CN111040886B

CN111040886B - Tea saponin dispersible tablet and preparation method and application thereof

Info

Publication number: CN111040886B
Application number: CN201911409610.6A
Authority: CN
Inventors: 杨建琼; 刘海; 黄浩; 李林福; 明良山
Original assignee: Gannan Medical University
Current assignee: Gannan Medical University
Priority date: 2019-12-31
Filing date: 2019-12-31
Publication date: 2021-11-05
Anticipated expiration: 2039-12-31
Also published as: CN111040886A

Abstract

The invention relates to a tea saponin dispersible tablet and a preparation method and application thereof, wherein the dispersible tablet comprises the following components in parts by weight: 65-99 parts of tea saponin, 0-14 parts of filler, 0.5-10 parts of povidone and 0.5-15 parts of disintegrant. The tea saponin dispersible tablet provided by the invention has the advantages of simple preparation process, high tea saponin content, quick disintegration in water, small hygroscopicity and the like, and is suitable for the production requirements of natural high-efficiency fruit and vegetable cleaning agents.

Description

Tea saponin dispersible tablet and preparation method and application thereof

Technical Field

The invention relates to a tea saponin dispersible tablet and a preparation method and application thereof.

Background

The overproof pesticide residue in edible fruits and vegetables is one of the main problems facing the food safety in China. China is the first major country of pesticide consumption in the world, 190 million tons of pesticides are produced annually, 60 million tons of raw pesticides are used, the dosage of chemical pesticides in unit area is 2.5-5 times higher than the dosage in the world, and the area of crops which are polluted by residual pesticides each year reaches 12 hundred million mu. Most fruits and vegetables are instant when being fresh and are eaten in large quantities, so that the pesticide residues of the fruits and the vegetables have great harm to human bodies, and the problem of pesticide residues of the fruits and the vegetables is related to the health of people and is paid enough attention.

At present, few products are sold in China, which are specially used for cleaning residual pesticides on vegetables and fruits, and many of the products are replaced by chemical products such as common tableware detergents. These products have two major drawbacks: on one hand, the pesticide residue removing efficiency is not ideal enough; on the other hand, chemical components such as sodium dodecyl benzene sulfonate in the products also remain in certain amount in vegetables and fruits after washing, which becomes a secondary pollution source. In addition, most of the detergents also contain a certain amount of elements harmful to human bodies, such as arsenic and some heavy metal elements such as mercury, lead, cadmium, chromium and the like, which are harmful to human bodies. In conclusion, a small amount of heavy metal elements contained in common detergents can cause great harm to human health, so that natural, nontoxic and efficient fruit and vegetable cleaning agents increasingly become the requirements of healthy life along with the attention of people on life quality and life health.

The camellia seeds contain natural surfactant tea saponin, can be used for washing vegetables and fruits, but a solid preparation which is used for washing fruits and takes the tea saponin as a main component is not sold in the market all the time, because the tea saponin has too strong hygroscopicity, the tea saponin is prepared into powder or granules, because the specific surface area is large, the hygroscopicity is strong, after the two reasons are superposed, the product is deteriorated and ineffective due to absorbing moisture (absorbing moisture) in the air after the product is produced, the product stability is poor, and the tea saponin is not easy to popularize in the market. The preparation of the tea saponin into the tablet with small specific surface area is one of the methods for solving the problems of strong hygroscopicity and poor stability of the tea saponin.

The preparation of the tea saponin powder into the tablet requires that the tea saponin powder is prepared into granules firstly and then tabletted. To achieve a good fruit cleaning effect, tea saponin with a certain concentration is needed, the content of tea saponin in the tablet is needed to be high, but the difficulty in preparing the high-content tea saponin tablet is high due to the fact that the hygroscopicity of the tea saponin is too strong and the granulation difficulty is high. 10-50% of CN102948418A tea saponin, 60% of CN106344421A tea saponin and 10-50% of CN107699394A tea saponin.

