CN111214641B - Traditional Chinese medicine preparation for treating diabetes - Google Patents

Traditional Chinese medicine preparation for treating diabetes Download PDF

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CN111214641B
CN111214641B CN201811403326.3A CN201811403326A CN111214641B CN 111214641 B CN111214641 B CN 111214641B CN 201811403326 A CN201811403326 A CN 201811403326A CN 111214641 B CN111214641 B CN 111214641B
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traditional chinese
chinese medicine
vitamin
diabetes
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CN111214641A (en
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刘文龙
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Henan Xurentang Biotechnology Co ltd
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Henan Xurentang Biotechnology Co ltd
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Abstract

The invention provides a traditional Chinese medicine preparation for treating diabetes, belonging to the technical field of traditional Chinese medicines. The Chinese medicinal preparation for treating diabetes is prepared from herba Saussureae Involueratae culture, ginseng radix, fructus Hippophae, rhizoma Polygonati Odorati, rhizoma Dioscoreae, semen Phaseoli vulgaris extract, yeast beta-dextran, lumbricus protein, L-arabinose, xanthophyll lipid, inulin, fructo-oligosaccharide, and vitamin B 1 Vitamin B 2 Vitamin B 6 Vitamin B 12 Isomalt, and is strictly expressedThe traditional Chinese medicine composition is prepared according to the principle of 'monarch, minister, assistant and guide' of the traditional Chinese medicine, has obvious effect of treating the diabetes, has short cure period and solves the defects of the traditional Chinese medicine for treating the diabetes at present. Meanwhile, the traditional Chinese medicine preparation stimulates islet beta cells to secrete insulin, repairs islet functions, increases the sensitivity of insulin receptors, inhibits the absorption of glucose, improves fatty acid metabolism and the like.

Description

Traditional Chinese medicine preparation for treating diabetes
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating diabetes.
Background
Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia due to multiple causes, and is a metabolic disease caused by defective insulin secretion or impaired insulin action. Persistent hyperglycemia and long-term metabolic disorders, among others, can lead to damage to tissues and organs throughout the body, particularly the eye, kidney, cardiovascular system and nervous system, as well as their dysfunction and failure. With the improvement of living standard of people, the incidence of diabetes mellitus rises year by year due to the frequent eating of high-calorie, high-sugar and high-fat foods in daily diet.
At present, diabetes is mainly treated by western medicines, but the western medicine therapy has great defects in the aspect of treating diabetes, wherein the most important expression is that the side effect is large, some medicines can influence water and electrolyte metabolism and influence blood fat and blood sugar metabolism, and some medicines can influence sexual functions after being taken for a long time. In addition, the blood sugar fluctuation is large in the blood sugar reducing process, especially in early or old diabetes, the medicine is very sensitive to western medicine blood sugar reducing medicines, the blood sugar can be reduced very low after the medicine is taken, even postural hypoglycemia occurs, the medicine dosage or times are reduced, and the blood sugar can be increased very quickly.
The traditional Chinese medicine comprehensive therapy has the advantages of stable curative effect, no adverse reaction, regulation of the environment in a body, improvement of the physique, reduction of the insulin resistance state, regulation of glycolipid metabolism, regulation of the immunity of the body and the like for the treatment of diabetes and complications thereof, has certain advantages in the prevention and treatment work of light and medium type diabetes, and particularly has obvious curative effect for the treatment of the complications of the diabetes. However, the traditional Chinese medicine composition for treating diabetes has long treatment course and slow effect for treating diabetes.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine preparation for treating diabetes, which has quick response and short treatment course for treating diabetes.
