CN111973874A - Photoelectric combined stimulation device and method - Google Patents
Photoelectric combined stimulation device and method Download PDFInfo
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Abstract
The invention discloses a photoelectric combined stimulation device and a method, which adopt a multi-sensor fusion photoelectric combined stimulation mode and simultaneously acquire movement intention signals of a brain and a spinal cord in different movement states aiming at a patient with movement function loss or partial loss caused by spinal cord injury. The difference between the brain electrical signals and the spinal cord electrical signals in different motion states is discussed in a contrast mode, high signal-to-noise ratio accurate acquisition without motion intention signals is achieved through signal fusion and preprocessing, the signals are finally converted into high-precision command issuing signals, and target stimulation activation of target nerves is achieved through the nerve selectivity of sub-threshold electrical stimulation and light stimulation.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a photoelectric combined stimulation device and method.
Background
Spinal cord injury is a common serious disabling disease, can directly cause motor, sensory and sphincter dysfunction of patients, seriously affects the living life of the patients, and even leads to death of severely injured patients. Spinal cord injury not only has catastrophic consequences for the patient, but also will place a heavy burden on the family, society and even the country. Among them, the loss of motor function caused by spinal cord injury can seriously affect the life of patients, so that the life cannot be self-managed, the psychological health condition of the patients is seriously affected, and even the life is affected.
At present, the technologies for repairing spinal cord injury and remodeling function mainly comprise surgical treatment, drug treatment, stem cell transplantation and the like, but the repairing and function remodeling effects are not ideal due to the complex clinical condition of spinal cord injury. In recent years, the spinal cord electrical stimulation function repair technology based on the brain/nerve interface technology has become a research hotspot in the field of spinal cord injury repair at home and abroad. However, the pure electrical stimulation technique has the following disadvantages: 1) the existing neural interface technology has low signal-to-noise ratio during signal extraction, and cannot accurately acquire an intention movement signal. Making the stimulus command issue ambiguous. 2) The motor intention signal extracted from the central nerve can not distinguish the motion states such as the action size, the speed and the like, and is not beneficial to sending an accurate command signal. 3) Due to the current flowing in the body, the stimulation position can only be one area, so that the nerve stimulation selectivity is low, and the target nerve cannot be stimulated in a targeted mode.
Therefore, how to realize issuing command signals with high precision and activate target nerves to realize spinal cord injury repair by targeted stimulation is a problem which needs to be solved urgently by those skilled in the art.
Disclosure of Invention
In view of the above, the present invention provides a photoelectric combined stimulation device and method, which employs a multi-sensor fusion photoelectric combined stimulation method for a patient with motor function loss or partial loss caused by spinal cord injury, and simultaneously acquires motor intention signals of the brain and the spinal cord in different motion states by using a multi-channel electrode. The difference between the brain electrical signals and the spinal cord electrical signals in different motion states is discussed in a contrast mode, high signal-to-noise ratio accurate acquisition without motion intention signals is achieved through signal fusion and preprocessing, the signals are finally converted into high-precision command issuing signals, and target stimulation activation of target nerves is achieved through the nerve selectivity of sub-threshold electrical stimulation and light stimulation.
In order to achieve the purpose, the invention adopts the following technical scheme:
a photoelectric combined stimulation device comprises an electroencephalogram electrode module, a processor integrated device, a pulse generator, a photoelectric combined stimulation electrode and a power supply; the electroencephalogram electrode module is wirelessly connected with the processor integrated device; the processor integrated device is connected with the pulse generator through a wire; the pulse generator is connected with the photoelectric combined stimulating electrode through a lead and a coupling optical fiber; the power supply is connected with the electroencephalogram electrode module and the processor integrated device.
Preferably, the electroencephalogram electrode module comprises a brain electrode, a conditioning amplifying circuit, an antenna and a wireless power supply module which are sequentially connected; the conditioning amplifying circuit and the antenna are connected with the wireless power supply module, and the wireless power supply module is wirelessly connected with the power supply and wirelessly supplies power through the power supply; the brain electrode collects brain electrical signals.
