CN111184825A

CN111184825A - Traditional Chinese medicine formula for treating chronic atrophic gastritis turbid toxin syndrome

Info

Publication number: CN111184825A
Application number: CN202010170814.5A
Authority: CN
Inventors: 李佃贵
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-03-12
Filing date: 2020-03-12
Publication date: 2020-05-22
Anticipated expiration: 2040-03-12
Also published as: CN111184825B

Abstract

The invention discloses a traditional Chinese medicine prescription for treating chronic atrophic gastritis with turbid toxin. The invention relates to a traditional Chinese medicine prescription for treating chronic atrophic gastritis with turbid toxin. The composition comprises the following raw materials: 12-15 g of wrinkled gianthyssop herb, 9-12 g of fortune eupatorium herb, 9-12 g of virgate wormwood herb, 9-12 g of coptis chinensis, 6-9 g of red yeast rice, 3-6 g of emblic leafflower fruit, 12-15 g of immature bitter orange, 12-15 g of nutgrass galingale rhizome, 6-9 g of murraya paniculata, 3-6 g of scorpion, 12-15 g of spreading hedyotis herb and 2-4 g of pseudo-ginseng. The invention has the beneficial effects that: the traditional Chinese medicine composition is simple in medicine composition, convenient and fast to take, safe, reliable, free of toxic and side effects, capable of promoting repair of gastric mucosa and improving self-healing capability of patients, and remarkable in effect.

Description

Traditional Chinese medicine formula for treating chronic atrophic gastritis turbid toxin syndrome

Technical Field

The invention relates to a Chinese medicinal formula for treating chronic atrophic gastritis with turbid toxin, in particular to a Chinese patent medicament prepared from Chinese medicinal herbs as raw materials.

Background

Chronic atrophic gastritis is a chronic digestive system disease characterized by atrophy, decreased number, thinning of gastric mucosa, thickening of mucosal basal layer, or accompanying pyloric and intestinal glandular metaplasia, or accompanying atypical hyperplasia of gastric mucosal epithelium and glands. It is usually manifested as vague pain, fullness and distention in the upper abdomen, belching, inappetence, emaciation, anemia, etc., and has no specificity. Is a disease with multiple pathogenic factors and precancerous lesion. The disease is one of common diseases of the digestive system, the incidence rate of chronic atrophic gastritis is very high in general people in China, and atrophic gastritis can be converted into gastric cancer.

At present, western medicines are usually selected for treating atrophic gastritis, but most of the medicines can only temporarily relieve pain of patients, the patients are difficult to cure radically, the recurrence rate is high, the western medicines are expensive, and certain toxic and side effects can be generated on the bodies after long-term administration.

The chronic atrophic gastritis belongs to the categories of fullness and epigastric pain and the like in the traditional Chinese medicine, and can be caused by invasion of exogenous pathogens, improper diet, overeating of paste and sorghum with thick taste, addiction to tobacco and wine, damage to spleen and stomach, damp generation and heat generation, generation of turbid pathogens due to long-term dampness, and generation of toxin; but also can cause discomfort of liver qi, stagnation of liver qi, wood-stasis and accumulation of earth, dysfunction of spleen in transportation, water accumulation and dampness generation and turbidity change for a long time due to emotional disorder or depression and anger; meanwhile, the spleen does not ascend the clear, the turbid qi does not descend, the spleen is stagnated in middle jiao, the damp turbidity is accumulated for a long time, the toxic pathogen is generated, the turbid toxin is mixed, and the stomach collaterals are damaged. Or mucosa atrophy gradually due to congenital deficiency, spleen and stomach deficiency, biochemical insufficiency, stomach malnutrition, dysfunction of transportation and transformation, turbid toxin accumulation, damage to gastric membrane. The evolution law is as follows: liver qi stagnation, wood hyperactivity, earth restriction, spleen deficiency and dampness abundance, followed by accumulation of dampness to turbidity, turbid stagnation transforming into heat, heat accumulation into toxin, turbid toxin deeply hidden in stomach vessel blood, finally forming the complicated pathological changes of chronic atrophic gastritis. TCM is mainly based on the holistic principle and based on the principles of treatment based on syndrome differentiation. According to the theory of turbid toxin syndrome of the tsukudani domestic medical masters, the turbid toxin intrinsic substance is considered to be the basic pathological mechanism of the chronic atrophic gastritis, and the turbid toxin intrinsic substance is the main syndrome type of the chronic atrophic gastritis, so that the chronic atrophic gastritis is treated by a turbid removing and detoxifying method, a good clinical curative effect is achieved, and no toxic or side effect exists.

