CN110946921A - Traditional Chinese medicine for relieving side effects of glucocorticoid medicaments - Google Patents
Traditional Chinese medicine for relieving side effects of glucocorticoid medicaments Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for relieving side effects of glucocorticoid medicaments, which is prepared from the following raw material medicaments in part by weight: 10-30 parts of buffalo horn, 10-30 parts of radix rehmanniae recen, 5-20 parts of herba epimedii and 3-12 parts of liquorice. The invention has the advantages that: in the traditional Chinese medicine components, the buffalo horn has the functions of clearing away heat and toxic material, cooling blood and arresting convulsion, the dried rehmannia root has the functions of clearing away heat and cooling blood, nourishing yin and promoting the production of body fluid, the epimedium has the effects of tonifying kidney yang, strengthening muscles and bones and dispelling wind and dampness, the liquorice has the effects of tonifying spleen and qi, relieving cough and eliminating phlegm, relieving spasm and relieving pain and harmonizing medicine properties; the medicines are used together to play the effects of clearing heat, purging intense fire, tonifying qi, benefiting less fire, relieving the disadvantages of intense fire and eating qi, effectively reducing the side effect of glucocorticoid, helping glucocorticoid to be smoothly stopped, reducing the total treatment cost of patients, improving the medication compliance and increasing the treatment confidence of patients.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine for relieving side effects of glucocorticoid medicaments.
Background
Glucocorticoids (GCs) are steroid hormones secreted by the adrenal cortex fasciculate band, are classical steroid structural hormones consisting of 21 carbon atoms, mainly comprise cortisol, also called as adrenocortical hormone, have strong effects of resisting inflammation, shock, allergy, immunosuppression and the like, are widely applied clinically, and are particularly used for treating respiratory diseases, rheumatic immune diseases, dermatological diseases, severe diseases and the like. Glucocorticoids are involved in glycoprotein, fat, water salt metabolism and other processes, and related side effects such as hypercortisolism, appetite increase, weight gain, water sodium retention, hypertension, steroid diabetes, osteoporosis, hypokalemia, peptic ulcer, mental symptom induction, femoral head necrosis, eye disease induction, adrenal insufficiency, post-hormone-withdrawal syndrome, rebound phenomenon, difficult wound healing, infection induction or aggravation can be generated in the medication process. At present, the serious adverse reactions of glucocorticoid medicaments, which are caused by difficult disease control, rebound phenomenon after hormone withdrawal, insufficient patient compliance and other reasons, are avoided by multiple methods of strictly controlling indications, eliminating contraindications, adjusting the dosage and frequency of administration, selecting different glucocorticoid medicaments, shortening the treatment course as much as possible and the like clinically, so that the side effects in the process of clinically using the glucocorticoid are obvious.
Glucocorticoid is a hormone secreted by adrenal cortex, has a certain day and night secretion rule, and has the lowest level in the morning and gradually increased later, and the peak is reached at 8 am, so that the activity and metabolism of the organism are promoted. The traditional Chinese medicine considers that the kidney is the congenital foundation, the physiological property of glucocorticoid belongs to yang, the physiological function has the effect of generating qi by a lack of fire, and the glucocorticoid plays an important role in regulating the development, growth, metabolism, immune function and the like of a human body and maintains the normal activity of the human body. After exogenous glucocorticoid is supplemented, yang heat is excessive, healthy qi of a human body is damaged, normal activities of the body are influenced, the body has the appearance of 'strong fire and eating qi', and heat clearing, fire purging and strong fire strengthening, qi tonifying and fire reducing are performed for syndrome differentiation treatment to maintain normal activities of the body. Therefore, the invention is urgently needed to invent the traditional Chinese medicine which has strict compatibility, high safety, low side effect, low treatment cost and high patient compliance and can effectively relieve the side effect of glucocorticoid medicaments.
Disclosure of Invention
The invention aims to provide the traditional Chinese medicine which has strict compatibility, high safety, low side effect, low treatment cost and high patient compliance and can effectively relieve the side effect of glucocorticoid medicaments.
In order to achieve the purpose, the invention adopts the following technical scheme: a traditional Chinese medicine for relieving the side effect of glucocorticoid medicaments is prepared from the following raw material medicaments in part by weight: 10-30 parts of buffalo horn, 10-30 parts of radix rehmanniae recen, 5-20 parts of herba epimedii and 3-12 parts of liquorice.
Further, the traditional Chinese medicine for relieving the side effect of the glucocorticoid medicaments comprises: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20 parts of buffalo horn, 18 parts of radix rehmanniae recen, 12 parts of herba epimedii and 6 parts of liquorice.
Through the implementation of the technical scheme, the invention has the beneficial effects that: in the traditional Chinese medicine components, the buffalo horn is cold in nature and bitter in taste, enters heart channel and liver channel, has the effects of clearing heat and removing toxicity, cooling blood and arresting convulsion, and is the monarch drug; the dried rehmannia root is cold in nature and sweet in taste, enters heart channel, liver channel and kidney channel, has the effects of clearing heat and cooling blood, nourishing yin and promoting the production of body fluid and serves as a minister; the herba epimedii is warm in nature, pungent and sweet in taste, enters liver and kidney meridians, has the effects of tonifying kidney yang, strengthening muscles and bones and dispelling wind and dampness, and is used as an adjuvant; the liquorice has moderate nature and sweet taste, enters heart channel, stomach channel, spleen channel and lung channel, has the effects of tonifying spleen and qi, relieving cough and eliminating phlegm, relieving spasm and relieving pain and harmonizing medicine property, and is used as a guide; the medicines are used together to play the functions of clearing heat, purging intense fire, tonifying qi, benefiting deficiency fire, relieving the disadvantages of intense fire and qi; the medicines are used together to play the functions of clearing heat, purging intense fire, tonifying qi, benefiting deficiency fire, relieving the disadvantages of intense fire and qi; the traditional Chinese medicine has strict compatibility, is prepared from the raw materials with high quality, treats both principal and secondary aspects of diseases, can effectively reduce the side effect of glucocorticoid medicaments, is beneficial to the better playing of the curative effect of the glucocorticoid medicaments, quickly and effectively controls the disease condition, reduces the total dosage of the glucocorticoid medicaments in the course of disease of a patient, shortens the course of treatment of the glucocorticoid medicaments, is beneficial to the smooth reduction of the glucocorticoid medicaments, can effectively avoid the side effects of glucocorticoid digestion reaction, infection and the like, reduces the risk of serious side effect of the patient, has high safety and low side effect, reduces the total treatment cost of the patient, improves the medication compliance of the patient, and increases the treatment confidence of the patient.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
The traditional Chinese medicine for relieving the side effect of the glucocorticoid medicaments is prepared from the following raw material medicaments in parts by weight: 10-30 parts of buffalo horn, 10-30 parts of radix rehmanniae recen, 5-20 parts of herba epimedii and 3-12 parts of liquorice, wherein the preferable parts by weight are as follows: 20 parts of buffalo horn, 18 parts of radix rehmanniae recen, 12 parts of herba epimedii and 6 parts of liquorice are decocted with water for two times per day for oral administration, and the decoction can prevent wind cold, free emotion, avoid eating fat, sweet, thick and greasy food and avoid eating spicy stimulation food during the administration period;
the invention has the advantages that: in the traditional Chinese medicine components, the buffalo horn is cold in nature and bitter in taste, enters heart channel and liver channel, has the effects of clearing heat and removing toxicity, cooling blood and arresting convulsion, and is the monarch drug; the dried rehmannia root is cold in nature and sweet in taste, enters heart channel, liver channel and kidney channel, has the effects of clearing heat and cooling blood, nourishing yin and promoting the production of body fluid and serves as a minister; the herba epimedii is warm in nature, pungent and sweet in taste, enters liver and kidney meridians, has the effects of tonifying kidney yang, strengthening muscles and bones and dispelling wind and dampness, and is used as an adjuvant; the liquorice has moderate nature and sweet taste, enters heart channel, stomach channel, spleen channel and lung channel, has the effects of tonifying spleen and qi, relieving cough and eliminating phlegm, relieving spasm and relieving pain and harmonizing medicine property, and is used as a guide; the medicines are used together to play the functions of clearing heat, purging intense fire, tonifying qi, benefiting deficiency fire, relieving the disadvantages of intense fire and qi; the medicines are used together to play the functions of clearing heat, purging intense fire, tonifying qi, benefiting deficiency fire, relieving the disadvantages of intense fire and qi; more modern pharmacological research shows that the buffalo horn has the functions of calming, resisting convulsion, resisting inflammation, resisting infection, protecting liver and the like; radix rehmanniae has effects of regulating immunity, resisting allergy, protecting cardiovascular system, resisting fungi, and resisting inflammation; herba Epimedii has effects in regulating hypothalamus-pituitary-gonadal axis function, regulating immunity, and increasing coronary blood flow; the Glycyrrhrizae radix has adrenocortical hormone effect, and has antiinflammatory, antiulcer, antiallergic, antibacterial, immunity regulating, and antioxidant effects; the traditional Chinese medicine has strict compatibility, is prepared from the raw materials with the Chinese herbal medicines, treats both principal and secondary aspects of diseases, can effectively reduce the side effect of glucocorticoid medicines, is beneficial to better exerting the curative effect of the glucocorticoid medicines, quickly and effectively controls the disease condition, reduces the total dosage of the glucocorticoid medicines in the course of the patient, shortens the course of treatment of the glucocorticoid medicines, is beneficial to smooth reduction of the glucocorticoid medicines, can effectively avoid the side effects of glucocorticoid digestion reaction, infection and the like, reduces the risk of serious side effect of the patient, has high use safety, reduces the total treatment cost of the patient, improves the medication compliance of the patient, and increases the treatment confidence of the patient.
