CN110946660B - Adjustable double-hole core inserting needle clamping device and stereotaxic apparatus comprising same - Google Patents
Adjustable double-hole core inserting needle clamping device and stereotaxic apparatus comprising same Download PDFInfo
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- CN110946660B CN110946660B CN201911400761.5A CN201911400761A CN110946660B CN 110946660 B CN110946660 B CN 110946660B CN 201911400761 A CN201911400761 A CN 201911400761A CN 110946660 B CN110946660 B CN 110946660B
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Abstract
The utility model provides a diplopore lock pin needle clamping device with adjustable, includes the fixed arm, the lower extreme of fixed arm is fixed type lock pin needle centre gripping arm, the lower extreme of fixed type lock pin needle centre gripping arm is provided with the first blind hole that is used for centre gripping lock pin needle, one side of fixed arm is provided with the scale, the scale with the fixed arm is perpendicular, the scale include the blade with gliding vernier on the scale, the lower extreme of vernier is provided with removal type lock pin needle centre gripping arm, the lower extreme of removal type lock pin needle centre gripping arm is provided with the second blind hole that is used for centre gripping lock pin needle. The invention can simplify the operation steps and shorten the operation time.
Description
Technical Field
The invention belongs to the technical field of neurology and particularly relates to an adjustable double-hole core inserting needle clamping device and a stereotaxic apparatus comprising the same.
Background
With the acceleration of life rhythm and the aging of population structure, the incidence of neuropsychiatric diseases is continuously increased, which not only increases the burden of patients and society, but also brings great challenges to the treatment and research of mental diseases. In this context, brain science has become one of the hot spots of international scientific research today. In 2013, the european union starts the brain engineering, and subsequently, the united states and the china also start corresponding brain research plans according to respective national conditions, national policies and social requirements, aiming at meeting some urgent social requirements, such as improvement of the brain health of people and development of new technologies, by utilizing basic research results of brain science. With the implementation of large brain programs, a new round of brain science research is marked.
One of the core problems in neuroscience research is how do neurons in the brain and their constituent neural circuits process information, modulate cognitive and driving behaviors? In order to understand the neural mechanisms of behavior from the neuron or neural circuit level, it is necessary to manipulate or observe the activity of the neuron/neural circuit while detecting causal relationships of activity changes to behavior. Optogenetics (optogenetics) is a technology combining optics (optics) and genetics (genetics) to express specific ion channels or GPCRs by gene manipulation techniques to transfer light sensing genes into specific types of neurons in the nervous system. Neurons are accurately manipulated in real time at the millisecond level by light of corresponding wavelengths to study their physiological functions. Through the optogenetic technology, the activity of specific types of neurons can be accurately controlled in living animals, even in brains, spinal cords, peripheral nerves and the like of freely moving animals. Optogenetic technology has become an important research tool in the field of neuroscience in the field of analytical neural circuit technology with its high temporal, spatial resolution and cell specificity. The technology is widely applied in the field of neuroscience at present, and can be used for treating various neurological and mental diseases, such as Parkinson's disease, Alzheimer's disease, spinal cord injury, schizophrenia and the like.
With the continuous expansion and deepening of the research field of optogenetics, products widely used in experiments at present comprise: a super-miniature wireless optogenetic system, a wired optogenetic system, an optical fiber recording system; in any product, there is a key step in the process of applying optogenetic technology, that is, guiding optical fiber into brain by surgical means, and controlling the photosensitive channel by controlling laser (fig. 1 a). The optical fiber implantation brain region sites are commonly distributed, namely a single brain region, the same brain region on both sides, different brain regions on one side and different brain regions on both sides;
at present, the optical fiber is implanted by adopting a core inserting needle holder (figure 1c) which can be connected with a stereotaxic instrument, and the core inserting needle can be clamped by rotating a sleeve clockwise, so that the optical fiber is accurately embedded into a corresponding nerve nucleus. The insertion needle is then fixed to the skull using dental cement and screws. The core needle may be connected to an optical fiber through a ceramic cannula to transmit light into a specific nerve nucleus. After the operation is finished, the sleeve barrel is rotated anticlockwise, and the core inserting needle can be released. However, in the process of implanting optical fibers, no matter which specification of holder is adopted, only one optical fiber can be implanted at a time, and at most two optical fibers can be implanted at a time by adopting a double-side inserting needle (fig. 1b, the optical fibers comprise two parts of a ceramic sleeve and the optical fibers, and the part entering into skull tissues is the optical fibers in the optical fiber implanting operation). The existing insertion core needle holder and the insertion core needle can only be implanted into a single brain area at a single time, or can be implanted into the same brain area at two sides with fixed distance and the same brain area at the same depth at two sides. In addition, aiming at the condition that different optical fibers are implanted into different brain areas on one side and different brain areas on two sides in an experiment, experimenters need to repeatedly position and implant the optical fibers, so that the condition not only increases the times of experiment operation and the difficulty of the experiment operation, but also causes the condition that target brain areas are repeatedly positioned in multiple times of implantation, and the deviation of sites exists.