Disclosure of Invention

The invention aims to solve the technical problem of providing a traditional Chinese medicine prescription for treating chronic atrophic gastritis turbid toxin syndrome aiming at the technical defects. The traditional Chinese medicine composition is simple in medicine composition, convenient and fast to take, safe, reliable, free of toxic and side effects, capable of promoting repair of gastric mucosa and improving self-healing capability of patients, and remarkable in effect.

The technical scheme adopted by the invention is as follows: provides a traditional Chinese medicine prescription for treating chronic atrophic gastritis turbid toxin syndrome, which consists of the following raw materials: 12-15 g of wrinkled gianthyssop herb, 9-12 g of fortune eupatorium herb, 9-12 g of virgate wormwood herb, 9-12 g of coptis chinensis, 6-9 g of red yeast rice, 3-6 g of emblic leafflower fruit, 12-15 g of immature bitter orange, 12-15 g of nutgrass galingale rhizome, 6-9 g of murraya paniculata, 3-6 g of scorpion, 12-15 g of spreading hedyotis herb and 2-4 g of pseudo-ginseng.

Preferably, the weight ratio of the medicinal raw materials is as follows: 15g of wrinkled gianthyssop herb, 12g of fortune eupatorium herb, 12g of virgate wormwood herb, 9g of coptis root, 6g of red yeast rice, 3g of emblic leafflower fruit, 12g of immature bitter orange, 12g of nutgrass galingale rhizome, 6g of murraya paniculata, 3g of scorpion, 15g of spreading hedyotis herb and 2g of pseudo-ginseng.

Preferably, the preparation and administration method of the traditional Chinese medicine comprises the following steps: taking each component of the raw materials, adding 400mL of water for the first decoction, soaking for 1h, decocting for 30min, and taking 200mL of juice; adding 400mL of water for the second decoction, decocting for 20min, and collecting 200mL of juice. Mixing the above 2 medicinal liquids, and taking 1 dose per day in the morning and evening with empty stomach 2 times. The treatment course is 2-3 (3 months for 1 treatment course).

Modern pharmacological studies show that agastache rugosus can inhibit spastic contraction of intestinal canals and visceral colic, increase gastric acid secretion and improve the activity of pepsin; the eupatorium total alkaloids have antitumor activity, and can stimulate gastric mucosa, promote gastric secretion, and promote digestion; herba Artemisiae Scopariae decoction and hot water extract have bile secretion and excretion promoting effects; the monascus has a nonspecific enhancing effect on immunity, and the monascus derivatives also have strong antioxidant and anticancer effects; the emblic leafflower fruit contains rich vitamin C; the immature bitter orange has double effects of inhibiting and exciting gastrointestinal tract movement; the rhizoma Cyperi extract has analgesic, antibacterial, antiemetic, and tranquilizing effects; the groundsel has the effects of anesthesia and analgesia; the scorpion effective anticancer component has obvious cytotoxicity and growth inhibition effect on human gastric cancer cell strain MGC-803; the herba Hedyotidis Diffusae has immunity enhancing and anti-tumor effects; notoginseng radix has antioxidant, antiaging, immunity regulating, and antitumor effects.