Disclosure of Invention

In order to overcome the problem of high difficulty in preparing the high-content tea saponin tablet, the invention provides the tea saponin dispersible tablet and the preparation method thereof, and the content of the tea saponin in the prepared tea saponin dispersible tablet can reach more than 65 percent.

In order to achieve the above object, the present invention provides a tea saponin dispersible tablet, which comprises, by weight, 100 parts: 65-99 parts of tea saponin, 0-14 parts of filler, 0.5-10 parts of povidone and 0.5-15 parts of disintegrant.

Preferably, the filler is one or more of lactose, sucrose, dextrin and starch.

Preferably, the disintegrant is one or more of sodium carboxymethyl starch, croscarmellose sodium and crospovidone.

According to a second aspect of the present invention, the present invention provides a method for preparing a dispersible tablet of tea saponin, the method comprising: uniformly mixing the tea saponin, the ethanol solution of povidone and an optional filler, granulating, drying to obtain dry granules, adding a disintegrating agent, uniformly mixing, and tabletting to obtain the tea saponin dispersible tablet, wherein the dosage of each component is as follows by weight: 65-99 parts of tea saponin, 0-14 parts of filler, 0.5-10 parts of povidone and 0.5-15 parts of disintegrant.

Preferably, the concentration of the ethanolic solution of povidone is 1-10% by weight, preferably 3-5% by weight.

Preferably, the filler is one or more of lactose, sucrose, dextrin and starch.

Preferably, the conditions of drying include: performing first drying under an inert atmosphere; then carrying out secondary drying in an oxygen-containing atmosphere; wherein the temperature of the first drying is 40-60 ℃, and the temperature of the second drying is 20-30 ℃ higher than that of the first drying.

Preferably, the inert atmosphere is a mixed gas of nitrogen and carbon dioxide, and the volume ratio of the nitrogen to the carbon dioxide is 0.1-0.4: 1.

Preferably, the temperature of the second drying is 70-90 ℃.

The invention provides a tea saponin dispersible tablet prepared according to the preparation method.

The invention provides application of a tea saponin dispersible tablet as a fruit and vegetable cleaning agent.

The tea saponin dispersible tablet provided by the invention has the advantages of simple preparation process, high tea saponin content, quick disintegration in water, small hygroscopicity and the like, and is suitable for the production requirements of natural high-efficiency fruit and vegetable cleaning agents.

Detailed Description

The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.

The invention provides a tea saponin dispersible tablet, which comprises the following components in 100 parts by weight: 65-99 parts of tea saponin, 0-14 parts of filler, 0.5-10 parts of povidone and 0.5-15 parts of disintegrant. The invention can prepare more than 65 weight percent of dispersible tablets containing tea saponin for the first time, and greatly improves the use value of the tea saponin dispersible tablets.

In the present invention, the kinds of the filler can be selected widely, and a common filler can be used in the present invention, and according to a preferred embodiment of the present invention, the filler is one or more of lactose, sucrose, dextrin and starch.

In the present invention, the optional range of the kind of the disintegrant is wide, and a common disintegrant can be used in the present invention, and according to a preferred embodiment of the present invention, the disintegrant is one or more of sodium carboxymethyl starch, croscarmellose sodium and crospovidone.

In the invention, the povidone is a nonionic high molecular compound, is an N-vinylamide polymer, and has a relative molecular mass of thousands to more than one million. The molecular weight of povidone is conventionally expressed in terms of K values, with different K values representing the corresponding ranges of molecular weight of povidone. The K value is actually a characteristic value related to the relative viscosity of the aqueous povidone solution, which in turn is a physical quantity related to the molecular weight of the high polymer, and thus the K value can be used to characterize the average molecular weight of PVP. In general, the larger the K value, the higher the viscosity, and the stronger the adhesiveness. The use of povidone is particularly suitable for the present invention, for which e.g. PVPK12, PVPK15, PVPK17, PVPK25, PVPK30, PVPK45, PVPK60, PVP/70, PVPK30, PVPK80, PVPK85, PVPK90, PVPK100, PVPK110, PVPK120, PVPK150, for which the K30 model of povidone (PVPK30) is particularly preferred.

