims abstract description 29
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000019270 ammonium chloride Nutrition 0.000 claims abstract description 24
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 22
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229940116229 borneol Drugs 0.000 claims abstract description 18
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 18
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000008159 sesame oil Substances 0.000 claims abstract description 18
- 235000011803 sesame oil Nutrition 0.000 claims abstract description 18
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 15
- 241000037740 Coptis chinensis Species 0.000 claims abstract description 15
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 13
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 13
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 13
- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 13
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 230000037314 wound repair Effects 0.000 claims abstract description 13
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 14
- 206010052428 Wound Diseases 0.000 claims description 14
- 208000027418 Wounds and injury Diseases 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 13
- 241001071917 Lithospermum Species 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
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- 239000007787 solid Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 240000006891 Artemisia vulgaris Species 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 3
- 241000218202 Coptis Species 0.000 claims description 2
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 19
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- 239000000463 material Substances 0.000 abstract description 15
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- 208000015181 infectious disease Diseases 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 231100000241 scar Toxicity 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 7
- 230000002588 toxic effect Effects 0.000 abstract description 7
- 208000003251 Pruritus Diseases 0.000 abstract description 6
- 206010072170 Skin wound Diseases 0.000 abstract description 6
- 230000000740 bleeding effect Effects 0.000 abstract description 6
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- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 238000005469 granulation Methods 0.000 abstract description 5
- 230000003179 granulation Effects 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 206010033078 Otitis media Diseases 0.000 abstract description 4
- 230000000172 allergic effect Effects 0.000 abstract description 4
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- 230000017531 blood circulation Effects 0.000 abstract description 4
- 206010002153 Anal fissure Diseases 0.000 abstract description 3
- 208000016583 Anus disease Diseases 0.000 abstract description 3
- 208000010445 Chilblains Diseases 0.000 abstract description 3
- 208000009531 Fissure in Ano Diseases 0.000 abstract description 3
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract description 3
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- 201000005404 rubella Diseases 0.000 abstract description 3
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- 241000196324 Embryophyta Species 0.000 abstract description 2
- 238000001816 cooling Methods 0.000 description 5
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- 230000035876 healing Effects 0.000 description 3
- 230000037387 scars Effects 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
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- 206010037844 rash Diseases 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
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- 230000000202 analgesic effect Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the technical field of skin surface wound repair, in particular to a pharmaceutical composition for skin surface wound repair, and a preparation method and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 1-1.5 parts of sal ammoniac, 10-15 parts of wormwood, 2-3 parts of coptis chinensis, 10-15 parts of borneol, 20-30 parts of sesame oil and 2-3 parts of beeswax. The composition can be applied to skin wound, and has effects of stopping bleeding, relieving pain, relieving itching, promoting granulation, relieving inflammation, detumescence, promoting blood circulation, removing blood stasis, promoting wound healing, and preventing scar. The preparation method is prepared from pure plant materials, has no toxic or side effect, no drug resistance and no allergic person. Can be widely used for repairing and treating skin wounds such as otitis media, canker sore, herpes, chilblain, rubella itching, burns and scalds, traumatic infection, anal fissure, bedsores and the like.
Description
Technical Field
The invention relates to the field of skin surface wound repair, in particular to a pharmaceutical composition for skin surface wound repair, and a preparation method and application thereof.
Background
The skin surface of human body is easy to generate various diseases or wounds due to exposure to the external environment, thereby inducing various inflammations, rashes, sores, infections and the like.
In the aspect of external medicine for skin wound, the variety is more, but the anti-inflammatory and analgesic effects are slower after the medicine is taken. The wound surface exudation time after the medicine is used is long, the infection is easy, the treatment effect is poor, and scars are easy to leave.
Disclosure of Invention
The first object of the present invention is to provide a pharmaceutical composition for repairing skin surface wounds, which has remarkable effects of promoting wound healing and preventing scars.
The second aim of the invention is to provide a preparation method of the pharmaceutical composition, which has the advantages of cheap and easily available medicinal materials, simple preparation method and high quality and good efficacy of the prepared pharmaceutical composition.
In order to achieve the above object of the present invention, the following technical solutions are specifically adopted:
a pharmaceutical composition for skin surface wound repair, the pharmaceutical composition comprising in parts by weight:
1-1.5 parts of sal ammoniac, 10-15 parts of wormwood, 2-3 parts of coptis chinensis, 10-15 parts of borneol, 20-30 parts of sesame oil and 2-3 parts of beeswax.
In a preferred embodiment, the white sal ammoniac is 1 part, the purple sal ammoniac is 1 part, the mugwort is 10 parts, the coptis is 2 parts, the borneol is 10 parts, the sesame oil is 20 parts and the beeswax is 2 parts by weight.
In a preferred embodiment, the pharmaceutical composition further comprises, in parts by weight: 2-3 parts of lithospermum.
In a preferred embodiment, the lithospermum is 2 parts by weight.
The preparation method of the pharmaceutical composition is characterized by comprising the following steps:
s1, weighing 1-1.5 parts of white sal ammoniac, 1-1.5 parts of sal ammoniac, 10-15 parts of wormwood, 2-3 parts of coptis chinensis, 10-15 parts of borneol, 20-30 parts of sesame oil and 2-3 parts of beeswax according to parts by weight;
s2, grinding the cyanide and the Bai Naosha into powder; dividing Ai Caoqie into small sections of 0.2 cm-3 cm;
s3, placing the cyanide powder, the white sal ammoniac powder and the Ai Caoduan obtained in the step S2, and the coptis chinensis, the borneol and the sesame oil into a container, and uniformly stirring;
s4, decocting the mixture obtained in the step S3 with medium fire for 10 minutes, and then decocting with slow fire for 0.8-1.2 hours;
s5, adding the beeswax, continuously decocting with slow fire and stirring until the beeswax is completely melted;
s6, filtering out solid impurities, standing at room temperature, and storing to naturally cool the mixture obtained in the step S5 to obtain the pharmaceutical composition.
In a preferred embodiment, 2-3 parts of lithospermum are added in the step S3.
In a preferred embodiment, in the step S4, the temperature of the medium fire is 120 ℃ to 150 ℃; in the step S5, the temperature of the slow fire is 90-110 ℃.
In a preferred embodiment, in the step S6, the time for standing and storing is 1 to 3 hours.
Use of said pharmaceutical composition for the preparation of a medicament for the treatment of skin surface wounds.
Compared with the prior art, the beneficial effects of the invention include, for example: the composition can be applied to skin wound, and has effects of stopping bleeding, relieving pain, relieving itching, promoting granulation, relieving inflammation, detumescence, promoting blood circulation, removing blood stasis, promoting wound healing, and preventing scar. The preparation method is prepared from pure plant materials, has no toxic or side effect, no drug resistance and no allergic person. Can be widely used for repairing and treating skin wounds such as otitis media, canker sore, herpes, chilblain, rubella itching, burns and scalds, traumatic infection, anal fissure, bedsores and the like.
Description of the embodiments
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The embodiment provides a pharmaceutical composition for repairing skin surface wounds, which comprises the following components in parts by weight:
1-1.5 parts of sal ammoniac, 10-15 parts of wormwood, 2-3 parts of coptis chinensis, 10-15 parts of borneol, 20-30 parts of sesame oil and 2-3 parts of beeswax.
The pharmaceutical composition is mainly used for repairing skin surface wounds from the aspects of stopping bleeding and relieving pain, relieving itching and promoting tissue regeneration, diminishing inflammation and reducing swelling, reducing the moisture and hot air in a patient, promoting qi circulation and blood circulation and removing blood stasis, promoting the metabolism of the wound surface, and avoiding scar of the wound surface. Through the proportion among a plurality of medicines with the effects, the medicine composition has no toxic or side effect, no drug resistance and no allergic symptoms, has strong antibacterial infection capability, can effectively avoid secondary infection of a wound surface, can relieve pain of a burn wound surface, improves the healing capability of the wound surface and avoids scars.