In order to achieve the purpose, the technical scheme adopted by the traditional Chinese medicine preparation for treating diabetes is that the traditional Chinese medicine preparation for treating diabetes is prepared from the following components in parts by weight: 4 to 6 portions of saussurea involucrate culture, 5 to 10 portions of ginseng, 4 to 6 portions of sea-buckthorn, 5 to 10 portions of polygonatum, 8 to 18 portions of yam, 5 to 10 portions of white kidney bean extract, 4 to 6 portions of yeast beta-glucan, 5 to 10 portions of earthworm protein, 4 to 6 portions of L-arabinose, leaf6 to 10 portions of flavin fat, 8 to 16 portions of inulin, 4 to 6 portions of fructo-oligosaccharide and vitamin B 1 3 to 6 portions of vitamin B 2 5 to 10 portions of vitamin B 6 4 to 8 portions of vitamin B 12 5 to 9 portions of isomaltitol and 3 to 8 portions of isomaltitol.
Preferably, the traditional Chinese medicine preparation for treating diabetes is prepared from the following components in parts by weight: 5 parts of lotus culture, 8 parts of ginseng, 5 parts of sea buckthorn, 7 parts of polygonatum, 12 parts of Chinese yam, 7 parts of white kidney bean extract, 5 parts of yeast beta-glucan, 8 parts of earthworm protein, 5 parts of L-arabinose, 7 parts of lutein ester, 12 parts of inulin, 5 parts of fructo-oligosaccharide, vitamin B 1 3 to 6 portions of vitamin B 2 5 to 10 portions of vitamin B 6 4 to 8 portions of vitamin B 12 5 to 9 portions of isomaltitol and 3 to 8 portions of isomaltitol.
The white kidney bean extract in the traditional Chinese medicine preparation contains active ingredients such as an alpha-amylase inhibitor, an alpha-sucrase inhibitor and the like, and can inhibit the activity of active enzymes such as alpha-amylase, alpha-sucrase and the like in the intestines and stomach and interfere the formation mechanism of glucose, so that the formation of hyperglycemia is solved, and the blood sugar is stably controlled.
The alpha-amylase inhibitor has effects on amylase hydrolysis, and is excreted from body via gastrointestinal tract, so it does not need to enter blood circulation system, does not suppress appetite, and has no side effects.
The L-arabinose in the traditional Chinese medicine preparation can inhibit the activities of sucrase and maltase in the small intestine, reduce the absorption of sucrose and maltose and control the blood sugar level in the human body.
The yeast beta-glucan in the traditional Chinese medicine preparation can protect and repair islet beta cells and improve insulin resistance and glucose metabolism.
The active substances of the ginseng in the traditional Chinese medicine preparation can enhance the action of oxidation and phosphoric acid of mitochondria and the activities of two kinds of respiratory enzymes, namely succinate dehydrogenase and cytochrome oxidase, and accelerate the aerobic oxidation process of sugar. Ginseng also has the effects of calming the mind, tonifying the five internal organs, and regulating qi and blood.
The earthworm protein in the Chinese medicinal preparation can dissolve fresh and old thrombus, improve the anticoagulation function, promote the regeneration of capillary vessels and establish collateral circulation.
The sea-buckthorn in the traditional Chinese medicine preparation can dredge microcirculation and smooth blood vessels, and the total flavonoids can increase the nutritional blood flow of heart machine and improve the cardiac muscle circulation.
The saussurea involucrate culture in the traditional Chinese medicine preparation provided by the invention has the effects of inhibiting platelet aggregation, reducing blood fat, improving blood circulation and regulating an immune system.
The Chinese yam in the Chinese medicinal preparation has the effects of nourishing and building body, delaying senility, preventing arteriosclerosis and coronary heart disease, tonifying deficiency and reducing blood sugar, and replenishing essence and reinforcing kidney.
The polygonatum in the traditional Chinese medicine preparation has the effects of resisting aging, nourishing yin and qi, moistening dryness and moistening lung, tranquilizing nerves, strengthening heart, reducing blood fat and blood sugar, treating excessive internal heat, preventing, improving and relieving complications.
The lutein ester in the traditional Chinese medicine preparation provided by the invention can supplement the macular pigment density in the retina and macula area of human eyes, and protect the glasses.
