CN111195392A - Implantable spinal cord stimulation system for spinal cord injury rehabilitation therapy - Google Patents
Implantable spinal cord stimulation system for spinal cord injury rehabilitation therapy Download PDFInfo
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- 230000000638 stimulation Effects 0.000 title claims abstract description 198
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36062—Spinal stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
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Abstract
The invention discloses a spinal cord stimulation system, which comprises an input device, a control device and a stimulation device, wherein the input device is used for acquiring user data related to the exercise will of a user and sending the user data to the control device; the control device can determine the exercise willingness of the user according to the user data, further trigger a stimulation strategy corresponding to the exercise willingness of the user, and send corresponding stimulation strategy data to the stimulation device; the stimulation device is capable of generating a specific stimulation signal sequence from the stimulation strategy data and outputting to one or more target locations. The invention can promote the user to complete the rehabilitation action through the stimulation output, assists the rehabilitation training and has great value for the rehabilitation treatment of spinal cord injury.
Description
Technical Field
The invention belongs to the field of medical treatment, and particularly relates to an implantable spinal cord stimulation system for spinal cord injury rehabilitation therapy.
Background
The world health organization estimates that 25 to 50 million people worldwide each year suffer some form of spinal cord injury, with severe spinal cord injury leading to physical paralysis. Some people have spinal distortions, but for spinal deformities, more often, diseases, poor posture, external force injuries, and malnutrition are the causes. The disease of the spine is characterized by needing long-term rehabilitation treatment and being easy to recur frequently under the inducements of jolt, vibration, improper force and the like. After the patients relapse, the patients cannot feel pain and cannot take care of life, the patients are paralyzed in bed in serious cases, great pains are brought to the life and the spirit of the patients and the families, and heavy economic burden is brought to families by seeking medical advice from four places. The most common treatment method of spondylopathy is that the patient lies on a hard bed board to recover naturally, and massage assistance is added, and said treatment method is characterized by that its treatment time is long, and the spondylopathy is not well restored, so that it is easy to recur after treatment.
Disclosure of Invention
Objects of the invention
The invention aims to provide an implanted spinal cord stimulation system for spinal cord injury rehabilitation therapy, which can be used for assisting rehabilitation therapy of spinal cord injury patients.
(II) technical scheme
To solve the above problems, a first aspect of the present invention provides a spinal cord stimulation system including an input device, a control device, and a stimulation device, wherein:
the input device is used for acquiring user data related to the exercise willingness of the user and sending the user data to the control device;
the control device can determine the exercise willingness of the user according to the user data, further trigger a stimulation strategy corresponding to the exercise willingness of the user, and send corresponding stimulation strategy data to the stimulation device;
the stimulation device is capable of generating a specific stimulation signal sequence from the stimulation strategy data and outputting to one or more target locations.
Preferably, the input means comprise bioelectric signal detection means capable of detecting a bioelectric signal correlated with the voluntary exercise of the user.
Preferably, the bioelectric signal comprises an electroencephalogram signal and/or an electromyogram signal of the user.
Preferably, the control means are able to define stimulation strategy data of the motor willingness based on a program set; the program group comprises at least one part of stimulation parameters which are defined according to the sport will and correspond to the user; the control device comprises a first storage unit for storing the stimulation strategy data;
the stimulation device is capable of generating a specific sequence of stimulation signals in response to the stimulation parameters of the program set.
Preferably, the stimulation strategy data includes identification information of each program group corresponding to the triggered stimulation strategy, and a corresponding duration of each program group;
the stimulation device comprises a second storage unit for storing data of the stimulation parameters contained in the respective program groups.
Preferably, the stimulation strategy data comprises identification information of the triggered stimulation strategy;
the stimulation device comprises a second storage unit, and the second storage unit is used for storing identification data and duration of a program group corresponding to each stimulation strategy and data of stimulation parameters of the program group corresponding to each stimulation strategy.
Preferably, the stimulation parameters comprise a contact parameter, an amplitude parameter, a pulse width parameter and/or a frequency parameter of a stimulation sequence of at least one stimulation signal channel.
The invention provides a spinal cord stimulation control device, which is used for a spinal cord stimulation system and comprises a first communication unit, a data processing unit and a second communication unit;
the first communication unit can communicate with an input device of the spinal cord stimulation system so as to acquire user data related to the exercise willingness of a user;
the data processing unit can analyze the user data, determine the exercise willingness of the user and further trigger a stimulation strategy corresponding to the exercise willingness of the user;
the second communication unit is capable of communicating with a stimulation device of the spinal cord stimulation system to transmit stimulation strategy data corresponding to the triggered stimulation strategy.
