CN102940818A - Medicine composition for treating dyspepsia - Google Patents
Medicine composition for treating dyspepsia Download PDFInfo
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- CN102940818A CN102940818A CN2012104279325A CN201210427932A CN102940818A CN 102940818 A CN102940818 A CN 102940818A CN 2012104279325 A CN2012104279325 A CN 2012104279325A CN 201210427932 A CN201210427932 A CN 201210427932A CN 102940818 A CN102940818 A CN 102940818A
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- fructus
- germinatus
- radix aucklandiae
- hordei germinatus
- fructus hordei
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Abstract
The invention discloses a medicine composition for treating dyspepsia, comprising costusroot, chicken's gizzard-membrane, fructus hordei germinatus, rice-grain sprout, and Chinese yam. The medicine composition disclosed herein can strengthen spleen and stomach, promote digestion, help digestion and stop diarrhea, and especially can treat appetite decreases, dyspepsia caused by yin deficiency of spleen and stomach, and the curative effect is exact.
Description
Technical field
The present invention relates to a kind of dyspeptic medicine for the treatment of, specifically the Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Hordei Germinatus, Fructus Setariae Germinatus and Rhizoma Dioscoreae are the pharmaceutical composition that raw material is made.
Background technology
Dyspepsia is a kind of common internal medicine digestive system disease, the morbidity crowd is many, its symptom main manifestations is for having by spells epigastric discomfort or pain, glutted, heartburn (acid regurgitation), belch, often be reluctant to take food or as far as possible few feed because of discomforts such as sense uncomfortable in chest, early full, abdominal distention, at night also be difficult to sleep peacefully, it is rear often with nightmare to sleep.Also have some patient's abdominal distention obvious, the abdominal part borborygmus, aerofluxus increases, even the indigested food debris of Chang Kejian in the stool.
The Western medicine kind for the treatment of dyspepsia disease is numerous at present, such as motilium, metoclopramide etc., although instant effect, good effect, but certain side effect is arranged, Chinese medicine is little with its toxic and side effects, the occupancy volume of the market share enlarges year by year, but usually has the problems such as curative effect is rapid not, effective ingredient is not obvious, medication dose is large.
Summary of the invention
Purpose of the present invention just provides a kind of instant effect, and dosage is little, the dyspeptic pharmaceutical composition of the treatment that has no side effect.
The technical scheme that solution of the present invention adopts is: a kind ofly treating dyspeptic pharmaceutical composition, is that raw material forms by the Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Hordei Germinatus, Fructus Setariae Germinatus and Rhizoma Dioscoreae.
Medicine of the present invention raw materials used weight proportion can be Radix Aucklandiae 10-25 part, Endothelium Corneum Gigeriae Galli 1-15 part, Fructus Hordei Germinatus 1-15 part, Fructus Setariae Germinatus 1-15 part, Rhizoma Dioscoreae 1-20 part.
The raw materials used optimum ratio of medicine of the present invention is: Radix Aucklandiae 10-20 part, Endothelium Corneum Gigeriae Galli 2-12 part, Fructus Hordei Germinatus 2-12 part, Fructus Setariae Germinatus 2-12 part, Rhizoma Dioscoreae 5-15 part.
The raw materials used more preferably proportioning of medicine of the present invention is: Radix Aucklandiae 12-16 part, Endothelium Corneum Gigeriae Galli 4-8 part, Fructus Hordei Germinatus 4-8 part, Fructus Setariae Germinatus 4-8 part, Rhizoma Dioscoreae 8-12 part.
The raw materials used best proportioning of medicine of the present invention is: 15 parts of the Radix Aucklandiae, 6 parts of Endothelium Corneum Gigeriae Galli, 6 parts in Fructus Hordei Germinatus, 6 parts of Fructus Setariae Germinatuss, 10 parts of Rhizoma Dioscoreaes.
The dosage form of medicine of the present invention can be any existing pharmaceutical dosage form in drop pill, tablet, capsule, soft capsule, the granule.
Pharmaceutical composition of the present invention can adopt but be not limited to following methods:
(1) gets Radix Aucklandiae medical material, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 8-10 times of volume, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Radix Aucklandiae extract.
