CN110946967B - Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof Download PDF

Info

Publication number
CN110946967B
CN110946967B CN201911336191.8A CN201911336191A CN110946967B CN 110946967 B CN110946967 B CN 110946967B CN 201911336191 A CN201911336191 A CN 201911336191A CN 110946967 B CN110946967 B CN 110946967B
Authority
CN
China
Prior art keywords
parts
traditional chinese
chinese medicine
preparation
radix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201911336191.8A
Other languages
Chinese (zh)
Other versions
CN110946967A (en
Inventor
蔡林
李宗林
邓正万
杨济铭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affiliated Hospital of North Sichuan Medical College
Original Assignee
Affiliated Hospital of North Sichuan Medical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affiliated Hospital of North Sichuan Medical College filed Critical Affiliated Hospital of North Sichuan Medical College
Priority to CN201911336191.8A priority Critical patent/CN110946967B/en
Publication of CN110946967A publication Critical patent/CN110946967A/en
Application granted granted Critical
Publication of CN110946967B publication Critical patent/CN110946967B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/586—Turtles; Tortoises, e.g. terrapins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/902—Sparganiaceae (Bur-reed family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The invention discloses a traditional Chinese medicine composition for treating hepatic fibrosis, a traditional Chinese medicine preparation and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 15-20 parts of radix bupleuri, 10-15 parts of radix paeoniae alba, 10-15 parts of liquorice, 10-15 parts of fructus aurantii, 10-20 parts of bighead atractylodes rhizome, 10-15 parts of angelica sinensis, 10-15 parts of rhizoma sparganii, 10-15 parts of curcuma zedoary, 20-40 parts of turtle shell, 10-15 parts of safflower carthamus, 10-30 parts of radix rehmanniae, 10-30 parts of medlar, 15-30 parts of caulis spatholobi, 10-15 parts of ginseng and 30-50 parts of astragalus membranaceus. The preparation method of the traditional Chinese medicine preparation comprises the following steps: pulverizing the Chinese medicinal materials, sieving with 80 mesh sieve to obtain medicinal powder, and making into powder or pill. The traditional Chinese medicine prescription preparation can effectively solve the problems that the existing western medicines can not reverse the fibrosis tissues and the existing traditional Chinese medicines are easy to damage liver yin and cause new diseases.

