CN112535695A - Traditional Chinese medicine extract composition for treating intestinal cancer, preparation method and application thereof in preparing medicines - Google Patents
Traditional Chinese medicine extract composition for treating intestinal cancer, preparation method and application thereof in preparing medicines Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
A Chinese medicinal extract composition for treating intestinal cancer, and its preparation method and application in preparing medicine are provided. The composition adopts the following raw material medicine extracts in percentage by weight: and (3) sophora flavescens extract: gentian extract = 1-15: 1 to 15. The radix Sophorae Flavescentis extract is water extract; the gentian extract is an aqueous extract. The invention is different from the traditional view that the traditional Chinese medicine compound decoction is superior to the respective extraction of each medicinal material, and provides a method for optimizing and combining extracts of each medicinal material, thereby realizing the precise control of the composition, remarkably improving the pharmacological effect and having positive guiding effect on the treatment method of the traditional Chinese medicine extract composition for treating the intestinal cancer.
Description
Technical Field
The invention relates to a composition of traditional Chinese medicine extracts for treating intestinal cancer, a preparation method of the composition for treating intestinal cancer; and the application of the composition for treating intestinal cancer in preparing medicaments for treating intestinal cancer.
Background
Intestinal cancer refers to cancer occurring in the intestinal tract, mainly colon cancer and rectal cancer, and is one of the most common malignant tumors worldwide. Due to changes of living environment and living habits of people, the incidence of intestinal cancer in China tends to rise year by year in recent years. Intestinal cancer can spread to other tissues and organs through lymph, blood circulation, direct spread and other ways, has no obvious symptoms in the early stage, and the patients often miss the opportunity of surgical treatment when finding the intestinal cancer. Because the pathogenesis of intestinal cancer is complex, the induction factors are more, the satisfactory treatment effect of chemical drugs is difficult to obtain, and the drugs have the defects of large side effect, easy relapse and the like. In recent years, conventional medicines have been important for the treatment of intestinal cancer.
Radix Sophorae Flavescentis is root of Sophora flavescens ait of Leguminosae. Has effects in clearing away heat, eliminating dampness, killing parasite, and promoting urination. Matrine, total matrine, oxymatrine, etc. have tumor cell inhibiting effect. In addition, the matrine and oxymatrine can inhibit type I hypersensitivity, increase leukocyte, and resist inflammation; sophocarpine and sophoramine can obviously enhance the function of mononuclear macrophage; radix Sophorae Flavescentis also has antiarrhythmic, blood pressure lowering, and blood lipid reducing effects. Radix Sophorae Flavescentis is commonly used for treating esophageal cancer, carcinoma of large intestine, bladder cancer, cervical cancer, etc.
The radix Gentianae is root of Gentiana scabra Bunge, Gentiana trifoliata Bunge and Gentiana striolata Bunge of Gentianaceae. Bitter and cold. Has effects in clearing away heat, eliminating dampness, and purging pathogenic fire in liver and gallbladder. The gentiana scabra bunge extract has an inhibiting effect on mouse sarcoma S180 and human cervical cancer JTC 26; the extract can inhibit cancer cell proliferation; in addition, gentian also has the functions of invigorating stomach, promoting secretion of saliva, gastric juice, pancreatic juice and bile, promoting gastrointestinal movement and digestive absorption, resisting inflammation, reducing blood pressure and the like. Gentian is commonly used for treating liver cancer, gallbladder cancer, pancreatic cancer, cervical cancer and the like in clinic.
Although the combined formula of radix sophorae flavescentis and radix gentianae is already used for clinically treating intestinal cancer and other diseases, the practical application has the reasons of unstable clinical curative effect, inconvenience in taking of patients and the like due to incomplete and clear effective substances, low preparation level and the like. These problems restrict the application effect of the compound preparation.
According to the traditional view, the active extract of the traditional Chinese medicine compound is obtained by mixing and extracting raw material medicines, generally an aqueous solution or an alcohol-soluble active ingredient is obtained, and the curative effect of the extract obtained by mixing and extracting is considered to be superior to the combination of the extracts obtained by independently extracting various medicinal materials. The research on the composition of the lightyellow sophora root and gentian extracts is not yet available. The invention researches the effect of the composition of the lightyellow sophora root extract and the gentian extract in treating intestinal cancer in a human intestinal cancer model.
Disclosure of Invention
Object of the Invention
A Chinese medicinal extract composition for treating intestinal cancer is provided. The composition can be used for treating intestinal cancer. The invention also provides a method for preparing the composition; and the application of the composition in preparing medicaments for treating intestinal cancer.
Technical scheme
A traditional Chinese medicine extract composition for treating intestinal cancer comprises the following raw material medicines: radix Sophorae Flavescentis and radix Gentianae; the composition is characterized in that the components are extracts of raw material medicines, and the weight ratio of each composition is as follows: and (3) sophora flavescens extract: gentian extract = 1-15: 1 to 15.
More specifically, the traditional Chinese medicine extract composition for treating intestinal cancer is characterized in that the weight ratio of each component in the composition is as follows: and (3) sophora flavescens extract: gentian extract = 10-15: 10 to 15.
The invention adopts the respective extraction optimization of the raw material medicines, selectively combines the extracts, realizes the progress of the preparation method and the optimized proportion of the extracts, realizes the optimal pharmacological effect, obviously reduces the clinical dosage, and is beneficial to the quality control of the composition and the preparation of various preparations.
In the above scheme, the sophora flavescens extract refers to: crushing a lightyellow sophora root medicinal material into 12-mesh coarse powder, soaking for 1 hour, extracting for 3 times with water at the extraction temperature of 80-90 ℃, 1 hour each time and 10 times of water, and stirring at the speed of 20rpm in the extraction process. Mixing extractive solutions, filtering, centrifuging at 3000r/min for 10 min, collecting supernatant, and concentrating to 1g crude drug per ml;
the gentian extract is characterized in that: crushing the gentian into 12-mesh coarse powder, soaking for 1 hour, extracting for 3 times with water at the extraction temperature of 80-90 ℃ for 1 hour and 10 times of water each time, and stirring at the stirring speed of 20rpm in the extraction process. Mixing extractive solutions, filtering, centrifuging at 3000r/min for 10 min, collecting supernatant, and concentrating to 1g crude drug per ml.
Advantageous effects
The invention discloses the application of the composition of the extracts of radix sophorae flavescentis and radix gentianae in preparing the medicine for treating intestinal cancer for the first time, the preparation performance of the composition is obviously improved through the optimization of the preparation method and the optimization of the combination of the extracts, the toxic and side effects are reduced while the functions of effective components are enhanced, and unexpected treatment effects are generated.
Drawings
FIG. 1 is a graph showing the results of the MTT method for detecting the inhibition rate of the herb extracts on tumor cells alone or in combination.
FIG. 2 is a graph showing the results of MTT assay for the inhibition of tumor cells by different ratios of herbal extracts.
Detailed Description
The invention is further described with reference to the drawings and the following detailed description, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated. The kit materials used in the following examples are all commercially available unless otherwise specified.
Example 1 preparation of herbal extracts
1. Pharmaceutical raw material
Radix Sophorae Flavescentis, and radix Gentianae.
2. Preparation method of extract
And (3) sophora flavescens extract: crushing a lightyellow sophora root medicinal material into 12-mesh coarse powder, soaking for 1 hour, extracting for 3 times with water at the extraction temperature of 80-90 ℃, 1 hour each time and 10 times of water, and stirring at the speed of 20rpm in the extraction process. Mixing extractive solutions, filtering, centrifuging at 3000r/min for 10 min, collecting supernatant, and concentrating to 1g crude drug per ml;
and (3) gentian extract: crushing the gentian into 12-mesh coarse powder, soaking for 1 hour, extracting for 3 times with water at the extraction temperature of 80-90 ℃ for 1 hour and 10 times of water each time, and stirring at the stirring speed of 20rpm in the extraction process. Mixing extractive solutions, filtering, centrifuging at 3000r/min for 10 min, collecting supernatant, and concentrating to 1g crude drug per ml.
EXAMPLE 2 synergistic Effect of the combination of extracts on inhibiting intestinal cancer cells
1. Experimental Material
(1) Medicine preparation: radix Sophorae Flavescentis extract, and radix Gentianae extract.
(2) Intestinal cancer cells: human intestinal cancer cells HCT116 cells and HT29 cells.
(3) Commercial MTT kit.
2. Experiment grouping
(1) The concentration gradient of the sophora flavescens extract is realized.
(2) Gradient of concentration of radix Gentianae extract.
(3) The sophora flavescens extract and the gentian extract are combined in equal proportion.
3. MTT method for detecting sensitivity of tumor cells to different traditional Chinese medicine extracts
(1) The human intestinal cancer cells HCT116 cells and HT29 cells are inoculated to a 96-well plate according to the number of 5000-9000 cells per well, and after the cells adhere to the wall, PBS solutions of radix sophorae flavescentis extract, radix gentianae extract or combination of the radix sophorae flavescentis extract and the radix gentianae extract with different crude drug concentrations are respectively added. After 24 hours of incubation, 10. mu.l of 5mg/ml MTT was added to each well for another 4 hours, and then 100. mu.l of DMSO was added to each well after discarding the culture solution, and the absorbance of each well was read at 490nm using a microplate reader. Statistical analysis was performed on the data.
(2) The analysis result is shown in fig. 1, which shows that the sophora flavescens extract and the gentian extract have certain inhibition effect on human intestinal cancer cells when used alone, and the inhibition rate of the sophora flavescens extract and the gentian extract on tumor cells after combined use is larger than the sum of the inhibition rates when used alone, so that the treatment effect of intestinal cancer is remarkably improved by using the sophora flavescens extract and the gentian extract in a combined manner, and the synergistic effect is realized.