(2) get the Endothelium Corneum Gigeriae Galli medical material, rub, add 6-10 times of volume water, regulate pH to 12 with 40%NaOH, 50 degrees centigrade of heating 3h filter collection filtrate, and filtering residue is repeated above operation 1 time, collect filtrate and also merge.Filtrate after the merging is transferred pH to 4 with 2molL-1 hydrochloric acid, and is centrifugal, gets precipitation.With ether or dehydrated alcohol dehydration, natural drying 48h gets Endothelium Corneum Gigeriae Galli extract to precipitate again.
(3) get Fructus Hordei Germinatus, pulverize, process with mechanical lapping, add the water of 8-10 times of volume 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid, is got supernatant after centrifugal, adds ethanol to 60% and precipitates, the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Hordei Germinatus extract.
(4) get Fructus Setariae Germinatus, pulverize, process with mechanical lapping, add the water of 8-10 times of volume 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid, is got supernatant after centrifugal, adds ethanol to 60% and precipitates, the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Setariae Germinatus extract.
(5) get the Rhizoma Dioscoreae defibrination, the water that adds 8-10 times of volume, regulate pH to 7-9 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in constant temperature (60-80 ℃) water-bath, the water that again adds 4-8 times of volume in the precipitation extracts, centrifugal collection supernatant, concentrating under reduced pressure (60 ℃) after mixing, 4 ℃ of 70% ethanol that add 0.3-1 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(6) the above-mentioned Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Rhizoma Dioscoreae extract are mixed, make acceptable various pharmaceutical dosage form.
In the pharmaceutical composition of the present invention, Radix Aucklandiae acrid in the mouth, hardship, warm in nature.Return spleen, stomach, large intestine, three warmers, gallbladder meridian.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Be used for breast side of body abdominal distention, heavy behind the dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).Be used for having loose bowels stomachache.
The Endothelium Corneum Gigeriae Galli sweet in the mouth, property is flat.Return spleen, stomach, small intestinal, urinary bladder channel.Function: strengthening the spleen to promote digestion; Arresting seminal emission; Xiao Disorder fossil.Cure mainly: dyspepsia; Eating accumulation; Vomiting regurgitation; The dysentery of having loose bowels; Infantile malnutrition; Seminal emission; The enuresis; Frequent micturition; Urinary system calculus and cholelithiasis; The mass in the abdomen amenorrhea; The sore throat tonsillitis; The ulcerative gingivitis aphtha.
The Fructus Hordei Germinatus sweet in the mouth, property is flat.Return spleen, stomach warp.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back newborn relieving distension.Be used for food stagnation and do not disappear, abdominal distention, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, women's ablactation.The Fructus Hordei Germinatus invigorating the spleen and regulating the stomach, soothing the liver circulation of qi promoting.Be used for insufficiency of the spleen lack of appetite, milk smoulders.The galactopoiesis of Fructus Hordei Germinatus (parched) promote qi circulation digestion promoting.Be used for food stagnation and do not disappear, women's ablactation.The Fructus Hordei Germinatus (parched to brown) relieving dyspepsia.Be used for food stagnation and do not disappear abdominal distention.The Fructus Jujubae sweet in the mouth, warm in nature.Return spleen, stomach, heart channel.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
The Fructus Setariae Germinatus sweet in the mouth, property is flat.Return spleen, stomach warp.Help digestion and in, spleen benefiting and stimulating the appetite.Be used for food stagnation and do not disappear abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, and is used for not hungry lack of appetite.The kind eliminate indigestion of Fructus Setariae Germinatus (parched to brown) stagnates, and being used for stagnating does not disappear.
The Rhizoma Dioscoreae sweet in the mouth, property is flat.Return lung, spleen, kidney channel.Function cures mainly: spleen reinforcing; Support lung; Reinforce the kidney; Benefit is smart.Main diarrhea due to hypofunction of the spleen; The lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; The frequent micturition of suffering from a deficiency of the kidney; Carbuncle is controlled in external; Scrofula.Have the intestinal motility of stimulation, promote the intestinal contents emptying.Other: contained nutritional labeling and phlegmatic temperament, amylase are relevant, and tonic effect is arranged, can be aid digestion.Antidiarrheal.Eliminate the phlegm.
The used various raw medicinal materials of the present invention are the Chinese crude drug that meets country or provincial standard regulation.The dyspeptic pharmaceutical composition for the treatment of of the present invention, as the basis take theory of Chinese medical science, in conjunction with clinical practice, from Chinese medicine material treasure-house, filter out have invigorating the stomach and promoting digestion, invigorating the spleen and benefiting QI, regulating QI to relieve pain, digestive pure purification of tcm form, but latent heat in the clearing stomach, let out the fire of liver taste, transfer the liver QI of the spleen and stomach, the symptoms such as the abdominal discomfort that causes for the treatment dyspepsia or pain, glutted, heartburn (acid regurgitation), belch have good curative effect.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
Embodiment 1
The dyspeptic pharmaceutical composition of the treatment that present embodiment is enumerated is comprised of the medicinal raw material of following weight: Radix Aucklandiae 15g, Endothelium Corneum Gigeriae Galli 6g, Fructus Hordei Germinatus 6g, Fructus Setariae Germinatus 6g, Rhizoma Dioscoreae 10g.
Above-mentioned medicinal raw material is prepared into soft capsule, and preparation method is as follows:
(1) gets Radix Aucklandiae medical material by embodiment 1 formula proportion, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 10 times of volumes, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Radix Aucklandiae extract.
(2) get the Endothelium Corneum Gigeriae Galli medical material by embodiment 1 formula proportion, rub, add 10 times of volume water, regulate pH to 12 with 40%NaOH, 50 degrees centigrade of heating 3h filter collection filtrate, and filtering residue is repeated above operation 1 time, collect filtrate and also merge.Filtrate after the merging is transferred pH to 4 with 2molL-1 hydrochloric acid, and is centrifugal, gets precipitation.With ether or dehydrated alcohol dehydration, natural drying 48h gets Endothelium Corneum Gigeriae Galli extract to precipitate again.
(3) get Fructus Hordei Germinatus by embodiment 1 formula proportion, pulverize, process with mechanical lapping, add the water of 10 times of volumes at 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid,, get supernatant after centrifugal, add ethanol to 60% and precipitate the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Hordei Germinatus extract.
(4) get Fructus Setariae Germinatus by embodiment 1 formula proportion, pulverize, process with mechanical lapping, add the water of 10 times of volumes at 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid,, get supernatant after centrifugal, add ethanol to 60% and precipitate the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Setariae Germinatus extract.
(5) get the Rhizoma Dioscoreae defibrination by embodiment 1 formula proportion, the water that adds 10 times of volumes, regulate pH to 9 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in 60 ℃ of water-baths of constant temperature, the water that again adds 4-8 times of volume in the precipitation extracts, centrifugal collection supernatant mixes rear 60 ℃ of concentrating under reduced pressure, and 4 ℃ of 70% ethanol that add 0.3 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(6) the above-mentioned Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Rhizoma Dioscoreae extract are mixed.
(7) with said mixture and vegetable oil 25g, mixing is made capsule casing material with gelatin, adopts existing soft capsule preparation technology, is pressed into soft capsule.
Embodiment 2
The dyspeptic pharmaceutical composition of the treatment that present embodiment is enumerated is comprised of the medicinal raw material of following weight: Radix Aucklandiae 25g, Endothelium Corneum Gigeriae Galli 10g, Fructus Hordei Germinatus 8g, Fructus Setariae Germinatus 4g, Rhizoma Dioscoreae 10g.
Above-mentioned medicinal raw material is prepared into tablet, and preparation method is as follows:
(1) gets Radix Aucklandiae medical material by embodiment 2 formula proportion, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 10 times of volumes, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Radix Aucklandiae extract.
