CN110975068A - Tumor micro-injection medicine detection method and multi-point micro-injector - Google Patents
Tumor micro-injection medicine detection method and multi-point micro-injector Download PDFInfo
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- CN110975068A CN110975068A CN201910950666.6A CN201910950666A CN110975068A CN 110975068 A CN110975068 A CN 110975068A CN 201910950666 A CN201910950666 A CN 201910950666A CN 110975068 A CN110975068 A CN 110975068A
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- drug
- medicine
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- needle tube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
- A61M5/3297—Needles arranged coaxially
Abstract
The invention discloses a tumor micro-injection drug detection method, which comprises the following steps of preparing a plurality of drugs such as a drug A, a drug B, a drug C and the like; injecting a plurality of medicines such as a medicine A, a medicine B, a medicine C and the like into a multi-point micro-injector; the multi-point micro-syringe is pushed to simultaneously inject a plurality of drugs, such as drug a, drug B, drug C, etc., onto the patient's body, thereby forming an a region containing only drug a, a B region containing only drug B, a C region containing only drug C, an AB region containing both drug a and drug B, and a BC region containing both drugs B and C on the patient's body. The invention realizes that medical workers can treat patients with different constitutions by adopting the best medicine, thereby having good treatment effect on the patients, shortening the curing time and avoiding unnecessary expenses for the patients.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and particularly relates to a tumor micro-injection drug detection method and a multi-point micro-injector.
Background
With the annual increase of the incidence of tumors and the widespread development of tumor screening, the diagnosis rate of solid tumors is higher and higher, such as nephroma, lung tumor, glioma, lymphoma and the like, and the treatment is still very troublesome. Comprehensive treatment such as radiotherapy, chemotherapy and surgery has become a standard strategy for treating solid tumors. With the development of anti-tumor drugs, more and more chemotherapeutics and targeted drugs are used in clinic, and the increase of treatment means makes tumors become a chronic disease. The heterogeneity of human body and tumor is very large, how to combine the medicine more accurately, achieve the best anti-tumor cell curative effect to different individual different tumors, realize the tumor synergy, inhibit tumor drug resistance, reduce metastasis and recurrence, finally lengthen the overall survival time. At present, no effective objective evaluation means and equipment exist clinically. .
The existing method is mainly based on pathological results and genetic molecular diagnosis results, first-line and second-line recommendation is carried out for drug selection according to clinical characteristics and clinical tests of large samples, and the existing method is not accurate enough and is easy to cause failure and waste of treatment time.
In the prior art, when a patient is injected with a medicament, only a single medicament can be injected, and patients with different constitutions have different effects on the single medicament, so that the patient is often required to inject different medicaments for multiple times to determine the most suitable medicament; this increases the pain experienced by the patient and also delays the duration of the treatment as multiple injections are required. At the same time, the effect of the combination between the drugs cannot be seen.
Disclosure of Invention
The invention provides a tumor microinjection drug detection method and a multipoint microinjector, which can obtain a drug with the optimal treatment effect on different patients in order to overcome the defects of the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme: a tumor microinjection drug detection method comprises the following steps:
1) preparing a plurality of medicines such as a medicine A, a medicine B, a medicine C and the like;
2) injecting a plurality of medicines such as a medicine A, a medicine B, a medicine C and the like into a multi-point micro-injector;
3) pushing the multi-point micro-injector to simultaneously inject a plurality of drugs such as drug A, drug B, drug C, etc. onto the body of the patient, thereby forming an area A containing only drug A, an area B containing only drug B, an area C containing only drug C, an area AB containing both drug A and drug B, and an area BC containing both drugs B and C on the body of the patient;
4) monitoring the drug treatment effects of a plurality of areas such as an area A, an area B, an area C, an area AB, an area BC and the like, and preferentially adopting the drugs corresponding to the areas with the optimal treatment effects to carry out subsequent treatment.
According to the invention, multiple medicines are injected into the body of a patient at the same time to form a plurality of treatment areas containing the corresponding medicines, and the comparison between the medicines is formed on the body of the patient, so that medical workers can conveniently treat the patient by adopting the optimal medicines according to the patients with different constitutions, thus the treatment effect on the patient is good, the healing time is shortened, and unnecessary expenses are avoided for the patient; and because a plurality of medicines are injected simultaneously, the condition that the patient changes the medicines is reduced, and the pain of the patient during receiving treatment is reduced.
Preferably, the medicines A, B and C are injected into the body of a patient in equal amount; the equal injection on the body of the patient realizes high contrast between areas, and reduces the influence on the effect of the drug treatment due to different dosage.
Preferably, the injection amount of the medicines A, B and C is 0.5-5 ml.
The invention also discloses a multi-point injector for tumor microinjection, which comprises a needle handle, a needle tube, a plurality of injection needles and an infusion tube for conveying injection to the injection needles, wherein the plurality of injection needles are annularly arranged in the needle tube.
Preferably, the device also comprises a driving structure for driving the needle tube to move up and down so as to cut off part of the tissue; the needle tube is pushed to act through the driving structure, so that the end part of the needle tube can conveniently cut human tissues, diseased tissues can be biopsied, and the operation is convenient.
Preferably, the driving structure is a connecting sleeve movably connected with the needle handle, and the connecting sleeve is in threaded connection with the needle tube; a hand-held part is arranged on the side wall of the needle tube, and the surface of the hand-held part is of a rough structure; by arranging the connecting sleeve, the structure is simple, the cost is low, and the operation is convenient; in the driving process, the needle tube can slowly move in a threaded connection mode, so that the speed and the depth of the movement of the needle tube can be conveniently controlled, and unnecessary damage to human tissues is avoided; the hand-held part is arranged, so that when the needle tube is operated to move downwards, fingers can clamp the hand-held part, and the stability of the needle tube during movement is guaranteed; the side wall arranged roughly can keep avoiding sliding, and the stability in the operation process is guaranteed.
Preferably, the cutting structure is an undercut part formed at the lower end of the needle tube, and a containing cavity for taking out human tissues is formed between the undercut part and the inner wall of the needle tube; can be convenient for cut off partial human tissue through setting up cutting structure to human tissue can fall into the holding chamber in the middle of, and then takes human tissue to take out from the health, its convenient operation and simple.
Preferably, the infusion tube is connected with the needle handle through a connecting structure.
Preferably, the connecting structure comprises a connecting sleeve connected with the needle handle and a plurality of joints arranged on the connecting sleeve, and one end of the infusion tube is connected with the joints; an anti-drop ring matched with the inner wall of the infusion tube is arranged on the connector; the infusion tube can be conveniently connected by arranging the joint, the connection is convenient, and the stable connection of the end part of the infusion tube can be realized; the anti-drop ring can keep the connection of the infusion tube and the joint, and the connection effect is good and the connection is stable.
In conclusion, the invention realizes that medical workers can treat patients with different constitutions by adopting the optimal medicine, thereby having good treatment effect on the patients, shortening the curing time and avoiding unnecessary expenses for the patients.
Drawings
Fig. 1 is a schematic view of the multi-point syringe of the present invention.
Fig. 2 is an exploded view of the multi-point syringe of the present invention.
Fig. 3 is an enlarged view of a in fig. 2.
Fig. 4 is an exploded view of the multi-point injector of the present invention.
Fig. 5 is a schematic structural diagram of the connector of the present invention.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention.
A tumor microinjection drug detection method comprises the following steps:
1) eight types of medicines, namely a medicine A, a medicine B, a medicine C, a medicine D, a medicine E, a medicine F, a medicine G and a medicine H, are prepared for screening the medicines for the cervical cancer, and the types of the medicines can be increased or decreased according to the guidance of a doctor;
2) pumping eight medicines, namely a medicine A, a medicine B, a medicine C, a medicine D, a medicine E, a medicine F, a medicine G, a medicine H and the like into a multi-point micro-injector for later use;
3) pushing the multi-point micro-injector to simultaneously and equivalently inject eight medicines of medicine A, medicine B, medicine C, medicine D, medicine E, medicine F, medicine G and medicine H to the affected part of the patient, wherein the amount of the injected medicines is 0.5-5 ml; thereby forming a plurality of treatment zones on the patient's body, the specific zones being as follows:
4) and (3) monitoring the drug treatment effect of each area in the step (3), and preferably adopting the drug corresponding to the area with the best treatment effect to carry out subsequent treatment.
As shown in fig. 1-5, this embodiment further discloses a multipoint microinjector in the above step 3), wherein the multipoint microinjector includes a needle handle 1, a needle tube 2, injection needles 3, an infusion tube 4 and a driving structure, wherein the needle tube 2 is a stainless steel metal needle tube, the injection needles 3 are microinjection needles, the number of the injection needles 3 is eight, the eight injection needles 3 are arranged in the needle tube 1 in a circle according to an annular arrangement, one end of each injection needle 3 penetrates into the needle handle 1, the infusion tube 4 is communicated with the injection needles 3 through a connecting structure, and the infusion tube 4 is a rubber hose.
Specifically, the connecting structure comprises a connecting sleeve 71 and a connecting head 72, the connecting sleeve 71 is a stainless steel metal sleeve which is in threaded connection with the upper part of the needle handle 1, the connecting sleeve 71 is connected with the upper part of the needle handle 72, the needle handle 1 is a plastic handle or a metal handle, and the connecting sleeve 71 is in threaded connection with the upper part of the needle handle 72; the connector 72 is a metal connector, and the connector 72 is connected with the connecting sleeve 71; the number of the connectors 72 is eight, the lower parts of the eight connectors 72 are inserted into the injection needle 3 one by one, the upper part of the connectors 72 is provided with an anti-falling ring 73, the infusion tube 4 is sleeved on the connectors 72, the anti-falling ring 73 is in contact with the inner wall of the infusion tube 4 to limit the infusion tube 4, and the infusion tube 4 is a rubber hose.
Further, a cutting structure is arranged on the needle tube 2 and is used for cutting off human tissues and bringing the human tissues out of the body, the cutting structure is a cutting part 6 formed at the lower end of the needle tube 2, and the cutting part 6 is a chamfering edge formed by cutting off a part of the inner wall of the needle tube; a space is provided between the undercut portion 6 and the inner wall of the needle tube 2, and the space forms a placing cavity 61 for placing the cut-off portion of the human tissue.
Specifically, the driving structure is used for driving the needle tube 2 to move up and down to cut off part of tissues of a human body, the driving structure is a connecting sleeve 5, the connecting sleeve 5 is a metal sleeve, the upper part of the connecting sleeve 5 is fixedly connected with the lower part of the needle handle 1, and the lower part of the connecting sleeve 5 is in threaded connection with the upper part of the needle tube 2, so that the needle tube 2 can move up and down by rotating the needle tube 2; meanwhile, the upper part of the needle tube 2 is also provided with a handheld part 21, and the handheld part 21 is a metal block with a rough surface; for the operation, the needle tube 2 is rotated to elongate the total length between the needle tube 2 and the needle shaft 1, and then the needle tube 2 is rotated in the reverse direction to cut a portion of the tissue entering the needle tube.
Meanwhile, eight letters A to H are arranged on the outer wall of the handheld part 21 or the needle tube 2, the eight letters are arranged in an annular shape and correspond to eight injection needles, and the connecting sleeve 5 is provided with a pointer mark facing the letters, so that when human tissue is cut, the area corresponding to the injected medicine can be judged through the letters, then when the human tissue is rotated, the human tissue is rotated clockwise for one circle, then rotated anticlockwise for one circle, and finally pulled to cut the tissue, and the cut human tissue corresponds to the injected medicine, so that accurate biopsy can be conveniently performed on the human tissue.
Meanwhile, in order to judge cut tissues conveniently, eight marker pieces 619 are arranged in the placing cavity 61, the eight marker pieces 619 are convex parts protruding out of the bottom of the placing cavity 61, and when the tissue enters the placing cavity 61, the marker pieces 619 are pressed by the marker pieces 619 and can form marks of grooves on corresponding biopsy tissues; it should be noted that the eight markers in the placement chamber 61 are of different shapes, wherein a corresponds to a conical marker, B corresponds to a rhomboid, C corresponds to a rhomboid, D corresponds to a cone with two side-by-side peaks, E corresponds to two rhomboid with side-by-side peaks, F corresponds to a rhomboid with G side-by-side two peaks, and H corresponds to a three-tip needle; of course, the specific shape of the present embodiment is only for convenience of understanding, and different shapes of the mark members can be designed according to needs.
It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A tumor microinjection drug detection method is characterized in that: comprises the following steps
1) Preparing a plurality of medicines such as a medicine A, a medicine B, a medicine C and the like;
2) injecting a plurality of medicines such as a medicine A, a medicine B, a medicine C and the like into a multi-point micro-injector;
3) pushing the multi-point micro-injector to simultaneously inject a plurality of drugs such as drug A, drug B, drug C, etc. onto the body of the patient, thereby forming an area A containing only drug A, an area B containing only drug B, an area C containing only drug C, an area AB containing both drug A and drug B, and an area BC containing both drugs B and C on the body of the patient;
4) monitoring the drug treatment effects of a plurality of areas such as an area A, an area B, an area C, an area AB, an area BC and the like, and preferentially adopting the drugs corresponding to the areas with the optimal treatment effects to carry out subsequent treatment.