Example 3 Effect of different combinations of herbal extracts on tumor cell inhibition
1. Experimental Material
(1) Medicine preparation: radix Sophorae Flavescentis extract, and radix Gentianae extract.
(2) Intestinal cancer cells: human intestinal cancer cells HCT116 cells and HT29 cells.
(3) Commercial MTT kit.
2. Experiment grouping
The radix Sophorae Flavescentis extract and radix Gentianae extract are combined at different ratios.
3. MTT method for detecting sensitivity of tumor cells to different traditional Chinese medicine extracts
(1) The human intestinal cancer cells HCT116 cells and HT29 cells are inoculated to a 96-well plate according to the number of 5000-9000 cells per well, and PBS solutions of radix sophorae flavescentis extract and radix gentianae extract combinations with different crude drug concentrations are respectively added after the cells adhere to the wall. After 24 hours of incubation, 10. mu.l of 5mg/ml MTT was added to each well for another 4 hours, and then 100. mu.l of DMSO was added to each well after discarding the culture solution, and the absorbance of each well was read at 490nm using a microplate reader. Statistical analysis was performed on the data.
(2) The analysis results are shown in fig. 2, and the combined use of the sophora flavescens extract and the gentian extract significantly enhances the inhibition effect on intestinal cancer cells. Preferably, the weight ratio of each component is as follows: and (3) sophora flavescens extract: gentian extract = 1-15: 1-15; particularly preferably, the weight ratio of each component is kuh-seng extract: gentian extract = 10-15: 10 to 15.
Claims (5)
1. A traditional Chinese medicine extract composition for treating intestinal cancer comprises the following raw material medicines: radix Sophorae Flavescentis and radix Gentianae; the pharmaceutical composition is characterized in that the components are extracts of raw material medicines, and the weight ratio of the components is as follows: and (3) sophora flavescens extract: gentian extract = 1-15: 1-15;
the radix sophorae flavescentis extract is as follows: crushing a lightyellow sophora root medicinal material into 12-mesh coarse powder, soaking for 1 hour, extracting for 3 times with water at the extraction temperature of 80-90 ℃, 1 hour and 10 times of water each time, stirring at the stirring speed of 20rpm in the extraction process, combining extracting solutions, filtering, centrifuging at 3000r/min for 10 minutes, taking a supernatant, and concentrating until each milliliter contains 1g of crude drug for later use;
the gentian extract is characterized in that: pulverizing radix Gentianae into 12 mesh coarse powder, soaking for 1 hr, extracting with water at 80-90 deg.C for 3 times, stirring at 20rpm during extraction, mixing extractive solutions, filtering, centrifuging at 3000r/min for 10 min, collecting supernatant, and concentrating to obtain extract containing 1g crude drug per ml.
2. The traditional Chinese medicine extract composition for treating intestinal cancer according to claim 1, wherein the weight ratio of the components is as follows: and (3) sophora flavescens extract: gentian extract = 1-15: 1 to 15.
3. The traditional Chinese medicine extract composition for treating intestinal cancer according to claim 1, wherein the weight ratio of the components is as follows: and (3) sophora flavescens extract: gentian extract = 10-15: 10 to 15.
4. The method of preparing a herbal extract composition for treatment of intestinal cancer according to claim 1, comprising the steps of:
(1) preparing radix Sophorae Flavescentis extract and radix Gentianae extract respectively;
(2) weighing the two extracts according to the required parts for later use;
(3) treating the above extracts with preparation technology or adjuvants, including cyclodextrin inclusion, dispersion, solubilization, moisture resistance, sustained release, pulverizing, sieving, and mixing;
(4) combining the two extracts according to a required proportion to prepare a medicament;
the radix sophorae flavescentis extract is as follows: crushing a lightyellow sophora root medicinal material into 12-mesh coarse powder, soaking for 1 hour, extracting for 3 times with water at the extraction temperature of 80-90 ℃, 1 hour and 10 times of water each time, stirring at the stirring speed of 20rpm in the extraction process, combining extracting solutions, filtering, centrifuging at 3000r/min for 10 minutes, taking a supernatant, and concentrating until each milliliter contains 1g of crude drug for later use;
the gentian extract is characterized in that: pulverizing radix Gentianae into 12 mesh coarse powder, soaking for 1 hr, extracting with water at 80-90 deg.C for 3 times, stirring at 20rpm during extraction, mixing extractive solutions, filtering, centrifuging at 3000r/min for 10 min, collecting supernatant, and concentrating to obtain extract containing 1g crude drug per ml.
5. The use of the composition of claim 1 for the treatment of intestinal cancer in the manufacture of a medicament for the treatment of intestinal cancer.
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