The inulin in the traditional Chinese medicine preparation can enhance the digestion and defecation functions, enhance the metabolism function, protect the liver function, rapidly increase the quantity of bifidobacteria in the intestinal tract and balance the improvement effect of intestinal microorganisms of human bodies and skin itch related to diabetes patients.
The vitamin group, vitamin B, in the Chinese medicinal preparation 1 Vitamin B 2 Vitamin B 6 The whole body supplements and enhances the immune function of the matrix.
The traditional Chinese medicine preparation disclosed by the invention is prepared by mixing materials according to the principle of 'monarch, minister, assistant and guide' of the traditional Chinese medicine strictly, has an obvious effect on treating diabetes, is short in cure period and solves the defects of the traditional Chinese medicine for treating diabetes at present. Meanwhile, the traditional Chinese medicine preparation stimulates islet beta cells to secrete insulin, repairs islet functions, increases the sensitivity of insulin receptors, inhibits the absorption of glucose, improves fatty acid metabolism and the like.
Monarch drug: ginseng radix has effects of repairing damaged cells, enhancing immunity, and recovering viscera function.
Ministerial drugs: the yam, the polygonatum and the saussurea involucrate culture increase the shortage of monarch drugs, improve the drug effect and comprehensively recover all large tissue cells.
Adjuvant drugs: yeast beta-glucan, earthworm protein, L-arabinose, inulin, fructo-oligosaccharide, isomalt, assistant ministerial drugs and assistant and guide drugs for rapidly repairing cells and eliminating complications.
A messenger drug: white kidney bean extract, lutein ester and vitamin B 1 Vitamin B 2 Vitamin B 6 Quickly reach the focus and control the complications and discomfort symptoms.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
The traditional Chinese medicine composition for treating diabetes is prepared from the following components in parts by weight: 5 parts of lotus culture, 8 parts of ginseng, 5 parts of sea buckthorn, 7 parts of polygonatum, 12 parts of Chinese yam, 7 parts of white kidney bean extract, 5 parts of yeast beta-glucan, 8 parts of earthworm protein, 5 parts of L-arabinose, 7 parts of lutein ester, 12 parts of inulin, 5 parts of fructo-oligosaccharide, vitamin B 1 2 portions of vitamin B 2 3 portions of vitamin B 6 2 portions of vitamin B 12 3 parts of isomalt and 5 parts of isomalt.
Example 2
The traditional Chinese medicine composition for treating diabetes is prepared from the following components in parts by weight: 4 parts of lotus culture, 5 parts of ginseng, 5 parts of sea buckthorn, 5 parts of polygonatum, 8 parts of Chinese yam, 10 parts of white kidney bean extract, 6 parts of yeast beta-glucan, 10 parts of earthworm protein, 6 parts of L-arabinose, 10 parts of lutein ester, 16 parts of inulin, 4 parts of fructo-oligosaccharide, and vitamin B 1 1 part of vitamin B 2 2 portions of vitamin B 6 3 portions of vitamin B 12 4 parts of isomalt and 3 parts of isomalt.
Example 3
The traditional Chinese medicine composition for treating diabetes is prepared from the following components in parts by weight: 6 parts of lotus culture, 10 parts of ginseng, 6 parts of sea buckthorn, 10 parts of polygonatum, 18 parts of Chinese yam, 5 parts of white kidney bean extract, 4 parts of yeast beta-glucan, 5 parts of earthworm protein, 4 parts of L-arabinose, 6 parts of lutein ester,8 parts of inulin, 6 parts of fructo-oligosaccharide and vitamin B 1 3 portions of vitamin B 2 4 parts of vitamin B 6 1 part of vitamin B 12 2 parts of isomalt and 8 parts of isomalt.
The preparation method of the traditional Chinese medicine preparation for treating diabetes is the same as the preparation method of the preparation in the prior art (such as isatis root preparation, brassica juncea Hu Keli preparation and the like), and detailed description is omitted here.
The invention has the advantages that: delay absorption of carbohydrates and sugars; does not inhibit the absorption of protein, trace elements and minerals; does not cause nutrient absorption disorder; the binding time with the enzyme is about 4-6 hours, after which the activity of the enzyme can be restored; is not metabolized by important organs such as liver, kidney, blood and the like, and has no toxic or side effect and accumulation function; contains various plant extracted components and new resource food raw materials, and can effectively finish and condition organisms.
The use method of the invention comprises the following steps: one bag (3 g per bag) is taken each time, 1-2 times per day, and the tea is taken 10-20 minutes before meal after being mixed with about 150ml warm boiled water (the temperature of the mixed water is not higher than 60 ℃).
The method is suitable for people: people with diabetes.
Not suitable for the crowd: infants, children under 14 years of age, pregnant women and lactating women.
Note that: when the blood glucose test instrument is used for people who are taking other blood glucose-reducing medicines and have abnormal glucose tolerance, attention should be paid to blood glucose test. Usage limit amount: the ginseng is used for no more than 3g per day, the inulin is used for no more than 15g per day, the lutein ester is used for no more than 12mg per day, and the isomaltulose alcohol is used for no more than 100g.
The invention has the following curative effects:
1. the blood sugar can be adjusted by high-risk people with diabetes after the high-risk people take the medicine in the same day, and the effective rate is 87 percent.
2. For patients with sensitive constitution or diabetes at first age who do not take hypoglycemic drugs continuously, the blood sugar value can be stably controlled without intentionally controlling staple food for three days, and no obvious hunger sensation and full energy exist before the second meal.
3. Western medicines can be gradually taken by patients with simple postprandial hyperglycemia for three days. Other diabetics take the medicine for 15-30 days, the postprandial blood sugar is gradually controlled, the western medicines are gradually reduced, more than three and less than one are obviously lightened, and the life quality is gradually improved.
4. After the medicine is taken for 90 days, most of patients can reduce the number of western medicines, the physical quality is greatly improved, and the self-feeling is good. And (4) reducing the dosage and the type of the western medicines according to the blood sugar detection condition until the western medicines are stopped.
5. After the health-care food is continuously taken, blood sugar is stable, beta cells are corrected, nourished and repaired, related complications are controlled, chronic diseases such as hyperlipidemia and hypertension are improved, and functions of viscera are strengthened.
6. The blood sugar is continuously stable after the medicine is continuously taken, the dosage of the medicine can be gradually reduced until the stable dosage of 1 bag is used for 7 days, and the risk of the type 2 diabetes of a patient with impaired glucose tolerance can be obviously reduced.
Test example
1. Clinical observations
Treatment group 1 the Chinese medicinal preparation described in example 1 of the present invention was selected to treat 50 patients with diabetes, of which 20 men and 30 women.
Treatment group 2 the Chinese medicinal preparation described in example 2 of the present invention was selected to treat 50 patients with diabetes, of which 20 men and 30 women.
Treatment group 3 the Chinese medicinal preparation described in example 3 of the present invention was selected to treat 50 patients with diabetes, 50 of which were treated by 20 men and 30 women.
All the patients meet the diagnosis standard of ADA diabetes mellitus in 2010.
2. Drug selection
Treatment group 1: the traditional Chinese medicine preparation disclosed in the embodiment 1 of the invention is used for treating three treatment courses (10 days as a treatment course), twice a day and one bag (5 g/bag) once.
Treatment group 2: the traditional Chinese medicine preparation disclosed in the embodiment 2 of the invention is used for treating three treatment courses (10 days and one treatment course) twice a day, and one bag (5 g/bag) is used once.
Treatment group 3: the traditional Chinese medicine preparation disclosed in the embodiment 2 of the invention has three treatment courses (10 days as a treatment course), is used twice a day and is bagged (5 g/bag)
3. Diagnostic criteria
Diagnosis standard for ADA diabetes in 2010:
1) And the glycosylated hemoglobin A1c is more than or equal to 6.5 percent.