Description

Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating hepatic fibrosis, a traditional Chinese medicine preparation and a preparation method thereof.
Background
The harm of chronic liver disease to human health is increasingly serious, about 1 hundred million hepatitis C virus carriers and 3 hundred million 5 million hepatitis B virus infectors exist all over the world at present, at least 2 million chronic hepatitis B patients exist in our country, and more than 16 million people are killed because chronic hepatitis B is converted into cirrhosis and liver cancer every year.
Hepatic fibrosis is a common pathological process of most chronic liver diseases and is an important link for the evolution of various chronic liver diseases to cirrhosis. The main pathophysiological basis is the massive proliferation of fibrous connective tissues caused by persistent or repeated inflammatory necrosis of liver parenchyma, but the degradation activity is insufficient, so that excessive extracellular matrix deposition is caused, the normal hepatic lobule structure is damaged, and the metabolic function of the liver is influenced. In recent years, the incidence of hepatic fibrosis is high, and if hepatic fibrosis is not treated in time, serious patients will cause cirrhosis, and cirrhosis is one of the common diseases and the main causes of death in clinic, and seriously harms the physical health of Chinese people. It has been shown that if appropriate treatment is given early in the course of the disease, not only can further progression of the disease be prevented, but also hepatic fibrosis can be reversed.
At present, the treatment method of hepatic fibrosis by western medicine is anti-inflammatory, inflammation in the liver is eliminated by taking medicine, and fibrosis aggravation is avoided, but the fibrotic liver tissue cannot be recovered by western medicine. The traditional Chinese medicine mainly has the effects of soothing liver, strengthening spleen and dredging collaterals, and achieves the purpose of treatment by strengthening and activating spleen, regulating liver, promoting blood circulation, removing blood stasis and dredging collaterals. However, most of the traditional Chinese medicines used in the treatment process are spicy and warm and dry, and the traditional Chinese medicines are more likely to damage liver yin after being taken for a long time, thereby causing new diseases.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition for treating hepatic fibrosis, a traditional Chinese medicine preparation and a preparation method thereof, and the traditional Chinese medicine preparation can effectively solve the problems that the existing western medicines cannot reverse the fibrotic tissues and the existing traditional Chinese medicines are easy to damage liver yin and cause new diseases.
In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows:
a traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 15-20 parts of radix bupleuri, 10-15 parts of radix paeoniae alba, 10-15 parts of liquorice, 10-15 parts of fructus aurantii, 10-20 parts of bighead atractylodes rhizome, 10-15 parts of angelica sinensis, 10-15 parts of rhizoma sparganii, 10-15 parts of curcuma zedoary, 20-40 parts of turtle shell, 10-15 parts of safflower carthamus, 10-30 parts of radix rehmanniae, 10-30 parts of medlar, 15-30 parts of caulis spatholobi, 10-15 parts of ginseng and 30-50 parts of astragalus membranaceus.
Further, the paint comprises the following components in parts by weight: 18 parts of radix bupleuri, 12 parts of radix paeoniae alba, 10 parts of liquorice, 10 parts of fructus aurantii, 10 parts of bighead atractylodes rhizome, 10 parts of angelica sinensis, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of turtle shell, 12 parts of safflower, 20 parts of radix rehmanniae, 20 parts of medlar, 20 parts of caulis spatholobi, 12 parts of ginseng and 40 parts of astragalus membranaceus.
The beneficial effects produced by adopting the scheme are as follows: the formula is a basic formula for treating hepatic fibrosis, and has a good treatment effect on hepatic fibrosis.
Further, the composition also comprises the following components in parts by weight: 8-12 parts of radix rehmanniae, 15-30 parts of uncaria, 10-30 parts of scutellaria baicalensis and 20-30 parts of radix cyathulae.
Further, the composition also comprises the following components in parts by weight: 10 parts of radix rehmanniae, 20 parts of uncaria, 15 parts of scutellaria and 20 parts of radix cyathulae.
The beneficial effects produced by adopting the scheme are as follows: the above formula is mainly suitable for patients with hyperactivity of liver yang.
Further, the composition also comprises the following components in parts by weight: 10-50 parts of prepared aconite, 5-10 parts of fennel and 10-15 parts of combined spicebush root.
Further, the composition also comprises the following components in parts by weight: 30 parts of prepared aconite, 5 parts of fennel and 10 parts of combined spicebush root.
The beneficial effects produced by adopting the scheme are as follows: the above formula is mainly suitable for patients with yang deficiency, aversion to cold and cold limbs.
Further, the composition also comprises the following components in parts by weight: 30-60 parts of oriental wormwood, 10-20 parts of cape jasmine, 10-15 parts of scutellaria baicalensis and 30-60 parts of desmodium.
Further, the composition also comprises the following components in parts by weight: 40 parts of oriental wormwood, 15 parts of cape jasmine, 10 parts of scutellaria baicalensis and 40 parts of desmodium.
The beneficial effects produced by adopting the scheme are as follows: the formula is mainly suitable for patients with serious dampness and heat.
Further, the composition also comprises the following components in parts by weight: 15-20 parts of white peony root, 20-40 parts of corydalis tuber and 12-15 parts of curcuma aromatica.
Further, the composition also comprises the following components in parts by weight: 15 parts of white peony root, 30 parts of corydalis tuber and 15 parts of curcuma aromatica.
The beneficial effects produced by adopting the scheme are as follows: the formula is mainly suitable for patients with liver pain and discomfort.
A traditional Chinese medicine preparation for treating hepatic fibrosis comprises the traditional Chinese medicine composition.
The dosage form of the traditional Chinese medicine preparation for treating hepatic fibrosis is powder.
The preparation method of the traditional Chinese medicine preparation for treating hepatic fibrosis comprises the following steps: pulverizing the materials in the formula, sieving with 80 mesh sieve to obtain medicinal powder, and making into powder or pill.
The beneficial effects produced by the invention are as follows:
in the formula, the radix bupleuri and the turtle shell are used as monarch drugs for cooperation, the radix bupleuri and the turtle shell are used for softening the soft nails and dissipating stagnation, the rhizoma sparganii, the rhizoma zedoariae, the safflower and the caulis spatholobi are used for activating blood and dissolving stasis in cooperation, the rhizoma atractylodis macrocephalae and the fructus aurantii are used for tonifying spleen and regulating qi, and the ginseng, the radix astragali and the liquorice are used for tonifying qi and regulating qi to assist blood circulation; chinese angelica and white peony root have the effects of nourishing blood and liver; the rehmannia root and the medlar nourish kidney yin, the angelica, the white paeony root, the rehmannia root and the medlar are used for jointly tonifying liver and kidney, the recipe mainly takes soothing liver and softening liver as main material and is assisted by promoting blood circulation and removing blood stasis, and liver and kidney tonifying yin and liver and kidney nourishing body are used for assisting, the aim of treating hepatic fibrosis is realized through complete formula compatibility, and after long-term administration, the fibrotic tissue can be recovered. The medicine property of the formula is mild, the problem of liver yin damage does not exist after long-term administration, and new diseases cannot be caused.