(2) get the Endothelium Corneum Gigeriae Galli medical material by embodiment 2 formula proportion, rub, add 10 times of volume water, regulate pH to 12 with 40%NaOH, 50 degrees centigrade of heating 3h filter collection filtrate, and filtering residue is repeated above operation 1 time, collect filtrate and also merge.Filtrate after the merging is transferred pH to 4 with 2molL-1 hydrochloric acid, and is centrifugal, gets precipitation.With ether or dehydrated alcohol dehydration, natural drying 48h gets Endothelium Corneum Gigeriae Galli extract to precipitate again.
(3) get Fructus Hordei Germinatus by embodiment 2 formula proportion, pulverize, process with mechanical lapping, add the water of 10 times of volumes at 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid,, get supernatant after centrifugal, add ethanol to 60% and precipitate the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Hordei Germinatus extract.
(4) get Fructus Setariae Germinatus by embodiment 2 formula proportion, pulverize, process with mechanical lapping, add the water of 10 times of volumes at 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid,, get supernatant after centrifugal, add ethanol to 60% and precipitate the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Setariae Germinatus extract.
(5) get the Rhizoma Dioscoreae defibrination by embodiment 2 formula proportion, the water that adds 10 times of volumes, regulate pH to 9 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in 60 ℃ of water-baths of constant temperature, the water that again adds 4-8 times of volume in the precipitation extracts, centrifugal collection supernatant mixes rear 60 ℃ of concentrating under reduced pressure, and 4 ℃ of 70% ethanol that add 0.3 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(6) the above-mentioned Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Rhizoma Dioscoreae extract are mixed.
(7) with said mixture and 200g starch, the 20g polyvidone mixes, and adopts existing pressed-disc technique, makes tablet.
Embodiment 3
The dyspeptic pharmaceutical composition of the treatment that present embodiment is enumerated is comprised of the medicinal raw material of following weight: Radix Aucklandiae 10g, Endothelium Corneum Gigeriae Galli 2g, Fructus Hordei Germinatus 3g, Fructus Setariae Germinatus 5g, Rhizoma Dioscoreae 1g.
Above-mentioned medicinal raw material is prepared into capsule, and preparation method is as follows:
(1) gets Radix Aucklandiae medical material by embodiment 3 formula proportion, add 55 ℃ of lixiviates of ethanol of 75% 3 times of 10 times of volumes, each 1.5 hours.Collect merge extractive liquid, and concentrated, drying gets Radix Aucklandiae extract.
(2) get the Endothelium Corneum Gigeriae Galli medical material by embodiment 3 formula proportion, rub, add 10 times of volume water, regulate pH to 12 with 40%NaOH, 50 degrees centigrade of heating 3h filter collection filtrate, and filtering residue is repeated above operation 1 time, collect filtrate and also merge.Filtrate after the merging is transferred pH to 4 with 2molL-1 hydrochloric acid, and is centrifugal, gets precipitation.With ether or dehydrated alcohol dehydration, natural drying 48h gets Endothelium Corneum Gigeriae Galli extract to precipitate again.
(3) get Fructus Hordei Germinatus by embodiment 3 formula proportion, pulverize, process with mechanical lapping, add the water of 10 times of volumes at 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid,, get supernatant after centrifugal, add ethanol to 60% and precipitate the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Hordei Germinatus extract.
(4) get Fructus Setariae Germinatus by embodiment 3 formula proportion, pulverize, process with mechanical lapping, add the water of 10 times of volumes at 35 ℃ of lower extractions 2 times, each 3h, merge extractive liquid,, get supernatant after centrifugal, add ethanol to 60% and precipitate the centrifugal supernatant of removing, collecting precipitation, vacuum lyophilization gets Fructus Setariae Germinatus extract.
(5) get the Rhizoma Dioscoreae defibrination by embodiment 3 formula proportion, the water that adds 10 times of volumes, regulate pH to 9 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in 60 ℃ of water-baths of constant temperature, the water that again adds 4-8 times of volume in the precipitation extracts, centrifugal collection supernatant mixes rear 60 ℃ of concentrating under reduced pressure, and 4 ℃ of 70% ethanol that add 0.3 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(6) the above-mentioned Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Rhizoma Dioscoreae extract are mixed.
(7) with said mixture and starch 80g mix homogeneously, adopt capsules preparation technique, make the pharmaceutical composition of capsule.
