CN1109551C

CN1109551C - Anticancer capsule 'Wushensu' and its extracting and preparing process

Info

Publication number: CN1109551C
Application number: CN00112429A
Authority: CN
Inventors: 赵富清; 张翠岚
Original assignee: Individual
Current assignee: Individual
Priority date: 2000-07-31
Filing date: 2000-07-31
Publication date: 2003-05-28
Anticipated expiration: 2020-07-31
Also published as: CN1283483A

Abstract

The present invention relates to an anticancer capsule, namely a 'Wushensu' capsule. The present invention adopts traditional Chinese medicines, such as dry manyprickle acanthopanax root powder, dry blister beetle powder, borneol and dry Chinese caterpillar fungus powder as raw materials, fat-soluble active substances and water-soluble active substances are respectively extracted from the raw materials; the fat-soluble active substances, the water-soluble active substances and a proper quantity starch are mixed and dried to obtain mixed powder, and the mixed powder is encapsulated to obtain the anticancer capsule. The present invention has the advantages of growth and propagation inhibition for cancers, relapse reduction, cancer transfer control, high efficiency, low toxicity, etc., is suitable for cancers, such as liver cancers, oesophagus cancers, stomach cancers, etc. and white cell deterioration, can be used as a medicine before operations or a medicine matching with chemotherapy, and can be used for controlling the state of illness, relieving symptoms, alleviating pain, or even gradually removing the cancers for terminal cancers.

Description

A kind of medicine for the treatment of cancer and preparation method thereof

Technical field:

The present invention relates to a kind of being rich in multiple biological alkali and amino acid whose fat-soluble and water-soluble actives of effective component extracting preparation from Chinese medicine and cancerous cell had restrain and the Chinese medicine of killing effect.

Background technology:

Tumor has optimum and pernicious branch, malignant tumor is commonly called as " cancer ", the treatment of malignant tumor is still global problem so far, Therapeutic Method commonly used at present mainly contains operation, radiotherapy, chemotherapy, Biotherapeutics and Chinese traditional treatment five big therapies, rise again recently cancerous cell is taked " hungry to death; as to freeze to death; the wait indefinitely method of topical therapeutic of heat; as but most the entity cancer not to be had tangible curative effect; that main cause is also to kill and wound normal cell when killing and wounding cancerous cell; patient's bone marrow and digestive tract are caused major injury, serious and the therapy discontinued of many patient Chang Yin toxic reactions, also there are many patients to accept operation, radiotherapy, chemotherapy, be almost recovered leave hospital after, the danger that still is faced with recurrence and shifts.

Summary of the invention:

The objective of the invention is to develop and a kind ofly can restrain cancerous protuberance growth, breeding, remove in the body remainingly, reduce a kind of medicine for the treatment of cancer of the high-efficiency low-toxicity that recurrence and control shifts and preparation method thereof.

A kind of medicine for the treatment of cancer of the present invention, be that extraction is formulated from comprise Chinese medicine Radix Et Caulis Acanthopanacis Senticosi dry powder, Mylabris dry powder, Borneolum Syntheticum, Cordyceps dry powder, its preparation parts by weight are: Radix Et Caulis Acanthopanacis Senticosi dry powder 100-200 part, Mylabris dry powder 10-30 part, Borneolum Syntheticum 40-100 part, Cordyceps dry powder 100-200 part.It extracts preparation method: 1, add an amount of chloroform in Radix Et Caulis Acanthopanacis Senticosi dry powder, Mylabris dry powder, Borneolum Syntheticum, Cordyceps dry powder, under 70-75 ℃ temperature, refluxed 2 hours, the cooling back goes out extracting solution with filter paper filtering, residue adds chloroform again and repeats to extract 1-3 time, extracting solution gets the thick extract of brownish black after merging the recovery chloroform, is fat-soluble active substance after the drying; 2, the residue that extracted fat-soluble active substance is added an amount of distilled water immersion, boil, the cooling back goes out extract with filter paper filtering, residue adding distil water again repeats to extract 1-3 time, extracting solution merges to change behind concentrating under reduced pressure and adds an amount of ethanol, stirring is left standstill the back and is extracted the clear and bright liquid in upper strata, precipitate adds ethanol again and repeats to extract 1-3 time, clear and bright liquid merging gets ethanol extract through reclaiming ethanol, ethanol extract adds an amount of distilled water again and stirs and be placed on deepfreeze and take out after 2 days, supernatant is slowly got saturated resin by 732 type ion exchange resin, clean saturated resin with ammonia and alcoholic acid mixed liquor, effusive liquid is water-soluble fluidity active substance through the brownish red eluent that volatilization removes after flavor is smelt in deammoniation after concentrating under condition of negative pressure; 3, get behind 1 part of 1 part of above-mentioned water-soluble actives and starch and an amount of abundant mixing of distilled water 4 parts of abundant mixings of fat-soluble active substance with an amount of dissolve with ethanol, the oven dry back is divided and is installed to the capsule finished product that is the treatment cancer drug in the capsule in 60-70 ℃ temperature again.

