CN110960652A - Preparation method of suppository for treating cervical cancer - Google Patents
Preparation method of suppository for treating cervical cancer Download PDFInfo
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- CN110960652A CN110960652A CN201911423895.9A CN201911423895A CN110960652A CN 110960652 A CN110960652 A CN 110960652A CN 201911423895 A CN201911423895 A CN 201911423895A CN 110960652 A CN110960652 A CN 110960652A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention belongs to the field of suppository preparation, and discloses a preparation method of a suppository for treating cervical cancer, which comprises the following steps: firstly, weighing zedoary, pinellia ternate, fructus cnidii and paclitaxel, and drying for 20-40 min under the condition of circulating hot air at 80-95 ℃. The preparation method of the suppository for treating cervical cancer provided by the invention has good effects of detoxifying, resisting cancer and resisting tumor, has a good effect of treating cervical cancer, adopts high-quality authentic traditional Chinese medicines as raw materials in the formula, has no toxic or side effect, has a remarkable effect of treating cervical cancer, and does not relapse after healing.
Description
Technical Field
The invention relates to the technical field of suppository preparation, in particular to a preparation method of a suppository for treating cervical cancer.
Background
Cervical cancer is one of the most common malignant tumors in female cancers at present, the cervical cancer is one of the most common tumors in human bodies, the cervical cancer accounts for the first place in female genital organ tumors, the cervical cancer is the most common tumor in various malignant tumors of women, the number of the malignant tumors is more than 35 years old, and early diagnosis of the cervical cancer and precancerous lesions is the key for improving the cure rate of the cervical cancer and the survival rate of patients.
There are four major current treatments for cervical cancer: the traditional Chinese medicine is used for surgical treatment, radiotherapy, chemotherapy and traditional Chinese medicine treatment, the surgical treatment requirement is high, complications and postoperative infection are easily caused, the risk is high, and the recurrence is easy; the radiation therapy and the chemotherapy have great harm to the patient, so that the patient is easy to suffer more pain, and the cure rate is low; however, the existing traditional Chinese medicine treatment is mainly based on the folk prescription, the effect and the side effect are not clear, and based on the problems, the preparation method of the suppository for treating the cervical cancer is provided.
Disclosure of Invention
Technical problem to be solved
1. Technical problem to be solved
Aiming at the problems in the prior art, the invention aims to provide the preparation method of the suppository for treating cervical cancer, which has the advantages of no side effect and good curative effect and solves the problems that the existing traditional Chinese medicine treatment is mainly based on a biased prescription and the effect and the side effect are not clear at the same time.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme:
a preparation method of the suppository for treating cervical cancer comprises the following steps:
firstly, weighing zedoary, pinellia ternate, fructus cnidii and paclitaxel, drying for 20-40 min under 80-95 ℃ circulating hot air, heating into a traditional Chinese medicine crusher, fully crushing, and sieving with a 150-180 mesh sieve to obtain powder A;
placing the powder A into an extraction tank, adding 95% ethanol four times the total amount of the powder A, soaking for 40-80 min, performing reflux extraction at 85-95 ℃ for 1-2 min, filtering to obtain an extracting solution, repeating the above operations, adding water for extraction for 3 times, and combining the extracting solutions to obtain an extracting solution B;
adding the extracting solution B into a double-effect concentration tank, heating and concentrating at low pressure until the water content is 50-60%, adding water with the volume being twice that of the extract, standing and precipitating, spray-drying the precipitate to form fine powder C, and recovering the volatile oil by using a recovery device in the heating and concentrating process to obtain volatile oil D;
dissolving the volatile oil D with a small amount of ethanol, adding into the melted suppository matrix, adding the fine powder C, heating and melting at 80-90 ℃, and pouring into a suppository mold coated with a lubricant in advance when the temperature is reduced to 40-50 ℃;
fifthly, curing at the temperature of 2-4 ℃, cutting off an overflowing part after complete solidification, and demolding to obtain the cervical cancer suppository;
and sixthly, inspecting finished products, sealing and packaging, and storing in a shade place.
Preferably, the mass ratio of the zedoary, the pinellia ternate, the fructus cnidii and the paclitaxel is 5: 1: 3: 2.
Preferably, the suppository base is one of oleaginous base, polyoxyethylene monostearate or poloxamer.
Preferably, the oleaginous base is selected from one or more of natural and semi-synthetic fatty glyceride, hydrogenated vegetable oil, cocoa butter, silicone and oleic acid.
Preferably, the rhizoma pinelliae palmatum is tuber of rhizoma pinelliae palmatum.
(III) advantageous effects
Compared with the prior art, the invention provides a preparation method of the suppository for treating cervical cancer, which has the following beneficial effects:
(1) the preparation method of the suppository for treating cervical cancer provided by the invention has good effects of detoxifying, resisting cancer and resisting tumor, has a good effect of treating cervical cancer, adopts high-quality authentic traditional Chinese medicines as raw materials in the formula, has no toxic or side effect, has a remarkable effect of treating cervical cancer, and does not relapse after healing.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
a preparation method of the suppository for treating cervical cancer comprises the following steps:
firstly, weighing zedoary, pinellia ternate, fructus cnidii and paclitaxel, drying for 20min under 80 ℃ circulating hot air, heating into a traditional Chinese medicine pulverizer, fully pulverizing, and sieving with a 150-mesh sieve to obtain powder A;
placing the powder A into an extraction tank, adding 95% ethanol four times the total amount of the powder A, soaking for 40min, reflux-extracting at 85 ℃ for 1.5min, filtering to obtain an extract, repeating the above operation, adding water, extracting for 3 times, and mixing the extracts to obtain an extract B;
adding the extracting solution B into a double-effect concentration tank, heating and concentrating at low pressure until the water content is 50%, adding water with the volume twice that of the extract, standing and precipitating, spray-drying the precipitate to form fine powder C, and recovering the volatile oil by using a recovery device in the heating and concentrating process to obtain volatile oil D;
dissolving the volatile oil D with a small amount of ethanol, adding into the melted suppository matrix, adding the fine powder C, heating to melt at 80 deg.C, cooling to 40 deg.C, and pouring into suppository mold coated with lubricant;
fifthly, curing at the temperature of 2 ℃, cutting off an overflowing part after complete solidification, and demolding to obtain the cervical cancer suppository;
and sixthly, inspecting finished products, sealing and packaging, and storing in a shade place.
Furthermore, the mass ratio of the zedoary, the pinellia ternate, the fructus cnidii and the paclitaxel is 5: 1: 3: 2.
Further, the suppository matrix is one of oleaginous matrix, polyoxyethylene monostearate or poloxamer.
Further, the oleaginous base is selected from one or more of natural and semisynthetic fatty glyceride, hydrogenated vegetable oil, cocoa butter, silicone, and oleic acid.
Further, the rhizoma Pinelliae is tuber of rhizoma Pinelliae
Example two:
a preparation method of the suppository for treating cervical cancer comprises the following steps:
firstly, weighing zedoary, pinellia ternate, fructus cnidii and paclitaxel, drying for 30min under circulating hot air at 90 ℃, then heating into a traditional Chinese medicine pulverizer, fully pulverizing, and sieving with a 165-mesh sieve to obtain powder A;
placing the powder A into an extraction tank, adding 95% ethanol four times the total amount of the powder A, soaking for 60min, performing reflux extraction at 85-95 ℃ for 1.5min, filtering to obtain an extracting solution, repeating the above operation, adding water for extraction for 3 times, and combining the extracting solutions to obtain an extracting solution B;
adding the extracting solution B into a double-effect concentration tank, heating and concentrating at low pressure until the water content is 55%, adding water with the volume twice that of the extract, standing and precipitating, spray-drying the precipitate to form fine powder C, and recovering the volatile oil by using a recovery device in the heating and concentrating process to obtain volatile oil D;
dissolving the volatile oil D with a small amount of ethanol, adding into the melted suppository matrix, adding the fine powder C, heating to melt at 85 deg.C, cooling to 45 deg.C, and pouring into suppository mold coated with lubricant;
fifthly, curing at the temperature of 3 ℃, cutting off an overflowing part after complete solidification, and demolding to obtain the cervical cancer suppository;
and sixthly, inspecting finished products, sealing and packaging, and storing in a shade place.
Furthermore, the mass ratio of the zedoary, the pinellia ternate, the fructus cnidii and the paclitaxel is 5: 1: 3: 2.
Further, the suppository matrix is one of oleaginous matrix, polyoxyethylene monostearate or poloxamer.
Further, the oleaginous base is selected from one or more of natural and semisynthetic fatty glyceride, hydrogenated vegetable oil, cocoa butter, silicone, and oleic acid.
Further, the rhizoma Pinelliae is tuber of rhizoma Pinelliae
Example three:
a preparation method of the suppository for treating cervical cancer comprises the following steps:
firstly, weighing zedoary, pinellia ternate, fructus cnidii and paclitaxel, drying for 40min under 95 ℃ circulating hot air, then heating into a traditional Chinese medicine pulverizer, fully pulverizing, and sieving with a 180-mesh sieve to obtain powder A;
placing the powder A into an extraction tank, adding 95% ethanol four times the total amount of the powder A, soaking for 80min, performing reflux extraction at 5 ℃ for 1min, filtering to obtain an extract, repeating the above operation, adding water for extraction for 3 times, and mixing the extracts to obtain an extract B;
adding the extracting solution B into a double-effect concentration tank, heating and concentrating at low pressure until the water content is 50%, adding water with the volume twice that of the extract, standing and precipitating, spray-drying the precipitate to form fine powder C, and recovering the volatile oil by using a recovery device in the heating and concentrating process to obtain volatile oil D;
dissolving the volatile oil D with a small amount of ethanol, adding into the melted suppository matrix, adding the fine powder C, heating to melt at 90 deg.C, cooling to 50 deg.C, and pouring into suppository mold coated with lubricant;
fifthly, curing at 4 ℃, cutting off an overflow part after complete solidification, and demolding to obtain the cervical cancer suppository;
and sixthly, inspecting finished products, sealing and packaging, and storing in a shade place.
