CN111000975A - Preparation method of peach gum soft capsule for reducing blood sugar - Google Patents
Preparation method of peach gum soft capsule for reducing blood sugar Download PDFInfo
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- CN111000975A CN111000975A CN202010047089.2A CN202010047089A CN111000975A CN 111000975 A CN111000975 A CN 111000975A CN 202010047089 A CN202010047089 A CN 202010047089A CN 111000975 A CN111000975 A CN 111000975A
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Abstract
The invention relates to the technical field of nutrient product production, in particular to a preparation method of a peach gum soft capsule for reducing blood sugar. The soft capsule health care product prepared by the preparation method of the peach gum soft capsule for reducing blood sugar has beautiful appearance, definite components, safety, reliability and no side effect, and has obvious effect of reducing hyperglycemia caused by type II diabetes.
Description
Technical Field
The invention relates to the technical field of production of nutritional products, in particular to a preparation method of a peach gum soft capsule for reducing blood sugar.
Background
Peach gum is a colloid semitransparent substance secreted by rose plant trunks after mechanical damage (such as insect bite, cutting wound and the like) or disease. According to the record of the original peach gum in Bencao gang mu, the bark is cut by a knife when the peach is full, the gum overflows after a long time, the peach gum is collected, the mulberry leaf ash decoction is soaked for drying, Minyao can become the peach gum recorded in food Bencao, the peach gum has the characteristics of bitter taste, smoothness and no toxicity, and the peach gum can be taken after refining, can keep the middle warmer and not hungry, harmonize blood and tonify qi, and remove stranguria caused by stone and relieve pain. The sea-buckthorn is rich in various chemical substances and bioactive components, is a tree species containing the most natural vitamins in the world, and is rich in more than 200 natural components and nutrient substances such as polyphenols, proteins, fatty acids and the like in the body.
The peach gum is interacted with the intestinal microorganisms in vivo, and is polysaccharide or metabolite of intestinal flora which is degraded and changed in the type and the quantity of the intestinal microorganisms has an influence on the blood sugar level, and the peach gum polysaccharide can obviously reduce the blood sugar level and the blood fat level. The sea buckthorn protein has the function of reducing blood sugar, has the function of reducing the weight of type II diabetic mice, and has the function of improving the symptoms of hyperlipidemia and hyperglycemia of the mice.
The soft capsule is prepared from gelatin, glycerol or other suitable medicinal adjuvants, and can be used alone or in combination.
The applicant researches and discovers that the original peach gum has a remarkable curative effect on the aspect of treating diabetes. The extracted protopanoxadiol polysaccharide can obviously reduce the blood sugar and blood fat levels of rats with type II diabetes models. The mechanism of polysaccharide to lower blood sugar is mainly focused on the following aspects:
improve the cell shape and function of insulin and promote the secretion of insulin;
increase insulin sensitivity;
improving activity of a carbohydrate metabolism-related enzyme;
the sea buckthorn protein has the function of reducing blood sugar, has the efficacy of reducing the weight of a type II diabetic mouse, and has the efficacy of improving the symptoms of hyperlipidemia and hyperglycemia of the mouse.
Disclosure of Invention
The invention provides a preparation method of peach gum soft capsules for reducing blood sugar, which comprises the steps of taking seabuckthorn seed meal as a main drug effect substance, extracting peach gum polysaccharide from raw peach gum through fermentation, crushing, dissolving, centrifuging, drying, mixing ingredients, sieving, packaging, processing a finished product, and preparing the peach gum microcapsules by using a soft capsule dripping pill technology.
The technical scheme adopted by the invention for solving the technical problems is as follows: a preparation method of peach gum soft capsules for reducing blood sugar comprises the following steps: (1) selecting materials: peach gum polysaccharide, sea buckthorn protein, beeswax, soybean oil and soybean phosphate; (2) and preparing peach gum polysaccharide: fermenting at 35-40 deg.C and pH of 2-6 to obtain peach gum polysaccharide solution I; the peach gum polysaccharide is fermented by using microbacterium, and 10% -14% of peach gum is utilized by the microbacterium; (3) and preparing the sea-buckthorn protein: extracting the sea buckthorn seed meal solution at a set temperature of 50-60 ℃ for 50-70min, carrying out centrifugal separation, regulating the pH of a supernatant to 5.0 with an acid solution, carrying out centrifugal separation, washing a precipitate with water for 2 times, regulating the pH of a small amount of deionized water to 6.5-7.5, carrying out vacuum freeze drying to obtain sea buckthorn seed meal protein, and preparing a sea buckthorn protein solution II; (4) mixing soybean oil, beeswax and soybean lecithin into a solution II, mixing the peach gum polysaccharide solution I with the mixed solution II to form a capsule glue solution, and preparing the soft capsule at the temperature of 35-48 ℃.
Further, the preparation method comprises the following steps of (4): 20-40 g of peach gum polysaccharide, 25-45 g of sea buckthorn protein, 28-32 g of beeswax, 10-20 g of soybean oil and 5-10 g of soybean phosphate.
The invention has the beneficial effects that the preparation method of the peach gum soft capsule for reducing blood sugar adopts seabuckthorn seed meal as a main drug effect substance, peach gum polysaccharide is extracted from raw peach gum through fermentation, seabuckthorn seed meal is subjected to crushing, dissolving, centrifuging, drying, mixing, sieving, packaging and finished product processing, the peach gum microcapsule is prepared by utilizing a soft capsule dropping pill technology, and the prepared soft capsule health-care product has beautiful appearance, definite components, safety, reliability and no side effect, and has obvious effect on reducing hyperglycemia caused by type II diabetes.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a flow chart of the production process of the present invention.
Detailed Description
Fig. 1 is a production process flow chart of the invention, and the preparation method of the peach gum soft capsule for reducing blood sugar comprises the following steps: (1) selecting materials: peach gum polysaccharide, sea buckthorn protein, beeswax, soybean oil and soybean phosphate; (2) and preparing peach gum polysaccharide: fermenting at 35-40 deg.C and pH of 2-6 to obtain peach gum polysaccharide solution I; the peach gum polysaccharide is fermented by using microbacterium, and 10% -14% of peach gum is utilized by the microbacterium; (3) and preparing the sea-buckthorn protein: extracting the sea buckthorn seed meal solution at a set temperature of 50-60 ℃ for 50-70min, carrying out centrifugal separation, regulating the pH of a supernatant to 5.0 with an acid solution, carrying out centrifugal separation, washing a precipitate with water for 2 times, regulating the pH of a small amount of deionized water to 6.5-7.5, carrying out vacuum freeze drying to obtain sea buckthorn seed meal protein, and preparing a sea buckthorn protein solution II; (4) mixing soybean oil, beeswax and soybean lecithin into a solution II, mixing the peach gum polysaccharide solution I with the mixed solution II to form a capsule glue solution, and preparing the soft capsule at the temperature of 35-48 ℃. The components in the step (4) are mixed according to the weight ratio as follows: 20-40 g of peach gum polysaccharide, 25-45 g of sea buckthorn protein, 28-32 g of beeswax, 10-20 g of soybean oil and 5-10 g of soybean phosphate.
The first embodiment is as follows: in the embodiment, interfering impurities are extracted and removed for multiple times, effective blood sugar reducing components are reserved, and 20g of peach gum polysaccharide, 25g of sea buckthorn protein, 28g of beeswax, 10g of soybean phosphate and 20g of soybean oil are added and mixed to obtain the soft capsule capable of reducing blood sugar, wherein the preparation method comprises the following steps: heating soybean oil to 30 deg.C, adding 28g Cera flava, 20g peach gum polysaccharide and 25g fructus Hippophae protein, stirring, adding 10g soybean phosphate, stirring, grinding with colloid mill, sieving with 80 mesh sieve, and repeating for 3 times to obtain suspension; soaking gelatin in water to obtain gelatin solution, mixing gelatin solution with suspension and water at a certain weight ratio to obtain mixed gelatin solution, making the gelatin solution into soft capsule of 8g each by soft capsule dripping pill, standing at 30 deg.C, grading, blow drying, and making into capsule.
The second embodiment is as follows: the soft capsule capable of reducing blood sugar is obtained by extracting and removing interfering impurities for multiple times, keeping components capable of effectively reducing blood sugar, and adding 25g of peach gum polysaccharide, 30g of sea buckthorn protein, 28g of beeswax, 10g of soybean phosphate and 20g of soybean oil for mixing, and the preparation method is as follows: heating soybean oil to 30 deg.C, adding 28g Cera flava, 25g peach gum polysaccharide and 30g fructus Hippophae protein, stirring, adding 10g soybean phosphate, stirring, grinding with colloid mill, sieving with 80 mesh sieve, and repeating for 3 times to obtain suspension; soaking gelatin in water to obtain gelatin solution, mixing gelatin solution with suspension and water at a certain weight ratio to obtain mixed gelatin solution, making the gelatin solution into soft capsule of 8g each by soft capsule dripping pill, standing at 30 deg.C, grading, blow drying, and making into capsule.