Preferably, the first communication unit is in a wired or wireless mode; the second communication unit is in a wireless mode.
Preferably, the data processing unit is configured to perform the steps of:
a step S1 of receiving user data related to the exercise will of the user;
step S2, analyzing the user data;
step S3, judging whether the user data identifies the exercise will, if yes, turning to step S4, otherwise, turning to step S1;
step S4, determining the stimulation strategy to be triggered according to the exercise will, and the program group and the stimulation time corresponding to the stimulation strategy, sending the data of the stimulation parameters of the first program group to the stimulation device, setting the stimulation time, and going to step S5;
step S5, judging whether the program group is sent completely, if yes, turning to step S2, otherwise, turning to step S6;
in step S6, data of the stimulation parameters of the next program group is transmitted and the stimulation time is set, and the process goes to step S5.
(III) advantageous effects
The technical scheme of the invention has the following beneficial technical effects:
according to the EEG signal, injury rehabilitation stimulation is carried out on different positions of the spinal cord through the electrodes, corresponding muscle movement is generated, walking and other movement are assisted to be completed, and therefore the function of assisting the whole rehabilitation training is achieved. Can also control the stimulation output in real time through in vitro program control software to complete the rehabilitation action and assist the rehabilitation training, and has great value for the rehabilitation treatment of spinal cord injury
Drawings
Fig. 1 is a schematic structural diagram of a spinal cord injury rehabilitation device according to an embodiment of the invention;
FIG. 2 is a schematic diagram of a stimulation strategy of a spinal cord injury rehabilitation device according to an embodiment of the present invention;
fig. 3 is a block diagram of a spinal cord injury rehabilitation device according to an embodiment of the present invention.
Fig. 4 is a flowchart of a control method of a spinal cord injury rehabilitation device according to an embodiment of the invention.
Reference numerals:
1: an input device; 2: a control device; 3: a stimulation device; 31: a communication module; 32: a pulse generator; 4: an electrode; 5: program group G1; 6: program group G2; 7: program group G3; 8: program group G4.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings in conjunction with the following detailed description. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
In the drawings a schematic view of a layer structure according to an embodiment of the invention is shown. The figures are not drawn to scale, wherein certain details are exaggerated and possibly omitted for clarity. The shapes of various regions, layers, and relative sizes and positional relationships therebetween shown in the drawings are merely exemplary, and deviations may occur in practice due to manufacturing tolerances or technical limitations, and a person skilled in the art may additionally design regions/layers having different shapes, sizes, relative positions, as actually required.
It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The invention will be described in more detail below with reference to the accompanying drawings. Like elements in the various figures are denoted by like reference numerals. For purposes of clarity, the various features in the drawings are not necessarily drawn to scale.
EEG is an abbreviation for brain wave, Electroencephalogram.
Fig. 1 is a schematic structural diagram of a spinal cord injury rehabilitation device according to an embodiment of the invention.
In one embodiment of the present invention, as shown in fig. 1, there is provided a spinal cord injury rehabilitation device, comprising:
an input device 1 for acquiring user data related to the user's exercise will and sending the user data to the control device 2.
The control device 2 can determine the exercise willingness of the user according to the user data, further trigger a stimulation strategy corresponding to the exercise willingness of the user, and send corresponding stimulation strategy data to the stimulation device 3.
A stimulation device 3 capable of generating a specific stimulation signal sequence from the stimulation strategy data and outputting to one or more target locations.
In a preferred embodiment, the input device 1 comprises an EEG detection device, so that the apparatus can perform injury rehabilitation stimulation on different positions of the spinal cord through electrodes according to EEG signals, generate corresponding muscle movement, assist in completing walking and other movements, and achieve the function of assisting the whole rehabilitation training function. The stimulation output can be controlled in real time through in vitro program control software to complete the rehabilitation action, assist the rehabilitation training and have great value for the rehabilitation treatment of spinal cord injury.
Alternatively, electrode 4 is any electrode known in the art suitable for implantable spinal cord stimulation.
Fig. 2 is a schematic diagram of a stimulation strategy of a spinal cord injury rehabilitation device according to an embodiment of the invention.