Furthermore, the mass ratio of the zedoary, the pinellia ternate, the fructus cnidii and the paclitaxel is 5: 1: 3: 2.
Further, the suppository matrix is one of oleaginous matrix, polyoxyethylene monostearate or poloxamer.
Further, the oleaginous base is selected from one or more of natural and semisynthetic fatty glyceride, hydrogenated vegetable oil, cocoa butter, silicone, and oleic acid.
Further, the rhizoma pinelliae palmatum is tuber of rhizoma pinelliae palmatum.
The zedoary, the pinellia ternate, the fructus cnidii and the paclitaxel in the formula have obvious functions of detoxification, cancer resistance and tumor resistance, have obvious effect of treating cervical cancer, are recorded in Chinese pharmacopoeia, and are as follows:
zedoary turmeric: pungent, bitter and warm; entering liver and spleen meridians; removing blood stasis, promoting circulation of qi, and relieving pain; inhibiting S180, L615 liver cancer entity type, and can be used for treating cervical cancer, hepatocarcinoma, gastric cancer, intestinal cancer, and thyroid cancer;
pinellia ternata medicinal materials:
fructus cnidii: warm in nature and bitter in taste; the functional indications are as follows: warming kidney, supporting yang, eliminating dampness, dispelling pathogenic wind, and killing parasite; can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; externally treating vulvar eczema, pudendal pruritus of women and trichomonas vaginitis;
paclitaxel: the taxol is white crystal powder, is odorless, tasteless, insoluble in water, and easily soluble in organic solvents such as methanol, acetonitrile, chloroform, acetone and the like, and the taxol is a natural secondary metabolite separated and purified from barks of a gymnosperm taxus chinensis.
The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.
Claims (5)
1. A preparation method of the suppository for treating cervical cancer is characterized in that: the method comprises the following steps:
firstly, weighing zedoary, pinellia ternate, fructus cnidii and paclitaxel, drying for 20-40 min under 80-95 ℃ circulating hot air, heating into a traditional Chinese medicine crusher, fully crushing, and sieving with a 150-180 mesh sieve to obtain powder A;
placing the powder A into an extraction tank, adding 95% ethanol four times the total amount of the powder A, soaking for 40-80 min, performing reflux extraction at 85-95 ℃ for 1-2 min, filtering to obtain an extracting solution, repeating the above operations, adding water for extraction for 3 times, and combining the extracting solutions to obtain an extracting solution B;
adding the extracting solution B into a double-effect concentration tank, heating and concentrating at low pressure until the water content is 50-60%, adding water with the volume being twice that of the extract, standing and precipitating, spray-drying the precipitate to form fine powder C, and recovering the volatile oil by using a recovery device in the heating and concentrating process to obtain volatile oil D;
dissolving the volatile oil D with a small amount of ethanol, adding into the melted suppository matrix, adding the fine powder C, heating and melting at 80-90 ℃, and pouring into a suppository mold coated with a lubricant in advance when the temperature is reduced to 40-50 ℃;
fifthly, curing at the temperature of 2-4 ℃, cutting off an overflowing part after complete solidification, and demolding to obtain the cervical cancer suppository;
and sixthly, inspecting finished products, sealing and packaging, and storing in a shade place.
2. The preparation method of the suppository for treating cervical cancer according to claim 1, wherein: the mass ratio of the zedoary, the pinellia ternate, the fructus cnidii and the paclitaxel is 5: 1: 3: 2.
3. The preparation method of the suppository for treating cervical cancer according to claim 1, wherein: the suppository matrix is one of oleaginous matrix or polyoxyethylene monostearate or poloxamer.
4. The preparation method of the suppository for treating cervical cancer according to claim 1, wherein: the oleaginous base is selected from one or more of natural and semisynthetic fatty glyceride, hydrogenated vegetable oil, cacao butter, silicone and oleic acid.
5. The preparation method of the suppository for treating cervical cancer according to claim 1, wherein: the rhizoma Pinelliae is tuber of rhizoma Pinelliae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911423895.9A CN110960652A (en) | 2019-12-16 | 2019-12-16 | Preparation method of suppository for treating cervical cancer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911423895.9A CN110960652A (en) | 2019-12-16 | 2019-12-16 | Preparation method of suppository for treating cervical cancer |
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| CN110960652A true CN110960652A (en) | 2020-04-07 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494982A (en) * | 2013-10-11 | 2014-01-08 | 哈尔滨欧替药业有限公司 | Vaginal dilation suppository for cervical cancer as well as preparation method and detection method thereof |
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- 2019-12-16 CN CN201911423895.9A patent/CN110960652A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494982A (en) * | 2013-10-11 | 2014-01-08 | 哈尔滨欧替药业有限公司 | Vaginal dilation suppository for cervical cancer as well as preparation method and detection method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 上海第一医院妇产科医院: "掌叶半夏治疗子宫颈癌的研究", 《中国药学杂志》 * |
| 杨今祥: "《抗癌中草药制剂》", 1 November 1998, 人民卫生出版社 * |
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Application publication date: 20200407 |