CN111053701A - Dandruff-removing and itching-relieving composition and application thereof - Google Patents

Dandruff-removing and itching-relieving composition and application thereof Download PDF

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Publication number
CN111053701A
CN111053701A CN202010157388.1A CN202010157388A CN111053701A CN 111053701 A CN111053701 A CN 111053701A CN 202010157388 A CN202010157388 A CN 202010157388A CN 111053701 A CN111053701 A CN 111053701A
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China
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dandruff
itching
composition
fatty
polysaccharide polymer
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CN202010157388.1A
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Chinese (zh)
Inventor
郭清泉
刘迪
舒均中
练英铎
夏树敏
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Guangdong University of Technology
Opal Cosmetics Huizhou Co Ltd
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Guangdong University of Technology
Opal Cosmetics Huizhou Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/006Antidandruff preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

Abstract

The invention belongs to the field of daily chemicals. An anti-dandruff and anti-itching composition comprises the following components in percentage by weight: 2-10% of anti-dandruff component, 2-20% of eugenol, 1-15% of dipotassium glycyrrhizinate, 5-40% of alcohol solubilizing component and the balance of water. The composition disclosed by the invention is mild and low in stimulation, anti-inflammatory and soothing, antibacterial, anti-inflammatory, antioxidant, and good in dandruff-removing and itching-relieving effects. The composition can be applied to hair cosmetics, and has effects of reducing irritation of hair cosmetics, promoting penetration and absorption of effective components, and relieving dandruff and itching with high efficiency and long-lasting effect.

Description

Dandruff-removing and itching-relieving composition and application thereof
Technical Field
The invention belongs to the field of daily chemicals, and relates to a dandruff-removing and itching-relieving composition and application thereof.
Background
Dandruff is a common scalp health problem, and typical dandruff refers to flaky dandruff on or in the scalp, most often accompanied by significant itching. Various internal factors and external environmental factors, such as sebum secretion, malassezia colonization, individual susceptibility and the like, are all causes of dandruff.
Malassezia is a lipotrophic fungus that parasitizes on the skin surfaces of humans and animals and secretes a variety of lipases with broad-spectrum activity that hydrolyze triglycerides in sebum to fatty acids. Since malassezia lacks D9 desaturase, metabolizes only saturated fatty acids and thereby produces proinflammatory unsaturated fatty acid aggregates, stimulates the skin barrier and thus causes stratum corneum exfoliation and head itching problems, it has been considered that this bacterium is the causative bacterium of dandruff and seborrheic dermatitis, the removal of dandruff requiring the inhibition of the hyperproliferation of malassezia.
ZPT, OCT and climbazole are mainly used as antidandruff agents in the washing and protecting antidandruff products in the market at present, but the ZPT, OCT and climbazole have high irritation and poor antidandruff effect. Therefore, there is a need to develop a scalp care composition with anti-dandruff and anti-itching effects.
The invention patent CN 104095784A discloses an anti-dandruff and itching-relieving shampoo which is prepared from a shampoo matrix and Chinese herbal medicine extract, although natural medicinal materials are adopted in the application, the content of an anti-dandruff agent in the components is limited, no substance for promoting the scalp to absorb effective components is contained, and the anti-dandruff effect is slow to take effect.
Disclosure of Invention
The technical problem to be solved by the invention is to provide the dandruff-removing and itching-relieving composition which is mild, low in stimulation, anti-inflammatory, soothing, antibacterial, anti-inflammatory, antioxidant and good in dandruff-removing and itching-relieving effects. The composition can be applied to hair cosmetics, and has effects of reducing irritation of hair cosmetics, promoting penetration and absorption of effective components, and relieving dandruff and itching with high efficiency and long-lasting effect.
The technical scheme of the invention is as follows:
an anti-dandruff and anti-itching composition comprises the following components in percentage by weight: 2-10% of anti-dandruff component, 2-20% of eugenol, 1-15% of dipotassium glycyrrhizinate, 5-40% of alcohol solubilizing component and the balance of water.
Further, the anti-dandruff ingredient is one selected from piroctone olamine salt, zinc pyrithione, and hexamidine di (isethionate) salt.
Further, the alcohol dissolution assisting component is at least one of propylene glycol, butanediol and ethanol.
The application of the anti-dandruff and anti-itching composition is applied to hair cosmetics, and the mass of the anti-dandruff and anti-itching composition in the hair cosmetics accounts for 2-20%.
Further, the hair cosmetic is in the form of one of a solution, a suspension, an emulsion, a cream, and a solid.
An anti-dandruff shampoo comprises the following components in percentage by weight: 2-20% of an antidandruff and antipruritic composition according to any one of claims 1-3, 5-30% of an anionic surfactant, 5-28% of an amphoteric surfactant, 0.01-6% of a nonionic surfactant, 0.05-5% of a non-volatile conditioning agent, 0.01-3% of a polysaccharide polymer, 0.1-4% of a suspending agent and the balance being purified water.
Further, the paint also comprises at least one of the following components: 0.01-3% of acid-base regulator, 0.01-1% of preservative, 0.01-3% of essence, 0.01-4% of viscosity regulator, 0.005-0.2% of chelating agent and 0.01-2% of ultraviolet absorbent.
(A) Anionic surface Activity
The anionic surfactant is at least one of lauryl alcohol polyoxyethylene ether sulfate, fatty acid monoglyceride sulfate, fatty alcohol ether sulfosuccinate, N-fatty acylamino acid salt, fatty acyl methyl taurate, monoalkyl sulfate, monoalkyl carboxylate and monoalkyl phosphate; lauryl alcohol polyoxyethylene ether sulfate, monoalkyl sulfate and fatty acyl methyl taurate are preferred.
(B) Amphoteric surfactant
The amphoteric surfactant is at least one of fatty acyl amphodiacetate, fatty acyl propyl betaine and fatty amide hydroxypropyl sulfobetaine; one or both of fatty acyl amphodiacetate and fatty acyl propyl betaine are preferred.
(C) Nonionic surfactant
The nonionic surfactant is at least one of fatty acyl monoethanolamide, fatty acyl diethanolamide, fatty acyl methyl monoethanolamide and alkyl glycoside; fatty acyl monoethanolamides and fatty acyl diethanolamides are preferred.
(D) Non-volatile conditioning agent
The non-volatile conditioning agent is one of polysiloxane, amino-terminated polydimethylsiloxane and higher fatty alcohol; preferably 30 to 50 million viscosity polysiloxane, 0.05 to 50 μm particle size polysiloxane and amino-terminated polydimethylsiloxane.
(E) Polysaccharide polymers
The polysaccharide polymer is at least one of an anionic polysaccharide polymer, a cationic polysaccharide polymer, a nonionic polysaccharide polymer and an amphoteric polysaccharide polymer;
the anionic polysaccharide polymer is at least one of alginic acid and derivatives thereof, pectin and derivatives thereof, carrageenan and derivatives thereof, xanthan gum and derivatives thereof, hyaluronic acid and derivatives thereof, acacia gum and derivatives thereof, karaya gum and derivatives thereof, tragacanth gum and derivatives thereof, carboxymethyl cellulose and derivatives thereof, and carboxymethyl chitin and derivatives thereof;
the cationic polysaccharide polymer is at least one of chitosan and derivatives thereof, cationic cellulose derivatives and cationic guar gum derivatives;
the cationic cellulose derivative has a general formula:
Figure 503384DEST_PATH_IMAGE001
wherein R1 is a glucoside residue; r2 is a hydroxyalkylene, alkyleneoxyalkylene, polyoxyalkylene, and combinations thereof; r3, R4 and R5 are respectively selected from alkyl long chains with the carbon number less than 20; x is at least one of halide anion, sulfate ion and methyl sulfate ion;
the preferred cationic cellulose derivative is polyquaternium-10, which has the following structural formula:
Figure 30311DEST_PATH_IMAGE002
the nitrogen content of the cationic cellulose derivative is 0.8-3.1%, and the viscosity of a 2% pure water solution is 10000-400000 cps; the charge density of the cationic guar gum derivative is 0.2-2.5 meq/g, and the molecular weight is 100000-2200000 g/mol.
The nonionic polysaccharide polymer is at least one of guar gum, hydroxypropyl guar gum, locust bean gum, methylcellulose and derivatives thereof, hydroxyethyl cellulose, hydroxypropyl cellulose, alkyl hydroxyethyl cellulose, nonyl phenol ether hydroxyethyl cellulose and modified starch water-soluble polymers.
(F) Suspending agent
The suspending agent is at least one of acyl derivatives, long-chain amine oxide, acrylic polymers and derivatives thereof, carbomer polymers, acrylic acid (ester)/C10-C30 alkanol acrylate copolymers, acrylate/C10-C30 alkanol acrylate cross-linked copolymers, acrylic acid (ester) copolymers, polyacrylate-1 cross-linked polymers, acrylic acid (ester)/steareth-20 methacrylate copolymers and hydroxystearic acid glyceride;
the acyl derivative is selected from fatty acid glycol ester containing 16-22 carbon atoms, long-chain hydrocarbon, long-chain ester of long-chain fatty acid, long-chain ester of long-chain alkanolamide;
the long-chain amine oxide is selected from dimethyl amine oxide with 16-22 carbon atoms, preferably fatty acid glycol diester with 18 carbon atoms;
the glyceryl hydroxystearate is obtained by esterifying hydroxystearic acid with glycerol, and is at least one of glyceryl monostearate, glyceryl distearate and glyceryl hydroxystearate triglyceride, preferably glyceryl hydroxystearate triglyceride.
The invention has the following beneficial effects:
the anti-dandruff component selected by the invention, piroctone olamine salt has the functions of sterilization and antioxidation, and the Minimum Inhibitory Concentration (MIC) of malassezia is 62.5 mug/mL; the hexamidine di (hydroxyethyl sulfonate) has broad-spectrum bactericidal action, and is favorable for enhancing the bactericidal and anti-dandruff actions due to the cationic property of the hexamidine di (hydroxyethyl sulfonate) which can generate adsorption action on hair; zinc pyrithione has strong malassezia resistance activity, has a Minimum Inhibitory Concentration (MIC) of 7.5 mug/mL, has a strong degreasing effect, and can destroy the living environment of malassezia. The selected eugenol has broad-spectrum bactericidal action, the Minimum Inhibitory Concentration (MIC) for malassezia is 312.5 mug/mL, the eugenol has better transdermal absorption performance, can promote the permeation of active ingredients, and the antioxidation can inhibit the peroxidation of scalp lipid, thereby achieving the effects of removing dandruff and relieving itching from the root. The dipotassium glycyrrhizinate has anti-inflammatory and anti-allergic effects, and can relieve the inflammation problem of the scalp.
According to the invention, through the mutual matching of the anti-dandruff component, the eugenol and the glycyrrhizic acid dimethyl, the composition has good transdermal absorption performance and anti-inflammatory and relieving effects, can effectively reduce the irritation of the anti-dandruff component to scalp, simultaneously improve the anti-bacterial and anti-dandruff effects of the anti-dandruff component, efficiently and durably remove dandruff, effectively kill malassezia, inhibit scalp lipid peroxidation, relieve scalp inflammation and relieve itching.
Detailed Description
