CN111151068B

CN111151068B - Automatic change solid-liquid separation's full faecal sample treater

Info

Publication number: CN111151068B
Application number: CN202010064070.9A
Authority: CN
Inventors: 高鹏; 周长仁; 孙克茂; 杨承凤; 其他发明人请求不公开姓名
Original assignee: Jiangsu Microdiag Biomedicine Technology Co ltd; Anhui Weizhen Bioengineering Technology Co ltd
Current assignee: Jiangsu Microdiag Biomedicine Technology Co ltd; Anhui Weizhen Bioengineering Technology Co ltd
Priority date: 2020-01-07
Filing date: 2020-01-20
Publication date: 2022-04-15
Anticipated expiration: 2040-01-20
Also published as: CN111151068A

Abstract

The processor that is used for excrement and urine sample collection, save, mixing and automatic solid-liquid separation is provided, includes: the excrement collecting container comprises an excrement collecting container and a solid-liquid separation part, wherein the solid-liquid separation part is a solid-liquid separation channel positioned in an outer wall or an interlayer of the inner wall and the outer wall of the container, the starting end of the channel is communicated with the inside of the container, the tail end of the channel is communicated with a supernatant receiving bin, the receiving bin is communicated with an inner cavity of the container through a waterproof breathable film, a filtering device and a one-way valve are arranged in the channel, and a raised ridge for uniformly mixing samples is arranged at the bottom or on the side wall of the container.

Description

Automatic change solid-liquid separation's full faecal sample treater

Background

Laboratory examinations of stool samples in medical tests are an important component of in vitro diagnostics. Physicians and clinicians often need to test stool samples, including detection of microorganisms such as pathogens, viruses, etc., as part of testing for colon or rectal cancer or to identify bacteria or viruses that may be involved in an infection. In addition, the clinical laboratory needs to assay for nucleic acids, proteins, fats or other analytes present in the stool sample. Thus, the collection of a stool sample for testing is the first step in sample processing for many tests, and the container containing the collected stool sample is not only suitable for laboratory storage of the sample, but also for transport and/or shipment of the sample to the laboratory where it is to be tested. The excrement needs to be subjected to pretreatment operations such as collection, transportation, storage, uniform mixing, solid-liquid separation and the like. Especially, higher difficulty and requirement are provided for the collection and treatment technology of the whole excrement sample.

The contents of the following three aspects are at least needed to be solved when the whole processes of sampling, storing, transporting, uniformly mixing and solid-liquid separation are carried out in the whole excrement closed environment:

firstly, sealing, wherein full sealing of the whole flow is required to be realized, and liquid and smell are not leaked;

secondly, stirring and uniformly mixing the whole excrement, wherein the whole excrement can be fully and uniformly mixed in a closed space, and the odor of a sample is not leaked;

thirdly, solid-liquid separation, namely, the integrated solid-liquid separation in the sampler is required to be realized.

Disclosure of Invention

The invention provides an automatic solid-liquid separation full excrement sample processor, which aims to collect, store, uniformly mix and carry out convenient operation on solid-liquid separation on a full excrement sample.

The invention provides a processor for collecting, storing, uniformly mixing and automatically separating solid and liquid of a fecal sample, which comprises: the excrement collecting container comprises an excrement collecting container and a solid-liquid separation part, wherein the solid-liquid separation part is a solid-liquid separation channel positioned in an outer wall or an interlayer of the inner wall and the outer wall of the excrement collecting container, the starting end of the channel is communicated with the inside of the excrement collecting container, the tail end of the channel is communicated with a supernatant receiving bin, and the receiving bin is communicated with the inner cavity of the excrement collecting container in a one-way air-permeable and watertight manner through a hole; at least 1 filtering device is arranged in the channel; be provided with bellied spine on the lateral wall or the bottom of excrement and urine collection container inner chamber, perhaps excrement and urine collection container inner chamber is the polygon, still is provided with at least 1 openable or penetrable supernatant thief hatch on the excrement and urine collection container, and the storehouse intercommunication is accepted with the supernatant to the supernatant thief hatch for accept the sample in the storehouse from the supernatant.

The fecal collection container includes: bottom, lateral wall, opening, lid.

The opening includes the openable upper shed that is used for accepting the excrement and urine sample, at least 1 opening of being connected with the initiating terminal of solid-liquid separation passageway to and at least 1 openable be used for getting the thief hole of the supernatant of separation, the thief hole is connected with the storehouse is accepted to the supernatant.