The third concrete embodiment: the soft capsule capable of reducing blood sugar is obtained by extracting and removing interfering impurities for multiple times, keeping components capable of effectively reducing blood sugar, and adding 30g of peach gum polysaccharide, 30g of sea buckthorn protein, 28g of beeswax, 10g of soybean phosphate and 20g of soybean oil for mixing, and the preparation method is as follows: heating soybean oil to 30 deg.C, adding 28g Cera flava, 30g peach gum polysaccharide and 35g fructus Hippophae protein, stirring, adding 10g soybean phosphate, stirring, grinding with colloid mill, sieving with 80 mesh sieve, and repeating for 3 times to obtain suspension; soaking gelatin in water to obtain gelatin solution, mixing gelatin solution with suspension and water at a certain weight ratio to obtain mixed gelatin solution, making the gelatin solution into soft capsule of 8g each by soft capsule dripping pill, standing at 30 deg.C, grading, blow drying, and making into capsule.
The fourth concrete embodiment: the soft capsule capable of reducing blood sugar is obtained by extracting and removing interfering impurities for multiple times, keeping components capable of effectively reducing blood sugar, and adding 30g of peach gum polysaccharide, 25g of sea buckthorn protein, 28g of beeswax, 10g of soybean phosphate and 20g of soybean oil for mixing, and the preparation method is as follows: heating soybean oil to 30 deg.C, adding 28g Cera flava, 30g peach gum polysaccharide and 25g fructus Hippophae protein, stirring, adding 10g soybean phosphate, stirring, grinding with colloid mill, sieving with 80 mesh sieve, and repeating for 3 times to obtain suspension; soaking gelatin in water to obtain gelatin solution, mixing gelatin solution with suspension and water at a certain weight ratio to obtain mixed gelatin solution, making the gelatin solution into soft capsule of 8g each by soft capsule dripping pill, standing at 30 deg.C, grading, blow drying, and making into capsule.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (2)
1. A preparation method of peach gum soft capsules for reducing blood sugar is characterized by comprising the following steps: (1) selecting materials: peach gum polysaccharide, sea buckthorn protein, beeswax, soybean oil and soybean phosphate; (2) and preparing peach gum polysaccharide: fermenting at 35-40 deg.C and pH of 2-6 to obtain peach gum polysaccharide solution I; the peach gum polysaccharide is fermented by using microbacterium, and 10% -14% of peach gum is utilized by the microbacterium; (3) and preparing the sea-buckthorn protein: extracting the sea buckthorn seed meal solution at a set temperature of 50-60 ℃ for 50-70min, carrying out centrifugal separation, regulating the pH of a supernatant to 5.0 with an acid solution, carrying out centrifugal separation, washing a precipitate with water for 2 times, regulating the pH of a small amount of deionized water to 6.5-7.5, carrying out vacuum freeze drying to obtain sea buckthorn seed meal protein, and preparing a sea buckthorn protein solution II; (4) mixing soybean oil, beeswax and soybean lecithin into a solution II, mixing the peach gum polysaccharide solution I with the mixed solution II to form a capsule glue solution, and preparing the soft capsule at the temperature of 35-48 ℃.
2. The preparation method of the peach gum soft capsule for reducing blood sugar according to claim 1, wherein the components in the step (4) are mixed according to the following weight ratio: 20-40 g of peach gum polysaccharide, 25-45 g of sea buckthorn protein, 28-32 g of beeswax, 10-20 g of soybean oil and 5-10 g of soybean phosphate.
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| CN202010047089.2A CN111000975A (en) | 2020-01-16 | 2020-01-16 | Preparation method of peach gum soft capsule for reducing blood sugar |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114009766A (en) * | 2021-11-17 | 2022-02-08 | 钱宝鸿 | Dietetic therapy composition for conditioning hypertension, hyperglycemia and hyperlipidemia and preparation method thereof |
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|---|---|---|---|---|
| CN102178821A (en) * | 2011-04-28 | 2011-09-14 | 柳正良 | Soft capsules for reducing blood sugar and preparation method thereof |
| US20130099403A1 (en) * | 2010-07-05 | 2013-04-25 | Jianzhong Ma | Semen cassiae soft capsule for reducing fat and losing weight and preparation method thereof |
| CN105061617A (en) * | 2015-07-31 | 2015-11-18 | 华中农业大学 | Extraction process and application of peach gum polysaccharide |
| CN106046113A (en) * | 2016-08-03 | 2016-10-26 | 西南科技大学 | Method for extracting sea-buckthorn protein from sea-buckthorn seed meal |
| CN110684090A (en) * | 2019-10-09 | 2020-01-14 | 完美（广东）日用品有限公司 | Alpha-amylase inhibitor and preparation process and application thereof |
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2020
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