The existing products, fig. 1b and fig. 1c are products from newton corporation, fig. 1b shows that two sides of the double-sided ferrule are double-sided ferrules, and the double-sided ferrules have two problems at present, namely, the length of an optical fiber needs to be customized, and the optical fiber can be specially customized only by different experiments; and secondly, the double-side inserting core needs to be matched with a high pass to customize the double-side jumper, so that the experimental budget is increased. Fig. 1c shows a ferrule needle holder, which is designed with a unique holding blade, and the holding rod is coaxial with the holding object in height, so that the present main problem lies in that the ferrule needle can be embedded once only in one experiment, and the operation is more complicated if special experiment requirements exist.
The defects of the prior art mainly comprise:
one is not an adjustable holder which can be exclusively used for the insertion core needle implantation.
Secondly, no matter the clamp holders of different types or the inserting core needles of different specifications can not meet the requirement of positioning different brain region sites at one time.
Third, in the process of implanting optical fibers, the conventional holder faces the situation of implanting different optical fibers into different brain areas on one side and different brain areas on two sides, and experimenters need to level the brain areas on the surface of the skull for many times (when dental cement is coated, the tail end of the holder is stained with dental cement carelessly, so that the expression of brain tissues is slightly lifted when the holder is removed, and the surface of the brain tissues is in a non-leveling state), position and implant, thereby increasing the number of experimental operations and the difficulty of the experimental operations, and further causing experimental errors to a certain extent.
Fourthly, when different optical fibers are implanted asynchronously, dental cement needs to be waited for many times to be solidified (the optical fibers can be better fixed on the surface of the skull when the dental cement needs to be solidified), and the time for experimenters to perform experimental operation is prolonged.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an adjustable double-hole core inserting needle clamping device and a stereotaxic apparatus comprising the same, which can solve the problems of complex operation, complex operation process, long waiting time and the like in the prior art, simplify the operation steps and shorten the operation time.
In order to achieve the purpose, the invention adopts the following technical scheme:
an adjustable double-hole core inserting needle clamping device comprises a fixed arm, the lower end of the fixed arm is a fixed core inserting needle clamping arm, the lower end of the fixed core inserting needle clamping arm is provided with a first blind hole for clamping a core inserting needle,
the utility model discloses a fixing arm, including fixed arm, scale, vernier, movable core pin needle centre gripping arm, fixed arm's one side is provided with the scale, the scale with the fixed arm is perpendicular, the scale include the blade with gliding vernier on the blade, the lower extreme of vernier is provided with movable core pin needle centre gripping arm, the lower extreme of movable core pin needle centre gripping arm is provided with the second blind hole that is used for centre gripping core pin.
In some embodiments, a screw is disposed on the fixed ferrule holding arm for securing the ferrule within the first blind hole.
In some embodiments, a screw is disposed on the movable core pin clamping arm for securing the core pin within the second blind hole.
In some embodiments, the stationary arm is provided with a key for securing the stationary arm to an X-arm of a stereotaxic apparatus.
In some embodiments, the scale is a digital display scale.
In some embodiments, a screw is disposed on the cursor for securing the cursor to the ruler body.
In some embodiments, a screw is provided on the key for fixedly connecting the key to the X-arm of the stereotaxic apparatus.
In some embodiments, the securing arm, the fixed core pin holding arm, and the blade are an integrally formed structure.
In some embodiments, the stationary arm, the stationary core pin holding arm, and the scale are made of stainless steel or aluminum alloy.