The turbid toxin of the chronic atrophic gastritis patient is accumulated in the stomach, which causes the damage of the stomach collateral, the hypofunction of decomposition, transportation and transformation, the lack of source of qi and blood, the deficiency of qi and blood, and the malnutrition of the gastric mucosa, resulting in the atrophy of the glands. Therefore, aiming at the pathogenesis of turbid toxin accumulation, the invention has good effect on treating chronic atrophic gastritis by a turbid pathogen dissolving and detoxifying method in clinic. According to the key pathogenesis of chronic atrophic gastritis caused by interior turbid toxin, the medicine adopts a comprehensive therapy of eliminating turbid pathogen with aromatics, clearing away heat and toxic materials, promoting blood circulation and removing meridian obstruction as a major method, comprehensively regulates digestive organs and comprehensively regulates human body functions.

The invention has the beneficial effects that: the traditional Chinese medicine composition is simple in medicine composition, convenient and fast to take, safe, reliable, free of toxic and side effects, capable of promoting repair of gastric mucosa and improving self-healing capability of patients, and remarkable in effect.

Detailed Description

The present invention will be described in further detail with reference to the following embodiments, but the present invention is not limited thereto.

A traditional Chinese medicine prescription for treating chronic atrophic gastritis turbid toxin syndrome comprises the following raw materials: 12-15 g of wrinkled gianthyssop herb, 9-12 g of fortune eupatorium herb, 9-12 g of virgate wormwood herb, 9-12 g of coptis chinensis, 6-9 g of red yeast rice, 3-6 g of emblic leafflower fruit, 12-15 g of immature bitter orange, 12-15 g of nutgrass galingale rhizome, 6-9 g of murraya paniculata, 3-6 g of scorpion, 12-15 g of spreading hedyotis herb and 2-4 g of pseudo-ginseng.

Example 1

The weight ratio of each raw material is as follows: 15g of wrinkled gianthyssop herb, 12g of fortune eupatorium herb, 12g of virgate wormwood herb, 9g of coptis root, 6g of red yeast rice, 3g of emblic leafflower fruit, 12g of immature bitter orange, 12g of nutgrass galingale rhizome, 6g of murraya paniculata, 3g of scorpion, 15g of spreading hedyotis herb and 2g of pseudo-ginseng.

Example 2

15g of wrinkled gianthyssop herb, 12g of fortune eupatorium herb, 12g of virgate wormwood herb, 9g of coptis root, 6g of red yeast rice, 6g of emblic leafflower fruit, 12g of immature bitter orange, 15g of nutgrass galingale rhizome, 6g of murraya paniculata, 3g of scorpion, 15g of spreading hedyotis herb and 4g of pseudo-ginseng.

The taking method of the invention can decoct the medicines with water, and one dose is taken every day; or grinding the raw materials into fine powder, and making into honeyed pill for administration; or decocting the raw materials and making into granule for administration. The specific operation method can be adjusted according to the actual situation.

The chronic atrophic gastritis has long course and is difficult to recover, the turbid toxin syndrome theory explains that the interior of turbid toxin is one of the main pathogenesis of precancerous lesion of gastric cancer, a turbid pathogen removing and detoxifying method is an effective method for treating the chronic atrophic gastritis, the turbid toxin is considered to be both a pathogenic factor and a pathological product, the chronic atrophic gastritis is closely related to damp turbidity, pathogenic damp turbidity is divided into internal and external pathogenic damp turbidity, the external damp turbidity is caused by the external damp turbidity, the internal damp turbidity is caused by the hypofunction or disorder of spleen and stomach, and the internal damp turbidity cannot be normally transported and transformed to cause the damp turbidity to grow from the interior. The mutual correlation between the internal and external damp-turbidity causes the exogenous damp-turbidity to stagnate in the spleen, which leads to the failure of the spleen to transport and transform, the stomach failing to descend and the endogenous damp-turbidity being liable to invade the exogenous damp-turbidity. The pathological changes of chronic atrophic gastritis are in the stomach, which belongs to yang earth, and the stomach diseases are easy to be transformed into heat and fire, namely yang excess. The two causes of heat toxicity are: the heat is even fire, and the fire entering the blood system is toxic; or, the initial stage of the disease is damp-heat, the damp-heat will accumulate turbid, the heat will be transformed into damp-heat, the damp-turbidity will transform into heat-toxin, and the toxin will grow from damp-turbidity, i.e. the heat will gradually transform into toxin, the toxin will become the extreme heat, the toxin will be contained in heat, and the heat will transform into toxin. The pathogenesis of the chronic atrophic gastritis and precancerous lesions thereof is theoretically clarified for the first time, and the theory basis is adopted to establish that three methods of dissolving turbidity, detoxifying and harmonizing stomach are combined to be mainly used for treating the precancerous lesions of the gastric cancer, thereby obtaining good curative effect.