The invention provides a preparation method of a tea saponin dispersible tablet, which comprises the following steps: uniformly mixing the tea saponin, the ethanol solution of povidone and an optional filler, granulating, drying to obtain dry granules, adding a disintegrating agent, uniformly mixing, and tabletting to obtain the tea saponin dispersible tablet, wherein the dosage of each component is as follows by weight: 65-99 parts of tea saponin, 0-14 parts of filler, 0.5-10 parts of povidone and 0.5-15 parts of disintegrant. By adopting the technical scheme, the dispersible tablet can be prepared, the disintegration time of the dispersible tablet can be shortened, and the hygroscopicity of the dispersible tablet can be reduced.

According to a preferred embodiment of the present invention, preferably, the concentration of the ethanolic solution of povidone is 1 to 10% by weight, preferably 3 to 5% by weight. By adopting the technical scheme, the dispersible tablet can be effectively prepared, the disintegration time of the dispersible tablet can be shortened, and the hygroscopicity of the dispersible tablet is reduced.

According to a preferred embodiment of the present invention, the filler is one or more of lactose, sucrose, dextrin and starch. By adopting the technical scheme, the dispersible tablet can be effectively prepared, the disintegration time of the dispersible tablet can be shortened, and the hygroscopicity of the dispersible tablet is reduced.

According to a preferred embodiment of the present invention, preferably, the disintegrant is one or more of sodium carboxymethyl starch, croscarmellose sodium and crospovidone. By adopting the technical scheme, the dispersible tablet can be effectively prepared, the disintegration time of the dispersible tablet can be shortened, and the hygroscopicity of the dispersible tablet is reduced.

According to a preferred embodiment of the present invention, the conditions of drying include: performing first drying under an inert atmosphere; then carrying out secondary drying in an oxygen-containing atmosphere; wherein, the temperature of the first drying is preferably 40-60 ℃, and the temperature of the second drying is preferably 20-30 ℃ higher than the first drying temperature.

According to a preferred embodiment of the present invention, the inert atmosphere is a mixed gas of nitrogen and carbon dioxide in a volume ratio of 0.1 to 0.4: 1.

According to a preferred embodiment of the present invention, wet granulation techniques are preferably used to prepare the wet granules. For example, a wet granulator is used to prepare a soft mass by shear granulation and the wet granulate is obtained by sieving through a 20 mesh sieve.

In the present invention, conventional tabletting methods can be used for tabletting, and the present invention has no particular requirement for this.

According to a preferred embodiment of the present invention, the temperature of the secondary drying is 70 to 90 ℃.

The time of the first drying and the time of the second drying are not particularly required in the present invention, and for the present invention, the time of the first drying is preferably 1 to 15 hours, preferably 2 to 10 hours, and the time of the second drying is preferably 1 to 15 hours, preferably 2 to 10 hours.

In the invention, the tea saponin is also called tea saponin, is a glucoside compound extracted from tea seeds (tea seeds and tea seeds), and is a natural surfactant with good performance.

Example 1

A tea saponin dispersible tablet comprises the following components in parts by weight: 65 parts of tea saponin, 14 parts of lactose, 5 parts of povidone (povidone K30) and 10 parts of croscarmellose sodium. The preparation method comprises the following steps: mixing tea saponin and lactose uniformly, adding anhydrous ethanol solution (3 wt%) of polyvidone, preparing soft material by shearing granulation method of wet granulator, and sieving with 20 mesh sieve to obtain wet granule; under the mixed gas of nitrogen and carbon dioxide (volume ratio is 0.4:1), carrying out first drying for 5h at 40 ℃, then carrying out second drying for 5h at 70 ℃ under the air atmosphere, and sieving with a 20-mesh sieve to obtain dry particles after drying; adding croscarmellose sodium into the dry granules, mixing, and tabletting to obtain tea saponin dispersible tablet.