In a further embodiment of the invention, as shown in fig. 2, the stimulation device 3 further comprises: the communication module 31 and the signal processing module 31 are used for triggering the motor will to trigger the spinal cord stimulation strategy.
The input device 1 may include an electroencephalogram detection unit for the scalp for acquiring an electroencephalogram signal of the motor cortex.
The input device 1 may further include a sensor detection unit, which may be voice detection, video detection, etc., and the control device 2 may recognize the exercise will according to the corresponding sensor input signal, and trigger the exercise stimulation strategy in real time.
In the normal operation process (such as walking), the brain generates exercise will, and signals are transmitted to corresponding muscles through the spinal cord to generate actions, so as to complete new walking. And the brain motor will signals of the spinal cord injured patient can not be transmitted to the muscle, so the spinal cord injury rehabilitation device has the function of converting the signals transmitted by the spinal cord into electric signals and playing a role in transmitting the motor will. The transmission process is carried out in real time, the shorter the delay is, the better the delay is, for example, the patient needs to take the right leg, and then the nerve is stimulated rapidly through the spinal cord injury rehabilitation treatment device, so that the action is realized. Experiments prove that the effect on the recovery of spinal cord injury is more obvious.
The detection mode of the input device 1 can also be that words spoken by a patient are acquired or videos are acquired, and then stimulation is started quickly according to sports wishes to realize quasi-real-time actions.
Optionally, the stimulation device 3 further comprises: a pulse generator 32, the pulse generator 32 generating a stimulation signal according to a spinal cord stimulation strategy.
Alternatively, the input device 1 transmits the electric signal to the control device 2 by a wireless communication method or a wired communication method.
Optionally, the control device 2 transmits the electrical signal to the stimulation device 3 by wireless communication or wired communication.
Preferably, the input device 1 transmits the electric signal to the control device 2 by wireless communication; the control device 2 transmits the electrical signal to the stimulation device 3 by wireless communication.
In a preferred embodiment, the input device 1 includes an electroencephalogram acquisition electrode, an amplification and sampling circuit module, a data communication module, and the like, data communication may be in a wired or wireless manner, a wireless communication method with the control device 2 may be bluetooth or wifi, and an electroencephalogram acquisition channel may be 1-64 channels. The input device 1 can also be an implanted device, collects the subcortical electroencephalogram, and wirelessly transmits electroencephalogram signals through Bluetooth.
The control device 2 can be a desktop converter, a notebook computer, a tablet computer or the like, a signal receiver and control software are installed on the control device 2, the main functions include data communication control, a motion decoding algorithm, stimulation strategy control and the like, the motor will can be decoded in real time through electroencephalogram signals, a spinal cord stimulation strategy which is researched and set before and is used for realizing rehabilitation motion is started, a control instruction is sent to a spinal cord stimulation pulse generator 32 implanted into the body of a patient in real time, and the pulse generator 32 outputs stimulation signals according to the stimulation strategy.
The communication between the pulse generator 32 and the control device 2 may be by radio frequency wireless communication using the bluetooth or MICS bands.
In a preferred embodiment, a plurality of stimulation program sets (e.g., 1-16) may be set in the parameter register of the pulse generator 32, and parameters such as stimulation contact, stimulation amplitude, stimulation frequency, stimulation pulse width, etc. of each program set may be different. The logic control circuit realizes all the communication, power management, parameter selection and pulse output control functions of the pulse generator 32, so that external command signals can be received through the communication circuit, required parameters of the stimulation program group are selected, and the stimulation pulse output circuit outputs the parameters. The electrodes 4 comprise two types of flat electrodes 4 and columnar electrodes 4, are implanted outside the spinal cord epidural space in need through a surgical operation or a puncture mode, and can be provided with 8, 16, 24 or 32 contacts, so that different stimulation positions can be selected conveniently.
Fig. 3 is a block diagram of a spinal cord injury rehabilitation device according to an embodiment of the present invention.
As shown in fig. 3, the detecting unit 1 acquires an electrical signal of a motor cortex of a patient; the electric signals are transmitted to the conversion unit 2 through wireless communication transmission, and are converted to obtain the exercise will; the sport will is transmitted to the signal processing module 21, and a spinal cord stimulation strategy is triggered according to the sport will; the stimulation strategy is sent to a pulse generator 32 in the body, the pulse generator 32 generating a stimulation signal, and the electrodes 4 stimulating the spinal cord in response to the stimulation signal. Corresponding muscle movement is generated to assist in finishing the movement of walking and the like, thereby realizing the function of assisting the whole rehabilitation training function.