Detailed Description
Example 1
A traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 15 parts of radix bupleuri, 10 parts of radix paeoniae alba, 10 parts of liquorice, 10 parts of fructus aurantii, 10 parts of bighead atractylodes rhizome, 10 parts of angelica sinensis, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 20 parts of turtle shell, 10 parts of safflower, 30 parts of radix rehmanniae, 10 parts of medlar, 15 parts of caulis spatholobi, 10 parts of ginseng, 30 parts of radix astragali, 20 parts of uncaria, 15 parts of radix scutellariae and 20 parts of radix cyathulae.
A Chinese medicinal preparation for treating hepatic fibrosis is in the form of powder, and the preparation method comprises the following steps: the components in the formula are crushed and sieved by a 80-mesh sieve to prepare the composition.
Example 2
A traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 20 parts of radix bupleuri, 15 parts of radix paeoniae alba, 15 parts of liquorice, 15 parts of fructus aurantii, 20 parts of bighead atractylodes rhizome, 15 parts of angelica sinensis, 15 parts of rhizoma sparganii, 15 parts of curcuma zedoary, 40 parts of turtle shell, 15 parts of safflower, 30 parts of radix rehmanniae, 30 parts of medlar, 30 parts of caulis spatholobi, 15 parts of ginseng, 50 parts of radix astragali, 30 parts of prepared aconite, 5 parts of fennel and 10 parts of radix linderae.
A Chinese medicinal preparation for treating hepatic fibrosis is in the form of powder, and the preparation method comprises the following steps: the components in the formula are crushed and sieved by a 80-mesh sieve to prepare the composition.
Example 3
A traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 18 parts of radix bupleuri, 12 parts of radix paeoniae alba, 10 parts of liquorice, 10 parts of fructus aurantii, 10 parts of bighead atractylodes rhizome, 10 parts of angelica sinensis, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of turtle shell, 12 parts of safflower, 20 parts of radix rehmanniae, 20 parts of medlar, 20 parts of caulis spatholobi, 12 parts of ginseng, 40 parts of radix astragali, 40 parts of oriental wormwood, 15 parts of cape jasmine, 10 parts of radix scutellariae and 40 parts of desmodium.
A Chinese medicinal preparation for treating hepatic fibrosis is in the form of powder, and the preparation method comprises the following steps: the components in the formula are crushed and sieved by a 80-mesh sieve to prepare the composition.
Example 4
A traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 16 parts of radix bupleuri, 30 parts of radix paeoniae alba, 12 parts of liquorice, 12 parts of fructus aurantii, 12 parts of bighead atractylodes rhizome, 10 parts of angelica sinensis, 15 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of turtle shell, 13 parts of safflower, 18 parts of radix rehmanniae, 18 parts of medlar, 23 parts of caulis spatholobi, 12 parts of ginseng, 40 parts of radix astragali, 30 parts of rhizoma corydalis and 15 parts of radix curcumae.
A Chinese medicinal preparation for treating hepatic fibrosis is in the form of powder, and the preparation method comprises the following steps: the components in the formula are crushed and sieved by a 80-mesh sieve to prepare the composition.
Comparative example 1
A traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 12 parts of white peony root, 10 parts of liquorice, 10 parts of fructus aurantii, 10 parts of bighead atractylodes rhizome, 10 parts of angelica, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of turtle shell, 20 parts of radix rehmanniae, 20 parts of medlar, 12 parts of ginseng, 40 parts of astragalus mongholicus, 40 parts of oriental wormwood, 15 parts of gardenia, 10 parts of scutellaria baicalensis and 40 parts of desmodium.
A Chinese medicinal preparation for treating hepatic fibrosis is in the form of powder, and the preparation method comprises the following steps: the components in the formula are crushed and sieved by a 80-mesh sieve to prepare the composition.
Comparative example 2
A traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 18 parts of radix bupleuri, 12 parts of radix paeoniae alba, 10 parts of liquorice, 10 parts of fructus aurantii, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of turtle shell, 12 parts of safflower, 20 parts of medlar, 20 parts of caulis spatholobi, 12 parts of ginseng, 40 parts of oriental wormwood, 15 parts of gardenia, 10 parts of radix scutellariae and 40 parts of herba lysimachiae.
A Chinese medicinal preparation for treating hepatic fibrosis is in the form of powder, and the preparation method comprises the following steps: the components in the formula are crushed and sieved by a 80-mesh sieve to prepare the composition.
Comparative example 3
A traditional Chinese medicine composition for treating hepatic fibrosis comprises the following components in parts by weight: 18 parts of rhizoma cyperi, 12 parts of radix paeoniae alba, 10 parts of liquorice, 10 parts of fructus aurantii, 10 parts of bighead atractylodes rhizome, 10 parts of angelica sinensis, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of oyster, 12 parts of safflower, 20 parts of radix rehmanniae, 20 parts of medlar, 20 parts of caulis spatholobi, 12 parts of ginseng, 40 parts of astragalus membranaceus, 40 parts of oriental wormwood, 15 parts of cape jasmine, 10 parts of scutellaria baicalensis and 40 parts of desmodium.
A Chinese medicinal preparation for treating hepatic fibrosis is in the form of powder, and the preparation method comprises the following steps: the components in the formula are crushed and sieved by a 80-mesh sieve to prepare the composition.
Test examples
The method comprises the steps of searching 35 patients with confirmed liver fibrosis, dividing the patients into 7 groups of 5 persons, wherein the patients in the first group are accompanied by symptoms of hyperactivity of liver yang, the patients in the second group are accompanied by symptoms of yang deficiency and chilly, the patients in the third group are accompanied by symptoms of damp heat, the patients in the fourth group are accompanied by symptoms of dull pain of liver area, and the patients in the fifth, sixth and seventh groups are also accompanied by symptoms of hyperactivity of liver yang, respectively taking the traditional Chinese medicine preparation in the examples 1-4 and the comparative examples 1-3 for seven times a day, wherein each time the dosage is equal to 20g of the original medicine material, continuously taking the traditional Chinese medicine preparation for 7 months, then examining the bodies of the patients again, observing and recording the change of the livers of the patients, and particularly finding the result in the table 1.
Table 1: liver change table of patient after taking medicine
Figure BDA0002330985990000061
Figure BDA0002330985990000071
As can be seen from the above table, after the Chinese medicinal preparation of the embodiments 1 to 4 of the invention is taken, the hepatic fibrosis grade of the patient is obviously reversed, the reversing degree is greater than that of the comparative examples 1 to 3, and the effective rate of the Chinese medicinal preparation of the embodiments 1 to 4 is also greater than that of the comparative examples 1 to 3. After the traditional Chinese medicine preparation is taken, other uncomfortable symptoms do not appear on patients.

Claims (4)

1. The traditional Chinese medicine composition for treating hepatic fibrosis is characterized by comprising the following components in parts by weight: 18 parts of radix bupleuri, 12 parts of radix paeoniae alba, 10 parts of liquorice, 10 parts of fructus aurantii, 10 parts of bighead atractylodes rhizome, 10 parts of angelica sinensis, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of turtle shell, 12 parts of safflower, 20 parts of radix rehmanniae, 20 parts of medlar, 20 parts of caulis spatholobi, 12 parts of ginseng, 40 parts of radix astragali, 40 parts of oriental wormwood, 15 parts of cape jasmine, 10 parts of radix scutellariae and 40 parts of desmodium.
2. The traditional Chinese medicine composition for treating hepatic fibrosis is characterized by comprising the following components in parts by weight: 16 parts of radix bupleuri, 30 parts of radix paeoniae alba, 12 parts of liquorice, 12 parts of fructus aurantii, 12 parts of bighead atractylodes rhizome, 10 parts of angelica sinensis, 15 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 30 parts of turtle shell, 13 parts of safflower, 18 parts of radix rehmanniae, 18 parts of medlar, 23 parts of caulis spatholobi, 12 parts of ginseng, 40 parts of radix astragali, 30 parts of rhizoma corydalis and 15 parts of radix curcumae.
3. A traditional Chinese medicine preparation for treating hepatic fibrosis, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1-2, wherein the preparation is in the form of powder or pills.
4. The method for preparing a Chinese medicinal preparation for treating hepatic fibrosis according to claim 3, comprising the following steps: pulverizing the materials in the formula, sieving with 80 mesh sieve to obtain medicinal powder, and making into powder or pill.
CN201911336191.8A 2019-12-23 2019-12-23 Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof Active CN110946967B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911336191.8A CN110946967B (en) 2019-12-23 2019-12-23 Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911336191.8A CN110946967B (en) 2019-12-23 2019-12-23 Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof

Publications (2)

Publication Number Publication Date
CN110946967A CN110946967A (en) 2020-04-03
CN110946967B true CN110946967B (en) 2021-11-02

Family

ID=69983391

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201911336191.8A Active CN110946967B (en) 2019-12-23 2019-12-23 Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof

Country Status (1)

Country Link
CN (1) CN110946967B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109248305A (en) * 2018-12-06 2019-01-22 深圳市龙岗区中医院 A kind of Chinese medicine composition and preparation method thereof for treating liver fibrosis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109700976B (en) * 2019-03-13 2021-07-13 广西中医药大学附属瑞康医院 Qie and zedoary liver-protecting paste

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109248305A (en) * 2018-12-06 2019-01-22 深圳市龙岗区中医院 A kind of Chinese medicine composition and preparation method thereof for treating liver fibrosis

Also Published As

Publication number Publication date
CN110946967A (en) 2020-04-03

Similar Documents

Publication Publication Date Title
CN1315525C (en) Chinese traditional medicine for treating breast disease and preparing technique
ZA200302647B (en) Novel medicinal herbal composition for treating liver diseases.
CN102579945A (en) Traditional Chinese medicinal composition for treating sicca syndrome
CN102805840B (en) Complex anti-tumor traditional Chinese medicine preparation
CN101569739B (en) Traditional Chinese medicine composition for treating cholecystitis and preparation method thereof
CN107789484B (en) Traditional Chinese medicine composition for treating irregular menstruation and preparation method thereof
CN104958448A (en) Medicine for treating puerperal infection
CN104383461A (en) Chinese medicinal composition for treating insomnia due to blood stasis
CN110946967B (en) Traditional Chinese medicine composition for treating hepatic fibrosis, traditional Chinese medicine preparation and preparation method thereof
CN103768449A (en) Medicine for treating psoriasis
CN108743887A (en) Treat the Chinese medicine composition and preparation method thereof of liver fibrosis and hepatic sclerosis
CN1060379C (en) Chines medicine for treating vitiligo and preparation method thereof
CN106334171A (en) Traditional Chinese medicine preparation for repairing liver damage and preparation method thereof
CN104771513A (en) Traditional Chinese medicine composition for treating cholecystitis
CN1814153A (en) Medicine composition for preventing and treating breast cancer and preparing method
CN110787227A (en) Chinese herbal medicine prescription for treating liver disease
CN110237171B (en) Medicine composition for femoral head necrosis and preparation method and application thereof
CN108567926B (en) Traditional Chinese medicine composition for treating blood stasis collateral blocking type autoimmune hepatitis and preparation method thereof
CN104547875A (en) Traditional Chinese medicine for treating arteries and veins stasis type chest stuffiness and pain
CN112972600B (en) Pharmaceutical composition for treating peripheral facial paralysis in neurology department and preparation method of pharmaceutical composition
CN1311863C (en) Chinese traditional medicine for treating hepatopathy and gallbladder disorder and process for preparing the same
CN105832944B (en) A kind of Chinese medicine composition for treating ALS and its Babu plaster
CN105056113A (en) Traditional Chinese medicine for oral administration and external application for treating liver cancer
CN112569326A (en) Traditional Chinese medicine composition for treating costalgia and preparation method thereof
CN105535366A (en) Method for preparing traditional Chinese medicine composition granules for treating jaundice hepatitis

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant