CN111094300A - 苯并杂芳基类衍生物、其制备方法及其在医药上的应用 - Google Patents

苯并杂芳基类衍生物、其制备方法及其在医药上的应用 Download PDF

Info

Publication number
CN111094300A
CN111094300A CN201980004474.4A CN201980004474A CN111094300A CN 111094300 A CN111094300 A CN 111094300A CN 201980004474 A CN201980004474 A CN 201980004474A CN 111094300 A CN111094300 A CN 111094300A
Authority
CN
China
Prior art keywords
group
compound
heteroaryl
atom
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201980004474.4A
Other languages
English (en)
Other versions
CN111094300B (zh
Inventor
杨方龙
张羚
韩吉慧
贺峰
陶维康
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN111094300A publication Critical patent/CN111094300A/zh
Application granted granted Critical
Publication of CN111094300B publication Critical patent/CN111094300B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及苯并杂芳基类衍生物、其制备方法及其在医药上的应用。具体而言，本发明涉及一种通式(I)所示的新的苯并杂芳基类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是作为PAR‑4拮抗剂的用途，其中通式(I)的各取代基与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (25)

  1. PCT国内申请，权利要求书已公开。
CN201980004474.4A 2018-01-31 2019-01-30 苯并杂芳基类衍生物、其制备方法及其在医药上的应用 Active CN111094300B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2018100940104 2018-01-31
CN201810094010 2018-01-31
CN201810100247 2018-02-01
CN2018101002479 2018-02-01
CN201810105598 2018-02-02
CN2018101055989 2018-02-02
PCT/CN2019/073815 WO2019149205A1 (zh) 2018-01-31 2019-01-30 苯并杂芳基类衍生物、其制备方法及其在医药上的应用

Publications (2)

Publication Number Publication Date
CN111094300A true CN111094300A (zh) 2020-05-01
CN111094300B CN111094300B (zh) 2022-09-16

Family

ID=67479569

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980004474.4A Active CN111094300B (zh) 2018-01-31 2019-01-30 苯并杂芳基类衍生物、其制备方法及其在医药上的应用

Country Status (3)

Country Link
CN (1) CN111094300B (zh)
TW (1) TW201934558A (zh)
WO (1) WO2019149205A1 (zh)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102241621A (zh) * 2010-05-11 2011-11-16 江苏恒瑞医药股份有限公司 5,5-双取代-2-亚氨基吡咯烷类衍生物、其制备方法及其在医药上的应用
CN104411713A (zh) * 2012-04-26 2015-03-11 百时美施贵宝公司 Par4激动剂肽
CN104540835A (zh) * 2012-04-26 2015-04-22 百时美施贵宝公司 用于治疗血小板聚集的作为蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑衍生物
CN104583218A (zh) * 2012-04-26 2015-04-29 百时美施贵宝公司 作为蛋白酶活化受体4(par4)抑制剂用于治疗血小板聚集的咪唑并噻二唑和咪唑并吡嗪的衍生物
CN104640869A (zh) * 2012-04-26 2015-05-20 百时美施贵宝公司 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑和咪唑并哒嗪衍生物
WO2017066863A1 (en) * 2015-10-19 2017-04-27 Universite De Montreal Heterocyclic compounds as inhibitors of platelet aggregation
CN107602589A (zh) * 2017-11-06 2018-01-19 中国药科大学 一种化合物的制备方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102241621A (zh) * 2010-05-11 2011-11-16 江苏恒瑞医药股份有限公司 5,5-双取代-2-亚氨基吡咯烷类衍生物、其制备方法及其在医药上的应用
CN104411713A (zh) * 2012-04-26 2015-03-11 百时美施贵宝公司 Par4激动剂肽
CN104540835A (zh) * 2012-04-26 2015-04-22 百时美施贵宝公司 用于治疗血小板聚集的作为蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑衍生物
CN104583218A (zh) * 2012-04-26 2015-04-29 百时美施贵宝公司 作为蛋白酶活化受体4(par4)抑制剂用于治疗血小板聚集的咪唑并噻二唑和咪唑并吡嗪的衍生物
CN104640869A (zh) * 2012-04-26 2015-05-20 百时美施贵宝公司 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑和咪唑并哒嗪衍生物
WO2017066863A1 (en) * 2015-10-19 2017-04-27 Universite De Montreal Heterocyclic compounds as inhibitors of platelet aggregation
CN107602589A (zh) * 2017-11-06 2018-01-19 中国药科大学 一种化合物的制备方法

Also Published As

Publication number Publication date
TW201934558A (zh) 2019-09-01
WO2019149205A1 (zh) 2019-08-08
CN111094300B (zh) 2022-09-16

Similar Documents

Publication Publication Date Title
CN111217797B (zh) Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
TWI756257B (zh) 吡啶酮醯胺類衍生物、其製備方法及其在醫藥上的應用
CN102459258B (zh) 1,2,4-三唑并[1,5a]吡啶衍生物的制备和用途
CN111440189B (zh) 稠环嘧啶氨基衍生物、其制备方法、中间体、药物组合物及应用
CN113286794A (zh) Kras突变蛋白抑制剂
CN106061976A (zh) 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
WO2016169421A1 (zh) 咪唑并异吲哚类衍生物、其制备方法及其在医药上的应用
CN105228997A (zh) Carm1抑制剂及其用途
CN115315423A (zh) 取代芳基类化合物
JP2024505732A (ja) ピリドピリミジノン系誘導体及びその製造方法と使用
CN111356695B (zh) 新的三环化合物
WO2021057882A1 (zh) Egfr抑制剂、组合物及其制备方法
CN112851668A (zh) Atr抑制剂及其在医药上的应用
CN116568681A (zh) Sos1抑制剂、包含其的药物组合物及其用途
CN113574058A (zh) 吲哚类大环衍生物、其制备方法及其在医药上的应用
WO2022199662A1 (zh) 一种多环化合物及其应用
CN113348170A (zh) 联苯类衍生物抑制剂、其制备方法和应用
WO2021104441A1 (zh) 作为egfr激酶抑制剂的多芳基化合物
CN111094300B (zh) 苯并杂芳基类衍生物、其制备方法及其在医药上的应用
CN112969694A (zh) Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
WO2020103817A1 (zh) TGF-βR1抑制剂及其应用
CN115785154A (zh) 杂芳环化合物及其医药用途
KR20230107271A (ko) 이환식 유도체를 포함하는 억제제 유리염기의 결정형, 이의 제조방법 및 용도
CN115515959A (zh) 用作tead结合剂的三环杂环
CN113880833A (zh) 联苯多环类衍生物抑制剂、其制备方法和应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant