CN111166692A - A composition with high moisture keeping effect - Google Patents
A composition with high moisture keeping effect Download PDFInfo
- Publication number
- CN111166692A CN111166692A CN202010191021.1A CN202010191021A CN111166692A CN 111166692 A CN111166692 A CN 111166692A CN 202010191021 A CN202010191021 A CN 202010191021A CN 111166692 A CN111166692 A CN 111166692A
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- CN
- China
- Prior art keywords
- sodium hyaluronate
- water
- transdermal
- decapeptide
- skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
Abstract
The invention discloses a high moisture retention composition, which comprises water, sodium hyaluronate and transdermal peptide, wherein the proportion of the water to the sodium hyaluronate is 1g, the sodium hyaluronate is 0.001-0.1g, and the transdermal peptide is 0.1-0.5mg, and the molecular weight of the sodium hyaluronate is selected from 1000-2000000 daltons.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a high moisture retention composition and a preparation method thereof.
Background
Sodium hyaluronate is also known as hyaluronic acid, is the best moisture retention component recognized in the skin care industry at present, is known as the 'moisture retention gold' of skin, is widely present in skin connective tissues and dermis layers, is responsible for storing moisture and increasing skin elasticity, but is only 15 grams in human bodies, and can be attenuated along with the increase of age. When the sodium hyaluronate in a human body is 15g, the human body looks moist, full, plump and elastic; when the amount of sodium hyaluronate in human body is less than 15g, the skin loses water storage capacity, gradually becomes dark and aged, and wrinkles are formed. The content of sodium hyaluronate in the skin directly determines the 'visual age' of the skin. The moisture content of healthy skin is about 15-20%, the water retention value of sodium hyaluronate is very high, 1g of sodium hyaluronate can absorb about 500 ml of water, and the sodium hyaluronate is one of the most accepted optimal moisturizing products. The existing very hot beauty project, namely water light injection, the injection components also contain sodium hyaluronate, and the water light injection is used for injecting the medicines into dermis. However, the parts after injection are slightly red and swollen, and the parts are dark purple. In addition to sodium hyaluronate for injection, there is also sodium hyaluronate for application. The average molecular weight of sodium hyaluronate is between 10 and 1000 kilodaltons, the molecular weight of the sodium hyaluronate prepared in the past is too large, and the small-molecular sodium hyaluronate prepared in the aspect of beauty by using nanotechnology is used at present, but the effect is very little relative to the absorption and permeability of the epidermis of skin.
The outermost layer of the skin has a stratum corneum, which has a form known as a brick pulp structure. In the stratum corneum, the so-called brick structure is composed of keratin-rich keratinocytes, while the so-called mortar structure is composed of lipids, such as ceramides, fatty acids or waxes, which fill the spaces between the keratinocytes. This structure prevents internal moisture from escaping from the skin surface and resists external attack. However, this structure has a very low permeability, precisely corresponding to its function. Only molecules with a molecular weight of 500 daltons or less are able to penetrate the skin by diffusion, mainly through the intracellular lipid layers of the mortar structure or the hydrophilic structures between the lipid layers.
Many chemical permeation enhancers are used to try to open the skin barrier, but most of the effects are not ideal. The existing chemical transdermal enhancer easily causes skin injury, inflammation, allergy, systemic toxicity and the like, and has great limitation on use. Common physical methods are iontophoresis, microneedles, etc. to prove transdermal effects to various molecules. However, physical methods have many disadvantages, including the use of special instruments, high cost, poor formulation flexibility, and the like, and are painful to various degrees, not suitable for home use, and the like. To overcome the above-mentioned deficiencies and thereby effectively enhance and/or facilitate the permeation of active molecules through the skin, patent No. CN106084006B discloses a method for the sequence synthesis of transdermal peptides (also referred to as transdermal decapeptide-4 in the present invention). The transdermal decapeptide-4 can realize transdermal absorption of active substances (small interfering RNA and growth factor protein macromolecules) without damaging the skin. There is no report on the transdermal effect of sodium hyaluronate with different molecular sizes.
Disclosure of Invention
The invention aims to overcome the difficulty of sodium hyaluronate transdermal penetration and provide a sodium hyaluronate moisturizing product which is convenient and safe to use and has a remarkable transdermal effect.
The invention is technically characterized in that: transdermal decapeptide-4 is added into the sodium hyaluronate stock solution to assist the sodium hyaluronate molecules to penetrate through the stratum corneum and enter the deep layer of the skin.
Compared with the prior art, the invention has the following characteristics and beneficial effects:
1. it is convenient for use, and can be directly applied at home. In contrast, the injection of the water-light needle type sodium hyaluronate ingredient needs to be carried out by a formal medical and aesthetic mechanism.