Treatment cancer drug of the present invention is a pure Chinese medicinal preparation, and chloroform, ethanol and the ammonia that uses in extracting process for preparation all is recovered before extracting end or volatilizees; Radix Et Caulis Acanthopanacis Senticosi is the top grade of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; Cantharidin in the Mylabris has good interference and suppresses proliferative effect tumor cell, can obviously destroy the synthetic of protein and nucleic acid in the tumor cell, is a kind of good cancer therapy drug, but because the toxicity of Mylabris is bigger, makes prestige and steps back; Borneolum Syntheticum has logical all keys, the stagnated fire of loosing, and removing nebula makes eye bright and Detoxication such as reducing swelling and alleviating pain; Cordyceps can play invigorating the lung and the kidney, effects such as hemostasis and phlegm and QI and blood regulating.The reasonable compatibility of treatment cancer drug both can alleviate the toxicity of Mylabris, can strengthen antitumous effect again, have and to restrain cancerous protuberance growth, breeding, reduce the advantages such as high-efficiency low-toxicity that recurrence and control are shifted, be applicable to cancers such as hepatocarcinoma, the esophageal carcinoma, gastric cancer, also be applicable to low leukocyte counts disease, also can be used as premedicate or combined with chemotherapy medication, also can disease controlling for terminal cancer, relief of symptoms and easing the pain, even the cancerous protuberance piece is cured by disappearing.

The specific embodiment:

The present invention is further described and illustrates as follows:

Example 1, get 100 parts in Radix Et Caulis Acanthopanacis Senticosi dry powder, 10 parts in Mylabris dry powder, 40 parts of Borneolum Syntheticums, Cordyceps dry powder is raw material for 100 parts, extracts fat-soluble active substance earlier, extracts water-soluble actives again, promptly can be made into the capsule finished product of treatment cancer drug then.

Example 2, get 100 parts in Radix Et Caulis Acanthopanacis Senticosi dry powder, 15 parts in Mylabris dry powder, 50 parts of Borneolum Syntheticums, Cordyceps dry powder is raw material for 150 parts, extracts fat-soluble active substance earlier, extracts water-soluble actives again, promptly can be made into the capsule finished product of treatment cancer drug then.

Example 3, get 200 parts in Radix Et Caulis Acanthopanacis Senticosi dry powder, 30 parts in Mylabris dry powder, 100 parts of Borneolum Syntheticums, Cordyceps dry powder is raw material for 200 parts, extracts fat-soluble active substance earlier, extracts water-soluble actives again, promptly can be made into the capsule finished product of treatment cancer drug then.

On the make, should from above-mentioned Chinese medicine, extract fat-soluble active substance earlier, extract water-soluble actives again, just can make the capsule finished product of treatment cancer drug then.It extracts compound method as previously mentioned.During use, each 20-80mg that is grown up, every day 3 times, 1 month is 1 course of treatment, taking can have positive effect 1-2 the course of treatment, continues to take to make tumor dwindle even disappear.

