CN111012764A - 一种睾丸降温贴及其制备方法 - Google Patents

一种睾丸降温贴及其制备方法 Download PDF

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CN111012764A
CN111012764A CN201911361218.9A CN201911361218A CN111012764A CN 111012764 A CN111012764 A CN 111012764A CN 201911361218 A CN201911361218 A CN 201911361218A CN 111012764 A CN111012764 A CN 111012764A
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施雪涛
宣承楷
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Guangzhou Shihe Biotechnology Co Ltd
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Abstract

本发明公开一种睾丸降温贴及其制备方法，该贴片由衬底材料、凝胶层和离型层构成。睾丸降温贴形状与睾丸匹配，本体开有缝隙，使贴合更加牢固。凝胶层由高分子材料10.0‑20.0份、保湿剂25.0‑35.0份、润滑剂0.2‑0.7份、防腐抗氧剂0.3‑1.0份、乳酸薄荷酯0.2‑0.7份、色素0.01‑0.05份、粘结剂0.5‑5.0份、纯化水45.0‑55.0份、医用乙醇5.0‑10.0份组成。本发明公开的降温贴片使用方便且可重复利用，不对皮肤造成损伤，无残留物，气味舒适，无毒无害，降温效果持久，可外用于睾丸降温生精。

Description

一种睾丸降温贴及其制备方法
技术领域
本发明属于医用材料领域，涉及一种睾丸降温贴。
技术背景
降温贴又称退热贴、冷敷贴，外用于人体皮肤表面，利用国际TDDS技术，使水分和药物渗入皮肤，然后通过水汽化吸热的物理变化达到降低体温效果。它属于物理降温用品，广泛用于发烧发热、曝晒后局部冷却、睾丸降温生精等。降温贴主要通过高分子凝胶保水，通过水缓慢汽化吸热达到长期降温的效果，当前市场上的睾丸降温贴由于使用材料的限制，其降温效果及降温时间不尽人意；另外，普通睾丸降温贴对复杂的人体部位表面，比如睾丸，存在粘附力不足、易脱落等问题，限制其使用范围。
发明内容
本发明是为了克服上述局限，提供一种降温效果好、时间长，组织粘附好的睾丸降温贴。
本发明的另一个目的是提供一种降温效果好、时间长，组织粘附好的睾丸降温贴的制备方法。
本发明提供一种睾丸降温贴。其特征在于：由衬底材料、凝胶层和离型层构成，凝胶层由高分子材料10.0-20.0份、保湿剂25.0-35.0份、润滑剂0.2-0.7份、防腐抗氧剂0.3-1.0 份、乳酸薄荷酯0.2-0.7份、色素0.01-0.05份、粘结剂0.5-5.0份、纯化水45.0-55.0份、医用乙醇5.0-10.0份组成。
优选的高分子材料为羟甲基纤维素钠、羟乙基纤维素、聚丙烯酸钠、明胶、聚乙烯醇、卡波姆、透明质酸，更优选高分子材料为羟甲基纤维素钠、聚丙烯酸钠、卡波姆、明胶、聚乙烯醇、透明质酸。
优选的保湿剂为甘油、丁二醇、丙二醇、聚乙二醇、山梨糖醇，更优选的保湿剂为甘油、聚乙二醇、山梨糖醇。
优选的润滑剂为蓖麻油及其衍生物。
优选的防腐抗氧剂为酒石酸、对羟基苯甲酸、山梨酸、三乙烯二胺，更优选的防腐抗氧剂为酒石酸、对羟基苯甲酸、三乙烯二胺。
优选的粘结剂为多巴胺及其衍生物、聚合引发剂。
优选的衬底材料为无纺布或弹力布。
优选的离型层是PE、PC或PET压纹膜。
本发明还提供一种降温效果好、时间长，对组织粘附好的睾丸降温贴的制备方法。该方法包括凝胶层的制备以及降温贴的制备：
(1)将润滑剂、防腐抗氧剂、乳酸薄荷酯、色素加入纯化水中，和医用乙醇混合物，搅拌使其分散均匀；
(2)将保湿剂加入上述(1)中，搅拌使其分散均匀；
(3)将高分子材料加入上述(2)中，混合搅拌，制得均匀凝胶；
(4)将上述得到的凝胶经涂布机涂到衬底材料上；
(5)将粘结剂涂到上述(4)中，同时覆盖离型层；
(6)裁成所需的形状和尺寸，封装。
本发明的优势是：提供一种降温效果好、时间长，对组织粘附好的睾丸降温贴。该贴片使用方便且可重复利用，对睾丸组织粘附好、不对皮肤造成损伤，无残留物，气味舒适，无毒无害，降温效果持久。可外用于睾丸降温生精等。
附图说明