Agastache rugosus and eupatorium fortunei have the effects of eliminating turbid with aromatics, and the aromatic products can nourish the spleen and activate the spleen, and eliminate damp turbidity internally; herba Artemisiae Scopariae clears away heat and promotes diuresis, and it is combined with herba Agastaches and herba Eupatorii to treat damp-heat in spleen, stomach, liver and gallbladder. Coptis root, rhizoma Coptidis, having the effects of clearing heat and drying dampness, purging fire and removing toxicity, is used for retention of damp-heat in the interior, etc.; red rice has the effects of invigorating spleen, promoting digestion, promoting blood circulation, and removing blood stasis. Emblic leafflower fruit, fructus Phyllanthi, as a main material, has the effects of clearing away heat and toxic materials, promoting the production of body fluid and quenching thirst. Zhi Shi breaks qi to remove food retention, resolve phlegm and relieve stuffiness. The nutgrass galingale rhizome regulates qi, relieves depression, promotes digestion and lowers qi. The groundsel herb has the effects of promoting qi and blood circulation, dissipating blood stasis and relieving pain, and detoxifying and reducing swelling; scorpio for removing toxic substance and dredging collaterals; oldenlandia diffusa, which has the effects of clearing heat, promoting diuresis and detoxifying; notoginseng, radix notoginseng, promotes blood circulation by removing blood stasis, and relieves swelling and pain. The medicines are combined together to play the roles of eliminating turbidity, detoxifying, promoting blood circulation and dredging collaterals, can eliminate gastric mucosal inflammation, effectively improve the blood flow condition of gastric mucosa and recover atrophic glands to reverse atrophic gastritis.

Typical case 1:

wuxx, male, 44 years old. The main complaints are: discomfort in the stomach, aversion to cold for 7-8 years, aggravation with bitter taste, halitosis, emaciation for more than 20 days.

The current medical history: the patient has no obvious inducement to discomfort in the gastric cavity and fear of cold seven years ago, the patient can see a doctor in local multi-hospitals without improvement, and the gastroscope diagnosis is carried out in the central hospital of the city of Western Ann 5-12 days in 2015: 1. chronic atrophic antral gastritis; 2. duodenal bulb polyps. Pathological changes show that: mild chronic inflammation of the gastric mucosa. Hp (-). After treatment, symptoms are mild and severe, and patients with bitter taste and halitosis, less appetite, cold intolerance and dry stool appear in nearly 20 days, so the traditional Chinese medicine preparation is prepared for thorough cure. The current symptoms are as follows: discomfort in the gastric cavity, cold intolerance, bitter taste in the mouth, bad breath, anorexia, 1-2 daily intake, cold intolerance, dry stool, plain stool in 4-5 days, and stool in nearly 6 days. Dark red tongue with yellow and greasy coating and wiry and thready pulse.

Laboratory examination: the diagnosis of gastroscopy in the central hospital of Xian city on 5, 12 and 5 months in 2015 is as follows: 1. chronic atrophic antral gastritis; 2. duodenal bulb polyps. And (3) pathology: mild chronic inflammation of the gastric mucosa, Hp (-).

