CN111094990A - 用于在血浆和全血中检测抗凝剂的方法和装置 - Google Patents

用于在血浆和全血中检测抗凝剂的方法和装置 Download PDF

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Publication number
CN111094990A
CN111094990A CN201880059719.9A CN201880059719A CN111094990A CN 111094990 A CN111094990 A CN 111094990A CN 201880059719 A CN201880059719 A CN 201880059719A CN 111094990 A CN111094990 A CN 111094990A
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China
Prior art keywords
factor
coagulation
microfluidic device
channels
sample
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Pending
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CN201880059719.9A
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English (en)
Chinese (zh)
Inventor
加利特·H·弗里德曼
穆罕默德·托纳
罗纳德·G·汤普金斯
帕万·本达普迪
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General Hospital Corp
Massachusetts Institute of Technology
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General Hospital Corp
Massachusetts Institute of Technology
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Publication of CN111094990A publication Critical patent/CN111094990A/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201880059719.9A 2017-07-28 2018-07-26 用于在血浆和全血中检测抗凝剂的方法和装置 Pending CN111094990A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762538618P 2017-07-28 2017-07-28
US62/538,618 2017-07-28
US201862699665P 2018-07-17 2018-07-17
US62/699,665 2018-07-17
PCT/US2018/043973 WO2019023508A1 (en) 2017-07-28 2018-07-26 METHODS AND DEVICES FOR DETECTION OF ANTICOAGULANTS IN PLASMA AND WHOLE BLOOD

Publications (1)

Publication Number Publication Date
CN111094990A true CN111094990A (zh) 2020-05-01

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ID=63405342

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880059719.9A Pending CN111094990A (zh) 2017-07-28 2018-07-26 用于在血浆和全血中检测抗凝剂的方法和装置

Country Status (10)

Country Link
US (4) US20190111431A1 (https=)
EP (1) EP3658920A1 (https=)
JP (1) JP7214712B2 (https=)
KR (1) KR20200034749A (https=)
CN (1) CN111094990A (https=)
AU (1) AU2018307799A1 (https=)
CA (1) CA3071295A1 (https=)
IL (1) IL272320A (https=)
SG (1) SG11202000688UA (https=)
WO (1) WO2019023508A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2750839C1 (ru) * 2020-05-18 2021-07-05 Общество с ограниченной ответственностью "Меднорд-Техника" (ООО "Меднорд-Т") Устройство и способ экспресс-оценки агрегационной активности форменных элементов крови
CN113945551A (zh) * 2021-10-19 2022-01-18 重庆医科大学附属永川医院 一种血小板功能的微流控分析检测模型

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12584930B2 (en) 2019-02-04 2026-03-24 Abram Scientific, Inc. Fluid property measurement devices and methods
US20220283190A1 (en) * 2021-03-08 2022-09-08 Galit H. Frydman Methods and devices for detection of coagulation impairment
US20250135454A1 (en) 2021-08-12 2025-05-01 Coagulo Medical Technologies, Inc. Closed microfluidic cartridge for evaluating multiple, isolated portions of a fluid sample
CN114558629B (zh) * 2022-03-03 2024-06-04 四川微康朴澜医疗科技有限责任公司 一种微流控式血栓弹力分析检测试剂盒
CN116930175A (zh) * 2022-04-07 2023-10-24 董嘉 一种试剂盒、快速检测凝血分析仪及其进行检测的方法
AU2023350742A1 (en) 2022-09-30 2025-04-10 Coagulo Medical Technologies, Inc. Modular apparatus for testing microfluidic cartridge, useful for point-of-care medical diagnostics and other applications
WO2025132678A1 (en) * 2023-12-19 2025-06-26 F. Hoffmann-La Roche Ag Qualitative test for direct oral anticoagulants (doacs)

Citations (3)

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US20140038214A1 (en) * 2012-06-27 2014-02-06 Colorado School Of Mines Microfluidic flow assay and methods of use
US20140236494A1 (en) * 2011-11-04 2014-08-21 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US20160258968A1 (en) * 2013-10-16 2016-09-08 President And Fellows Of Harvard College A microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2040073A1 (en) 2007-09-20 2009-03-25 Iline Microsystems, S.L. Microfluidic device and method for fluid clotting time determination
US20140038204A1 (en) 2012-07-31 2014-02-06 Baxter Healthcare S.A. Selective measurement of active human protease coagulation factors
EA033382B1 (ru) 2014-09-09 2019-10-31 Perosphere Tech Inc Универсальный анализ коагуляции на основе микрожидкостного чипа

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140236494A1 (en) * 2011-11-04 2014-08-21 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US20140038214A1 (en) * 2012-06-27 2014-02-06 Colorado School Of Mines Microfluidic flow assay and methods of use
US20160258968A1 (en) * 2013-10-16 2016-09-08 President And Fellows Of Harvard College A microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ABHISHEK JAIN, ET AL.: "A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function" *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2750839C1 (ru) * 2020-05-18 2021-07-05 Общество с ограниченной ответственностью "Меднорд-Техника" (ООО "Меднорд-Т") Устройство и способ экспресс-оценки агрегационной активности форменных элементов крови
CN113945551A (zh) * 2021-10-19 2022-01-18 重庆医科大学附属永川医院 一种血小板功能的微流控分析检测模型

Also Published As

Publication number Publication date
US20190111431A1 (en) 2019-04-18
KR20200034749A (ko) 2020-03-31
EP3658920A1 (en) 2020-06-03
CA3071295A1 (en) 2019-01-31
JP2020529593A (ja) 2020-10-08
JP7214712B2 (ja) 2023-01-30
IL272320A (en) 2020-03-31
SG11202000688UA (en) 2020-02-27
WO2019023508A1 (en) 2019-01-31
AU2018307799A1 (en) 2020-02-13
US20230166255A1 (en) 2023-06-01
US20230158498A1 (en) 2023-05-25
US20230158499A1 (en) 2023-05-25

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