Preferably, the processor integrated device comprises an integrally arranged spinal cord electrode module, a processor, a signal receiving device, an electrical stimulation programmer and the wireless power supply module; the spinal cord electrode module comprises a spinal cord electrode and a conditioning and amplifying circuit, the spinal cord electrode collects spinal cord electric signals and is electrically connected with the conditioning and amplifying circuit, and the spinal cord electric signals are transmitted to the processor through the conditioning and amplifying circuit; the wireless power supply module of the processor integrated device is connected with the signal receiving device, the processor and the electrical stimulation programmer; the power supply is wirelessly connected with the wireless power supply module of the processor integrated device to realize wireless power supply; the signal receiving device and the electrical stimulation programmer are connected with the processor; the electrical stimulation programmer is connected with the pulse generator; the signal receiving device is wirelessly connected with the antenna.
Preferably, the processor is provided with a serial port and a Bluetooth module, and the processor is connected with the upper computer for communication through the serial port or the Bluetooth module. The parameters of a processor in the processor integrated device can be set through the upper computer, and the adjustment of the photoelectric combined stimulation device is realized.
Preferably, the photoelectric combined stimulation electrode adopts a subthreshold electrical stimulation mode; the photoelectric combined stimulation electrode is used for stimulating the motor nerve of the spinal cord in a targeted mode.
Preferably, the photoelectric combined stimulation electrode adopts a multi-channel array electrode, adopts a flexible polymer material as a substrate, and is distributed and attached with a plurality of channel electrode contacts; the electrode contact consists of an optical fiber contact and electrode plates, and each electrode plate corresponds to different regions of the spinal cord; each electrode contact is provided with a channel, each channel is provided with a coupling optical fiber and a conducting wire, each coupling optical fiber is correspondingly connected with one optical fiber contact, each conducting wire is correspondingly connected with one electrode plate, and all the coupling optical fibers and the conducting wires are gathered to one end of the multi-channel array electrode and led out by a bus.
Preferably, the conditioning and amplifying circuit receives an electrical signal, and the processing of the electrical signal includes pre-amplification, high/low pass filtering, 50HZ notch, post method and level-up in sequence.
A photoelectric combined stimulation method comprises the following specific steps:
step 1: the electroencephalogram electrode module and the spinal cord electrode module simultaneously acquire electroencephalogram signals and spinal cord electric signals and send the electroencephalogram signals and the spinal cord electric signals to the processor;
step 2: the processor receives the signals, performs characteristic identification on the signals, and compares and identifies characteristic differences through an algorithm;
and step 3: determining a movement intention by comparing the identified characteristic signals, coding the movement intention and converting the movement intention into a stimulation command signal;
and 4, step 4: transmitting the stimulation command signal to a pulse generator;
and 5: the pulse generator converts the received stimulation command signal into a specific stimulation signal, and the specific stimulation signal is sent to the photoelectric combined stimulation electrode through a lead and a coupling optical fiber to perform targeted stimulation on target nerve tissues so as to realize coordinated movement.
According to the technical scheme, compared with the prior art, the invention discloses and provides a photoelectric combined stimulation device and a method, brain electrical signals and spinal electrical signals are synchronously acquired through a brain electrode and a spinal electrode and are transmitted to a processor for identifying the movement intention characteristics, a portable stimulation control command is transmitted to the photoelectric combined stimulation electrode through a pulse generator according to the obtained movement intention, the photoelectric combined stimulation electrode stimulates a target area in a sub-threshold electrical stimulation mode, the stimulation target nerve is accurately selected by applying near infrared light, the high-precision activation of the nerve is realized, the electrical stimulation is combined with the optical stimulation, the electrical stimulation is in a sub-threshold state, the optical stimulation is added at the moment to irradiate the target nerve, and the highly selected stimulation target nerve can generate action potential without influencing other irrelevant nerves by adding two energies, not only can ensure the stimulation safety, but also can ensure the stimulation accuracy.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a photoelectric combined stimulation apparatus provided by the present invention;
FIG. 2 is a schematic diagram of a photoelectric combined stimulating electrode structure provided by the present invention;
fig. 3 is a schematic diagram of an electrode contact structure provided by the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention discloses a photoelectric combined stimulation device, which comprises an electroencephalogram electrode module, a processor integrated device, a pulse generator, a photoelectric combined stimulation electrode and a power supply, wherein the processor integrated device is connected with the electroencephalogram electrode module; the electroencephalogram electrode module is wirelessly connected with the processor integrated device; the processor integrated device is connected with the pulse generator through a wire; the pulse generator is connected with the photoelectric combined stimulating electrode through a lead and a coupling optical fiber; the power supply is connected with the electroencephalogram electrode module and the processor integrated device.
