CN111068368A - Formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry and application of formula - Google Patents
Formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry and application of formula Download PDFInfo
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- CN111068368A CN111068368A CN202010041032.1A CN202010041032A CN111068368A CN 111068368 A CN111068368 A CN 111068368A CN 202010041032 A CN202010041032 A CN 202010041032A CN 111068368 A CN111068368 A CN 111068368A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/01—Separation of suspended solid particles from liquids by sedimentation using flocculating agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry, which comprises a clarifying agent and a settling agent, and comprises the following raw materials in parts by weight, wherein the clarifying agent comprises 2-5 parts of edible Arabic gum, 1-3 parts of edible gelatin and 3-4 parts of sodium carboxymethylcellulose, the settling agent comprises 5-6 parts of beta-cyclodextrin and 4-5 parts of montmorillonite, and when the formula is used, the clarifying agent and the settling agent are respectively added into 200 kg of liquid medicine, and the amount of each of the 200-fold organic solvent is 300 g.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine extracting solution precipitation, and relates to a formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry and application thereof.
Background
Impurities in the traditional Chinese medicine extracting solution cause the liquid medicine to be very turbid, not only influence the absorption and utilization of active ingredients, but also have adverse effect on human bodies, so that the clarification and purification of the extracting solution play an important role in the quality of the liquid medicine. In the prior art, for example, common alcohol precipitation method and single adsorbent such as activated carbon have poor precipitation effect.
Disclosure of Invention
The invention aims to provide a formula for precipitating impurities in a traditional Chinese medicine extracting solution for livestock and poultry, which solves the problem of influence of high temperature on the livestock and poultry.
On one hand, the invention provides a formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry, which comprises a clarifying agent and a settling agent, wherein the clarifying agent comprises 2-5 parts by weight of edible Arabic gum, 1-3 parts by weight of edible gelatin and 3-4 parts by weight of sodium carboxymethylcellulose, and the settling agent comprises 5-6 parts by weight of beta-cyclodextrin and 4-5 parts by weight of montmorillonite.
Further, the clarifying agent comprises 3 parts of edible Arabic gum, 2 parts of edible gelatin and 3 parts of sodium carboxymethylcellulose, and the settling agent comprises 5 parts of beta-cyclodextrin and 4 parts of montmorillonite.
On the other hand, the invention provides application of a formula for precipitating impurities in the traditional Chinese medicine extracting solution for livestock and poultry, which comprises the clarifying agent and the settling aid.
Further, the method comprises the following steps:
1) preparing a clarifying agent into a solution with the mass percentage of ten, and preparing a settling agent into a turbid solution with the mass percentage of ten;
2) decocting the Chinese medicinal materials, concentrating to desired amount, stirring, adding clarifier, stirring, adding settling agent, stirring, standing for 24 hr to clear the flocculated liquid, centrifuging, boiling, refrigerating, fine filtering, and bottling.
Further, when the clarifying agent is prepared, the clarifying agent is firstly added with water to be dissolved overnight, and then the mixture is sheared and ground in a colloid mill to be fully dissolved.
Further, when the settling agent is prepared, the settling agent is fully and uniformly stirred in a colloid mill and is soaked overnight, and when the settling agent is used, the settling agent is uniformly stirred and added into the liquid medicine.
Further, 200 g of clarifying agent and 300g of settling agent are respectively added into every 200 kg of liquid medicine.
Compared with the prior art, the invention has the following characteristics and beneficial effects:
firstly, the liquid medicine clarified by the clarifying agent and the settling agent has good clarity, is easy to filter, saves time, is stable after long-term storage, is obviously superior to a single adsorbent such as an alcohol precipitation method, active carbon and the like, and is particularly suitable for the method which can not clarify by a conventional method to achieve a good effect.
Secondly, the method does not affect the small molecular components of flavone, polysaccharide, glycoside, alkaloid, organic acid and the like in the liquid medicine, and can keep more effective components in the liquid medicine compared with the alcohol precipitation method.
And thirdly, the cost is low, and is thirty percent of the cost of the alcohol precipitation method.
Detailed Description
The invention will now be further illustrated, but not by way of technical limitation, with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
Example 1
The embodiment provides a formula for precipitating impurities in a traditional Chinese medicine extracting solution for livestock and poultry, which comprises a clarifying agent and a settling aid, wherein the clarifying agent comprises 2 parts by weight of edible acacia, 1 part by weight of edible gelatin and 3 parts by weight of sodium carboxymethylcellulose, and the settling aid comprises 5 parts by weight of beta-cyclodextrin and 4 parts by weight of montmorillonite.
The three substances in the clarifying agent are uniformly mixed and subpackaged for standby, and because the clarifying agent is slowly dissolved in water and is difficult to uniformly disperse in a short time, the clarifying agent is firstly dissolved in water overnight before use, then is sheared and ground in a colloid mill to be fully dissolved, and is added into the liquid medicine after being diluted to ten percent of the solution.
The two components of the settling agent are uniformly mixed for later use, water is firstly added to dilute the settling agent into ten percent of turbid liquid before use, the turbid liquid is fully and uniformly stirred in a colloid mill and is soaked overnight, and the turbid liquid is uniformly stirred and added into the liquid medicine when in use.
Decocting the traditional Chinese medicine, concentrating to required amount, adding clarifying agent after stirring uniformly, then adding settling agent, stirring uniformly, adding 300g of clarifying agent and settling agent respectively per 200 kg of liquid medicine, standing for 24 hours, then generating liquid medicine for clearing floccules, then passing the liquid medicine through a centrifuge to obtain clarified liquid medicine, boiling, refrigerating, then fine filtering according to the preparation requirement, and encapsulating.
The clarifying agent is a natural water-soluble food-grade gum compound and mainly adsorbs macromolecular suspended impurities such as flocculation protein, tannin, pectin, grease and the like. The settling agent is a natural molecular sieve capable of swelling in water, and can accelerate the clarification speed, improve the clarity of the liquid medicine and improve the filterability. The aqueous solution of the clarifying agent is added with the liquid medicine and then is subjected to electrostatic adsorption polymerization with the auxiliary agent molecular sieve, a water-soluble flocculent cloud cluster can be formed and then is subjected to gravity settling, the molecular sieve in the cloud cluster selectively and electrostatically adsorbs macromolecular impurity colloid suspension particles in the liquid medicine, a larger flocculent cluster is formed and is rapidly settled to the bottom of the container, and solid-liquid separation and liquid medicine clarification are realized.
Example 2
The embodiment provides a formula for precipitating impurities in a traditional Chinese medicine extracting solution for livestock and poultry, which comprises a clarifying agent and a settling aid, wherein the clarifying agent comprises 3 parts by weight of edible acacia gum, 2 parts by weight of edible gelatin and 3 parts by weight of sodium carboxymethylcellulose, and the settling aid comprises 5 parts by weight of beta-cyclodextrin and 4 parts by weight of montmorillonite.
The three substances in the clarifying agent are uniformly mixed and subpackaged for standby, and because the clarifying agent is slowly dissolved in water and is difficult to uniformly disperse in a short time, the clarifying agent is firstly dissolved in water overnight before use, then is sheared and ground in a colloid mill to be fully dissolved, and is added into the liquid medicine after being diluted to ten percent of the solution.
The two components of the settling agent are uniformly mixed for later use, water is firstly added to dilute the settling agent into ten percent of turbid liquid before use, the turbid liquid is fully and uniformly stirred in a colloid mill and is soaked overnight, and the turbid liquid is uniformly stirred and added into the liquid medicine when in use.
Decocting the traditional Chinese medicine, concentrating to required amount, adding clarifying agent after stirring uniformly, then adding settling agent, stirring uniformly, adding 300g of clarifying agent and settling agent respectively per 200 kg of liquid medicine, standing for 24 hours, then generating liquid medicine for clearing floccules, then passing the liquid medicine through a centrifuge to obtain clarified liquid medicine, boiling, refrigerating, then fine filtering according to the preparation requirement, and encapsulating.
Example 3
The embodiment provides a formula for precipitating impurities in a traditional Chinese medicine extracting solution for livestock and poultry, which comprises a clarifying agent and a settling aid, wherein the clarifying agent comprises 5 parts by weight of edible acacia, 3 parts by weight of edible gelatin and 4 parts by weight of sodium carboxymethylcellulose, and the settling aid comprises 6 parts by weight of beta-cyclodextrin and 5 parts by weight of montmorillonite.
The three substances in the clarifying agent are uniformly mixed and subpackaged for standby, and because the clarifying agent is slowly dissolved in water and is difficult to uniformly disperse in a short time, the clarifying agent is firstly dissolved in water overnight before use, then is sheared and ground in a colloid mill to be fully dissolved, and is added into the liquid medicine after being diluted to ten percent of the solution.
The two components of the settling agent are uniformly mixed for later use, water is firstly added to dilute the settling agent into ten percent of turbid liquid before use, the turbid liquid is fully and uniformly stirred in a colloid mill and is soaked overnight, and the turbid liquid is uniformly stirred and added into the liquid medicine when in use.
Decocting the traditional Chinese medicine, concentrating to required amount, adding clarifying agent after stirring uniformly, then adding settling agent, stirring uniformly, adding 300g of clarifying agent and settling agent respectively per 200 kg of liquid medicine, standing for 24 hours, then generating liquid medicine for clearing floccules, then passing the liquid medicine through a centrifuge to obtain clarified liquid medicine, boiling, refrigerating, then fine filtering according to the preparation requirement, and encapsulating.
Test examples
Traditional Chinese medicine extracting solution: 15g of Chinese violet, 5g of astragalus, 7g of dandelion, 2g of tripterygium wilfordii and 2g of honeysuckle, 10 times of water is added for extraction for 2 hours, and an extracting solution is prepared.
The extract was divided into two parts, the illuminance was kept on and the test group was kept on, ethanol was added to the control group until the alcohol content reached 80%, the mixture was allowed to settle for 24 hours, and the supernatant was filtered, and the test group was allowed to stand for 24 hours by adding 250g of a clarifying agent and 250g of a settling aid to each kg of the solution according to the method of example 2, and the filtrate was filtered. The clear solutions of the control group and the test group were measured for light transmittance at λ of 620nm, and the results are shown in the following table:
| group of | Transmittance T/%) |
| Control group | 86.4 |
| Test group | 90.6 |
As can be seen from the table, the formula of the invention has better clarification effect.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (7)
1. A prescription for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry comprises a clarifying agent and a settling agent, and is characterized by comprising the following raw materials in parts by weight, wherein the clarifying agent comprises 2-5 parts of edible Arabic gum, 1-3 parts of edible gelatin and 3-4 parts of sodium carboxymethylcellulose, and the settling agent comprises 5-6 parts of beta-cyclodextrin and 4-5 parts of montmorillonite.
2. The formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry according to claim 1 is characterized by comprising the following raw materials in parts by weight, wherein the clarifying agent comprises 3 parts of edible gum arabic, 2 parts of edible gelatin and 3 parts of sodium carboxymethylcellulose, and the settling aid comprises 5 parts of beta-cyclodextrin and 4 parts of montmorillonite.
3. An application of a prescription for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry, which is characterized by comprising the clarifying agent and the settling agent in claim 1 or 2.
4. The application of the formula for precipitating impurities in the traditional Chinese medicine extracting solution for livestock and poultry according to claim 3 is characterized by comprising the following steps of:
1) preparing a clarifying agent into a solution with the mass percentage of ten, and preparing a settling agent into a turbid solution with the mass percentage of ten;
2) decocting the Chinese medicinal materials, concentrating to desired amount, stirring, adding clarifier, stirring, adding settling agent, stirring, standing for 24 hr to clear the flocculated liquid, centrifuging, boiling, refrigerating, fine filtering, and bottling.
5. The use of the formulation of claim 4, wherein the formulation of the clarifying agent comprises dissolving the clarifying agent in water overnight, and then shearing and grinding in a colloid mill to dissolve it sufficiently.
6. The use of the formulation according to claim 4 for precipitating impurities from Chinese medicinal extracts for livestock and poultry, wherein the precipitation aid is prepared by stirring thoroughly in a colloid mill, soaking overnight, and adding into the liquid medicine.
7. The application of the prescription for precipitating the impurities in the Chinese medicinal extracting solution for livestock and poultry according to claim 4, which is characterized in that 200 g of clarifying agent and 300g of settling aid are respectively added into every 200 kg of liquid medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010041032.1A CN111068368A (en) | 2020-01-15 | 2020-01-15 | Formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry and application of formula |
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| CN202010041032.1A CN111068368A (en) | 2020-01-15 | 2020-01-15 | Formula for precipitating impurities in traditional Chinese medicine extracting solution for livestock and poultry and application of formula |
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| US20110195136A1 (en) * | 2008-10-06 | 2011-08-11 | Jianming Chen | Drop pill for treating coronary heart disease and preparation thereof |
| CN102389140A (en) * | 2011-10-14 | 2012-03-28 | 南昌大学 | Method for solving compatibility problem of grape seed extract and collagen aqueous solution |
| DE102011087137A1 (en) * | 2011-11-25 | 2013-05-29 | Fim Biotech Gmbh | A method for separating microorganisms from an aqueous phase and an apparatus for carrying out this method |
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| CN102389140A (en) * | 2011-10-14 | 2012-03-28 | 南昌大学 | Method for solving compatibility problem of grape seed extract and collagen aqueous solution |
| DE102011087137A1 (en) * | 2011-11-25 | 2013-05-29 | Fim Biotech Gmbh | A method for separating microorganisms from an aqueous phase and an apparatus for carrying out this method |
| CN103508533A (en) * | 2012-06-28 | 2014-01-15 | 索尼公司 | Flocculant mixture and flocculation method |
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Application publication date: 20200428 |