The beneficial effects of the drug of the invention are illustrated by clinical trials as follows:
1. the source of the cases is: to confirm the clinical efficacy of the prescription, 90 patients treated with glucocorticoid drugs were selected in the traditional Chinese medicine hospital of Zhang hong Kong City.
2. The treatment method comprises the following steps: the decoction of the patent medicine is taken according to a conventional method, one dose is taken every day, each dose is 400ml water decocted to obtain 200ml decoction, the decoction is taken twice in the morning and at night, 4 weeks are taken as 1 treatment course, spicy food and wine are forbidden during the treatment period, and fatigue, cold and the like are avoided.
3. Clinical observation of the therapeutic effect standard: according to the guiding principle of clinical research of new traditional Chinese medicines in 2002: examination of the book of changes
① is significant in that the integral of the two times before and after the treatment of the patient is reduced by more than or equal to 70%.
② is effective in that the integral of the two times before and after patient treatment is reduced by more than or equal to 50%.
③ improved the reduction in the score of the patient between the two times before and after treatment was ≥ 20%.
④ is ineffective, the integral of the two times before and after limb treatment is reduced by < 20%.
Note: calculation formula (nimodipine method): [ (pre-treatment integral-post-treatment integral) ÷ pre-treatment integral ] × 100%.
4. The observation results of the curative effect are as follows: 29 cases of significant effect, 43 cases of effect, 10 improvement cases and 8 cases of ineffectiveness, and the total effective rate is 80%; the prescription can effectively reduce the side effect of glucocorticoid, is beneficial to smooth reduction of glucocorticoid, reduces the total treatment cost of patients, improves the medication compliance, increases the treatment confidence of patients, and is worthy of clinical popularization.
To give an example of only two specific clinical classic cases, the following are specified:
case 1: the medicine is suitable for male, the age of 63 is old, the history of rheumatoid arthritis is more than 5 years, the medicine is regularly taken before 4 months, the methotrexate is 10mgqw, the sulfasalazine is 0.75gbid and the prednisone acetate is 15mgqd, the prednisone acetate is reduced to 5mgqd before 2 months, stomach discomfort and burning sensation exist, joint swelling and pain repeatedly occur after the prednisone acetate is stopped, 2019-03-15 diagnosis is carried out after clinic visit of the family, the prednisone acetate is stopped after the Chinese medicine preparation 15 of the invention is taken, the joint swelling and pain is not repeated, and the stomach discomfort and burning sensation are obviously improved.
Case 2: the medicine is suitable for male, 42 years old, has a gout history of more than 3 years, has frequent attack, has 1 attack every 1-2 months, is statically pushed by 5mg of dexamethasone for 5 days, is changed into prednisone acetate oral anti-inflammatory therapy, has repeated attack of joint swelling and pain after being reduced, has 3 times of excrement occult blood (+), monitors 162/94mmHg of the highest blood pressure, 2019-05-23, treats the department clinic due to the 'multiple joint sudden swelling and pain for 2 days', gradually reduces the weight after being given 5mg of dexamethasone for 4 days, then changes into prednisone acetate 15mgqd, gradually reduces the weight to 3 weeks, and stops taking the medicine preparation 28 in the invention in combination. After prednisone acetate is stopped, joint swelling and pain are not repeated, the systolic pressure is 130-140 mmHg, and the diastolic pressure is 80-90 mmHg.
Claims (2)
1. A traditional Chinese medicine for relieving the side effect of glucocorticoid medicaments is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 10-30 parts of buffalo horn, 10-30 parts of radix rehmanniae recen, 5-20 parts of herba epimedii and 3-12 parts of liquorice.
2. The traditional Chinese medicine for relieving the side effect of the glucocorticoid medicine, according to the claim 1, is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20 parts of buffalo horn, 18 parts of radix rehmanniae recen, 12 parts of herba epimedii and 6 parts of liquorice.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911146479.9A CN110946921A (en) | 2019-11-21 | 2019-11-21 | Traditional Chinese medicine for relieving side effects of glucocorticoid medicaments |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733244A (en) * | 2005-08-31 | 2006-02-15 | 上海新药研究开发中心 | Chinese traditional medicine composition for relieving side effects of hormones |
| CN101966254A (en) * | 2010-10-08 | 2011-02-09 | 河南中医学院 | Application of raw rehmannia aqueous extract in preparing medicines for treating woman climacteric syndrome caused by hyposecretion of in-vivo female hormones |
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2019
- 2019-11-21 CN CN201911146479.9A patent/CN110946921A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733244A (en) * | 2005-08-31 | 2006-02-15 | 上海新药研究开发中心 | Chinese traditional medicine composition for relieving side effects of hormones |
| CN101966254A (en) * | 2010-10-08 | 2011-02-09 | 河南中医学院 | Application of raw rehmannia aqueous extract in preparing medicines for treating woman climacteric syndrome caused by hyposecretion of in-vivo female hormones |
Non-Patent Citations (1)
| Title |
|---|
| 张云璧；等: "犀角(水牛角)地黄汤对急性皮炎及变态反应性皮炎动物模型作用的实验研究", 《中国实验方剂学杂志》 * |
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