CN111032075A - 用于治疗癌症的方法和组合物 - Google Patents

用于治疗癌症的方法和组合物 Download PDF

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Publication number
CN111032075A
CN111032075A CN201880053084.1A CN201880053084A CN111032075A CN 111032075 A CN111032075 A CN 111032075A CN 201880053084 A CN201880053084 A CN 201880053084A CN 111032075 A CN111032075 A CN 111032075A
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CN
China
Prior art keywords
cancer
elane
polypeptide
composition
amino acid
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Pending
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CN201880053084.1A
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English (en)
Chinese (zh)
Inventor
莱芙·贝克尔
崔畅
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University of Chicago
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University of Chicago
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/26—Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
    • C12Y301/26003—Ribonuclease III (3.1.26.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21037—Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201880053084.1A 2017-06-15 2018-06-15 用于治疗癌症的方法和组合物 Pending CN111032075A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762520325P 2017-06-15 2017-06-15
US62/520,325 2017-06-15
US201762610711P 2017-12-27 2017-12-27
US62/610,711 2017-12-27
PCT/US2018/037800 WO2018232273A1 (en) 2017-06-15 2018-06-15 Methods and compositions for treating cancer

Publications (1)

Publication Number Publication Date
CN111032075A true CN111032075A (zh) 2020-04-17

Family

ID=64659547

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880053084.1A Pending CN111032075A (zh) 2017-06-15 2018-06-15 用于治疗癌症的方法和组合物

Country Status (9)

Country Link
US (1) US12564623B2 (https=)
EP (2) EP4292606B1 (https=)
JP (3) JP7189160B2 (https=)
CN (1) CN111032075A (https=)
AU (1) AU2018285710B2 (https=)
CA (1) CA3066738A1 (https=)
DK (1) DK3638293T5 (https=)
ES (2) ES2962985T3 (https=)
WO (1) WO2018232273A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112812150A (zh) * 2021-01-29 2021-05-18 深圳海创生物科技有限公司 一种活性环肽、活性环肽组合物及其在制备具有抗氧化或抗炎作用的产品中的应用
CN113736742A (zh) * 2021-09-08 2021-12-03 河南省医药科学研究院 Prtn3基因作为肿瘤免疫治疗中激活细胞毒性免疫细胞靶点的应用
CN115040642A (zh) * 2022-06-30 2022-09-13 德博尔(成都)生物科技有限公司 一种胰弹性蛋白酶的新用途
CN116261592A (zh) * 2020-08-18 2023-06-13 昂希莱斯制药公司 经修饰的丝氨酸蛋白酶前蛋白
CN118443941A (zh) * 2024-04-29 2024-08-06 山东大学齐鲁医院 中性粒细胞作为诊疗膀胱癌的靶标的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019403393B2 (en) * 2018-12-20 2026-04-16 The University Of Chicago Methods and compositions related to therapeutic peptides for cancer therapy
EP4199947A4 (en) * 2020-08-18 2024-10-16 Onchilles Pharma, Inc. Modified porcine pancreatic elastase proteins

Citations (4)

* Cited by examiner, † Cited by third party
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US5698518A (en) * 1994-03-30 1997-12-16 Oklahoma Medical Research Foundation Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
US20050257285A1 (en) * 2004-05-14 2005-11-17 Goutam Gupta Compositions and methods for the treatment of Pierce's disease
CN102165075A (zh) * 2008-07-18 2011-08-24 奥洁克公司 用于检测和治疗结肠直肠癌的组合物
WO2016125330A1 (ja) * 2015-02-02 2016-08-11 原　英彰 網膜再生促進薬