Example 2

A tea saponin dispersible tablet comprises the following components in parts by weight: 99 parts of tea saponin, 1 part of povidone and 0.5 part of crospovidone (povidone K30). The preparation method comprises the following steps: weighing tea saponin with a prescription amount, adding 5 wt% of anhydrous ethanol solution of polyvidone, preparing soft material by using a shearing granulation method of a wet granulator, and sieving with a 10-mesh sieve to obtain wet granules; under the mixed gas of nitrogen and carbon dioxide (volume ratio is 0.1:1), carrying out primary drying for 7h at 60 ℃, then carrying out secondary drying for 2h at 80 ℃ under the air atmosphere, sieving with a 10-mesh sieve, and granulating to obtain dry particles; adding polyvinylpolypyrrolidone into the dry granules, mixing uniformly, and tabletting to obtain the tea saponin dispersible tablet.

Example 3

A tea saponin dispersible tablet comprises the following components in parts by weight: 80 parts of tea saponin, 9 parts of cane sugar, 3 parts of povidone and 5 parts of sodium carboxymethyl starch. The preparation method comprises the following steps: uniformly mixing tea saponin and sucrose, adding 1 wt% of anhydrous ethanol solution of polyvidone as adhesive, granulating by fluidized granulation method, performing first drying at 50 deg.C for 10h under mixed gas of nitrogen and carbon dioxide (volume ratio of 0.2:1), performing second drying at 80 deg.C for 7h under air atmosphere, sieving with 14 mesh sieve, grading, adding sodium carboxymethyl starch into the dried granules, uniformly mixing, and tabletting to obtain tea saponin dispersible tablet.

Example 4

A tea saponin dispersible tablet comprises the following components in parts by weight: 76 parts of tea saponin, 12 parts of starch, 4 parts of povidone (povidone K30), 3 parts of sodium carboxymethyl starch and 5 parts of croscarmellose sodium. The preparation method comprises the following steps: uniformly mixing tea saponin and starch, adding 10 wt% of anhydrous ethanol solution of polyvidone as binder, granulating by fluidized granulation method, sieving with 16 mesh sieve, grading, performing primary drying at 50 deg.C for 7 hr under mixed gas of nitrogen and carbon dioxide (volume ratio of 0.2:1), performing secondary drying at 70 deg.C for 6 hr under air atmosphere, and sieving with 14 mesh sieve to obtain dry granules; adding sodium carboxymethyl starch into the dry granules, mixing, and tabletting to obtain tea saponin dispersible tablet.

Example 5

A tea saponin dispersible tablet comprises the following components in parts by weight: 70 parts of tea saponin, 12 parts of lactose, 5 parts of povidone and 10 parts of croscarmellose sodium. The preparation method comprises the following steps: uniformly mixing tea saponin and lactose, using 2 parts of an absolute ethyl alcohol solution of povidone as a binder, granulating by a fluidized granulation method, using 3 parts of an absolute ethyl alcohol solution (4 wt%) of povidone as a coating solution, coating the granules, sieving by a 16-mesh sieve, grading, performing first drying for 6 hours at 60 ℃ under the mixed gas of nitrogen and carbon dioxide (the volume ratio is 0.2:1), and performing second drying for 4 hours at 80 ℃ under the air atmosphere to obtain dry granules; adding croscarmellose sodium into the dry granules, mixing, and tabletting to obtain tea saponin dispersible tablet.

Example 6

The dispersible tablets were prepared according to the method of example 2 except that the drying was carried out directly in an air atmosphere at 90 ℃ for 9 h.

Test example 1

Moisture absorption stability test

The tea saponin dispersible tablets prepared in the examples are packaged by aluminum plastic bubble caps, samples are stored for 6 months under the conditions that the temperature is 40 +/-2 ℃, the relative humidity is RH75 +/-5% and the direct irradiation of light is avoided, and the samples are placed for 1, 2, 3 and 6 months for moisture absorption weight increment examination. The results are shown in Table 1.