The curative effect of medicine of the present invention and advantage thereof are proved by following clinical trial:
1, experiment crowd:
Be divided into A, B, three experimental grouies of C by disease symptom:
2, drug administration method:
The dyspeptic medicine for the treatment of that the oral embodiment of the invention 3 makes, every day is early, middle and late respectively to take 2 after the meal, serve on 5 days.
3, efficacy evaluation:
Symptom is invalid without alleviation or DeGrain; Symptom disappears substantially or complete obiteration is effectively.
4, therapeutic effect:
Claims (4)
1. treat dyspeptic pharmaceutical composition, the medicament that it is mainly made by the raw material of following weight parts proportioning for one kind:
Radix Aucklandiae 10-25 part, Endothelium Corneum Gigeriae Galli 1-15 part, Fructus Hordei Germinatus 1-15 part, Fructus Setariae Germinatus 1-15 part, Rhizoma Dioscoreae 1-20 part.
2. pharmaceutical composition according to claim 1, it is characterized in that: the weight portion proportioning of described each crude drug is:
Radix Aucklandiae 10-20 part, Endothelium Corneum Gigeriae Galli 2-12 part, Fructus Hordei Germinatus 2-12 part, Fructus Setariae Germinatus 2-12 part, Rhizoma Dioscoreae 5-15 part.
3. pharmaceutical composition according to claim 2, it is characterized in that: the weight portion proportioning of described each crude drug is:
Radix Aucklandiae 12-16 part, Endothelium Corneum Gigeriae Galli 4-8 part, Fructus Hordei Germinatus 4-8 part, Fructus Setariae Germinatus 4-8 part, Rhizoma Dioscoreae 8-12 part.
4. pharmaceutical composition according to claim 3, it is characterized in that: the weight portion proportioning of described each crude drug is:
15 parts of the Radix Aucklandiae, 6 parts of Endothelium Corneum Gigeriae Galli, 6 parts in Fructus Hordei Germinatus, 6 parts of Fructus Setariae Germinatuss, 10 parts of Rhizoma Dioscoreaes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104279325A CN102940818A (en) | 2012-10-31 | 2012-10-31 | Medicine composition for treating dyspepsia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104279325A CN102940818A (en) | 2012-10-31 | 2012-10-31 | Medicine composition for treating dyspepsia |
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| CN102940818A true CN102940818A (en) | 2013-02-27 |
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| CN2012104279325A Pending CN102940818A (en) | 2012-10-31 | 2012-10-31 | Medicine composition for treating dyspepsia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692808A (en) * | 2017-01-23 | 2017-05-24 | 四川叁仁堂健康科技有限公司 | Spleen and stomach-nourishing, digestion-promoting and stubborn stool-removing traditional Chinese medicine composition and use method |
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| CN1221615A (en) * | 1997-12-30 | 1999-07-07 | 陈辉 | Instant powder for strengthening stomach and relieving dyspepsia |
| CN1915086A (en) * | 2006-06-16 | 2007-02-21 | 李永新 | Appetitive stomachic health care food |
| CN102579942A (en) * | 2011-01-05 | 2012-07-18 | 孟青锋 | Preparation method of medicament for treating anorexia |
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2012
- 2012-10-31 CN CN2012104279325A patent/CN102940818A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1221615A (en) * | 1997-12-30 | 1999-07-07 | 陈辉 | Instant powder for strengthening stomach and relieving dyspepsia |
| CN1915086A (en) * | 2006-06-16 | 2007-02-21 | 李永新 | Appetitive stomachic health care food |
| CN102579942A (en) * | 2011-01-05 | 2012-07-18 | 孟青锋 | Preparation method of medicament for treating anorexia |
Non-Patent Citations (1)
| Title |
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| 卢裕武: "健运复元汤治疗功能性消化不良76例", 《中国医药科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692808A (en) * | 2017-01-23 | 2017-05-24 | 四川叁仁堂健康科技有限公司 | Spleen and stomach-nourishing, digestion-promoting and stubborn stool-removing traditional Chinese medicine composition and use method |
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Application publication date: 20130227 |