CN110960667A - 一种治疗脂肪瘤的外用组合物及其制备方法与应用 - Google Patents
一种治疗脂肪瘤的外用组合物及其制备方法与应用 Download PDFInfo
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Abstract
本发明涉及一种治疗脂肪瘤的外用组合物及其制备方法,所述治疗脂肪瘤的外用组合物,包括陈皮,花椒,生姜,细辛、包谷酒等七味苗药的组合,利用七味苗药各自的功效及相互协同作用,进而增强治疗脂肪瘤苗药组合物的药理性,达到治疗脂肪瘤疾病的效果。本发明治疗脂肪瘤不需动手术,疗效显著,无毒副作用,使用简单方便,不易复发。
Description
技术领域
本发明属于苗药技术领域,具体涉及一种治疗脂肪瘤的外用组合物及其制备方法与应用。
背景技术
脂肪瘤(lipoma)是由增生的成熟脂肪组织形成的良性肿瘤。多见于40~50岁的成年人。瘤体质地柔软,圆形或分叶状,位于皮下,可以推动;瘤体大小不等,小的如枣大,用手摸方能触知,大的可隆起皮面,但表面皮肤正常。肿瘤单发或多发,见于体表的任何部位,以肩、背、腹部为多见。多无自觉症状。血管脂肪瘤为一特殊类型的脂肪瘤,以年轻人较为多见,好发于下肢,可自觉疼痛,触之亦有压痛。现虽有治疗脂肪瘤的多种药物,但大多存在疗效差、见效慢、其疗效并不尽人意,而中药制备的外用药物中所用原料药成分药效单一,原料药种类较多,有的中药原料药与其他原料药没有发生协同作用,影响了中药组合物的整体疗效。此外,现有的中药组合物多数是将所用原料直接粉碎入药,没有对原料内的活性成分进行提取分离,非有效成分没有除去,杂质较多,使中药组合物的组方过大,不利于患者服用,进一步影响中药组合物的疗效。因此,亟待研究一种能够有效治疗脂肪瘤的药物。
发明内容
本发明目的是提供一种治疗脂肪瘤的外用组合物。
本发明的技术方案为:
本发明的治疗脂肪瘤的组合物,制备所述组合物的重要原料重量份组成为:包谷酒450~500g 、陈皮 3-5g、花椒3-5g、生姜 3-5g、细辛2-4g、土茯苓90—100g、桂枝0.01---0.03g。
本发明的治疗脂肪瘤的组合物,各组分协同配伍,能快速发挥药效,消肿散结,活化人体机能失调,对脂肪瘤疗效显著,安全方便且无毒副作用。
另外,本发明上述的治疗脂肪瘤的组合物,还可以具备如下附加的技术特征:
作为本发明优选的实施方式,所述的治疗脂肪瘤的组合物,包括如下重量份数的原料:包谷酒450g、陈皮3g、花椒3g、生姜3g、细辛2g、土茯苓90g、桂枝0.01g。
作为本发明优选的实施方式,所述的治疗脂肪瘤的组合物,包括如下重量份数的原料:包谷酒500g、陈皮5g、花椒5g、生姜5g、细辛4g、土茯苓100g、桂枝0.03g。
作为本发明优选的实施方式,所述的治疗脂肪瘤的组合物,包括如下重量份数的原料:包谷酒480g、陈皮4g、花椒4g、生姜4g、细辛3g、土茯苓95g、桂枝0.02g。
本发明的另一个目的在于提出所述的治疗脂肪瘤的组合物的制备方法。
所述的治疗脂肪瘤的组合物的制备方法,包括如下步骤:将所述原料研磨成粉,所得粉末加入450-500g的包谷酒中,加热至53-55℃,充分搅拌并浸泡2-3个月,过滤所得药液即为外用组合物。
本发明的再一个目的在于提出所述的组合物在制备治疗脂肪瘤药物中的应用。
本发明的治疗脂肪瘤的组合物组方科学合理,其原料药来源如下:
陈皮:为芸香科植物橘及其栽培变种的干燥成熟果皮,药材分为“陈皮”和“广陈皮”,采摘成熟果实,剥取果皮,晒干或低温干燥。苦、辛,温,归肺、脾经。理气健脾,燥湿化痰,用于胸脘胀满,食少吐泻,咳嗽痰多。
花椒:为芸香科植物,属落叶小乔木,用作中药有温中行气、逐寒、止痛、杀虫等功效。治胃腹冷痛、呕吐、泄泻、血吸虫、蛔虫等症。又作表皮麻醉剂。
生姜:生姜皮性辛凉,治皮肤浮肿,行皮水;生姜汁辛温,辛散胃寒力量强,多用于呕吐;干姜辛温,温中煽动寒,回阳通脉,温脾寒力量大,炮姜味辛苦走里不走表,温下焦之寒;炮姜炭性温,偏于温血分之寒;煨姜苦温,偏于温肠胃之寒。生姜辛而散温,益脾胃,善温中降逆止呕,除湿消痞,止咳祛痰,以降逆止呕为长。
细辛:马兜铃科多年生草本植物。以全草入药。含有多种挥发油,主要为甲基丁香酚、甲基胡椒酚、优香芹酮、黄樟醚、派烯、龙脑、细辛酮等。味辛、性温。有祛风散寒、开窍止痛的功能。主治风寒头痛、鼻炎、牙痛、痰饮咳嗽、哮喘、风湿痹痛等症。
土茯苓:性味:甘、淡,平。归经:归肝、胃经。功效:解毒,除湿,通利关节。主治:梅毒及汞中毒所致的肢体拘挛,筋骨疼痛;湿热淋浊,带下,痈肿,瘰疬,疥癣。