Therapeutic effect to this medicine illustrates as follows:

Case 1: poplar, the woman, 58 years old, performed the operation because of breast carcinoma before 2 years, in the recent period because of cough, chest pain, show " two lung transfer " through CT examination.Took this medicine 1 month, conscious pain subtracts greatly, and cough, chest pain all are clearly better, and along with the prolongation of medicine time, the symptom of poplar fades away, and beat cancer is filled with unbounded confidence.

Case 2: Lee, the man, 60 years old, during health check-up, found that right kidney stage casing essence space-occupying mass reached 6.3 * 6.1 * 5.8CM before half a year, though there is not clinical symptoms, consider mostly to be renal carcinoma, through taking this medicine 1 month, check shows that lump obviously reduces, existing a small amount of liquify area and calcification point in the lump, continuing to take medicine can be expected to cure.

Case 3: Liu, the woman, 73 years old, because of superior lobe of right lung pulmonary carcinoma is treated late period, patient's spirit, diet extreme difference were become thin at that time, and breast expands, legs and feet pain.After taking this medicine first quarter moon, diet takes a turn for the better, and breast expands and alleviates, and when obeying two weeks again, dietary amount increases, 1 kilogram of weight increase, and breast expands and the legs and feet pain relief, and clinical symptoms takes a turn for the better, state of an illness basic controlling.

Case 4: Lu, the woman, 57 years old, because of left lower limb neurofibrosarcoma, take this medicine first quarter moon after, the tumor body has dwindled 2CM, take first quarter moon again after, the tumor body has dwindled 3CM, it is clear that the border becomes, pain disappears, illustrating also has good efficacy to benign tumor.

Claims

1, a kind of medicine for the treatment of cancer, it is characterized in that from comprise Chinese medicine Radix Et Caulis Acanthopanacis Senticosi dry powder, Mylabris dry powder, Borneolum Syntheticum, Cordyceps dry powder, extracting formulated, its preparation parts by weight are: Radix Et Caulis Acanthopanacis Senticosi dry powder 100-200 part, Mylabris dry powder 10-30 part, Borneolum Syntheticum 40-100 part, Cordyceps dry powder 100-200 part.

2, the preparation method of the medicine of claim 1, it is characterized in that: 1, in Radix Et Caulis Acanthopanacis Senticosi dry powder, Mylabris dry powder, Borneolum Syntheticum, Cordyceps dry powder, add an amount of chloroform, under 70-75 ℃ temperature, refluxed 2 hours, the cooling back goes out extracting solution with filter paper filtering, residue adds chloroform again and repeats to extract 1-3 time, extracting solution gets the thick extract of brownish black after merging the recovery chloroform, is fat-soluble active substance after the drying; 2, the residue that extracted fat-soluble active substance is added an amount of distilled water immersion, boil, the cooling back goes out extract with filter paper filtering, residue adding distil water again repeats to extract 1-3 time, extracting solution merges to change behind concentrating under reduced pressure and adds an amount of ethanol, stirring is left standstill the back and is extracted the clear and bright liquid in upper strata, precipitate adds ethanol again and repeats to extract 1-3 time, clear and bright liquid merging gets ethanol extract through reclaiming ethanol, ethanol extract adds an amount of distilled water again and stirs and be placed on deepfreeze and take out after 2 days, supernatant is slowly got saturated resin by 732 type ion exchange resin, clean saturated resin with ammonia and alcoholic acid mixed liquor, effusive liquid is water-soluble fluidity active substance through the brownish red eluent that volatilization removes after flavor is smelt in deammoniation after concentrating under condition of negative pressure; 3, get behind 1 part of 1 part of above-mentioned water-soluble actives and starch and an amount of abundant mixing of distilled water 4 parts of abundant mixings of fat-soluble active substance with an amount of dissolve with ethanol, the oven dry back is divided and is installed to the capsule finished product that is the treatment cancer drug in the capsule in 60-70 ℃ temperature again.