2. The method for detecting tumor microinjection drugs according to claim 1, wherein: the medicines A, B and C are injected into the body of a patient in equal amount during injection.
3. The method for detecting tumor microinjection drugs according to claim 1, wherein: the injection amount of the medicines A, B and C is 0.5-5 ml.
4. A multi-point microinjector, comprising: the infusion device comprises a needle handle (1), a needle tube (2), a plurality of injection needles (3) and an infusion tube (4) for conveying injection to the injection needles (3), wherein the injection needles (3) are annularly arranged in the needle tube (1).
5. The multi-point microinjector of claim 4, wherein: the device also comprises a driving structure for driving the needle tube (2) to move up and down so as to cut off part of tissue.
6. The multi-point microinjector of claim 4, wherein: the driving structure is a connecting sleeve (5) connected with the needle handle (1), and the connecting sleeve (5) is in threaded connection with the upper part of the needle tube (2); the side wall of the needle tube (2) is provided with a handheld part (21), and the surface of the handheld part (21) is of a rough structure.
7. The multi-point microinjector of claim 4, wherein: the needle tube (2) is provided with a cutting structure for cutting off and taking out part of human tissue.
8. The multi-point microinjector of claim 7, wherein: the cutting structure is an inverted cutting part (6) formed at the lower end of the needle tube (2), and an accommodating cavity (61) used for taking out human tissues is formed between the inverted cutting part (6) and the inner wall of the needle tube (2).
9. The multi-point microinjector of claim 8, wherein: the infusion tube (4) is connected with the needle handle (1) through a connecting structure.
10. The multi-point microinjector of claim 9, wherein: the connecting structure comprises a connecting sleeve (71) connected with the needle handle (1) and a plurality of joints (72) arranged on the connecting sleeve (71), and one end of the infusion tube (4) is connected with the joints (72); an anti-drop ring (73) matched with the inner wall of the infusion tube (4) is arranged on the connector (72).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910950666.6A CN110975068B (en) | 2019-10-08 | 2019-10-08 | Tumor micro-injection medicine detection method and multi-point micro-injector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910950666.6A CN110975068B (en) | 2019-10-08 | 2019-10-08 | Tumor micro-injection medicine detection method and multi-point micro-injector |
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| Publication Number | Publication Date |
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| CN110975068A true CN110975068A (en) | 2020-04-10 |
| CN110975068B CN110975068B (en) | 2023-02-17 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482187B1 (en) * | 2000-10-23 | 2002-11-19 | Fred O. Gibbs | Animal identification and medication syringe |
| CN102961174A (en) * | 2012-11-12 | 2013-03-13 | 王学昌 | Arc-shaped-edge needle knife |
| US20150265730A1 (en) * | 2010-12-09 | 2015-09-24 | Rutgers, The State University Of New Jersey | Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs |
| CN105050639A (en) * | 2013-03-15 | 2015-11-11 | 希普罗特克有限公司 | Multi-chamber injection device |
| US20150351862A1 (en) * | 2014-06-09 | 2015-12-10 | Cook Medical Technologies Llc | Screw-Driven Handles and Systems for Fiducial Deployment |
-
2019
- 2019-10-08 CN CN201910950666.6A patent/CN110975068B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482187B1 (en) * | 2000-10-23 | 2002-11-19 | Fred O. Gibbs | Animal identification and medication syringe |
| US20150265730A1 (en) * | 2010-12-09 | 2015-09-24 | Rutgers, The State University Of New Jersey | Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs |
| CN102961174A (en) * | 2012-11-12 | 2013-03-13 | 王学昌 | Arc-shaped-edge needle knife |
| CN105050639A (en) * | 2013-03-15 | 2015-11-11 | 希普罗特克有限公司 | Multi-chamber injection device |
| US20150351862A1 (en) * | 2014-06-09 | 2015-12-10 | Cook Medical Technologies Llc | Screw-Driven Handles and Systems for Fiducial Deployment |
| CN106456213A (en) * | 2014-06-09 | 2017-02-22 | 库克医药技术有限责任公司 | Screw-driven handles and systems for fiducial deployment |
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| CN110975068B (en) | 2023-02-17 |
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