The solid-liquid separation channel of the solid-liquid separation part is a detachable part, can be in a cavity form or an independent channel form, and is embedded to the outer wall of the excrement collection container in a buckling, threaded, spinning, bonding and other modes.

The solid-liquid separation channel of the solid-liquid separation part can also be integrally formed and fixed or embedded into the outer wall of the excrement collection container or an interlayer of the inner wall and the outer wall of the excrement collection container.

The shape of the solid-liquid separation channel of the solid-liquid separation part can be spiral-rising or zigzag or other shapes which are symmetrical relative to the central axis of the excrement collecting container or other shapes which can achieve dynamic balance.

The starting end of the solid-liquid separation channel of the solid-liquid separation part is communicated with the interior of the excrement collection container in a valve, a filter screen, a rubber plug and other modes, and the valve is selected from a plug valve, a gate valve, a ball valve and the like.

The valve may be sealed by a suitable packing material such as polytetrafluoroethylene.

Preferably, the receiving bin is communicated with the inner cavity of the excrement collecting container through a waterproof breathable film.

Preferably, the filter means in the channel is arranged at the opening of the faecal collection container into the channel, or at the beginning of the channel, or in the channel or at least 1 place at the end of the channel.

More preferably, the filtration means may be selected from a sieve, a membrane, a cartridge, and the like.

More preferably, the apertures of the sieve are smaller closer to the uptake bin.

Preferably, at least 1 transit bin is provided in the channel, more preferably the location of the transit bin is above the level of the sample in the faeces collection container.

More preferably, the transfer chamber is disposed at the zigzag transition when the passage is in the zigzag rising shape.

More preferably, the bottom of the transfer chamber is tapered or rounded.

Preferably, 1 or more one-way valves may also be provided in the channels.

More preferably, the one-way valve in the passage is provided at the transfer bin inlet.

In another aspect, a full stool sample processor may be used to collect a medical sample of full stool, and conventional containers are sized to hold a stool collection container of a complete stool specimen, typically having a diameter large enough that it is difficult for a small or weak person to hold the stool collection container and/or a stool collection container lid, making opening, closing, and/or sealing inconvenient. Thus, aspects of the present invention also contemplate a convenient and comfortable collection of a stool sample for a user, ease of use by a subject of the stool sample, and a sample processor including features that facilitate use by a human subject.

The inner cavity of the excrement collecting container can be in the shapes of a cylinder, a polygonal (such as a quadrilateral, a pentagon, a hexagram and the like) cylinder and the like, and can also be in other shapes which are convenient for sampling and holding.

The excrement and urine collection container is inside through set up the spine of 1 or a plurality of protruding forms on bottom or inner wall for vortex becomes the stirring that circulates the vortex about the vortex and realize excrement and urine sample.

Preferably, the positive and negative intermittent alternate rotation of the fecal collection container further facilitates adequate agitation of the fecal sample.

In another aspect, the present invention also provides improved designs for preventing leakage during handling or shipping.

The cap is combined with the upper opening of the feces collection container in a threaded manner. Specifically, the cover enters the upper opening of the excrement collecting container in an internal spiral mode.

The cap may also be combined with the upper opening of the fecal collection container by snap, or a combination of a threaded combination.

The lid and the upper opening are realized through the sealing of compound form, including realizing the top side sealing through the flaring edge, realizing the top sealing through sealed the pad, realizing the thread sealing through the screw-thread fit, realizing the bottom side sealing through the necking edge.

The excrement collecting container and/or the solid-liquid separation part can be arranged in a fully transparent, partially transparent or semitransparent mode so as to be convenient to cooperate with observation or machine automatic monitoring.

After the excrement is fully and uniformly stirred, the excrement homogenate enters a channel through the centrifugal force generated by the rotation of a processor and the combined action of the gravity, the elasticity and the like of the liquid homogenate, and solid-liquid separation is realized through filtering by a filter screen and a filter membrane or/and precipitation by a transit bin. Preferably, the rotation is positive and negative alternate intermittent rotation for better solid-liquid separation.

The scheme of the invention can achieve the following beneficial effects: (1) the receiving bin is communicated with the inner cavity of the excrement collecting container through a waterproof breathable film or a valve, and has a deodorization effect. (2) Good sealing effect, full sealing, and prevention of pollution and peculiar smell. (3) Can realize fully-automatic integrated excrement sample homogenate, solid-liquid separation and supernatant sampling. (4) The operation and the use are convenient, and the use and the mailing of the samples are convenient for families.

Drawings

Fig. 1 is a schematic diagram of one form of fecal sample processor.

Fig. 2 is a schematic view of the construction of one form of fecal collection container.

FIG. 3 is a schematic view of the structure of a solid-liquid separation section in one form.

Fig. 4 is a schematic view of one form of sealing between the cover and the upper port.

FIG. 5 is a schematic view of a solid-liquid separation channel of another form of fecal sample processor.

Description of reference numerals: 1-excrement collecting container, 2-solid-liquid separating part, 3-cover, 4-filtering device, 5-valve, 6-special-shaped sealing gasket, 7-sealing gasket and 8-screw thread; 11-container bottom, 12-container side wall, 13-container upper opening, 14-hole, 15-ridge, 16-supernatant sampling hole and 17-necking edge; 21-channel, 22-supernatant receiving bin, 23-transit bin, and 24-one-way valve; 31-flared edges.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

Referring to fig. 1-4, a form of feces sample collection, preservation, blending and automatic solid-liquid separation processor is provided, which comprises a feces collection container 1 and a solid-liquid separation part 2, wherein the feces collection container 1 and the solid-liquid separation part 2 are partially transparent, the solid-liquid separation part is a detachable part, is connected to the outer wall of the feces collection container through a buckle and is arranged in a symmetrical mode relative to the central axis of the processor, the solid-liquid separation part is an arc-shaped sheet, a semi-open solid-liquid separation channel 21 is arranged in the sheet, one end (initial end) of the channel is communicated with the interior of the feces collection container through a valve 5, a filter device 4 is arranged between a plug valve and the inner cavity of the feces collection container, the channel is in a zigzag rising shape, a conical bottom or a round bottom transfer bin 23 is arranged at the turning part of the channel, a bin communicated with the tail end of the channel is a supernatant receiving bin 22, the receiving bin is communicated with the inner cavity of the excrement collecting container through a hole 14 by a waterproof breathable film. And, the junction of transit storehouse and passageway all is provided with filter equipment 4, and the entrance of transit storehouse still is provided with check valve 24, and the nearer the passageway end, the smaller is the filter screen aperture. The excrement collecting container also comprises a supernatant sampling hole 16 which can be opened and closed and is used for taking and separating supernatant and is communicated with the supernatant receiving bin.

Referring to fig. 2, the side walls and bottom of the faecal collection container are provided with a symmetrical plurality of raised ridges 15.

The excrement collecting container also comprises a preserving fluid for preserving and pretreating the excrement sample.

When the device is used, a subject receives the whole excrement into the excrement collecting container and screws down the cover.

The inspection personnel will contain the treater of full excrement and urine sample to fix on suitable machine, under the plug valve closed condition, carry out a period of rotation or vibrate, realize stirring of excrement and urine sample, become the thin homogenate state. The following two modes of operation can then be selected:

(1) the plug valve is opened to the automated instrument, the liquid level begins to balance under the action of gravity, excrement homogenate in the excrement collection container can enter a channel of a solid-liquid separation part through a screen, and further rises to enter a transfer bin, when monitoring that the liquid level reaches a target position in the transfer bin through transparent outer wall automated equipment, the valve is closed, the centrifugation of homogenate after a small amount of filtration in the channel is carried out, liquid in the channel is under the pressure of centrifugal force, the further filtration is carried out, the supernatant liquid is finally entered to accept the bin, and then sampling is carried out by opening a sampling port. If the supernatant is not enough, the steps can be repeated for replenishing the liquid.

(2) Opening the plug valve, selecting proper centrifugal speed, centrifuging for proper time or intermittently rotating for a period of time, and filtering the homogenate layer by layer through the filter screen and precipitating in the transfer bin under the combined action of centrifugal force, gravity and the like to obtain separated supernatant in the supernatant receiving bin at the tail end of the channel. And finally, sampling through a supernatant sampling port.

Example 2

Referring to fig. 5, the present embodiment provides another form of processor for collecting, storing, mixing and automatically separating solid and liquid feces samples, which includes a feces collection container and a solid-liquid separation part, wherein a channel 21 of the solid-liquid separation part is in a spiral rising shape and is integrally formed with an outer wall of the feces collection container, a plurality of filter screens 4 are disposed in the channel, a terminal of the channel leads to a supernatant receiving bin 22, and a supernatant sampling hole 16 which can be opened and closed and is used for taking separated supernatant is further disposed on the feces collection container. Other features such as vent, cap, one-way valve, ridge in the fecal collection container or shape of the fecal collection container interior are similar to those of example 1.

The inspection personnel will contain the treater of full excrement and urine sample to fix on suitable machine, and under the plug valve closed condition, carry out the rotation of a period of time or vibrate, realize stirring of excrement and urine sample, become thin homogenate state, later open passageway entrance valve, select suitable centrifugal rotational speed, centrifugation a period, under the combined action of centrifugal force and gravity isodynamic, the homogenate filters layer by layer through the filter screen, and the supernatant that obtains the separation in accepting the storehouse at the terminal supernatant of passageway. And finally, sampling through a supernatant sampling port.

The above description is only two embodiments of the present invention, and not intended to limit the present invention, and any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. It should be noted that, for those skilled in the art, without departing from the technical principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be construed as the protection scope of the present invention.

Claims

1. The utility model provides a fecal sample processor, includes excrement collection container (1) and solid-liquid separation part (2), and excrement collection container includes container bottom (11), container lateral wall (12), container upper shed (13) and lid (3), its characterized in that: the solid-liquid separation part (2) comprises a channel (21), the channel (21) is positioned in the outer wall or the interlayer of the inner wall and the outer wall of the excrement collection container, the starting end of the channel is communicated with the inside of the excrement collection container in a switchable manner, the tail end of the channel is communicated with a supernatant receiving bin (22), and the supernatant receiving bin (22) is communicated with the inner cavity of the excrement collection container in a one-way breathable and watertight manner through a hole (14); at least 1 filtering device (4) is arranged in the channel or at the opening of the excrement collecting container; the side wall or the bottom of the inner cavity of the excrement collecting container is provided with a raised ridge (15), or the inner cavity of the excrement collecting container is polygonal, the excrement collecting container is further provided with at least 1 openable or penetrable supernatant sampling hole (16), and the supernatant sampling hole (16) is communicated with a supernatant receiving bin (22).

2. Faecal sample handler according to claim 1, the shape of the channel (21) is such that a dynamic equilibrium is achieved.

3. The faecal sample handler according to claim 1, wherein the channel (21) is a detachable part in the form of a cavity or separate channel, which is snap fit, threaded, spun on, adhesively attached to the outer wall of the faecal collection container.

4. Faecal sample handler according to claim 3, the channel (21) is sealed to the faecal collection container wall by means of a profiled gasket (6).

5. Faecal sample handler according to claim 1 or 2, the channel (21) is integrally formed in the wall of the faecal collection container.

6. Faecal sample processor according to any of the claims 1-4, wherein the beginning of said channel (21) is connected to the interior of the faecal collection container by means of a valve (5) or plug, the valve being selected from the group consisting of a plug valve, a gate valve, a ball valve.

7. Faecal sample handler according to any of the claims 1-4, the filter means (4) in said channel (21) being arranged at the opening of the faecal collection container into the channel, or at the beginning of the channel, or in the channel or at least 1 of the ends of the channel; the filtering device is selected from a filter screen, a filter membrane and a filter element.

8. Fecal sample processor according to any of the claims 1-4, the supernatant receiving compartment (22) is in communication with the fecal collection container lumen through a water proof gas permeable membrane.

9. Faecal sample handler according to any of the claims 1-4, at least 1 transfer chamber (23) is arranged in the tunnel, the position of the transfer chamber being above the sample level in the faecal collection container.

10. Faecal sample handler according to any of the claims 1-4, 1 or more one-way valves (24) are arranged in the channel.

11. Faecal sample handler according to any of the claims 1-4, the upper receptacle opening (13) of the faecal collection container is threadedly engaged with the cover (3), in particular the cover is internally threaded into the upper receptacle opening.

12. Faecal sample handler according to any of the claims 1-4, the cover (3) and the upper opening are realised by a composite form of sealing, comprising top side sealing by a flared rim (31), top sealing by a sealing gasket (7), thread sealing by a thread (8) fit, bottom side sealing by a necked rim (17).