Wherein, the white sal ammoniac: has effects of resolving food stagnation, softening hard mass, removing blood stasis, and resolving hard mass;
sal ammoniac has the effects of removing blood stasis, removing food retention, softening hard mass and removing corrosion;
the wormwood has the effects of eliminating dampness, dispelling cold, warming channels and stopping bleeding;
borneol has the effects of clearing heat, detoxicating, preventing corrosion and promoting tissue regeneration;
rhizoma Coptidis has effects of clearing heat, removing dampness, purging pathogenic fire, and removing toxic substances;
sesame oil has the effects of promoting cell division, preventing corrosion and promoting granulation;
beeswax has antibacterial, antiinflammatory, toxic materials clearing away, and analgesic effects;
further, the pharmaceutical composition comprises 1 part of white sal ammoniac, 1 part of sal ammoniac, 10 parts of wormwood, 2 parts of coptis chinensis, 10 parts of borneol, 20 parts of sesame oil and 2 parts of beeswax according to parts by weight.
Further, the pharmaceutical composition comprises the following components in parts by weight: 2-3 parts of lithospermum.
The lithospermum has the effects of clearing away heat and toxic materials, promoting blood circulation, cooling blood, promoting eruption and removing spots, and the addition of lithospermum can further enhance the effects of the pharmaceutical composition in clearing away heat and toxic materials, removing blood stasis, stopping bleeding, healing sore and promoting granulation.
Further, the lithospermum is 2 parts by weight.
The present embodiment also provides a method for preparing a pharmaceutical composition, comprising the steps of:
s1, weighing 1-1.5 parts of white sal ammoniac, 1-1.5 parts of sal ammoniac, 10-15 parts of wormwood, 2-3 parts of coptis chinensis, 10-15 parts of borneol, 20-30 parts of sesame oil and 2-3 parts of beeswax according to parts by weight;
s2, grinding the cyanide and the Bai Naosha into powder; dividing Ai Caoqie into small sections of 0.2 cm-3 cm;
s3, placing the cyanide powder, the white sal ammoniac powder and the Ai Caoduan obtained in the step S2, and the coptis chinensis, the borneol and the sesame oil into a container, and uniformly stirring;
s4, decocting the mixture obtained in the step S3 for 10 minutes under the medium fire condition of 120-150 ℃, and then decocting with slow fire at 90-110 ℃ for 0.8-1.2 hours;
s5, adding the beeswax, continuously decocting with slow fire and stirring until the beeswax is completely melted, and then stopping heating;
s6, filtering out solid impurities, standing and storing for 1-3 hours at room temperature, and naturally cooling the mixture obtained in the step S5 to obtain the pharmaceutical composition.
Furthermore, an ultrasonic vibration extraction method can be adopted to extract the solvent, and when the method is adopted, the ultrasonic frequency is 600-800 Hz, and the ultrasonic time is 15-25 min.
According to the preparation method provided by the embodiment, the used medicinal materials are low in cost and easy to obtain, the preparation method is simple, and the prepared medicinal composition is high in quality and good in medicinal effect.
The features and capabilities of the present invention are described in further detail below in connection with the following examples:
examples
The present embodiment provides a pharmaceutical composition for skin surface wound repair, comprising:
bai Naosha 1g, 1g of cyanide, 10g of wormwood, 2g of coptis chinensis, 10g of borneol, 20g of sesame oil and 2g of beeswax.
The preparation method of the pharmaceutical composition comprises the following steps:
grinding cyanide and sal ammoniac into powder, and pulverizing Ai Caoqie; mixing and stirring Sal Ammoniacus, folium Artemisiae Argyi, coptidis rhizoma, borneolum Syntheticum and oleum Sesami to obtain mixed medicinal material, decocting the mixed medicinal material at 130deg.C under medium fire for 10 min, and decocting with slow fire at 90deg.C for 1 hr; adding the beeswax, continuously decocting with slow fire at 90 ℃ and stirring until the beeswax is completely melted, and stopping heating; filtering solid impurities, standing at room temperature for 2 hr, and naturally cooling the obtained mixture.