The stereo positioning instrument comprises the adjustable double-hole core inserting needle clamping device, and the adjustable double-hole core inserting needle clamping device is fixed on an X arm of the stereo positioning instrument.
The invention also provides application of the stereotaxic instrument in positioning the brain region locus.
Compared with the prior art, the adjustable double-hole mortise needle clamping device has the following advantages:
the adjustable double-hole core inserting needle clamping device is provided with two ceramic core inserting needle clamping arms, namely a fixed core inserting needle clamping arm and a movable core inserting needle clamping arm, and can be used for clamping two ceramic core inserting needles simultaneously, and the distance between the fixed core inserting needle clamping arm and the movable core inserting needle clamping arm can be changed according to experiment requirements.
The moving distance of the movable core inserting needle clamping arm can be synchronously and directly read on the digital display scale. When the cursor is fixed, the movable core inserting needle clamping arm can be fixed at the same time, and the ceramic core inserting needle on the fixed core inserting needle clamping arm and the movable core inserting needle clamping arm can be fixed by screws.
Compared with the prior art, the adjustable double-hole ferrule needle clamping device is easy to operate, can meet the experiment requirement of implanting optical fibers in a single brain area and the same brain area on two sides at a time, can realize synchronous positioning of different brain area sites at a time, can implant double ferrule needles to different brain areas on one side and different brain areas on two sides synchronously, and can wait for solidification of dental cement of the double ferrule needles simultaneously, so that the experiment operation is simplified, and the experiment operation time is shortened.
The device can also meet the experimental requirements of implanting the core inserting needle at different target depths in the same brain area on both sides.
Drawings
FIG. 1 is a skull surface optical nerve interface and corresponding components of the prior art;
wherein a is a schematic diagram of the optical neural interface on the surface of the skull;
b is a core inserting needle with one side (upper part) and two sides (lower part);
c different types of ferrule needle holders;
FIG. 2 is a schematic structural diagram of an adjustable dual-hole core-inserting needle clamping device according to an embodiment of the present invention;
FIG. 3 is a partial side view of an adjustable dual-hole core pin clamping device according to an embodiment of the present invention;
FIG. 4 is a schematic view of a fiber clamping portion of an adjustable dual-hole core-inserting needle clamping device according to an embodiment of the present invention;
FIG. 5 is a schematic view of a stereotaxic apparatus according to an embodiment of the present invention;
FIG. 6 is a partial structural view of a connecting portion of the clamping device and the stereotaxic apparatus according to an embodiment of the present invention;
description of reference numerals:
1-a stationary arm; 2-a fixed core inserting needle clamping arm; 3-a first blind hole; 4-a scale; 5-a movable core inserting needle clamping arm; 6-second blind hole; 7-a screw; 8-a screw; 9-a screw; a 10-bond; 11-a screw; 12-a base; 13-X arm; 14-Y arm; 15-Z arm.
Detailed Description
In order that the objects, technical solutions and advantages of the present invention will become more apparent, the present invention will be further described in detail with reference to the accompanying drawings in conjunction with the following specific embodiments.
In the description of the present invention, reference to "one embodiment" means that a particular feature, structure, or parameter, step, or the like described in the embodiment is included in at least one embodiment according to the present invention. Thus, appearances of the phrases such as "in one embodiment," "in one embodiment," and the like in this specification are not necessarily all referring to the same embodiment, nor are other phrases such as "in another embodiment," "in a different embodiment," and the like. Those of skill in the art will understand that the particular features, structures or parameters, steps, etc., disclosed in one or more embodiments of the present description may be combined in any suitable manner.
In the description of the present invention, the terms "front", "rear", "left", "right", "upper", "lower", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood as appropriate by those of ordinary skill in the art.
As shown in fig. 2-4, the adjustable dual-hole ferrule needle clamping device provided by the present invention includes a fixed arm 1, a fixed ferrule needle clamping arm 2 is provided at a lower end of the fixed arm 1, a first blind hole 3 for clamping a ferrule needle is provided at a lower end of the fixed ferrule needle clamping arm 2, and the ferrule needle can be fixed in the first blind hole 3 by a screw 7 after being inserted into the first blind hole 3.