Traditional Chinese medicine diagnosis: stomach fullness (turbid toxin in the interior, qi stagnation and blood stasis).

And (3) Western diagnosis: 1. chronic atrophic antral gastritis; 2. duodenal bulb polyps.

Therapeutic method: resolve turbidity, remove toxicity, promote qi and blood circulation.

The prescription is as follows: 15g of wrinkled gianthyssop herb, 12g of fortune eupatorium herb, 12g of virgate wormwood herb, 9g of coptis root, 6g of red yeast rice, 3g of emblic leafflower fruit, 12g of immature bitter orange, 12g of nutgrass galingale rhizome, 6g of murraya paniculata, 3g of scorpion, 15g of spreading hedyotis herb and 2g of pseudo-ginseng. Decocting 1 dose twice a day with slow fire for 40 min each time, collecting 400ml decoction, and taking half an hour before breakfast and supper.

And B, diagnosis: the patients have defecated stool, bitter taste and halitosis and reduced aversion to cold, still have less appetite, eat 1-2 days for two days, have good sleep, convenient adjustment, dark red tongue, yellow and greasy tongue coating, and wiry and thready pulse. The symptoms of the patients are relieved, and the effect is not more effective.

According to the language: in this example, the patient has interior turbid toxin, qi stagnation and blood stasis. Satisfactory effect is obtained by adopting a turbid-removing detoxification method. In the formula, the oldenlandia diffusa, the wrinkled gianthyssop, the eupatorium and the oriental wormwood are used for dissolving turbidity and detoxifying, promoting qi and activating blood circulation, and the clinical curative effect is obvious.

Typical case 2:

liu X, female, 49 years old. The main complaints are: the distending pain of the gastric cavity is interrupted for more than 10 years, with aggravation for more than 1 month.

The current medical history: before 10 years, the patient has no obvious inducement to the occurrence of epigastric distending pain, and is not paid attention. The later illness state is repeated, and the electronic gastroscopy is found in Hebei province in 2016, 2, 18 days: 1. polyps of the stomach (clamped); 2. chronic non-atrophic gastritis with erosion. Pathology report: 1. the stomach body considers polyps of the fundus stomach; 2. moderate chronic inflammation of pyloric mucosa, mild intestinal metaplasia of glands; hp (-). For systematic treatment, we see a doctor in his hospital. The current major symptoms are: distending pain in the stomach, mainly distending pain, mild sensation in the stomach, mild sleep, defecation with one stool a day, mild nature, dark red tongue, slightly greasy coating in the middle and root, and wiry and thready pulse.

Laboratory examination: the electronic gastroscopy was obtained in Hospital of traditional Chinese medicine in Hebei province in 2016 (2 months and 18 days): 1. polyps of the stomach (clamped); 2. chronic non-atrophic gastritis with erosion, blotchy gastric mucosa, smooth surface, moderate mucus lake volume, turbidity; the gastric mucosa is speckled, the fold is arranged regularly, 2 small bulges can be seen on the front wall, the sizes are all 0.1-0.2 cm, the surface is smooth and soft, and the front wall is removed by a disposable biopsy forceps; the mucosa of the antrum of the stomach is red and white, mainly red, and is seen scattered in the ridge erosion and not seen in the blood vessels under the mucosa; the pylorus deformed and opened, and the anterior wall was seen with macula-like erosion and soft texture. And (3) pathological report: 1. the stomach body considers polyps of the fundus stomach; 2. moderate chronic inflammation of pyloric mucosa, mild intestinal metaplasia of glands; hp (-).

Traditional Chinese medicine diagnosis: epigastric pain (stagnation of qi and dampness, blood stasis in the stomach).

And (3) Western diagnosis: 1. chronic atrophic gastritis, mild epithelial metaplasia of the glands; 2. polyps (clamped) develop in the stomach.

