CN111150663A - Novel tooth filling material and preparation method thereof - Google Patents
Novel tooth filling material and preparation method thereof Download PDFInfo
- Publication number
- CN111150663A CN111150663A CN202010117989.XA CN202010117989A CN111150663A CN 111150663 A CN111150663 A CN 111150663A CN 202010117989 A CN202010117989 A CN 202010117989A CN 111150663 A CN111150663 A CN 111150663A
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- China
- Prior art keywords
- filling material
- hibiscus
- extract
- collagen matrix
- tideglusib
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- Pending
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- 238000011049 filling Methods 0.000 title claims abstract description 18
- 239000000463 material Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000011159 matrix material Substances 0.000 claims abstract description 21
- 102000008186 Collagen Human genes 0.000 claims abstract description 18
- 108010035532 Collagen Proteins 0.000 claims abstract description 18
- 229920001436 collagen Polymers 0.000 claims abstract description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241000218033 Hibiscus Species 0.000 claims abstract description 16
- 235000005206 Hibiscus Nutrition 0.000 claims abstract description 16
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- PMJIHLSCWIDGMD-UHFFFAOYSA-N tideglusib Chemical compound O=C1SN(C=2C3=CC=CC=C3C=CC=2)C(=O)N1CC1=CC=CC=C1 PMJIHLSCWIDGMD-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229950005284 tideglusib Drugs 0.000 claims abstract description 10
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 8
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 8
- 229940046009 vitamin E Drugs 0.000 claims abstract description 8
- 239000011709 vitamin E Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 210000002826 placenta Anatomy 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 230000005070 ripening Effects 0.000 claims description 2
- 239000011550 stock solution Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 240000004153 Hibiscus sabdariffa Species 0.000 claims 1
- 235000001018 Hibiscus sabdariffa Nutrition 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 abstract description 5
- 239000012567 medical material Substances 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 240000005959 Abelmoschus manihot Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 235000001642 Hibiscus manihot Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010031149 Osteitis Diseases 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 208000008312 Tooth Loss Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000001178 neural stem cell Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 208000004480 periapical periodontitis Diseases 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention belongs to the technical field of medical materials, and discloses a novel tooth filling material and a preparation method thereof, wherein the novel tooth filling material comprises the following components in percentage by weight: the dental caries-resistant material comprises, by weight, 60-85% of a collagen matrix, 5-10% of a hibiscus makino extract, 5-10% of Tideglusib, 2-5% of pure water, 1.5-3% of an excipient and 1.5-3% of vitamin E, wherein the collagen matrix, the hibiscus makino extract, the Tideglusib, the excipient and the vitamin E are respectively weighed according to the weight ratio, fully mixed and ground into a paste, mixed and ground into the paste, added with the pure water and uniformly stirred, and uniformly stirred again.
Description
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a novel tooth filling material and a preparation method thereof.
Background
Teeth are the organs of humans that chew food. Teeth are the hardest organs of the human body. Generally, teeth are white in color and hard in texture. Different sites have different shapes and uses including tearing, grinding, cutting food. Teeth are the hardest organs in the human body and the main component is hydroxyapatite.
Dental caries, also known as caries or decayed tooth, is a bacterial disease, and can be secondary to pulpitis and periapical periodontitis, and even alveolar bone and jaw inflammation in severe cases. If not treated in time, the lesion continues to develop, forming a cavity, eventually the crown is completely destroyed and disappears, the end result of which is the loss of teeth. Untreated caries cavities do not heal on their own.
The method for treating decayed teeth at present mainly comprises filling, namely, decayed tissues are removed to be clean and made into a certain hole shape, the decayed tissues are filled with filling dental repair materials after being cleaned and disinfected, and the shape of the defect of the teeth is recovered. The tooth filling material can inhibit bacteria, inhibit inflammation, relieve pain, and promote the regeneration of tooth tissue of the affected tooth.
Disclosure of Invention
In order to solve the above problems in the prior art, the present invention aims to provide a novel dental filling material having antibacterial, inflammation-inhibiting, pain-relieving, and tooth tissue regeneration-promoting functions, and a preparation method thereof.
The technical scheme adopted by the invention is as follows: a novel tooth filling material and a preparation method thereof comprise the following components in percentage by weight: 60-85% of collagen matrix, 5-10% of hibiscus makinoi extract, 5-10% of Tideglusib, 2-5% of pure water, 1.5-3% of excipient and 1.5-3% of vitamin E.
Further, the collagen matrix, the hibiscus makinoi extract, the Tideglusib, the excipient and the vitamin E are respectively weighed according to the weight ratio, fully mixed and ground into a paste, the paste is added with pure water and stirred uniformly, and the paste is stirred uniformly again.
Further, the main components in the composition are: the Hibiscus makinoi extract and Tidegluusib are fully mixed together to be used as main acting raw materials, and are uniformly mixed in the processing process to be used as main acting raw materials, the Hibiscus makinoi extract adopts Hibiscus makinoi planted for more than 3 years, mature rhizomes of Hibiscus makinoi are used as medicine raw materials, and after a ripening period (enzyme conversion) of 365 days, the collected Hibiscus makinoi placenta can be biochemically extracted by ethanol, and about 5kg of stock solution is extracted and separated out about every 100 kg.
Furthermore, the components of the formulation are added with collagen matrix as matrix component, and the collagen matrix and the main action raw materials are uniformly mixed in the processing process.
The invention has the beneficial effects that:
1. the Hibiscus manihot extract material has the functions of resisting bacteria, resisting virus, diminishing inflammation and relieving pain.
2. The Tideglusib material disclosed by the invention has the effects of stimulating the differentiation of neural stem cells and the differentiation of dental tissue stem cells.