In order to further optimize the technical scheme, the electroencephalogram electrode module comprises a brain electrode, a conditioning amplifying circuit, an antenna and a wireless power supply module which are sequentially connected; the conditioning amplifying circuit and the antenna are connected with the wireless power supply module, the wireless power supply module is wirelessly connected with a power supply, and the wireless power supply module wirelessly supplies power in vitro through the power supply; the brain electrode collects brain electrical signals.
In order to further optimize the technical scheme, the brain electrode is integrated with a power supply module to supply power to the brain electrode.
In order to further optimize the technical scheme, the processor integrated device comprises a spinal cord electrode module, a processor, a signal receiving device, an electrical stimulation programmer and a wireless power supply module which are integrally arranged; the spinal cord electrode module comprises a spinal cord electrode and a conditioning and amplifying circuit, the spinal cord electrode collects spinal cord electric signals and is electrically connected with the conditioning and amplifying circuit, and the spinal cord electric signals are transmitted to the processor through the conditioning and amplifying circuit; the wireless power supply module of the processor integrated device is connected with the signal receiving device, the processor and the electrical stimulation programmer; the wireless power supply module of the power supply wireless connection processor integrated device realizes wireless power supply; the signal receiving device and the electrical stimulation programmer are connected with the processor; the electrical stimulation programmer is connected with the pulse generator; the signal receiving device is wirelessly connected with the antenna.
In order to further optimize the technical scheme, the wireless power supply module and the power supply are used for supplying power wirelessly, and the electromagnetic induction technology is utilized, and the electromagnetic induction coil is utilized to convert electric energy into magnetic energy for wireless transmission and reception.
In order to further optimize the technical scheme, the processor is provided with a serial port and a Bluetooth module and is connected with the upper computer for communication through the serial port or the Bluetooth module.
In order to further optimize the technical scheme, the photoelectric combined stimulation electrode adopts a sub-threshold electric stimulation mode; the photoelectric combined stimulation electrode is used for stimulating the motor nerve of the spinal cord in a targeted mode.
In order to further optimize the technical scheme, the photoelectric combined stimulation electrode adopts a multi-channel array electrode, adopts a flexible polymer material as a substrate 1, and a plurality of channel electrode contacts 2 are distributed and attached on the substrate 1; the electrode contact 2 consists of an optical fiber contact 21 and electrode plates 22, and each electrode plate 22 corresponds to different regions of the spinal cord; each electrode contact 2 is provided with a channel, each channel is provided with a coupling optical fiber and a conducting wire, each coupling optical fiber is correspondingly connected with one optical fiber contact 21, each conducting wire is correspondingly connected with one electrode slice 22, and one end of all the coupling optical fibers and the conducting wires which are gathered to the multi-channel array electrode is led out by the bus 3. The stimulation command signal sent by the electrical stimulation programmer is converted into a stimulation pulse signal through the pulse generator, so that different coupling optical fibers and wires are triggered, and nerves in different areas are stimulated through optical fiber contacts and electrode plates in different areas. When a human body moves, each motion corresponds to the activation of a group of nerves, the nerves correspond to different positions of a spinal cord, as long as the motion type can be identified, the corresponding position to be activated can be obtained, and a certain motion can be realized by activating the corresponding position.
In order to further optimize the technical scheme, the conditioning and amplifying circuit receives an electric signal, and the processing of the electric signal comprises pre-amplification, high/low pass filtering, 50HZ trap, post-method and level lifting in sequence.
A photoelectric combined stimulation method comprises the following specific steps:
s1: the electroencephalogram electrode module and the spinal cord electrode module simultaneously acquire electroencephalogram signals and spinal cord electric signals and send the electroencephalogram signals and the spinal cord electric signals to the processor;
s2: the processor receives the signals, performs characteristic identification on the signals, and compares and identifies characteristic differences through an algorithm;
s3: determining a movement intention by comparing the identified characteristic signals, coding the movement intention and converting the movement intention into a stimulation command signal;
s4: transmitting a stimulation command signal to a pulse generator;
s5: the pulse generator converts the received stimulation command signal into a specific stimulation signal, and the specific stimulation signal is sent to the photoelectric combined stimulation electrode through a lead and a coupling optical fiber to perform targeted stimulation on target nerve tissues so as to realize coordinated movement.