Syndrome analysis: liver qi stagnation affecting spleen and stomach, qi movement disorder, ascending and descending disorder, and gastric cavity distention, qi stagnation and damp obstruction, blood stasis in stomach collaterals, and pain due to obstruction of qi flow, manifested as epigastralgia; qi stagnation transforming into heat, damp-heat accumulating inside, so the root of the tongue coating is slightly greasy; dark red tongue with slightly greasy coating in the middle and root of the tongue coating, and wiry and thready pulse are the symptoms of qi stagnation, damp-heat obstruction in the middle and blood stasis in the stomach collateral.

Therapeutic method: move qi and remove dampness, activate blood and resolve stasis.

The prescription is as follows: 15g of wrinkled gianthyssop herb, 12g of fortune eupatorium herb, 12g of virgate wormwood herb, 9g of coptis root, 6g of red yeast rice, 6g of emblic leafflower fruit, 12g of immature bitter orange, 15g of nutgrass galingale rhizome, 6g of murraya paniculata, 3g of scorpion, 15g of spreading hedyotis herb and 4g of pseudo-ginseng. The medicines are decocted by slow fire twice, 40 minutes each time, 400ml of juice is taken together, and the decoction is taken warm half an hour before breakfast and supper.

According to the language: chronic gastritis is a chronic inflammation of the gastric mucosa caused by various causes, and the causes are mostly related to helicobacter pylori infection, diet and environmental factors, autoimmunity and the like. According to the symptoms of the disease, the traditional Chinese medicine classifies the disease into the categories of 'fullness in the abdomen', 'epigastric pain' and the like, and the pathogenesis of the disease is that the disease mostly enters the interior by exterior pathogenic factors, food stagnation and middle obstruction, phlegm-dampness stagnation, seven-emotion disharmony, weakness of spleen and stomach and the like. The patients suffer from liver depression and qi stagnation, transverse invasion of spleen and stomach, disorder of qi movement, dysfunction of ascending and descending, spleen and stomach weakness, water and body fluid distribution failure, qi movement disorder, retention of water-damp-phlegm retention of food and drink, toxic heat accumulation after a long time, qi stagnation and collateral obstruction, blood channel malnutrition and stomach nourishment failure, so the diseases are caused. According to the clinical manifestations and disease changes of the patient, treatment based on syndrome differentiation is performed, and the treatment is modified according to the symptoms, in the treatment process, based on the theory of turbid toxin, the treatment methods of soothing the liver, regulating qi, eliminating dampness, activating spleen, eliminating turbid, detoxifying, strengthening spleen and stomach, promoting blood circulation, removing blood stasis and the like are successively applied, and the clinical effect is obvious.

Claims

1. A traditional Chinese medicine prescription for treating chronic atrophic gastritis turbid toxin syndrome is characterized in that: the composition is prepared from the following raw materials: 12-15 g of wrinkled gianthyssop herb, 9-12 g of fortune eupatorium herb, 9-12 g of virgate wormwood herb, 9-12 g of coptis chinensis, 6-9 g of red yeast rice, 3-6 g of emblic leafflower fruit, 12-15 g of immature bitter orange, 12-15 g of nutgrass galingale rhizome, 6-9 g of murraya paniculata, 3-6 g of scorpion, 12-15 g of spreading hedyotis herb and 2-4 g of pseudo-ginseng.

2. The traditional Chinese medicine formula for treating chronic atrophic gastritis with turbid toxin according to claim 1, is characterized in that: the weight ratio of each raw material is as follows: 15g of wrinkled gianthyssop herb, 12g of fortune eupatorium herb, 12g of virgate wormwood herb, 9g of coptis root, 6g of red yeast rice, 3g of emblic leafflower fruit, 12g of immature bitter orange, 12g of nutgrass galingale rhizome, 6g of murraya paniculata, 3g of scorpion, 15g of spreading hedyotis herb and 2g of pseudo-ginseng.