The shape of the stationary arm 1 may be a cylinder or a prism (e.g. a hexagonal prism), the height may be 10-25cm, e.g. 15cm, 18cm, 20cm, 22cm, etc., and the diameter may be 6-10cm, e.g. 7cm, 7.9cm, 8.5cm, 9cm, etc. The fixed type core pin holding arm 2 may have a height of 4 to 6cm, for example, 4.5cm, 5cm, 5.5cm, etc., an outer diameter of 0.3 to 0.5cm, for example, 0.4cm, a diameter of the first blind hole 3 may be 0.2 to 0.4cm, for example, 0.3cm, and the size of the first blind hole 3 may be determined according to the specification of the ceramic core pin to be held. The screw 7 may have a length of 0.6-1.0cm, for example 0.8cm, and a diameter of 0.2-0.4cm, for example 0.3 cm.
The measuring scale 4 is arranged on one side of the fixing arm 1, the measuring scale 4 is perpendicular to the fixing arm 1, the measuring scale 4 comprises a scale body 41 and a vernier 42 sliding on the scale body 41, a movable type plug pin clamping arm 5 is arranged at the lower end of the vernier 42, a second blind hole 6 used for clamping a plug pin is arranged at the lower end of the movable type plug pin clamping arm 5, and after the plug pin is inserted into the second blind hole 6, the plug pin can be fixed in the second blind hole 6 through a screw 8. The scale 4 can determine the distance between the fixed type of the plunger pin holding arm 2 and the movable type of the plunger pin holding arm 5. The cursor 42 can be fixed by means of a screw 9 in order to read the distance between the fixed type of gripper arm 2 and the mobile type of gripper arm 5. Preferably, the fixing arm 1, the fixing type core pin holding arm 2 and the blade 41 are integrally formed, and may be made of stainless steel material or other alloy material (e.g., aluminum alloy, etc.).
In one embodiment, the size of the screw 8 may be the same as the size of the screw 7. The screw 9 may have a length of 1.0-1.5cm, for example 1.2cm, and a diameter of 0.5-1.0cm, for example 0.7 cm.
The blade 41 has an accuracy of 0.1cm and a maximum scale of 6.0 cm. The accuracy of the cursor 42 is 0.002cm, with a maximum range of 4.9 cm. Preferably, the scale 4 may also be a digital display scale.
The cursor 42 may also be made of stainless steel, or other alloy materials, such as aluminum alloy, may be used to reduce the overall weight of the device.
The height of the mobile core pin holding arm 5 may be 2-4cm, for example 3cm, the outer diameter may be 0.3-0.5cm, for example 0.4cm, the diameter of the blind hole 6 may be 0.2-0.4cm, for example 0.3cm, the size of the blind hole 6 may be determined according to the specifications of the ceramic core pin to be held.
In other embodiments, the blind holes of the fixed and movable plunger pin holder arms 2 and 5 can also hold a positioning pin of a suitable length for positioning brain region operations. The positioning needle is used for determining the position of a brain area in animal experiments, and in some embodiments, the positioning needle can be replaced by a syringe needle or a toothpick.
In one embodiment, the specific procedure for determining the location of the hippocampal brain region using a locating needle is as follows: moving the metal positioning needle downwards to the upper part of the sagittal suture, and then moving the positioning needle forwards and backwards to position the positioning needle to the bregma; a point is positioned 2mm behind bregma and 2.5mm beside the sagittal suture by using a positioning needle, namely the plane position of the hippocampus, and then a small round hole is drilled on the skull by using a drilling needle at the point.
In an embodiment of the present invention, a key 10 is disposed on the fixing arm 1, a screw 11 is disposed on the key 10, the key 10 can be connected with a key slot on an X-arm of a stereotaxic apparatus, and the position of the key 10 on the fixing arm 1 can be properly adjusted.
The screw 11 may have a length of 1.5-2.0cm, for example 1.8cm, and a diameter of 1.0-1.5cm, for example 1.3 cm.
Fig. 5 is a schematic view of a stereotaxic apparatus according to an embodiment of the present invention, in which an X arm 13, a Y arm 14, and a Z arm 15 are provided on a base 12, respectively, and a clamping device according to the present invention may be fixed to the X arm 13 so as to be movable in front-rear, left-right, and up-down directions on the stereotaxic apparatus. As shown in fig. 6, the key 10 has a V-shaped cross-section, which can be fitted into a V-shaped key slot on the X-arm of the stereotaxic apparatus and fixed to the key slot by a screw 11.