The present invention will be described in detail with reference to examples, which are only preferred embodiments of the present invention and are not intended to limit the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
In the following detailed description, unless otherwise specified, all conventional methods are used; raw materials, reagent materials, and the like used in the following embodiments are all commercially available products unless otherwise specified; unless otherwise indicated, percentages in the present invention are percentages by mass.
The following table shows the formulation (unit:%) of 5 examples and 5 comparative examples of the anti-dandruff antipruritic composition according to the invention.
Figure 246267DEST_PATH_IMAGE003
The following table shows the formulation (unit:%) of 5 examples of anti-dandruff shampoos of the present invention and 5 comparative examples.
Figure 251263DEST_PATH_IMAGE004
First, bacteriostasis test
The experimental principle of the bacteriostatic zone is that the bacteriostatic agent is dissolved in a culture medium and continuously diffuses to form different concentration gradients so as to display the bacteriostatic action of the bacteriostatic agent, and whether the bacteriostatic ability of the bacteriostatic agent exists or not is judged according to the size of a bacteriostatic ring. If the diameter of the antibacterial ring is larger than 7mm, the antibacterial effect is achieved, and if the diameter of the antibacterial ring is smaller than or equal to 7mm, the antibacterial effect is not achieved. The test strain is Malassezia furfur with concentration of (1-2) x 106CFU/mL。
Bacteriostatic tests were performed on anti-dandruff shampoos of examples a-e and comparative examples a-e of the present invention, and the diameters (mm) of the zone of inhibition are shown in the following table.
Group of Example a Example b Example c Example d Example e Comparative example a Comparative example b Comparative example c Comparative example d Comparative example e
Diameter of bacteriostatic circle/(mm) 15.7 12.5 12.7 13.6 15.3 10.1 11.7 9.5 8.3 15.2。
The anti-dandruff composition of example a had no anti-dandruff ingredient added, and the zone diameter decreased from 15.7mm to 10.1mm compared to comparative example a.
The anti-dandruff composition of example b has no eugenol added, and the zone of inhibition diameter decreases from 15.7mm to 11.7mm compared to comparative example b.
The anti-dandruff composition of example c, without eugenol added, had a zone of inhibition diameter decreasing from 12.5mm to 9.5mm compared to comparative example c.
The anti-dandruff composition of example d had no eugenol added, and the zone of inhibition diameter decreased from 12.7mm to 8.3mm compared to comparative example d.
The anti-dandruff composition of example e was not added with dipotassium glycyrrhizinate, and the diameter of the zone of inhibition was not much different from that of comparative example e.
Therefore, the anti-dandruff composition simultaneously comprises the anti-dandruff component and the eugenol, and the bacteriostatic effect on the malassezia is higher than that of the combination containing only the anti-dandruff agent or only the eugenol.
Second, evaluation of human body test
Shampoo of the invention comparative examples a-e and comparative examples a-e were tested for mildness. 150 tested persons are selected, 75 male and female volunteers are respectively subjected to half-head comparison test, the period is 28 days, and the test subjects are revisited every week. Scoring from the aspect of dandruff scratchy condition. The questionnaire was filled out according to the experience of use with a rating scale of 1 point-no dandruff, 2 points-sporadic dandruff, 3 points-few dandruff, 4 points-more dandruff, 5 points-large dandruff. And counting the evaluation of the dandruff and head itching, and taking the average value to be listed in the following table.
Figure DEST_PATH_IMAGE005
The anti-dandruff composition in shampoo of comparative example a, to which no anti-dandruff ingredient was added, had a score of 1.08 to 1.65 evaluated using sensory test after 28 days, and the anti-dandruff and anti-itching effect was deteriorated, compared to example a.
The anti-dandruff composition of comparative example b, in which eugenol was not added, had a score of 1.08 to 1.34 evaluated using a sensory test after 28 days, and the anti-dandruff and anti-itching effect was deteriorated, compared to example b.
The anti-dandruff composition of comparative example c, to which eugenol was not added, changed in score from 1.33 to 1.45 evaluated using a sensory test after 28 days, and deteriorated anti-dandruff and anti-itching effect, compared to example c.
The anti-dandruff composition of comparative example d, in which eugenol was not added, had a score of 1.38 to 1.68 evaluated using a sensory test after 28 days, and the anti-dandruff and anti-itching effect was deteriorated, compared to example d.
The anti-dandruff composition of comparative example e, to which dipotassium glycyrrhizinate was not added, had a score of 1.08 to 1.34 evaluated using a sensory test after 28 days, and the anti-dandruff and anti-itching effect was deteriorated, as compared with example e.