Examples
(1) The sciatic nerve separated from the lumbar enlargement part of the spinal cord extends to the muscles of the lower limbs, and different muscles of the lower limbs are respectively controlled by receiving motion signals from the brain and the spinal cord in the motion process of the lower limbs, so that a certain action is coordinately completed. The human body walking can be divided into the following stages:
1) single leg stance guide limb forward phase:
the lower abdomen is tightened to keep the trunk stable, the iliocolumbus muscles contract and bend the hip, the leashes contract and bend the knee with the shank, the tibialis anterior muscle and the peroneal muscle contract to generate ankle bending (foot hooking action), when the limb is guided to move forwards, the contralateral shoulder joint approaches to the contralateral hip joint, and the extensor of the toe contracts to generate foot hooking tip action (toe extension);
2) heel contact with ground
The hip flexion is stopped, the quadriceps femoris contracts and stretches the knee, and the ankle flexion and toe extension actions are stopped;
3) center of gravity forward moving, single leg supporting stage
The quadriceps femoris muscle tightens up, and the hip muscle group begins to contract;
4) the gravity center moves forward continuously and falls forward
Hip contraction and extension are carried out on the hip, stability is maintained in other places, and contraction of muscles of the crus and the feet is obvious;
5) a pushing stage:
the hip is continuously tightened and stretched, the quadriceps femoris continues to exert force to stretch the knee, and the side supporting limb is completely stretched to the swing limb to be about to touch the ground;
in the swinging process, the opposite side shoulder can be close to the swinging limb hip joint, and the toe flexor is used for exerting force at the end of the swinging stage, namely the toes also need to exert force during walking;
6) when the swing limb contacts the ground, a new cycle begins.
The muscle and coordinated contraction process involved in the normal walking process of the human body is just described, if the normal swing of the lower limbs of a patient with spinal cord injury is realized, different muscles need to be activated once according to the process, and the process needs to design and stimulate different areas of the spinal cord so as to control different muscles in a targeted mode, enable the muscles to contract in a coordinated mode and complete the swing of the lower limbs. The stimulation in different areas is in sequence, the algorithm is required to support the on-off or light of each channel in the multi-channel electrode, the optimal area is stimulated, and finally the core muscle group is controlled in a targeted mode to complete the swing of the lower limbs.
(2) Stimulation by electrodes requires the following two actions:
1. different stimulation modes are selected, and different electrode slices in the electrodes correspond to different regions of the spinal cord, so that different parts are stimulated. The method comprises the steps of acquiring electroencephalogram signals and spinal cord electrical signals by electrodes, obtaining signal characteristic parameters through mode recognition processing, obtaining interaction among central nerve cells by adopting correlation analysis, fusing the spinal cord electrical signals and the electroencephalogram signals mutually to realize comprehensive characteristic fusion of spinal cord and brain signals so as to obtain an exercise intention, compiling stimulation codes supported by the algorithm according to the exercise intention in an electrical stimulation programmer, executing the codes to form a set of stimulation modes, and sending electric pulses generated by running specific different stimulation modes and changed to a photoelectric combined stimulation electrode by a pulse generator to finally finish stimulation.
Different stimulation modes can be programmed into the electrical stimulation programmer in advance, different stimulation modes can be called by identifying different movement intentions, the real-time programming difficulty is reduced, and the realization degree is higher. The specific movement pattern can realize walking action in a grading way according to the analyzed intensity of the movement intention signal. The device can be divided into three different grades (slow, medium and fast), including leg striding speed and swing amplitude. Different motion states are correspondingly realized.
2. Analyzing the motor intention signal, wherein the collected electroencephalogram signal and spinal cord electric signal need characteristic identification and processing, and the signal code is converted into a stimulation command signal.