TABLE 1 weight gain of samples

	1 month	2 month	3 month	6 month
					Example 1	0.2％	0.4％	0.5％	1.1％
Example 2	0.5％	0.4％	0.7％	0.9％
					Example 3	0.3％	0.5％	0.6％	0.8％
Example 4	0.3％	0.6％	0.8％	1.2％
					Example 5	0.4％	0.5％	0.8％	1.3％
Example 6	0.5％	0.6％	0.7％	1.2％

The stability examination result shows that when the sample packaged by the aluminum-plastic blister is stored for 6 months at the temperature of 40 +/-2 ℃ and the relative humidity of RH75 +/-5% under the condition of avoiding direct light irradiation, the moisture absorption and weight increase of the sample are not significant (the weight increase of 5% is significant change according to the regulation of chemical drug stability research guidelines), and the sample is basically stable.

Test example 2

Examination of disintegration time limit

The dispersible tablets of tea saponin prepared in examples were examined for disintegration time according to the disintegration time examination method of 0921, the four guidelines of the pharmacopoeia of the people's republic of china (2015 edition), and the results showed that: the dispersible tablets of tea saponin prepared in example 2 completely disintegrated within 3 minutes, the dispersible tablets of tea saponin prepared in the other examples completely disintegrated within 2 minutes, and the dispersible tablets of tea saponin prepared in example 6 completely disintegrated within 4 minutes.

Test example 3

And (5) testing the washing effect.

The tea saponin dispersible tablets of the samples of examples 1-6 were added to water and, after disintegration, prepared into 0.1% aqueous solutions to clean the pesticide residues on the green beans and cherry tomatoes. The experimental procedure was performed according to appendix A of GB/T24691-2009.

The experimental results are as follows: the tea saponin dispersible tablet has good removing effect on residual pesticides of beans and cherry tomatoes. The results are shown in Table 2, and the results in Table 2 are the average results of examples 1-6.

TABLE 2 results of the removal rate of residual pesticide from tea saponin dispersible tablets

The results show that the tea saponin dispersible tablets have obvious effect of removing residual pesticides on fruits and vegetables.

The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.

Claims

1. The tea saponin dispersible tablet is characterized by comprising the following components in parts by weight based on 100 parts by weight: 65-99 parts of tea saponin, 0-14 parts of filler, 0.5-10 parts of povidone and 0.5-15 parts of disintegrant;

the filler is one or more of lactose, sucrose, dextrin and starch; the disintegrant is one or more of sodium carboxymethyl starch, croscarmellose sodium and crospovidone; the polyvidone is one or more of PVPK12, PVPK15, PVPK17, PVPK25, PVPK30, PVPK45, PVPK60, PVPK80, PVPK85, PVPK90, PVPK100, PVPK110, PVPK120 and PVPK 150;

the preparation method of the dispersible tablet comprises the following steps:

mixing tea saponin, ethanol solution of polyvidone and optional filler, granulating, drying to obtain dry granule, adding disintegrating agent, mixing, and tabletting to obtain tea saponin dispersible tablet;

the drying conditions are as follows: performing first drying under an inert atmosphere; then carrying out secondary drying in an oxygen-containing atmosphere; wherein the first drying temperature is 40-60 ℃, the drying time is 1-15h, the inert atmosphere is a mixed gas of nitrogen and carbon dioxide, the volume ratio of the nitrogen to the carbon dioxide is 0.1-0.4:1, the second drying temperature is 70-90 ℃, and the drying time is 1-15 h.

2. The dispersible tablet of tea saponin according to claim 1 wherein the concentration of the ethanolic solution of povidone is 1-10% by weight.

3. The dispersible tablet of tea saponin according to claim 2 wherein the concentration of the ethanolic solution of povidone is 3-5% by weight.

4. Use of the dispersible tablet of tea saponin according to any one of claims 1 to 3 as a fruit and vegetable cleaning agent.