2. The use is safe, an invasive transdermal mode is avoided, and physical damage to the skin is avoided.
3. Can bring sodium hyaluronate components with different molecular sizes into skin to achieve the effects of moisturizing and resisting wrinkles. The macromolecule and the middle molecule sodium hyaluronate are stable and have long action time, and are generally used for resisting wrinkles, but cannot penetrate through the stratum corneum. The micromolecule sodium hyaluronate can partially penetrate into skin, is easy to decompose, has short action time and mainly plays a role in moisturizing, so that most of the coated sodium hyaluronate products on the market are micromolecule sodium hyaluronate components.
The raw materials in the invention are purchased from Guangzhou Yuanji Biotechnology GmbH, and the catalog numbers of the products are as follows:
water catalog number: 06260
Sodium hyaluronate catalog no: 06722
The sequence of transdermal peptide (transdermal decapeptide-4) was synthesized by Guangzhou Yuanji Biotech, Inc., as shown in Chinese granted patent CN 106084006B.
Detailed Description
The invention discloses a method for preparing a transdermal sodium hyaluronate high-moisture-retention composition. Those skilled in the art can now appreciate from this disclosure that appropriate modifications of the process parameters and adjuvants/starting components can be made, and it is specifically intended that all such similar substitutes and modifications which are obvious to those skilled in the art are deemed to be within the scope of the invention. While the skin care compositions of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications of the products and methods described herein, as well as appropriate variations and combinations of the same, can be made to implement and use the techniques of the present invention without departing from the spirit and scope of the invention. The following examples are merely illustrative, and the present invention is not limited to these examples.
Example 1
Adding sodium hyaluronate with molecular weight of 1000 daltons and water into a water phase pot of a homogenizing and emulsifying machine, stirring at 400 r/min, and adding transdermal decapeptide-4 with molecular weight after 20 minutes, wherein the ratio of the sodium hyaluronate to the water is 1 g: 0.001g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, and further stirring was continued for 10 minutes to obtain the moisturizing skin care product of example 1.
Example 2
Essentially the same as example 1, except that the ratio of the three is 1g of water: 0.005g sodium hyaluronate: 0.5mg transdermal decapeptide-4, the moisturizing skin care product of example 2 was obtained.
Example 3
Essentially the same as example 1, except that the ratio of the three is 1g of water: 0.01g sodium hyaluronate: 0.5mg transdermal decapeptide-4, the moisturizing skin care product of example 3 was obtained.
Example 4
Essentially the same as example 1, except that the ratio of the three is 1g of water: 0.05g of sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 4 was obtained.
Example 5
Essentially the same as example 1, except that the ratio of the three is 1g of water: 0.1g sodium hyaluronate: 0.5mg transdermal decapeptide-4, the moisturizing skin care product of example 6 was obtained.
Example 6
Adding sodium hyaluronate with the molecular weight of 5000 daltons and water into a water phase pot of a homogenizing and emulsifying machine, stirring at 400 rpm, adding transdermal decapeptide-4 with the molecular weight after 20 minutes, wherein the ratio of the sodium hyaluronate to the water to the transdermal decapeptide-4 is 1 g: 0.001g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, and further stirring was continued for 10 minutes to obtain the moisturizing skin care product of example 6.
Example 7
Essentially the same as example 6, except that the ratio of the three is 1g of water: 0.005g sodium hyaluronate: 0.5mg transdermal decapeptide-4, the moisturizing skin care product of example 7 was obtained.
Example 8
Essentially the same as example 6, except that the ratio of the three is 1g of water: 0.01g sodium hyaluronate: 0.5mg transdermal decapeptide-4, the moisturizing skin care product of example 8 was obtained.
Example 9
Essentially the same as example 6, except that the ratio of the three is 1g of water: 0.05g of sodium hyaluronate: 0.5mg transdermal decapeptide-4, the moisturizing skin care product of example 9 was obtained.
Example 10
Essentially the same as example 6, except that the ratio of the three is 1g of water: 0.1g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 10 was obtained.
Example 11
Adding sodium hyaluronate with molecular weight of 50000 daltons and water into a water phase pot of a homogenizing and emulsifying machine, stirring at 400 rpm, adding transdermal decapeptide-4 with molecular weight after 20 minutes, wherein the ratio of the sodium hyaluronate to the water to the transdermal decapeptide-4 is 1 g: 0.001g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, and further stirring was continued for 10 minutes to obtain the moisturizing skin care product of example 11.
Example 12
Essentially the same as example 11, except that the ratio of the three was 1g of water: 0.005g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 12 was obtained.
Example 13
Essentially the same as example 11, except that the ratio of the three was 1g of water: 0.01g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 13 was obtained.
Example 14
Essentially the same as example 11, except that the ratio of the three was 1g of water: 0.05g of sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 14 was obtained.
Example 15
Essentially the same as example 11, except that the ratio of the three was 1g of water: 0.1g sodium hyaluronate: 0.5mg transdermal decapeptide-4, the moisturizing skin care product of example 15 was obtained.
Example 16
Adding sodium hyaluronate with molecular weight of 200000 daltons and water into a water phase pot of a homogenizing and emulsifying machine, stirring at 400 rpm, adding transdermal decapeptide-4 with molecular weight after 20 minutes, wherein the ratio of the sodium hyaluronate to the water to the transdermal decapeptide-4 is 1 g: 0.001g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, and further stirring was continued for 10 minutes to obtain the moisturizing skin care product of example 16.
Example 17
Essentially the same as example 16, except that the ratio of the three was 1g of water: 0.005g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 20 was obtained.
Example 18
Essentially the same as example 16, except that the ratio of the three was 1g of water: 0.01g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 20 was obtained.
Example 19
Basically the same as example 16, except that the ratio of the three is: 1g of water: 0.05g of sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 20 was obtained.
Example 20
Essentially the same as example 16, except that the ratio of the three was 1g of water: 0.1g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 20 was obtained.
Example 21
Adding sodium hyaluronate with molecular weight of 2000000 daltons and water into a water phase pot of a homogenizing and emulsifying machine, stirring at 400 rpm, adding transdermal decapeptide-4 with molecular weight after 20 minutes, wherein the ratio of the sodium hyaluronate to the water to the transdermal decapeptide-4 is 1 g: 0.001g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, and further stirring was continued for 10 minutes to obtain the moisturizing skin care product of example 21.
Example 22
Essentially the same as example 21, except that the ratio of the three was 1g of water: 0.005g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 22 was obtained.
Example 23
Essentially the same as example 21, except that the ratio of the three was 1g of water: 0.01g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 23 was obtained.
Example 24
Essentially the same as example 21, except that the ratio of the three was 1g of water: 0.05g of sodium hyaluronate: transdermal decapeptide-4, 0.5mg, yielded the moisturizing skin care product of example 24.
Example 25
Essentially the same as example 21, except that the ratio of the three was 1g of water: 0.1g sodium hyaluronate: 0.5mg of transdermal decapeptide-4, the moisturizing skin care product of example 25 was obtained.
Example 26 moisturizing Effect test on skin
Skin stratum corneum hydration test: the working principle is that the capacitor is used as an instrument probe, and as water is a substance with the largest dielectric constant on the skin, when the moisture content of the skin changes, the capacitance value of the skin also changes, so that the moisture content on the surface of the skin can be analyzed by measuring the capacitance value of the skin. A commonly used instrument is Corneometer CM 825.
The experimental method comprises the following steps: marking out 3X 3cm on the bent side of the left and right forearms of the person to be tested2The test area of each test piece was measured by using a Corneometer CM825 after uniformly applying 1ml of the moisturizing skin care product prepared in examples 1 to 25 of the present invention (only sodium hyaluronate and water as a control) to the left arm and applying a control to the corresponding symmetric area of the right arm, respectivelyThe water content of the test parts is repeated for 5 times respectively to obtain an average value. The hydration rate was calculated by the following formula.
Hydration ═ (test value-blank value)/blank value × 100%
TABLE 11000 Dalton hyaluronic acid moisturizing effect test result
Table 25000 dalton hyaluronic acid moisturizing effect test results
Table 350000 dalton hyaluronic acid moisturizing effect test results
Table 4200000 dalton hyaluronic acid moisturizing effect test results
TABLE 5200000 hyaluronic acid moisturizing Effect test results
As shown in tables 1-5 above, compared with the control group, transdermal decapeptide-4 can assist hyaluronic acid with various molecular weights to enter the skin and play a role in moisturizing, and the proportion of the three is 1g of water: 0.01g hyaluronic acid: the best combination is 0.5mg transdermal decapeptide-4.
Example 27
60 women of 28-55 years old are selected, and 20 cases of dry, neutral and oily skin are selected. The compositions obtained in examples 1 to 25 were used in the moisturizing group, and the control group contained only sodium hyaluronate and water, and the moisturizing group and the control group contained 10 cases each. Applying 3-5ml of left-handed ring finger in the morning and evening, continuously using for 3 days, and observing the flatness, glossiness and furrows depth of the skin surface under a microscope on the fourth day. The evaluation criteria are as follows:
0-4 min: in terms of flatness, the skin is very rough; dull skin in terms of glossiness; the furrows were deep and clearly visible in the furrows.