In the embodiment of the invention, the operation process of implanting the core inserting needle by using the adjustable double-hole core inserting needle clamping device of the invention is as follows: and trimming a ceramic ferrule needle with a proper length, putting one ceramic ferrule needle into the first blind hole 3 of the fixed type ferrule needle clamping arm 2, screwing a screw 7, putting the other ceramic ferrule needle into the second blind hole 6 of the movable type ferrule needle clamping arm 5, and screwing a screw 8. Meanwhile, the heights of the uppermost ends of the ceramic ferrule needles fixed in the first blind holes 3 of the fixed type ferrule needle clamping arms and the second blind holes 6 of the movable type ferrule needle clamping arms 5 are ensured to be consistent. Then, the clamping device is arranged on a V-shaped key groove on an X arm 13 of the stereotaxic apparatus by using a screw 10, and the vertical height of the fixing arm 1 on the X arm 13 can be adjusted by using an inner hexagonal wrench.
After the skull surface of the experimental animal is fixed, leveled and punched, the ceramic core inserting needle on the fixed core inserting needle clamping arm 2 is moved to the position above the target brain area, and meanwhile, the ceramic core inserting needle on the movable core inserting needle clamping arm 5 is horizontally moved to the position above the other target brain area. The screw 9 is fixed and then the numerical value on the scale is read, namely the horizontal distance between different brain areas. And rotating a Z-axis knob of the stereotaxic apparatus, slowly descending the fixed arm 1 until the ceramic ferrule pin on the fixed ferrule pin clamping arm 2 contacts the surface of the brain, and then slowly implanting the ferrule pin on the fixed ferrule pin clamping arm 5 into the target brain region site after the movable ferrule pin clamping arm also descends by the same height.
1) Experiments were conducted with the same target depth for implantation of the fiber in the same brain area bilaterally.
The ceramic core inserting needle (the lower end is an optical fiber) on the fixed core inserting needle clamping arm 2 is slowly implanted into the target brain area depth on one side, and the ceramic core inserting needle on the movable core inserting needle clamping arm 5 is also implanted into the brain area on the other side with the same depth.
2) Experiments aimed at implanting optical fibers in the same brain area on both sides, at different target depths.
And trimming a ceramic ferrule needle with a proper length and fixing before the experiment is started. Firstly, slowly implanting the ceramic core inserting needle on the fixed core inserting needle clamping arm 2 into a target brain area with a shallow depth on one side, and then continuously descending the fixed arm 1 until the ceramic core inserting needle on the movable core inserting needle clamping arm 5 is implanted into the brain area on the other side with a second depth.
3) Experiments were conducted at the same target depth for implanting optical fibers into different brain regions on a single side. Only one different brain region site needs to be located, other implantation procedures are similar to 1).
4) Aiming at experiments of implanting the ceramic ferrule needle into different brain areas on one side and different target depths. Only one different brain region site needs to be located, other implantation procedures are similar to 2).
Finally, dental cement with proper thickness is coated near different ceramic ferrule needles, and after the cement is solidified, the screw 7 and the screw 8 are sequentially loosened. And rotating a Z-axis knob of the stereotaxic apparatus, slowly lifting the fixed arm 1 until a certain height is reached, unscrewing the screw 10, and taking down the whole device.
Therefore, the adjustable double-hole core inserting needle clamping device mainly solves the problems that in the existing optical fiber implantation operation in neurobiology optogenetic research, only one optical fiber is implanted once, and when a plurality of target brain region sites are implanted, repeated positioning and repeated implantation are faced. The device can avoid repeated positioning and complex implantation operation in experiments, is also suitable for positioning of multiple brain region sites and meets the requirements of experiments on the sites of two brain regions on the same side, the same brain region on two sides and different brain regions on two sides by synchronously implanting optical fibers in a single operation implantation process.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An adjustable double-hole core inserting needle clamping device is characterized by comprising a fixed arm, wherein the lower end of the fixed arm is a fixed core inserting needle clamping arm, the lower end of the fixed core inserting needle clamping arm is provided with a first blind hole for clamping a core inserting needle,
a scale is arranged on one side of the fixed arm and is perpendicular to the fixed arm, the scale comprises a scale body and a vernier sliding on the scale body, a movable core inserting needle clamping arm is arranged at the lower end of the vernier, and a second blind hole for clamping a core inserting needle is formed in the lower end of the movable core inserting needle clamping arm;
the fixed arm, the fixed core inserting needle clamping arm and the ruler body are of an integrally formed structure.