3. The collagen matrix material has excellent adhesion performance and three-dimensional space presentation, and the collagen matrix is added as a matrix component with higher specific gravity, so that the collagen matrix material can be used as a pad bottom for filling caries, a thickening agent and a water retention agent and can provide three-dimensional space for stem cell differentiation.
4. The invention can effectively improve the acid-resistant and antibacterial abilities of the teeth, the anti-inflammatory and analgesic effects and the regeneration effect of tooth tissues.
Detailed Description
The present invention is further illustrated below with reference to specific examples.
Example 1:
the embodiment provides a novel tooth filling material and a preparation method thereof, and the novel tooth filling material comprises the following components in percentage by weight: 60-85% of collagen matrix, 5-10% of hibiscus makinoi extract, 5-10% of Tideglusib, 2-5% of pure water, 1.5-3% of excipient and 1.5-3% of vitamin E.
Respectively weighing the collagen matrix of-70 percent, the hibiscus manihot extract of-10 percent, the Tideglusib of-10 percent, the pure water of-5 percent and the excipient of 2.5 to 2.5 percent by weight, fully mixing and grinding into a paste, adding the pure water, uniformly stirring, and uniformly stirring again.
The components are added with a large amount of collagen matrix, the collagen matrix material has excellent adhesive property and three-dimensional space presentation, and the collagen matrix and the main action raw materials are uniformly mixed in the processing process. The collagen matrix can be used as a cavity-filling backing, a thickening agent, and a moisture-retaining agent, as well as providing a three-dimensional space for stem cell differentiation.
Vitamin E is added into the components with proper amount, is a fat-soluble vitamin, is one of the most main antioxidants, is insoluble in water and is stable to heat and acid.
The present invention is not limited to the above-described alternative embodiments, and various other forms of products can be obtained by anyone in light of the present invention. The above detailed description should not be taken as limiting the scope of the invention, which is defined in the claims, and which the description is intended to be interpreted accordingly.
Claims (4)
1. A novel tooth filling material and a preparation method thereof are characterized in that: comprises the following components in percentage by weight: 60-85% of collagen matrix, 5-10% of hibiscus makinoi extract, 5-10% of Tideglusib, 2-5% of pure water, 1.5-3% of excipient and 1.5-3% of vitamin E.
2. The novel dental filling material and the method for preparing the same according to claim 1, wherein: respectively weighing the collagen matrix, the hibiscus sabdariffa extract, the Tideglusib, the pure water, the excipient and the vitamin E according to the weight ratio, fully mixing and grinding into a paste, adding the pure water, uniformly stirring, and uniformly stirring again.
3. The novel dental filling material and the method for preparing the same according to claim 2, wherein: the main components in the composition are as follows: the Hibiscus makinoi extract is fully mixed with Tideglusib and is mixed to become a raw material with main action in the processing process, the Hibiscus makinoi extract is prepared by planting Hibiscus makinoi for more than 3 years, taking mature rhizome of Hibiscus makinoi as a raw material for medicine, and performing biochemical extraction in a ripening period (enzyme conversion) of 365 days, wherein the collected placenta of the rhizome of Hibiscus makinoi is extracted by ethanol, and about 5kg of stock solution is extracted and separated every 100kg of placenta.
4. A novel dental filling material and a method for preparing the same according to claim 3, wherein: the components of the formulation are added with collagen matrix as matrix component and are evenly mixed in the processing process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010117989.XA CN111150663A (en) | 2020-02-26 | 2020-02-26 | Novel tooth filling material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010117989.XA CN111150663A (en) | 2020-02-26 | 2020-02-26 | Novel tooth filling material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111150663A true CN111150663A (en) | 2020-05-15 |
Family
ID=70566470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010117989.XA Pending CN111150663A (en) | 2020-02-26 | 2020-02-26 | Novel tooth filling material and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111150663A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309523A (en) * | 2011-05-18 | 2012-01-11 | 深圳市光明创博生物制品发展有限公司 | Dentoidin sponginum and preparation method thereof |
| CN102335457A (en) * | 2010-07-28 | 2012-02-01 | 郭山辉 | Composition for tooth regeneration |
| CN110114048A (en) * | 2016-10-21 | 2019-08-09 | 伦敦国王学院 | Dental treatment |
-
2020
- 2020-02-26 CN CN202010117989.XA patent/CN111150663A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335457A (en) * | 2010-07-28 | 2012-02-01 | 郭山辉 | Composition for tooth regeneration |
| CN102309523A (en) * | 2011-05-18 | 2012-01-11 | 深圳市光明创博生物制品发展有限公司 | Dentoidin sponginum and preparation method thereof |
| CN110114048A (en) * | 2016-10-21 | 2019-08-09 | 伦敦国王学院 | Dental treatment |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210208 Address after: 461000 room 1801, building 1, Jixiang community, Tadong street, Weidu District, Xuchang City, Henan Province Applicant after: Guo Kunfu Applicant after: Sixiaoyan Address before: Office 1608, 16th floor, Linhai science and technology innovation center, 695 Linhai Avenue, Dayang street, Linhai City, Taizhou City, Zhejiang Province Applicant before: Taizhou Yanfu Medical Technology Co.,Ltd. Effective date of registration: 20210208 Address after: Office 1608, 16th floor, Linhai science and technology innovation center, 695 Linhai Avenue, Dayang street, Linhai City, Taizhou City, Zhejiang Province Applicant after: Taizhou Yanfu Medical Technology Co.,Ltd. Address before: No.08, group 2, xiangdongping village, Jianxing Town, Nanbu County, Nanchong City, Sichuan Province Applicant before: Sixiaoyan |
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| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200515 |