下面结合附图说明和实施方式对本发明作进一步详细描述。
图1为本发明的结构示意图。
图2为图1中P-P向的剖视图。
其中：a-离型层，b-凝胶层，c-衬底材料，d-缝隙，e-睾丸降温贴本体。
具体实施方式
为了加深对本发明的理解，以下将结合附图说明和实施案例，对本发明作进一步描述，该实施案例仅用于解释本发明，不构成对本发明保护范围的限定。
实施案例1
如图1和图2所示，本发明的睾丸降温贴本体e，睾丸降温贴本体e由衬底材料c、凝胶层b和离型层a构成，衬底材料c由无纺布或弹力布构成，凝胶层b为高分子凝胶层，离型层a由PE、PC、或PET压纹膜构成。睾丸降温贴形状与睾丸匹配，本体开有缝隙，使贴合更加牢固。
其中高分子凝胶层由通过以下方法制得：
取质量份数甘油13.0份、丙二醇11.0份、聚丙烯酸钠7.0份、山梨糖醇3.5份、明胶4.0份、聚乙烯醇1.0份、羟甲基纤维素钠1.5份、薄荷醇0.5份、聚乙二醇0.5份、蓖麻油0.5份、酒石酸0.15份、对羟基苯甲酸0.15份、三乙烯二胺0.1份、色素0.02份、纯化水47.1份、医用乙醇10.0份、多巴胺及其聚合引发剂溶液1.0份，制成降温贴凝胶层。
实施案例2
如图1和图2所示，本发明的睾丸降温贴本体e，睾丸降温贴本体e由衬底材料c、凝胶层b和离型层a构成，衬底材料c由无纺布或弹力布构成，凝胶层b为高分子凝胶层，离型层a由PE、PC、或PET压纹膜构成。睾丸降温贴形状与睾丸匹配，本体开有缝隙，使贴合更加牢固。
其中高分子凝胶层由通过以下方法制得：
取质量份数甘油28.0份、聚丙烯酸钠7.0份、山梨糖醇3.5份、明胶7.0份、聚乙烯醇2.0份、羟甲基纤维素钠1.5份、薄荷醇0.5份、聚乙二醇0.5份、蓖麻油0.5份、酒石酸 0.15份、对羟基苯甲酸0.15份、三乙烯二胺0.1份、色素0.05份、纯化水55份、医用乙醇6.8份、多巴胺及其聚合引发剂溶液5.0份，制成降温贴凝胶层。
实施案例3
如图1和图2所示，本发明的睾丸降温贴本体e，睾丸降温贴本体e由衬底材料c、凝胶层b和离型层a构成，衬底材料c由无纺布或弹力布构成，凝胶层b为高分子凝胶层，离型层a由PE、PC、或PET压纹膜构成。睾丸降温贴形状与睾丸匹配，本体开有缝隙，使贴合更加牢固。
其中高分子凝胶层由通过以下方法制得：
取质量份数甘油24.0份、丁二醇2.0份、聚丙烯酸钠5.0份、山梨糖醇4.0份、明胶3.5份、透明质酸0.5份、聚乙烯醇2.0份、羟甲基纤维素钠1.5份、薄荷醇0.5份、聚乙二醇0.8份、蓖麻油0.5份、酒石酸0.15份、对羟基苯甲酸0.15份、三乙烯二胺0.15份、色素0.02份、纯化水50.1份、医用乙醇5.0份、多巴胺及其聚合引发剂溶液0.5份，制成降温贴凝胶层。
实施案例4
如图1和图2所示，本发明的睾丸降温贴本体e，睾丸降温贴本体e由衬底材料c、凝胶层b和离型层a构成，衬底材料c由无纺布或弹力布构成，凝胶层b为高分子凝胶层，离型层a由PE、PC、或PET压纹膜构成。睾丸降温贴形状与睾丸匹配，本体开有缝隙，使贴合更加牢固。
其中高分子凝胶层由通过以下方法制得：
取质量份数甘油23.24份、聚丙烯酸钠6.3份、卡波姆2.0份、山梨糖醇4.5份、明胶5.0份、透明质酸1.5份、聚乙烯醇2.0份、羟甲基纤维素钠1.5份、薄荷醇0.5份、聚乙二醇0.5份、蓖麻油0.2份、酒石酸0.2份、对羟基苯甲酸0.15份、三乙烯二胺0.1份、色素0.01份、纯化水50.8份、医用乙醇5.0份多巴胺及其聚合引发剂溶液1.0份，制成降温贴凝胶层。
实施案例5
如图1和图2所示，本发明的睾丸降温贴本体e，睾丸降温贴本体e由衬底材料c、凝胶层b和离型层a构成，衬底材料c由无纺布或弹力布构成，凝胶层b为高分子凝胶层，离型层a由PE、PC、或PET压纹膜构成。睾丸降温贴形状与睾丸匹配，本体开有缝隙，使贴合更加牢固。
其中高分子凝胶层由通过以下方法制得：
取质量份数甘油24.0份、聚丙烯酸钠5.0份、山梨糖醇5.0份、明胶3.5份、透明质酸0.5份、聚乙烯醇3.0份、羟甲基纤维素钠1.0份、羟乙基纤维素0.5份、薄荷醇0.4份、聚乙二醇0.95份、丁二醇0.45份、蓖麻油0.7份、酒石酸0.15份、对羟基苯甲酸0.15份、三乙烯二胺0.1份、色素0.02份、纯化水45份、医用乙醇10.0份、多巴胺及其聚合引发剂溶液1.3份，制成降温贴凝胶层。
本发明可用于其他不违背本发明的精神或主要特征的具体形式来概括。因此，无论从哪一点来看，本发明的上述实施案例都只可能以为是对本发明的说明而不能限制本发明，权利要求书指出了本发明的范围，因此，在于本发明的权利要求书相当的含义和范围内的任何改变，都应以为是包括在权利要求书的范围。