Examples
The present embodiment provides a pharmaceutical composition for skin surface wound repair, comprising:
bai Naosha 1g, 1g of cyanide, 15g of wormwood, 3g of coptis chinensis, 15g of borneol, 30g of sesame oil and 3g of beeswax.
The preparation method of the pharmaceutical composition comprises the following steps:
grinding cyanide and sal ammoniac into powder, and pulverizing Ai Caoqie; mixing and stirring Sal Ammoniacus, folium Artemisiae Argyi, coptidis rhizoma, borneolum Syntheticum and oleum Sesami to obtain mixed medicinal material, decocting the mixed medicinal material at 120deg.C under medium fire for 10 min, and decocting with slow fire at 100deg.C for 1 hr; adding the beeswax, continuously decocting with slow fire at 90 ℃ and stirring until the beeswax is completely melted, and stopping heating; filtering solid impurities, standing at room temperature for 2 hr, and naturally cooling the obtained mixture.
Examples
The present embodiment provides a pharmaceutical composition for skin surface wound repair, comprising:
bai Naosha 1g, 1g of cyanide, 2g of lithospermum, 15g of wormwood, 3g of coptis chinensis, 15g of borneol, 30g of sesame oil and 3g of beeswax.
The preparation method of the pharmaceutical composition comprises the following steps:
grinding cyanide and sal ammoniac into powder, and pulverizing Ai Caoqie; mixing and stirring Sal Ammoniacus, radix Arnebiae, folium Artemisiae Argyi, coptidis rhizoma, borneolum Syntheticum and oleum Sesami to obtain mixed medicinal material, decocting the mixed medicinal material at 120deg.C under medium fire for 10 min, and decocting with slow fire at 100deg.C for 1 hr; adding the beeswax, continuously decocting with slow fire at 90 ℃ and stirring until the beeswax is completely melted, and stopping heating; after filtering out solid impurities, standing at room temperature for 2 hours, and naturally cooling the obtained mixture.
Examples
The present embodiment provides a pharmaceutical composition for skin surface wound repair, comprising:
bai Naosha 1.5.5 g, 1.5g of cyanide, 2g of lithospermum, 13g of wormwood, 3g of coptis chinensis, 15g of borneol, 30g of sesame oil and 2g of beeswax.
The preparation method of the pharmaceutical composition comprises the following steps:
grinding cyanide and sal ammoniac into powder, and pulverizing Ai Caoqie; mixing and stirring Sal Ammoniacus, radix Arnebiae, folium Artemisiae Argyi, coptidis rhizoma, borneolum Syntheticum and oleum Sesami to obtain mixed medicinal material, decocting the mixed medicinal material at 120deg.C under medium fire for 10 min, and decocting with slow fire at 100deg.C for 1 hr; adding the beeswax, continuously decocting with slow fire at 90 ℃ and stirring until the beeswax is completely melted, and stopping heating; filtering solid impurities, standing at room temperature for 2 hr, and extracting by ultrasonic vibration extraction method to obtain medicinal liquid with ultrasonic frequency of 600Hz and ultrasonic time of 20 min.
The pharmaceutical composition can be applied to: repairing and treating skin wound such as otitis media, canker sore, herpes, chilblain, rubella itching, burn and scald, traumatic infection, anal fissure, bedsore, etc. When in use, the product is applied to the affected part, or the gauze can be used for wrapping the affected part.
According to clinical application observation, no allergic person is found, and the medicine has no toxic or side effect and no drug resistance. The pharmaceutical composition has effects of diminishing inflammation, removing toxic substances, relieving swelling and pain, removing putrefaction, promoting granulation, astringing and stopping bleeding, and can be used for conditioning infectious wound, trauma and burn, and also has effects of removing dampness, healing sore, killing parasites and treating tinea.
Test example:
1. zhang Mou A male, 5 years old, has a chest scalded with boiled water, a second degree of scalding grade, and the pain is relieved after 24 hours of application of the pharmaceutical composition of example 1, and the skin becomes red after one week of continuous application, grows new skin, and is completely recovered after two weeks of continuous application.
