AU2018307799A1 - Methods and devices for detection of anticoagulants in plasma and whole blood - Google Patents

Methods and devices for detection of anticoagulants in plasma and whole blood Download PDF

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Publication number
AU2018307799A1
AU2018307799A1 AU2018307799A AU2018307799A AU2018307799A1 AU 2018307799 A1 AU2018307799 A1 AU 2018307799A1 AU 2018307799 A AU2018307799 A AU 2018307799A AU 2018307799 A AU2018307799 A AU 2018307799A AU 2018307799 A1 AU2018307799 A1 AU 2018307799A1
Authority
AU
Australia
Prior art keywords
factor
coagulation
channels
microfluidic device
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2018307799A
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English (en)
Inventor
Pavan Bendapudi
Galit H. Frydman
Ronald G. Tompkins
Mehmet Toner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Massachusetts Institute of Technology
Original Assignee
General Hospital Corp
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Massachusetts Institute of Technology filed Critical General Hospital Corp
Publication of AU2018307799A1 publication Critical patent/AU2018307799A1/en
Abandoned legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2018307799A 2017-07-28 2018-07-26 Methods and devices for detection of anticoagulants in plasma and whole blood Abandoned AU2018307799A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762538618P 2017-07-28 2017-07-28
US62/538,618 2017-07-28
US201862699665P 2018-07-17 2018-07-17
US62/699,665 2018-07-17
PCT/US2018/043973 WO2019023508A1 (en) 2017-07-28 2018-07-26 METHODS AND DEVICES FOR DETECTION OF ANTICOAGULANTS IN PLASMA AND WHOLE BLOOD

Publications (1)

Publication Number Publication Date
AU2018307799A1 true AU2018307799A1 (en) 2020-02-13

Family

ID=63405342

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018307799A Abandoned AU2018307799A1 (en) 2017-07-28 2018-07-26 Methods and devices for detection of anticoagulants in plasma and whole blood

Country Status (10)

Country Link
US (4) US20190111431A1 (https=)
EP (1) EP3658920A1 (https=)
JP (1) JP7214712B2 (https=)
KR (1) KR20200034749A (https=)
CN (1) CN111094990A (https=)
AU (1) AU2018307799A1 (https=)
CA (1) CA3071295A1 (https=)
IL (1) IL272320A (https=)
SG (1) SG11202000688UA (https=)
WO (1) WO2019023508A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12584930B2 (en) 2019-02-04 2026-03-24 Abram Scientific, Inc. Fluid property measurement devices and methods
RU2750839C1 (ru) * 2020-05-18 2021-07-05 Общество с ограниченной ответственностью "Меднорд-Техника" (ООО "Меднорд-Т") Устройство и способ экспресс-оценки агрегационной активности форменных элементов крови
US20220283190A1 (en) * 2021-03-08 2022-09-08 Galit H. Frydman Methods and devices for detection of coagulation impairment
US20250135454A1 (en) 2021-08-12 2025-05-01 Coagulo Medical Technologies, Inc. Closed microfluidic cartridge for evaluating multiple, isolated portions of a fluid sample
CN113945551A (zh) * 2021-10-19 2022-01-18 重庆医科大学附属永川医院 一种血小板功能的微流控分析检测模型
CN114558629B (zh) * 2022-03-03 2024-06-04 四川微康朴澜医疗科技有限责任公司 一种微流控式血栓弹力分析检测试剂盒
CN116930175A (zh) * 2022-04-07 2023-10-24 董嘉 一种试剂盒、快速检测凝血分析仪及其进行检测的方法
AU2023350742A1 (en) 2022-09-30 2025-04-10 Coagulo Medical Technologies, Inc. Modular apparatus for testing microfluidic cartridge, useful for point-of-care medical diagnostics and other applications
WO2025132678A1 (en) * 2023-12-19 2025-06-26 F. Hoffmann-La Roche Ag Qualitative test for direct oral anticoagulants (doacs)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2040073A1 (en) 2007-09-20 2009-03-25 Iline Microsystems, S.L. Microfluidic device and method for fluid clotting time determination
WO2013067536A1 (en) * 2011-11-04 2013-05-10 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US9709579B2 (en) * 2012-06-27 2017-07-18 Colorado School Of Mines Microfluidic flow assay and methods of use
US20140038204A1 (en) 2012-07-31 2014-02-06 Baxter Healthcare S.A. Selective measurement of active human protease coagulation factors
US9562914B2 (en) * 2013-10-16 2017-02-07 President And Fellows Of Harvard College Microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation
EA033382B1 (ru) 2014-09-09 2019-10-31 Perosphere Tech Inc Универсальный анализ коагуляции на основе микрожидкостного чипа

Also Published As

Publication number Publication date
US20190111431A1 (en) 2019-04-18
KR20200034749A (ko) 2020-03-31
EP3658920A1 (en) 2020-06-03
CN111094990A (zh) 2020-05-01
CA3071295A1 (en) 2019-01-31
JP2020529593A (ja) 2020-10-08
JP7214712B2 (ja) 2023-01-30
IL272320A (en) 2020-03-31
SG11202000688UA (en) 2020-02-27
WO2019023508A1 (en) 2019-01-31
US20230166255A1 (en) 2023-06-01
US20230158498A1 (en) 2023-05-25
US20230158499A1 (en) 2023-05-25

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application