In a preferred embodiment, the stimulation strategy consists of 4 program groups, each containing the following parameters.
Program group G1: a stimulation contact 1, a stimulation pulse width 1, a stimulation amplitude 1, a stimulation frequency 1 and a stimulation time 1;
program group G2: a stimulation contact 2, a stimulation pulse width 2, a stimulation amplitude 2, a stimulation frequency 2 and a stimulation time 2;
program group G3: a stimulation contact 3, a stimulation pulse width 3, a stimulation amplitude 3, a stimulation frequency 3 and a stimulation time 3;
program group G4: stimulation contact 4, stimulation pulse width 4, stimulation amplitude 4, stimulation frequency 4, stimulation time 4.
The specific parameters are used for stimulating the specific position outside the spinal epidural to generate specific muscle movement, for example, the lumbar vertebra 1-5 segment spinal nerves mainly control leg muscle movement, a group of specific stimulation positions (corresponding to specific contacts on electrodes) and stimulation parameter combinations can correspondingly generate an action (such as flexion and extension of hip joints, knee joints and the like), and the motion stimulation strategy refers to that different set program groups are selected to stimulate at different times in sequence, so that a series of actions can be realized, and then leg walking movement is completed. According to the individual condition of each patient, the program groups and stimulation time needed for completing rehabilitation walking action are found in advance, and the needed program groups are set in the pulse generator, the number of the program groups is identified by n, for example, one stimulation strategy needs n to 4 program groups, the program group 1 (indicated by G1) stimulates the contact 5+/2-, the stimulation amplitude 2mA, the frequency 40Hz and the pulse width 200us, other program groups are G2, G3 and G4, and the stimulation strategy is exemplified as follows: g1200 ms, G2300 ms, G3500ms, G4100 ms.
And starting stimulation strategy control each time the exercise willingness signal is recognized, and circulating the steps. Stimulation strategy control has two embodiments.
One is that the internal pulse generator 32 only stores the needed stimulation program group, and the stimulation sequence and the stimulation time control of different program groups are realized by external control software; therefore, only parameter information such as stimulation sequence, stimulation time and the like needs to be transmitted between the stimulation device and the control device, and detailed parameters of each program group do not need to be transmitted, so that the communication time is saved, and the response speed is accelerated.
The other one is that the in vivo pulse generator stores a complete stimulation strategy, which comprises different program groups, a stimulation sequence and a stimulation time thereof, and the control device only sends a stimulation strategy trigger notice to the stimulation device. In such an embodiment, the amount of communication data between the control device and the stimulation device is less, and a faster response speed can be obtained.
After stimulating the spinal cord by a program group every time, judging whether all the program groups of stimulation to the nerves required for completing the exercise defined by the stimulation strategy are reached, and if not, performing stimulation operation of the next program group; if the trigger is reached, the strategy is ended, and the sport intention triggering is waited again.
Fig. 4 is a flowchart of a control method of a spinal cord injury rehabilitation device according to an embodiment of the invention.
As shown in fig. 4, the present embodiment provides a control method of a spinal cord injury rehabilitation device, including: acquiring user data related to the exercise willingness of the user; detecting according to the user data, and analyzing whether a sport will exists; generating corresponding stimulation signals according to the exercise desire; releasing current according to the stimulation signal.
Optionally, the control method of the spinal cord injury rehabilitation therapy device may further include: and matching a spinal cord stimulation strategy according to the motor will.
Optionally, the control method of the spinal cord injury rehabilitation therapy device may further include: sending the stimulation strategy to generate corresponding stimulation signals.
Optionally, the electrical signal is transmitted to the outside of the body for conversion.
Optionally, the transmission mode includes: wireless communication or wired communication.
Alternatively, the discharge of current is performed using electrodes.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.
Claims (10)
1. A spinal cord stimulation system comprising an input device, a control device, and a stimulation device, wherein:
the input device is used for acquiring user data related to the exercise willingness of the user and sending the user data to the control device;
the control device can determine the exercise willingness of the user according to the user data, further trigger a stimulation strategy corresponding to the exercise willingness of the user, and send corresponding stimulation strategy data to the stimulation device;
the stimulation device is capable of generating a specific stimulation signal sequence from the stimulation strategy data and outputting to one or more target locations.