2) And the fasting blood glucose FPG is more than or equal to 7.0 mmol/L. Fasting is defined as no caloric intake for at least 8 h.
3) And the blood sugar is more than or equal to 11.1 mmol/L in 2h of oral glucose tolerance test.
4) In patients with typical hyperglycemia or hyperglycemia crisis, random blood glucose is greater than or equal to 11.1 mmol/L.
5) When there is no definite hyperglycemia, criteria 1 to 3 should be confirmed by repeated tests.
4. Standard of therapeutic effect
The effect is shown: after treatment, the symptoms basically disappear, fasting blood sugar is less than 7.2 mmol/L (130 mg/dL), blood sugar is less than 8.3 mmol/L (150 mg/dL) after 2 hours of meal, the total urine sugar amount at 24 hours is less than 10.0 g, or the total urine sugar amount at 24 hours is reduced by more than 30 percent compared with the total urine sugar amount before treatment.
The method has the following advantages: the symptoms are obviously improved after treatment, the fasting blood sugar is less than 8.3 mmol/L (150 mg/dL), the blood sugar is less than 10.0 mmol/L (180 mg/dL) after 2 hours of meal, the total urine sugar in 24 hours is less than 25.0 g, or the total urine sugar in 24 hours is reduced by more than 10 percent compared with the total urine sugar before treatment.
And (4) invalidation: the symptoms are not obviously improved after treatment, and the reduction of blood sugar and urine sugar does not meet the standards.
5. Therapeutic results
Table 1 treatment groups 1-3 clinical trial efficacy assessment (n = 50)
Figure DEST_PATH_IMAGE001
The treatment results show that the traditional Chinese medicine preparation has remarkable effect of treating diabetes.
Typical cases
Case 1: certain plum, female, age 41, has diabetes for 4 years, fasting blood glucose is 9mmol/L, postprandial blood glucose is 19 mmol/L; after the Chinese medicinal preparation is taken for 2 times a day, the fasting blood sugar of a patient is reduced to 6 mmol/L and the postprandial blood sugar is reduced to 10 mmol/L after three months.
Case 2: after taking the medicine for 2 months, the symptoms of diabetes mellitus of a certain Wang male, 46 years old and Zhengzhou people in Henan province are obviously improved.
Case 3: when a certain amount of plum is male, 55 years old, and Xu Changshi people in Henan province, the symptoms are obviously improved after the pill is taken for 3 months, wherein the diabetes mellitus is suffered for 5 years.
Case 4: when a person who is male and 55 years old, kai city, qi county, henan province, suffers from diabetes for 3 years, and after taking the traditional Chinese medicine for 2.5 months, symptoms are obviously improved.
Case 5: a certain person, male, 59 years old, zhou kou city, henan province, suffered from diabetes for 3 years, and after taking the medicine for 3 months, the symptoms are obviously improved.
Case 6: in the case of Puyang people, henan province, aged 53 years, suffered from diabetes for 2 years, and after drinking for 2 months, the symptoms were significantly improved.
Case 7: the disease is diabetes for 2 years in a certain history, male, 52 years old, shanqiu city people in Henan province, and the symptoms are obviously improved after drinking 3 of the invention for 1.5 months.

Claims (1)

1. The traditional Chinese medicine preparation for treating diabetes is characterized by being prepared from the following components in parts by weight: 5 parts of lotus culture, 8 parts of ginseng, 5 parts of sea buckthorn, 7 parts of polygonatum, 12 parts of Chinese yam, 7 parts of white kidney bean extract, 5 parts of yeast beta-glucan, 8 parts of earthworm protein, 5 parts of L-arabinose, 7 parts of lutein ester, 12 parts of inulin, 5 parts of fructo-oligosaccharide, vitamin B 1 2 portions of vitamin B 2 3 portions of vitamin B 6 2 portions of vitamin B 12 3 parts of isomalt and 5 parts of isomalt.
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