Claims (9)

1.一种睾丸降温贴，其特征在于：由衬底材料、凝胶层、离型层构成。降温贴形状与睾丸匹配，本体开有缝隙，使贴合更加牢固。凝胶层由高分子材料10.0-20.0份、保湿剂25.0-35.0份、润滑剂0.2-0.7份、防腐抗氧剂0.3-1.0份、乳酸薄荷酯0.2-0.7份、色素0.01-0.05份、粘结剂0.5-5.0份、纯化水45.0-55.0份、医用乙醇5.0-10.0份组成。
2.根据权利要求1所述的一种降温贴，其特征在于：所述的高分子材料由羟甲基纤维素钠、卡波姆、羟乙基纤维素、聚丙烯酸钠、明胶、聚乙烯醇、透明质酸中的一种或几种组成。
3.根据权利要求1所述的一种降温贴，其特征在于：所述的保湿剂由甘油、丁二醇、丙二醇、聚乙二醇、山梨糖醇中的一种或几种组成。
4.根据权利要求1所述的一种降温贴，其特征在于：所述的润滑剂由蓖麻油及其衍生物的一种或几种组成。
5.根据权利要求1所述的一种降温贴，其特征在于：所述的防腐抗氧剂由酒石酸、对羟基苯甲酸、山梨酸、三乙烯二胺中的一种或几种组成。
6.根据权利要求1所述的一种降温贴，其特征在于：所述的粘结剂由多巴胺及其衍生物、聚合引发剂中的一种或几种组成。
7.根据权利要求1所述的一种降温贴，其特征在于：所述的衬底材料是无纺布或弹力布。
8.根据权利要求1所述的一种降温贴，其特征在于：所述的离型层是PE、PC或PET压纹膜。
9.根据权利要求1-8所述的一种降温贴制备方法，其特征在于：所述的制备方法如下：
(1)将润滑剂、防腐抗氧剂、乳酸薄荷酯、色素加入纯化水中，和医用乙醇混合物，搅拌使其分散均匀；
(2)将保湿剂加入上述(1)中，搅拌使其分散均匀；
(3)将高分子材料加入上述(2)中，混合搅拌，制得均匀凝胶；
(4)将上述得到的凝胶经涂布机涂到衬底材料上；
(5)将粘结剂涂到上述(4)中，同时覆盖离型层；
(6)裁成所需的形状和尺寸，封装。
CN201911361218.9A 2019-12-24 2019-12-24 一种睾丸降温贴及其制备方法 Pending CN111012764A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263318A (zh) * 2013-05-27 2013-08-28 施敬东 一种睾丸冷敷贴及其制备方法
CN103316078A (zh) * 2013-06-18 2013-09-25 安徽万邦医药科技有限公司 一种舒眠降温贴剂及其制备方法
CN104688408A (zh) * 2015-03-12 2015-06-10 施敬东 医用退热贴及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263318A (zh) * 2013-05-27 2013-08-28 施敬东 一种睾丸冷敷贴及其制备方法
CN103316078A (zh) * 2013-06-18 2013-09-25 安徽万邦医药科技有限公司 一种舒眠降温贴剂及其制备方法
CN104688408A (zh) * 2015-03-12 2015-06-10 施敬东 医用退热贴及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LU HAN ET AL: ""Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization"", 《ACS NANO》 *
PEYMAN DELPARASTAN，ET AL: ""Direct Evidence for the Polymeric Nature of Polydopamine"", 《ANGEW CHEM INT ED ENGL.》 *

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