(3) The installation mode of the device of the invention is as follows:
the brain electrode is implanted into cerebral cortex to collect brain electrical signals, the spinal cord electrode is implanted into T7-T8 spinal cord epidural to collect spinal cord electrical signals, the spinal cord electrode and the processor are integrated together, and a signal receiving device is integrated for receiving brain electrical signals. The electroencephalogram signal and the spinal cord electric signal are transmitted to a processor through the preprocessing of a conditioning amplifying circuit, the characteristics of the signals are identified through the processor, different types of movement intention signals are identified, and the signals are encoded and converted into stimulation command signals. The preprocessing reduces the processing difficulty and power consumption of the processor on one hand, and can improve the processing speed on the other hand. The pulse generator is connected with the multichannel photoelectric combined stimulation electrode through a lead, and the photoelectric combined stimulation electrode is implanted outside a lumbar enlargement (L1-S2) dura mater and is used for the targeted stimulation of spinal motor nerves. The processor integrated device is connected with the pulse generator through a lead (namely, the electric stimulation programmer is connected with the pulse generator through a lead, the electric stimulation programmer issues different stimulation modes to the pulse generator), stimulation command signals are issued to the pulse generator, the pulse generator generates stimulation pulse signals through coordinating the photoelectric stimulation modes, and the stimulation pulse signals are sent to the photoelectric combined stimulation electrode to be used for stimulating nerves in a targeted mode.
(4) Accurate acquisition of brain and spinal cord motor intention signals
The position (point or area) of a motion signal in spinal nerves is determined, a multichannel array electrode meeting the collection requirement of central nerve electrical signals is adopted, the accurate positioning of the electrode in the spinal nerves is researched, the signal-to-noise ratio of a motion intention signal is improved, and the accurate collection of the electrophysiological signal is realized.
The multi-channel array electrode is shown in fig. 2, the electrode plate is shown in fig. 3, the multi-channel array electrode adopts a flexible polymer material (polydimethylsiloxane (PDMS), Polyimide (PI), Parylene (Parylene) and the like) as a substrate, 16 channel electrode contacts are distributed and attached to the substrate, and the contacts are composed of optical fiber contacts and the electrode plate, so that the electrode can conduct electricity and conduct light. Each channel of 16 channels is provided with a coupling optical fiber and a conducting wire, and finally the coupling optical fibers and the conducting wires are gathered to one end of the electrode and led out by a bus, the diameter of each optical fiber is 1mm, and the length of each electrode sheet is 4mm, and the width of each electrode sheet is 1.5 mm.
(5) Motor intention feature recognition (brain and spinal cord) based on different motor states
Based on the extracted brain and spinal cord movement intention signals, different experimental strategies are adopted to identify the movement intention signals of the patient in different movement states (action speed, action amplitude and the like). And comparing the difference between the brain electrical signals and the spinal cord electrical signals in different motion states, and fusing and preprocessing the spinal cord neural signals and the brain electrical signals to finally realize accurate motion characteristic identification without the motion states.
The process of identifying the movement intention features comprises the following steps: for the action A, an action command is given to a normal person (experimenter), after the experimenter receives the command, the brain sends an action signal, the signal is transmitted to a target muscle group through the spinal cord, and the target muscle group starts to make a corresponding action after receiving the command signal. In the process, the brain sends out a command and simultaneously releases certain electrophysiological signals, and the electric signals are received by the outside in an overall fixed form, and the signals are also called electroencephalogram signals, namely the overall reflection of the electrophysiological activity of brain nerve cells on the surface of the cerebral cortex or scalp. By analyzing the electroencephalogram signal of a specific action, the characteristic identification can be carried out on the electroencephalogram signal by utilizing wavelet transformation or an artificial neural network algorithm, the specific action is matched with the characteristic of the electroencephalogram signal correspondingly, and when the electroencephalogram signal is collected, an experimenter can be shown to carry out action A. This entire process, also referred to as "motor intention signal acquisition and recognition" of a particular action.
(6) Movement function remodeling based on photoelectric combined stimulation
The target area is stimulated by adopting a subthreshold electrical stimulation mode, and the target nerve is accurately selected and stimulated by applying near infrared light, so that the high-precision activation of the nerve is realized. When the nervous system is stimulated by current or voltage, the nervous system is induced to generate an action potential when the stimulation signal reaches a certain value, which is also called a stimulation threshold, and the action potential is transmitted to the target muscle to cause contraction of the target muscle. When the stimulation signal is close to but lower than the stimulation threshold, the action potential can not be generated, if a certain light stimulation is added to the stimulation nerve in the state, the receptor nerve can reach the stimulation threshold through the addition of the two energies, so that the action potential is generated, and the target muscle is induced to contract.