It can be seen that the anti-dandruff shampoo of comparative examples a-e was more effective in removing dandruff and relieving itching as the use time increased after 28 days of continuous use.
In summary, when only the anti-dandruff composition comprises the anti-dandruff component, the eugenol and the dipotassium glycyrrhizinate, the anti-dandruff shampoo containing the anti-dandruff composition has good anti-dandruff effect, and when the composition of the anti-dandruff composition changes, the anti-dandruff effect of the anti-dandruff shampoo is poor.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. The anti-dandruff and anti-itching composition is characterized by comprising the following components in percentage by weight: 2-10% of anti-dandruff component, 2-20% of eugenol, 1-15% of dipotassium glycyrrhizinate, 5-40% of alcohol solubilizing component and the balance of water.
2. The composition for removing dandruff and relieving itching according to claim 1, wherein the dandruff-removing component is one selected from the group consisting of piroctone olamine salt, zinc pyrithione, and hexamidine bis (isethionate) salt.
3. The composition according to claim 1, wherein the alcohol solubilizing aid is at least one of propylene glycol, butylene glycol and ethanol.
4. Use of the anti-dandruff and anti-itching composition according to any one of claims 1 to 3, characterized in that the anti-dandruff and anti-itching composition is used in hair cosmetics in an amount of 2 to 20% by weight of the hair cosmetics.
5. The use of the composition for removing dandruff and relieving itching according to claim 4, wherein the hair cosmetic is in the form of one of solution, suspension, emulsion, cream, and solid.
6. The anti-dandruff shampoo is characterized by comprising the following components in percentage by weight: 2-20% of an antidandruff and antipruritic composition according to any one of claims 1-3, 5-30% of an anionic surfactant, 5-28% of an amphoteric surfactant, 0.01-6% of a nonionic surfactant, 0.05-5% of a non-volatile conditioning agent, 0.01-3% of a polysaccharide polymer, 0.1-4% of a suspending agent and the balance being purified water.
7. The anti-dandruff shampoo according to claim 6, wherein the anionic surfactant is at least one of laureth sulfate, fatty acid monoglyceride sulfate, fatty alcohol ether sulfosuccinate, N-fatty acylamino acid salt, fatty acyl methyl taurate, monoalkyl sulfate, monoalkyl carboxylate, monoalkyl phosphate; the amphoteric surfactant is at least one of fatty acyl amphodiacetate, fatty acyl propyl betaine and fatty amide hydroxypropyl sulfobetaine; the nonionic surfactant is at least one of fatty acyl monoethanolamide, fatty acyl diethanolamide, fatty acyl methyl monoethanolamide and alkyl glycoside.
8. The anti-dandruff shampoo of claim 6, wherein the non-volatile conditioning agent is one of a polysiloxane, an amodimethicone, and a higher fatty alcohol.
9. The anti-dandruff shampoo according to claim 6, wherein the polysaccharide polymer is at least one of an anionic polysaccharide polymer, a cationic polysaccharide polymer, a non-ionic polysaccharide polymer, and an amphoteric polysaccharide polymer.
10. The anti-dandruff shampoo according to claim 6, wherein the suspending agent is at least one of acyl derivatives, long-chain amine oxides, acrylic polymers and derivatives thereof, carbomer polymers, acrylic acid/C10-C30 alkanol acrylate copolymers, acrylic acid/C10-C30 alkanol acrylate cross-linked copolymers, acrylic acid/ester copolymers, polyacrylate-1 cross-linked polymers, acrylic acid/steareth-20 methacrylate copolymers, and glyceryl hydroxystearate.
CN202010157388.1A 2020-03-09 2020-03-09 Dandruff-removing and itching-relieving composition and application thereof Pending CN111053701A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101516327A (en) * 2006-09-25 2009-08-26 纳幕尔杜邦公司 Cosmetic compositions
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CN106389154A (en) * 2016-10-25 2017-02-15 澳宝化妆品(惠州)有限公司 Multi-effect balanced shampoo and preparation method thereof
CN107468560A (en) * 2017-07-31 2017-12-15 澳宝化妆品(惠州)有限公司 A kind of hair-washing composition containing tea extraction
CN109646326A (en) * 2018-12-04 2019-04-19 澳宝化妆品(惠州)有限公司 A kind of scalp care compositions of the solid-state structure containing liquid crystal

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CN102639108A (en) * 2009-06-04 2012-08-15 宝洁公司 Multiple product system for hair
CN106389154A (en) * 2016-10-25 2017-02-15 澳宝化妆品(惠州)有限公司 Multi-effect balanced shampoo and preparation method thereof
CN107468560A (en) * 2017-07-31 2017-12-15 澳宝化妆品(惠州)有限公司 A kind of hair-washing composition containing tea extraction
CN109646326A (en) * 2018-12-04 2019-04-19 澳宝化妆品(惠州)有限公司 A kind of scalp care compositions of the solid-state structure containing liquid crystal

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祝世讷: "《中医新知识辞典》", 31 December 1994, 中国医药科技出版社 *

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Application publication date: 20200424