CN111148535A - 治疗实体癌和血液癌的组合疗法 - Google Patents

治疗实体癌和血液癌的组合疗法 Download PDF

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Publication number
CN111148535A
CN111148535A CN201880028490.2A CN201880028490A CN111148535A CN 111148535 A CN111148535 A CN 111148535A CN 201880028490 A CN201880028490 A CN 201880028490A CN 111148535 A CN111148535 A CN 111148535A
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seq
amino acid
acid sequence
human
light chain
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Chinese (zh)
Inventor
P·T·曼宁
R·普罗
J·C·阿尔马格罗
R·W·卡尔
B·J·卡波恰
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Anchi Oncology
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Anchi Oncology
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Priority claimed from US15/871,802 external-priority patent/US20180142019A1/en
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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CN201880028490.2A 2017-03-22 2018-03-22 治疗实体癌和血液癌的组合疗法 Pending CN111148535A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762475032P 2017-03-22 2017-03-22
US201762475036P 2017-03-22 2017-03-22
US62/475,032 2017-03-22
US62/475,036 2017-03-22
US15/871,802 2018-01-15
US15/871,802 US20180142019A1 (en) 2016-10-21 2018-01-15 Therapeutic cd47 antibodies
PCT/US2018/023860 WO2018175790A1 (en) 2017-03-22 2018-03-22 Combination therapy for the treatment of solid and hematological cancers

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CN111148535A true CN111148535A (zh) 2020-05-12

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CN201880028490.2A Pending CN111148535A (zh) 2017-03-22 2018-03-22 治疗实体癌和血液癌的组合疗法

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EP (1) EP3600393A4 (https=)
JP (1) JP7170331B2 (https=)
CN (1) CN111148535A (https=)
AU (1) AU2018240377A1 (https=)
CA (1) CA3057139A1 (https=)
SG (1) SG11201908602UA (https=)
WO (1) WO2018175790A1 (https=)

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US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
MX2015007446A (es) 2012-12-12 2015-12-07 Vasculox Inc Anticuerpos terapeuticos para cd47.
BR112018005322A2 (pt) 2015-09-18 2018-12-11 Arch Oncology, Inc. anticorpo monoclonal ou seu fragmento de ligação a antígenos, composição farmacêutica, anticorpo monoclonal ou seu fragmento de ligação a antígenos para uso, método de tratamento de lesão de isquemia-reperfusão, método de tratamento de câncer em um paciente humano, método de avaliação da expressão de cd47 em células tumorais e/ou imunes usando um anticorpo monoclonal ou seu fragmento de ligação a antígenos
EP3529276A4 (en) 2016-10-21 2020-06-17 Arch Oncology, Inc. CD47 THERAPEUTIC ANTIBODIES
EP3892637A1 (en) * 2018-12-03 2021-10-13 Shanghai Pharmaexplorer Co., Ltd. Cd47 antibody, preparation method therefor and uses thereof
WO2020232427A2 (en) * 2019-05-16 2020-11-19 Arch Oncology, Inc. Therapeutic compositions and methods for treating cancer in combination with analogs of interleukin proteins
CN114206912B (zh) 2019-06-07 2025-02-11 Alx肿瘤生物技术公司 用于在血清学测定中减少结合cd47的药物的干扰的方法和试剂
JP2022553410A (ja) * 2019-10-23 2022-12-22 アーチ オンコロジー，インコーポレイテッド 固形がんおよび血液がんを処置するための併用療法
JP7369297B2 (ja) 2019-12-17 2023-10-25 ファイザー・インク Ｃｄ４７、ｐｄ－ｌ１に特異的な抗体、およびその使用
JP7789304B2 (ja) * 2020-07-31 2025-12-22 バイオ－テラ ソリュ－ションズ，エルティーディー． Ｃｄ４７抗体及びその応用
WO2022120286A1 (en) 2020-12-06 2022-06-09 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays

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CN101133083A (zh) * 2003-11-11 2008-02-27 中外制药株式会社 人源化的抗cd47抗体
CN104271757A (zh) * 2012-02-06 2015-01-07 印希彼有限责任公司 Cd47抗体及其使用方法
US20160137733A1 (en) * 2012-12-12 2016-05-19 Vasculox Inc. Therapeutic cd47 antibodies
WO2017049251A2 (en) * 2015-09-18 2017-03-23 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies

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PT2242773T (pt) * 2008-02-11 2017-09-15 Cure Tech Ltd Anticorpos monoclonais para o tratamento de tumores
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EP2744830A4 (en) * 2012-06-21 2015-06-17 Compugen Ltd LSR ANTIBODIES AND USES THEREOF FOR THE TREATMENT OF CANCER
CN105101997B (zh) * 2013-02-06 2018-11-09 印希彼有限合伙公司 不减少血小板和不减少血红细胞的cd47抗体及其使用方法

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CN101133083A (zh) * 2003-11-11 2008-02-27 中外制药株式会社 人源化的抗cd47抗体
CN104271757A (zh) * 2012-02-06 2015-01-07 印希彼有限责任公司 Cd47抗体及其使用方法
US20160137733A1 (en) * 2012-12-12 2016-05-19 Vasculox Inc. Therapeutic cd47 antibodies
WO2017049251A2 (en) * 2015-09-18 2017-03-23 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies

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XIAOJUAN LIU 等: "CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors", 《NAT MED.》 *
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CA3057139A1 (en) 2018-09-27
JP7170331B2 (ja) 2022-11-14
WO2018175790A1 (en) 2018-09-27
EP3600393A4 (en) 2020-12-23
AU2018240377A1 (en) 2019-10-31
JP2020511481A (ja) 2020-04-16
SG11201908602UA (en) 2019-10-30

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