JP7214712B2 - 血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス - Google Patents

血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス Download PDF

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JP7214712B2
JP7214712B2 JP2020504364A JP2020504364A JP7214712B2 JP 7214712 B2 JP7214712 B2 JP 7214712B2 JP 2020504364 A JP2020504364 A JP 2020504364A JP 2020504364 A JP2020504364 A JP 2020504364A JP 7214712 B2 JP7214712 B2 JP 7214712B2
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factor
blood sample
clotting
clot formation
formation time
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JP2020529593A (ja
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フリードマン，ガリト・エイチ
トナー，メーメット
トンプキンス，ロナルド・ジー
ベンダプディ，パバン
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Massachusetts Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2020504364A 2017-07-28 2018-07-26 血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス Active JP7214712B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762538618P 2017-07-28 2017-07-28
US62/538,618 2017-07-28
US201862699665P 2018-07-17 2018-07-17
US62/699,665 2018-07-17
PCT/US2018/043973 WO2019023508A1 (en) 2017-07-28 2018-07-26 METHODS AND DEVICES FOR DETECTION OF ANTICOAGULANTS IN PLASMA AND WHOLE BLOOD

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JP2020529593A JP2020529593A (ja) 2020-10-08
JP2020529593A5 JP2020529593A5 (https=) 2021-08-26
JP7214712B2 true JP7214712B2 (ja) 2023-01-30

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US (4) US20190111431A1 (https=)
EP (1) EP3658920A1 (https=)
JP (1) JP7214712B2 (https=)
KR (1) KR20200034749A (https=)
CN (1) CN111094990A (https=)
AU (1) AU2018307799A1 (https=)
CA (1) CA3071295A1 (https=)
IL (1) IL272320A (https=)
SG (1) SG11202000688UA (https=)
WO (1) WO2019023508A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12584930B2 (en) 2019-02-04 2026-03-24 Abram Scientific, Inc. Fluid property measurement devices and methods
RU2750839C1 (ru) * 2020-05-18 2021-07-05 Общество с ограниченной ответственностью "Меднорд-Техника" (ООО "Меднорд-Т") Устройство и способ экспресс-оценки агрегационной активности форменных элементов крови
US20220283190A1 (en) * 2021-03-08 2022-09-08 Galit H. Frydman Methods and devices for detection of coagulation impairment
US20250135454A1 (en) 2021-08-12 2025-05-01 Coagulo Medical Technologies, Inc. Closed microfluidic cartridge for evaluating multiple, isolated portions of a fluid sample
CN113945551A (zh) * 2021-10-19 2022-01-18 重庆医科大学附属永川医院 一种血小板功能的微流控分析检测模型
CN114558629B (zh) * 2022-03-03 2024-06-04 四川微康朴澜医疗科技有限责任公司 一种微流控式血栓弹力分析检测试剂盒
CN116930175A (zh) * 2022-04-07 2023-10-24 董嘉 一种试剂盒、快速检测凝血分析仪及其进行检测的方法
AU2023350742A1 (en) 2022-09-30 2025-04-10 Coagulo Medical Technologies, Inc. Modular apparatus for testing microfluidic cartridge, useful for point-of-care medical diagnostics and other applications
WO2025132678A1 (en) * 2023-12-19 2025-06-26 F. Hoffmann-La Roche Ag Qualitative test for direct oral anticoagulants (doacs)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140038214A1 (en) 2012-06-27 2014-02-06 Colorado School Of Mines Microfluidic flow assay and methods of use
US20140038204A1 (en) 2012-07-31 2014-02-06 Baxter Healthcare S.A. Selective measurement of active human protease coagulation factors
JP2014038109A (ja) 2007-09-20 2014-02-27 Iline Microsystems Sl マイクロ流体デバイスおよび流体の凝固時間測定方法
US20140236494A1 (en) 2011-11-04 2014-08-21 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US20160069913A1 (en) 2014-09-09 2016-03-10 Perosphere Inc. Microfluidic chip-based, universal coagulation assay
JP2016534714A (ja) 2013-10-16 2016-11-10 プレジデント アンド フェローズ オブ ハーバード カレッジ 全血凝固のリアルタイムの臨床モニタリングおよび定量的評価

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014038109A (ja) 2007-09-20 2014-02-27 Iline Microsystems Sl マイクロ流体デバイスおよび流体の凝固時間測定方法
US20140236494A1 (en) 2011-11-04 2014-08-21 Massachusetts Institute Of Technology Multi-parameter thrombotic assay apparatus, systems, and methods
US20140038214A1 (en) 2012-06-27 2014-02-06 Colorado School Of Mines Microfluidic flow assay and methods of use
US20140038204A1 (en) 2012-07-31 2014-02-06 Baxter Healthcare S.A. Selective measurement of active human protease coagulation factors
JP2016534714A (ja) 2013-10-16 2016-11-10 プレジデント アンド フェローズ オブ ハーバード カレッジ 全血凝固のリアルタイムの臨床モニタリングおよび定量的評価
US20160069913A1 (en) 2014-09-09 2016-03-10 Perosphere Inc. Microfluidic chip-based, universal coagulation assay

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Abhishek Jain，A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function，Nat. Commun.，2016年01月06日，Vol.7，Page.10176
Jerome Duchemin，Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma，Thromb Haemost，2008年03月12日，Vol.99，Page.767-773
S Nayak，Using a Systems Pharmacology Model of the Blood Coagulation Network to Predict the Effects of Various Therapies on Biomarkers，CPT Pharmacometrics Syst. Pharmacol.，2015年06月19日，Vol.4，Page.396-405
Shannon M. Bates，Coagulation Assays，Circulation，2005年，Vol.112，Page.e53-e60

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Publication number Publication date
US20190111431A1 (en) 2019-04-18
KR20200034749A (ko) 2020-03-31
EP3658920A1 (en) 2020-06-03
CN111094990A (zh) 2020-05-01
CA3071295A1 (en) 2019-01-31
JP2020529593A (ja) 2020-10-08
IL272320A (en) 2020-03-31
SG11202000688UA (en) 2020-02-27
WO2019023508A1 (en) 2019-01-31
AU2018307799A1 (en) 2020-02-13
US20230166255A1 (en) 2023-06-01
US20230158498A1 (en) 2023-05-25
US20230158499A1 (en) 2023-05-25

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