2. The adjustable dual-hole ferrule needle clamping device according to claim 1, wherein a screw is disposed on the fixed ferrule needle clamping arm for fixing the ferrule needle in the first blind hole.
3. The adjustable dual-bore ferrule needle clamping device according to claim 1, wherein a screw is disposed on the movable ferrule needle clamping arm for fixing the ferrule needle within the second blind hole.
4. The adjustable dual-hole ferrule holding device as claimed in claim 1, wherein a key is provided on the fixing arm for fixing the fixing arm to an X-arm of a stereotaxic apparatus.
5. The adjustable dual-hole core pin clamping device as claimed in claim 4, wherein a screw is provided on the key for fixedly connecting the key to an X-arm of a stereotaxic apparatus.
6. The adjustable dual-hole mortise needle clamping device according to claim 1, wherein the scale is a digital display scale.
7. The adjustable dual-hole mortise needle clamping device according to claim 1, wherein a screw is disposed on the cursor for fixing the cursor on the ruler body.
8. The adjustable dual-hole ferrule needle clamping device according to claim 1, wherein the fixed arm, the fixed type ferrule needle clamping arm and the scale are made of stainless steel or aluminum alloy.
9. Stereotaxic apparatus comprising an adjustable dual bore pin holder according to any one of claims 1 to 8, the adjustable dual bore pin holder being secured to an X-arm of the stereotaxic apparatus.
10. Use of a stereotaxic apparatus according to claim 9 for locating brain region sites for non-diagnostic and non-therapeutic purposes.
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| CN2406623Y (en) * | 2000-01-27 | 2000-11-22 | 陈国强 | Multifunctional instrument for stereoscopic directional operation on cranium and brain |
| CN2489731Y (en) * | 2001-06-09 | 2002-05-08 | 孙勇 | Intracerebral focal puncture locator |
| CN2492200Y (en) * | 2001-08-25 | 2002-05-22 | 余惠平 | Simple direction meter for operatino on cranium and brain |
| CN2664610Y (en) * | 2003-07-21 | 2004-12-22 | 石广志 | Intracerebral stereotaxic instrument |
| CN201160895Y (en) * | 2007-07-25 | 2008-12-10 | 林�建 | Spine puncture guide |
| US8858459B2 (en) * | 2008-10-10 | 2014-10-14 | The Regents Of The University Of Michigan | Optical microsensor and methods for monitoring intracranial pressure |
| CN201283004Y (en) * | 2008-10-20 | 2009-08-05 | 淮北正华生物仪器设备有限公司 | Constant-temperature digital display type stereotaxic apparatus |
| CN201384591Y (en) * | 2009-04-17 | 2010-01-20 | 蒋常文 | Brain solid positioner |
| CN201431517Y (en) * | 2009-06-15 | 2010-03-31 | 成都中医药大学附属医院 | Ventricular puncture positioning device |
| CN102830138A (en) * | 2012-09-24 | 2012-12-19 | 中国科学院半导体研究所 | Photoelectrode array for neuron stimulation and electric signal recording and preparing method of array |
| FR3010321A1 (en) * | 2013-09-06 | 2015-03-13 | Commissariat Energie Atomique | IMPLANTABLE DEVICE FOR OPTICAL BRAIN STIMULATION COMPRISING AN ENHANCEMENT FORMING A HOUSING CONNECTING THE FIRST AND SECOND PARTS |
| CN104921784A (en) * | 2015-06-15 | 2015-09-23 | 张宝国 | Lateral ventricle frontal angle puncture guiding device |
| CN106955425A (en) * | 2017-04-20 | 2017-07-18 | 杭州纽顿科技有限公司 | A kind of light stimulation device |
| CN209203620U (en) * | 2018-09-27 | 2019-08-06 | 中国人民解放军第四军医大学 | It is a kind of can bidirectional modulation double optical fiber embedding devices |
| CN109998648A (en) * | 2019-05-05 | 2019-07-12 | 杨俊� | Brain lesion target spot Needle localization method and its puncture positioning device |
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