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US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
UA27035C2 (uk) 1990-08-03 2000-02-28 Вертекс Фармас'Ютікалс Інкорпорейтід Кристал білка, зшитого багатофуhкціоhальhим зшивальним агеhтом (варіаhти), пристрій, що містить кристал білка та спосіб отримаhhя аспартаму
AU2003231981A1 (en) * 2002-03-29 2003-10-13 Incyte Corporation Protein modification and maintenance molecules
CA2500405A1 (en) 2002-09-30 2004-04-15 Oncotherapy Science, Inc. Genes and polypeptides relating to human myeloid leukemia
JP4408615B2 (ja) 2002-10-07 2010-02-03 独立行政法人科学技術振興機構 好酸球カチオン性タンパク質を含有する組成物
US8068990B2 (en) 2003-03-25 2011-11-29 Hologic, Inc. Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids
EP1639090A4 (en) * 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
EP1649289B1 (en) 2003-07-21 2008-10-22 Roche Diagnostics GmbH Use of proteins proteinase 3 (prn3) and leukocyte elastase inhibitor (ileu) as a marker for colorectal cancer
US20060008891A1 (en) 2004-06-23 2006-01-12 The Government Of Usa As Repersented By The Secretary, Department Of Health And Human Services Cathepsin G-related peptides as modulators of formylpeptide receptors (FPR)
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698518A (en) * 1994-03-30 1997-12-16 Oklahoma Medical Research Foundation Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
US20050257285A1 (en) * 2004-05-14 2005-11-17 Goutam Gupta Compositions and methods for the treatment of Pierce's disease
CN102165075A (zh) * 2008-07-18 2011-08-24 奥洁克公司 用于检测和治疗结肠直肠癌的组合物
WO2016125330A1 (ja) * 2015-02-02 2016-08-11 原　英彰 網膜再生促進薬

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* Cited by examiner, † Cited by third party
Title
AI-SHENG HO等: "Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers", 《ONCOTARGET》 *
PRISCILA OLIVEIRA DE LIMA等: "Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability", 《MOLECULAR AND CLINICAL ONCOLOGY》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116261592A (zh) * 2020-08-18 2023-06-13 昂希莱斯制药公司 经修饰的丝氨酸蛋白酶前蛋白
CN112812150A (zh) * 2021-01-29 2021-05-18 深圳海创生物科技有限公司 一种活性环肽、活性环肽组合物及其在制备具有抗氧化或抗炎作用的产品中的应用
CN113736742A (zh) * 2021-09-08 2021-12-03 河南省医药科学研究院 Prtn3基因作为肿瘤免疫治疗中激活细胞毒性免疫细胞靶点的应用
CN113736742B (zh) * 2021-09-08 2023-07-21 河南省医药科学研究院 Prtn3基因作为肿瘤免疫治疗中激活细胞毒性免疫细胞靶点的应用
CN115040642A (zh) * 2022-06-30 2022-09-13 德博尔(成都)生物科技有限公司 一种胰弹性蛋白酶的新用途
CN115040642B (zh) * 2022-06-30 2025-03-28 德博尔(成都)生物科技有限公司 一种胰弹性蛋白酶的新用途
CN118443941A (zh) * 2024-04-29 2024-08-06 山东大学齐鲁医院 中性粒细胞作为诊疗膀胱癌的靶标的应用

Also Published As

Publication number Publication date
JP7189160B2 (ja) 2022-12-13
EP4292606B1 (en) 2025-11-12
AU2018285710B2 (en) 2025-02-13
EP4292606A3 (en) 2024-02-21
DK3638293T5 (da) 2024-08-26
EP4292606A2 (en) 2023-12-20
EP3638293A4 (en) 2021-03-10
US20210299234A1 (en) 2021-09-30
WO2018232273A1 (en) 2018-12-20
JP2020524141A (ja) 2020-08-13
AU2018285710A1 (en) 2020-01-23
EP3638293A1 (en) 2020-04-22
JP2023022242A (ja) 2023-02-14
ES3055526T3 (en) 2026-02-12
EP3638293B1 (en) 2023-10-04
DK3638293T3 (da) 2023-11-06
ES2962985T3 (es) 2024-03-22
CA3066738A1 (en) 2018-12-20
US12564623B2 (en) 2026-03-03
JP7529754B2 (ja) 2024-08-06
JP2024150679A (ja) 2024-10-23

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