2. The spinal cord stimulation system according to claim 1, characterized in that said input device comprises a bioelectrical signal detection device capable of detecting a bioelectrical signal related to the motor will of the user.
3. The spinal cord stimulation system according to claim 2, characterized in that said bioelectric signals comprise electrical brain signals and/or electrical muscle signals of said user.
4. Spinal cord stimulation system according to claim 1 or 2, characterized in that the control device is able to define stimulation strategy data of the motor willingness on the basis of a program group; the program group comprises at least one part of stimulation parameters which are defined according to the sport will and correspond to the user; the control device comprises a first storage unit for storing the stimulation strategy data;
the stimulation device is capable of generating a specific sequence of stimulation signals in response to the stimulation parameters of the program set.
5. The spinal cord stimulation system according to claim 4, wherein the stimulation strategy data includes identification information of each program group to which the triggered stimulation strategy corresponds, and a corresponding duration of each program group;
the stimulation device comprises a second storage unit for storing data of the stimulation parameters contained in the respective program groups.
6. The spinal cord stimulation system according to claim 4, characterized in that the stimulation strategy data comprises identification information of the triggered stimulation strategy;
the stimulation device comprises a second storage unit, and the second storage unit is used for storing identification data and duration of a program group corresponding to each stimulation strategy and data of stimulation parameters of the program group corresponding to each stimulation strategy.
7. Spinal cord stimulation system according to claim 4, characterized in that the stimulation parameters comprise a contact parameter, an amplitude parameter, a pulse width parameter and/or a frequency parameter of a stimulation sequence of at least one stimulation signal channel.
8. The spinal cord stimulation control device is characterized by being used for a spinal cord stimulation system and comprising a first communication unit, a data processing unit and a second communication unit;
the first communication unit can communicate with an input device of the spinal cord stimulation system so as to acquire user data related to the exercise willingness of a user;
the data processing unit can analyze the user data, determine the exercise willingness of the user and further trigger a stimulation strategy corresponding to the exercise willingness of the user;
the second communication unit is capable of communicating with a stimulation device of the spinal cord stimulation system to transmit stimulation strategy data corresponding to the triggered stimulation strategy.
9. The spinal cord stimulation control device according to claim 8, wherein the first communication unit is wired or wireless; the second communication unit is in a wireless mode.
10. The spinal cord stimulation control device according to claim 8 or 9, characterized in that said data processing unit is configured to perform the following steps:
a step S1 of receiving user data related to the exercise will of the user;
step S2, analyzing the user data;
step S3, judging whether the user data identifies the exercise will, if yes, turning to step S4, otherwise, turning to step S1;
step S4, determining the stimulation strategy to be triggered according to the exercise will, and the program group and the stimulation time corresponding to the stimulation strategy, sending the data of the stimulation parameters of the first program group to the stimulation device, setting the stimulation time, and going to step S5;
step S5, judging whether the program group is sent completely, if yes, turning to step S2, otherwise, turning to step S6;
in step S6, data of the stimulation parameters of the next program group is transmitted and the stimulation time is set, and the process goes to step S5.
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| CN201911414728.8A CN111195392A (en) | 2019-12-31 | 2019-12-31 | Implantable spinal cord stimulation system for spinal cord injury rehabilitation therapy |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111973874A (en) * | 2020-08-14 | 2020-11-24 | 北京航空航天大学 | Photoelectric combined stimulation device and method |
| CN111973875A (en) * | 2020-08-14 | 2020-11-24 | 北京航空航天大学 | Nerve photoelectric combined stimulation device and method |
| CN116747442A (en) * | 2023-08-14 | 2023-09-15 | 北京析芒医疗科技有限公司 | Consciousness disturbance rehabilitation-oriented wake-promoting system |
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2019
- 2019-12-31 CN CN201911414728.8A patent/CN111195392A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111973874A (en) * | 2020-08-14 | 2020-11-24 | 北京航空航天大学 | Photoelectric combined stimulation device and method |
| CN111973875A (en) * | 2020-08-14 | 2020-11-24 | 北京航空航天大学 | Nerve photoelectric combined stimulation device and method |
| WO2022033039A1 (en) * | 2020-08-14 | 2022-02-17 | 北京航空航天大学 | Photoelectric combined stimulation apparatus and method for nerve |
| CN116747442A (en) * | 2023-08-14 | 2023-09-15 | 北京析芒医疗科技有限公司 | Consciousness disturbance rehabilitation-oriented wake-promoting system |
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