5-7 min: in the aspect of flatness, the skin is rough; the skin is darker and slightly glossy in glossiness; the depth of the furrows is slightly shallower in the furrows.
8-10 min: in the aspect of flatness, the skin is smooth and flat; the skin is fine and glossy in the aspect of glossiness; the furrows were shallow and barely visible.
Test result of moisturizing effect of hyaluronic acid in table 61000 Dalton
Table 75000 dalton hyaluronic acid moisture retention effect test result
TABLE 850000 hyaluronic acid moisturizing Effect test results
TABLE 9200000 hyaluronic acid moisturizing Effect test results
TABLE 102000000 hyaluronic acid moisturizing Effect test results
From the above table 6-10, it is shown that compared with the control group, transdermal decapeptide-4 can assist hyaluronic acid of various sizes to enter the skin, playing a role in moisturizing, and the proportion of the three is 1g water: 0.01g hyaluronic acid: the best combination is 0.5mg transdermal decapeptide-4.
Claims (5)
1. A high moisture retention composition comprising water, a transdermal peptide and sodium hyaluronate, wherein the sodium hyaluronate has a molecular weight of from 1000 to 2000000 daltons.
2. The composition according to claim 1, characterized in that the ratio of water, transdermal peptide and sodium hyaluronate is 1g of water: 0.1-0.5mg of transdermal peptide: 0.001-0.1g sodium hyaluronate.
3. The composition according to claim 2, characterized in that the ratio of water, transdermal peptide and sodium hyaluronate is 1g of water: 0.5mg of transdermal peptide: 0.01g sodium hyaluronate.
4. A preparation method of a high moisture retention composition is characterized in that water and sodium hyaluronate are added into a water phase pot of a homogenizing emulsifying machine to be stirred at a speed of 400 revolutions per minute, the transdermal peptide is added after stirring for twenty minutes, and stirring is continued for ten minutes, wherein the proportion of the water to the sodium hyaluronate is 1 g: 0.001-0.1g sodium hyaluronate: 0.1-0.5mg of transdermal peptide.
5. The preparation method according to claim 4, wherein the water and the sodium hyaluronate are added into a water phase pot of a homogenizing and emulsifying machine to be stirred at 400 rpm, the transdermal peptide is added after stirring for twenty minutes, and stirring is continued for ten minutes, wherein the ratio of the water to the sodium hyaluronate is 1 g: 0.01g sodium hyaluronate: 0.5mg of transdermal peptide.
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| US20130059769A1 (en) * | 2010-05-10 | 2013-03-07 | Eva Turley | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
| US20160199498A1 (en) * | 2013-08-12 | 2016-07-14 | 3M Innovative Properties Company | Peptides for enhancing transdermal delivery |
| CN106084006A (en) * | 2016-06-23 | 2016-11-09 | 普锐尼斯生物科技有限公司 | A kind of transdermal peptide and application thereof |
| CN106236695A (en) * | 2016-06-02 | 2016-12-21 | 哈尔滨源茂达生物技术有限公司 | One peptide species anti-acne repairs essence and preparation method thereof |
| CN109091413A (en) * | 2018-10-31 | 2018-12-28 | 成都元素平衡生物科技有限公司 | A kind of transdermal characteristic botulinum toxin type A, preparation method and application |
| CN110237022A (en) * | 2019-07-03 | 2019-09-17 | 斯微(上海) 生物科技有限公司 | A kind of freeze-dried powder, solvent and its application |
-
2020
- 2020-03-18 CN CN202010191021.1A patent/CN111166692A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100113348A1 (en) * | 2007-03-01 | 2010-05-06 | Fumio Kamiyama | Percutaneously absorbable preparation, process for production thereof and method for percutaneous absorption |
| US20130059769A1 (en) * | 2010-05-10 | 2013-03-07 | Eva Turley | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
| US20160199498A1 (en) * | 2013-08-12 | 2016-07-14 | 3M Innovative Properties Company | Peptides for enhancing transdermal delivery |
| CN106236695A (en) * | 2016-06-02 | 2016-12-21 | 哈尔滨源茂达生物技术有限公司 | One peptide species anti-acne repairs essence and preparation method thereof |
| CN106084006A (en) * | 2016-06-23 | 2016-11-09 | 普锐尼斯生物科技有限公司 | A kind of transdermal peptide and application thereof |
| CN109091413A (en) * | 2018-10-31 | 2018-12-28 | 成都元素平衡生物科技有限公司 | A kind of transdermal characteristic botulinum toxin type A, preparation method and application |
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