If electrical stimulation is used alone, since current can spread around the stimulation site, it is easy to misfire other nerves, causing other muscles to contract, resulting in incomplete action. The light stimulation is highly selective, and only stimulates the directly irradiated part, but the light stimulation alone is easily limited by the damage threshold and the stimulation threshold which are 2 times, and easily causes tissue damage. Therefore, the electrical stimulation can be combined with the optical stimulation, the electrical stimulation is in a sub-threshold state, the optical stimulation is added to irradiate the target nerve, and the target nerve can be excited to generate action potential through the addition of the two energies without influencing other irrelevant nerves, so that the stimulation safety can be ensured, and the stimulation accuracy can be realized.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A photoelectric combined stimulation device is characterized by comprising an electroencephalogram electrode module, a processor integrated device, a pulse generator, a photoelectric combined stimulation electrode and a power supply; the electroencephalogram electrode module is wirelessly connected with the processor integrated device; the processor integrated device is connected with the pulse generator through a wire; the pulse generator is connected with the photoelectric combined stimulating electrode through a lead and a coupling optical fiber; the power supply is connected with the electroencephalogram electrode module and the processor integrated device.
2. The photoelectric combined stimulation device is characterized in that the brain electrode module comprises a brain electrode, a conditioning and amplifying circuit, an antenna and a wireless power supply module which are sequentially connected; the conditioning amplifying circuit and the antenna are connected with the wireless power supply module, and the wireless power supply module is wirelessly connected with the power supply to realize wireless power supply; the brain electrode collects brain electrical signals.
3. The optoelectronic combination stimulation device according to claim 2, wherein the processor integrated device comprises an integrated spinal electrode module, a processor, a signal receiving device, an electrical stimulation programmer and the wireless power supply module; the spinal cord electrode module comprises a spinal cord electrode and a conditioning and amplifying circuit, the spinal cord electrode collects spinal cord electric signals and is electrically connected with the conditioning and amplifying circuit, and the spinal cord electric signals are transmitted to the processor through the conditioning and amplifying circuit; the wireless power supply module of the processor integrated device is connected with the signal receiving device, the processor and the electrical stimulation programmer; the power supply is wirelessly connected with the wireless power supply module of the processor integrated device to realize wireless power supply; the signal receiving device and the electrical stimulation programmer are connected with the processor; the electrical stimulation programmer is connected with the pulse generator; the signal receiving device is wirelessly connected with the antenna.
4. The optoelectronic combination stimulation device as claimed in claim 3, wherein the processor is provided with a serial port and a Bluetooth module, and is connected and communicated with an upper computer through the serial port or the Bluetooth module.
5. The optoelectronic combination stimulation device according to claim 1, wherein the optoelectronic combination stimulation electrode employs subthreshold electrical stimulation; the photoelectric combined stimulation electrode is used for stimulating the motor nerve of the spinal cord in a targeted mode.
6. The optoelectronic combination stimulation device according to claim 1, wherein the optoelectronic combination stimulation electrode is a multi-channel array electrode, a flexible polymer material is used as a substrate, and a plurality of channel electrode contacts are distributed and attached on the substrate; the electrode contact consists of an optical fiber contact and electrode plates, and each electrode plate corresponds to different regions of the spinal cord; each electrode contact is provided with a channel, each channel is provided with a coupling optical fiber and a conducting wire, each coupling optical fiber is correspondingly connected with one optical fiber contact, each conducting wire is correspondingly connected with one electrode plate, and all the coupling optical fibers and the conducting wires are gathered to one end of the multi-channel array electrode and led out by a bus.
7. The OPU device of claim 2 or claim 3, wherein the conditioning and amplification circuitry receives the electrical signal and the processing of the electrical signal comprises pre-amplification, high/low pass filtering, 50Hz notch, post-processing and level-up in that order.
8. The photoelectric combined stimulation method according to claims 1 to 7, characterized by comprising the following specific steps:
step 1: the electroencephalogram electrode module and the spinal cord electrode module simultaneously acquire electroencephalogram signals and spinal cord electric signals and send the electroencephalogram signals and the spinal cord electric signals to the processor;
step 2: the processor receives the signals, performs characteristic identification on the signals, and compares and identifies characteristic differences through an algorithm;
and step 3: determining a movement intention by comparing the identified characteristic signals, coding the movement intention and converting the movement intention into a stimulation command signal;
and 4, step 4: transmitting the stimulation command signal to a pulse generator;
and 5: the pulse generator converts the received stimulation command signal into a specific stimulation signal, and the specific stimulation signal is sent to the photoelectric combined stimulation electrode through a lead and a coupling optical fiber to perform targeted stimulation on target nerve tissues so as to realize coordinated movement.
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