2. Zhang Mou A woman, a woman suffering from facial injury, and a woman suffering from facial injury, and suffering from facial injury, has no scar after 2 days after the application of the pharmaceutical composition of example 2.
3. Zhou Mou A female, age 56, otitis media resulted in-ear running water, and the redness and swelling disappeared after 24 hours and the running water disappeared after 10 days of wiping after applying the pharmaceutical composition of example 3.
4. Shao Mou A female, 65 years old, diabetic sequelae, plantar skin ulceration, is coated with the pharmaceutical composition of example 1, and after 3 days new meat grows out, ten days skin returns to normal.
5. A female, 48 years old, has a second degree burn of open flame, is painful to the arm, is unable to heal, and after the application of the pharmaceutical composition of example 4, the pain is reduced, and after half a month the position of the chapping gradually heals, and returns to normal for about 1 month.
While particular embodiments of the present invention have been illustrated and described, it will be appreciated that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.
Claims (9)
1. A pharmaceutical composition for skin surface wound repair, characterized in that the pharmaceutical composition comprises, in parts by weight:
1-1.5 parts of sal ammoniac, 10-15 parts of wormwood, 2-3 parts of coptis chinensis, 10-15 parts of borneol, 20-30 parts of sesame oil and 2-3 parts of beeswax.
2. The pharmaceutical composition for skin surface wound repair according to claim 1, wherein the white sal ammoniac is 1 part, the mugwort is 10 parts, the coptis is 2 parts, the borneol is 10 parts, the sesame oil is 20 parts, and the beeswax is 2 parts by weight.
3. The pharmaceutical composition for skin surface wound repair according to claim 1, further comprising, in parts by weight: 2-3 parts of lithospermum.
4. The pharmaceutical composition for skin surface wound repair according to claim 3, wherein the lithospermum is 2 parts by weight.
5. A process for the preparation of a pharmaceutical composition according to claim 1 or 2, comprising the steps of:
s1, weighing 1-1.5 parts of white sal ammoniac, 1-1.5 parts of sal ammoniac, 10-15 parts of wormwood, 2-3 parts of coptis chinensis, 10-15 parts of borneol, 20-30 parts of sesame oil and 2-3 parts of beeswax according to parts by weight;
s2, grinding the cyanide and the Bai Naosha into powder; dividing Ai Caoqie into small sections of 0.2 cm-3 cm;
s3, placing the cyanide powder, the white sal ammoniac powder and the Ai Caoduan obtained in the step S2, and the coptis chinensis, the borneol and the sesame oil into a container, and uniformly stirring;
s4, decocting the mixture obtained in the step S3 with medium fire for 10 minutes, and then decocting with slow fire for 0.8-1.2 hours;
s5, adding the beeswax, continuously decocting with slow fire and stirring until the beeswax is completely melted;
s6, filtering out solid impurities, standing at room temperature, and storing to naturally cool the mixture obtained in the step S5 to obtain the pharmaceutical composition.
6. The method for preparing a pharmaceutical composition according to claim 5, wherein 2-3 parts of lithospermum is added in the step S3.
7. The method for preparing a pharmaceutical composition according to claim 5, wherein in the step S4, the medium fire is at a temperature of 120 ℃ to 150 ℃; in the step S5, the temperature of the slow fire is 90-110 ℃.
8. The method of claim 5, wherein in step S6, the standing time is 1 to 3 hours.
9. Use of a pharmaceutical composition according to any one of claims 1 to 4 for the preparation of a medicament for skin surface wounds.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311120939.7A CN116832087A (en) | 2023-09-01 | 2023-09-01 | Pharmaceutical composition for repairing skin surface wound and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311120939.7A CN116832087A (en) | 2023-09-01 | 2023-09-01 | Pharmaceutical composition for repairing skin surface wound and preparation method and application thereof |
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| CN202311120939.7A Pending CN116832087A (en) | 2023-09-01 | 2023-09-01 | Pharmaceutical composition for repairing skin surface wound and preparation method and application thereof |
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| Country | Link |
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| CN (1) | CN116832087A (en) |
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