桂枝:性味辛、甘,温,入肺、心、膀胱经,是主治里寒常用的温里药,具有补元阳、通血脉、暖脾胃之功效。能发汗解表,温经通脉,助阳化气,散寒止痛。主风寒表证;寒湿痹痛;四肢厥冷;经闭痛经;症瘕结块;胸痹;心悸;痰饮;小便不利。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。
本发明的有益效果是:疗效明确,药源广、成本低廉、生产和服用方便,治疗脂肪瘤与纤维瘤效果显著。
具体实施方式
下面详细描述本发明的实施例,所述实施例是示例性的,旨在用于解释本发明,而不能理解为对本发明的限制。
实施例1:
本实施例提供一种治疗脂肪瘤的组合物,该组合物包括以下重量克数的原料:
包谷酒450g、陈皮3g、花椒3g、生姜3g、细辛2g、土茯苓90g、桂枝0.01g
本实施例还提供了一种治疗脂肪瘤的组合物的制备方法,包括如下步骤:
S1、称取处方量的陈皮、花椒、生姜、细辛、土茯苓、桂枝6味原料药,研磨成粉;
S2、称取处方量的包谷酒,均匀搅拌并加热至53℃,将S1所得的原料加并搅拌,浸泡时间3个月;
S3、将S2所得苗药组合物过滤,即得治疗脂肪瘤的组合物。
实施例2:
本实施例提供一种治疗脂肪瘤的组合物,该组合物包括以下重量克数的原料:
包谷酒500g、陈皮5g、花椒5g、生姜5g、细辛4g、土茯苓100g、桂枝0.03g。
其中,本实施例的治疗脂肪瘤的组合物的制备方法,和实施例1相同。
实施例3:
本实施例提供一种治疗脂肪瘤的组合物,该组合物包括以下重量克数的原料:
包谷酒480g、陈皮4g、花椒4g、生姜4g、细辛3g、土茯苓95g、桂枝0.02g。
其中,本实施例的治疗脂肪瘤的组合物的制备方法,和实施例1相同。
毒性试验
选体重为18~22g的小白鼠300只(雌雄各150只),分为3组,每组雌雄各25只,小白鼠背部去毛露出外表皮,去毛范围2cm×2cm,分别涂抹本发明实施例1至实施例3制备得到的中药组合物,给药剂量为0.5g,连续给药30天。给药期间及停药后1周时,观察白鼠生长状态和活动饮食,鉴定血液学、血液生化学、脏器组织结构以及尿常规等。结果发现所有小白鼠均健康生存,无任何毒副作用;解剖观察血象、肝功能、各脏器组织状态,与正常小白鼠比较无差异。实验证明,本发明提供的中药组合物无毒,用药安全可靠。
具体实施案例
病例一:吴某,男,45岁,于2018年7月8日初诊,自诉发现背部包块5天,检体:背部肩甲区皮下有单个包块,直径约1CM,质地柔软,境界清楚,无其他不适症状,考虑为脂肪瘤,使本药液外涂并轻轻按揉患处,治疗4天后包块明显缩小,治疗10天痊愈,随诊1周未复发。
病例二:张某,女,61岁,于2018年11月21日初诊,自诉腹部包块10天,生长缓慢,检体:表面皮肤正常,左侧上腹部皮下有单个包块,直径约1.5CM,质地柔软,境界清楚,无其他不适症状,考虑为脂肪瘤,使本药液外涂并轻轻按揉患处,治疗1周后包块明显缩小,治疗2周痊愈,随诊1周未复发。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (6)
1. 一种治疗脂肪瘤的外用组合物,其特征在于,制备所述组合物的主要原料重量份组成为:包谷酒450~500g、陈皮 3-5g、花椒3-5g、生姜 3-5g、细辛2-4g、土茯苓90—100g、桂枝0.01---0.03g。
2. 根据权利要求1所述的治疗脂肪瘤的外用组合物,其特征在于,包括如下重量份数的原料:包谷酒450g 、陈皮 3g、花椒3g、生姜 3g、细辛2g、土茯苓90g、桂枝0.01g。
3.根据权利要求1所述的治疗脂肪瘤的外用组合物,其特征在于,包括如下重量份数的原料:包谷酒500g、陈皮5g、花椒5g、生姜5g、细辛4g、土茯苓100g、桂枝0.03g。
4.根据权利要求1所述的治疗脂肪瘤的外用组合物,其特征在于,包括如下重量份数的原料:包谷酒480g、陈皮4g、花椒4g、生姜4g、细辛3g、土茯苓95g、桂枝0.02g。
5.权利要求1-4任一项所述的组合物在制备治疗脂肪瘤药物中的应用。
6. 一种治疗脂肪瘤的外用组合物的制备方法,其特征在于,包括如下步骤:将陈皮 3-5g、花椒3-5g、生姜 3-5g、细辛2-4g、土茯苓90—100g、桂枝0.01---0.03g,研磨成粉,加入450-500g包谷酒,加热至53-55℃,均匀搅拌并浸泡2-3个月,过滤,得到治疗脂肪瘤的外用苗药组合物。
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