CN215192572U

CN215192572U - Brain stereotaxic instrument for tracing nerve loop

Info

Publication number: CN215192572U
Application number: CN202121255339.8U
Authority: CN
Inventors: 刘阳
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-06-04
Filing date: 2021-06-04
Publication date: 2021-12-17
Anticipated expiration: 2031-06-04

Abstract

The utility model provides a brain stereotaxic instrument is used to neural loop spike relates to neurobiology technical field. This brain stereotaxic apparatus for neural loop tracer includes the brain locater body, the symmetry is provided with two ear's centre gripping subassemblies on the brain locater body, be provided with the supersound imaging unit that is used for brain formation of image on the ear's centre gripping subassembly. The utility model has the advantages of, through setting up brain imaging unit at ear's centre gripping subassembly to show brain information on imaging system, can effectively assist the user and correctly look for the brain district, reduce experimental error, raise the efficiency.

Description

Brain stereotaxic instrument for tracing nerve loop

Technical Field

The utility model relates to a neurobiology technical field particularly, relates to a neural circuit brain stereotaxic instrument for spike.

Background

In the fields of nerve anatomy, neurophysiology, neuropharmacology, neurosurgery and the like, when the brain functions of various experimental animals are researched, an electrode must be correctly inserted into a target part under the cortex and the position of the electrode is kept not to move, so the brain must be fixed in the test process, and a currently commonly used fixing instrument is a brain positioning instrument (stereotaxic apparatus). Different types of brain positioning (fixation) devices are designed for different animals. Specifically, the three-dimensional coordinate system defined by the marks or other reference points outside the skull is used to determine the position of some nerve structures in the subcortical layer so as to carry out directional stimulation, damage, medicine injection, electric potential guidance and other researches under the condition of non-direct-view exposure. Can be used for the researches of Parkinson's disease animal model establishment, epilepsy animal model establishment, intracerebral tumor model establishment, learning and memory, intracerebral neural stem cell transplantation, cerebral ischemia and the like.

At present, some brain positioning instruments are available on the market and are generally used in the fields of neuroanatomy, neurophysiology, neuropharmacology, neurosurgery and the like. In the using process, people also encounter some problems, and some patents are provided for specifically solving the problems, for example, the patent publication No. CN111888036A discloses a fixing structure of a rat brain stereotaxic apparatus, which comprises an operation board, wherein the operation board is connected with a fixing column through an adjusting mechanism, and a tooth fixing mechanism is mounted on the fixing column; the top of the operating panel is fixedly connected with two symmetrically arranged fixed blocks a. According to the fixing structure of the rat brain stereotaxic apparatus, the adjusting precision is high, and the condition that teeth bleed or eardrum rupture caused by improper adjustment can not occur in the process of fixing rats and mice; the magnet a and the magnet b are arranged at the top of the supporting plate, so that the effect of fixing tissues or cloth mats is facilitated, and the situation that the supporting plate is polluted due to incontinence of urine and feces in the process of a large mouse or a small mouse in a test is avoided; the height of the supporting plate can be lifted as required, so that the ear rod and the tooth fixing rod can be conveniently and quickly used for fixing the big mouse and the small mouse, and the experimental efficiency is improved. The existing brain locator has brain positioning difficulty, a brain area needs to be tested each time, and then a corresponding position is found for testing; meanwhile, the positioning ear rod is too hard, so that the ear canal of the mouse is easily damaged.

However, in the practical use process, the following problems still exist in the products of the above patents:

1. in the using process, the target brain region needs to be found through experience, and different research and development personnel have different experiences, so that the test cannot progress or serious errors occur in the direction, and the precious time of the research and development personnel is wasted.

2. When fixed, present ear fixing device is all directly inserts experimental animal's ear canal with the ear stick, and in the insertion process, if inexperience, then can lead to experimental animal's ear to appear damaging, probably lead to experimental result to appear serious error, perhaps in experimental development to the later stage, experimental animal arouses the back and violently struggles, also can lead to experimental animal ear to destroy, influences later stage experimental result.

An effective solution to the problems in the related art has not been proposed yet. Therefore, if a cerebrometer capable of solving the above problems can be provided, it will play an important role in the research of neurobiology.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a neural loop is brain stereotaxic instrument for spike, it can be through brain imaging unit auxiliary user seeking brain district, reduces experimental error.

The embodiment of the utility model is realized like this:

the embodiment of the application provides a brain stereotaxic apparatus for neural loop tracer, including the brain locater body, the symmetry is provided with two ear's centre gripping subassemblies on the brain locater body, be provided with the supersound imaging unit that is used for brain formation of image on the ear's centre gripping subassembly.

In some embodiments of the utility model, above-mentioned brain stereotaxic apparatus is used in neural loop tracer, ear's centre gripping subassembly includes that grip slipper and centre gripping are in ear stick on the grip slipper, be provided with on the grip slipper and be used for adjusting first horizontal adjustment mechanism and the first vertical adjustment mechanism of ear stick.

In some embodiments of the present invention, the neural circuit tracking brain stereotaxic apparatus further comprises a tip cover for protecting the ear canal, wherein the tip cover of the ear rod is provided with a tip cover for protecting the ear canal.

In some embodiments of the present invention, the neural circuit tracking brain stereotaxic apparatus further comprises a buffer layer disposed on the tip sleeve.

The utility model discloses an in some embodiments, above-mentioned neural circuit brain stereotaxic instrument for spike, all be provided with the ultrasonic imaging unit on two ear's centre gripping subassemblies, two the ultrasonic imaging unit is mutually supported and is formed the detection chamber.

In some embodiments of the utility model, above-mentioned brain stereotaxic instrument is used in neural loop spike, the supersound formation of image unit is including fixed cover and two supersound imaging member, fixed cover is located on the ear centre gripping subassembly, two supersound imaging member symmetry set up in the upper and lower both sides of fixed cover form a semicircle.

In some embodiments of the present invention, the neural circuit tracking brain stereotaxic apparatus further includes a tooth portion clamping assembly, the tooth portion clamping assembly includes a base and a tooth portion fixing member, and further includes a second horizontal adjusting mechanism and a second vertical adjusting mechanism, which are disposed on the base and used for adjusting the tooth portion fixing member.

In some embodiments of the utility model, above-mentioned neural circuit brain stereotaxic instrument for spike, still be provided with the working component on the brain locater body, can dismantle on the working component and be provided with any one of electrode, craniotomy subassembly and application of sample subassembly.

In some embodiments of the utility model, above-mentioned neural loop brain stereotaxic apparatus for tracer still includes imaging system, supersound formation of image spare includes arc support, ultrasonic probe and signal processing module, ultrasonic probe installs on the arc support and with the signal processing module electricity is connected, signal processing module with imaging system communication connection, imaging system be used for with the ultrasonic signal of ultrasonic probe feedback changes the image into.

In some embodiments of the present invention, the neural circuit tracking brain stereotaxic apparatus further comprises an arc-shaped support.

Compared with the prior art, the embodiment of the utility model has following advantage or beneficial effect at least:

effect one, the utility model provides a neural circuit brain stereotaxic appearance for spike through set up brain imaging unit at ear's centre gripping subassembly to show brain information on imaging system, can effectively assist the user and correctly look for the brain district, reduce experimental error, raise the efficiency.

Effect two, through set up the tip cover on the ear stick, avoided ear stick and the fragile skin direct contact of ear, set up anti-skidding line on the tip cover simultaneously, damage the duct when preventing experimental animal struggle, still set up the buffer layer at the point portion of tip cover in addition, further avoid the pointed end of ear stick to the damage of ear.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention, and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is an overall structure diagram of the neural circuit tracing brain stereotaxic apparatus of the present invention;

fig. 2 is a schematic structural diagram of the ear clamping assembly of the neural loop tracking brain stereotaxic apparatus of the present invention without an ultrasonic detection unit;

fig. 3 is a schematic structural diagram of the ear clamping assembly of the neural loop tracking brain stereotaxic apparatus of the present invention having an ultrasonic detection unit;

fig. 4 is a schematic structural diagram of the combined two ultrasonic detection units of the neural circuit tracing stereotaxic apparatus of the present invention;

fig. 5 is a schematic diagram of the structure of the ear tip of the neural circuit tracking stereotaxic instrument.

Icon: 100-brain locator body; 1-an operation table; 2-an ear grip assembly; 21-a clamping seat; 22-ear stick; 23-tip sheathing; 231-a buffer layer; 24-an ultrasound imaging unit; 241-an ultrasonic imaging member; 2411-arc support; 2412-probe; 2413-a signal processing module; 242-a fixation sleeve; 3-a tooth gripping assembly; 31-a base; 32-tooth fixtures; 4-working assembly.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the accompanying drawings, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the embodiments of the present invention, it should be noted that, if the terms "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the position or positional relationship based on the position or positional relationship shown in the drawings, or the position or positional relationship which is usually placed when the product of the present invention is used, the description is only for convenience of description and simplification, but the indication or suggestion that the device or element to be referred must have a specific position, be constructed and operated in a specific position, and thus, cannot be understood as a limitation to the present invention. Furthermore, the appearances of the terms "first," "second," "third," and the like, if any, are only used to distinguish one description from another, and are not to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not require that the components be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the embodiments of the present invention, "a plurality" means at least 2 if appearing.

In the description of the embodiments of the present invention, it should be further noted that unless explicitly stated or limited otherwise, the terms "disposed," "mounted," "connected," and "connected" should be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

Examples

Please refer to fig. 1-5. The embodiment provides a brain stereotaxic instrument for tracing a neural circuit, which has the following specific structure:

this brain stereotaxic apparatus for neural circuit tracer includes brain locater body 100, and the symmetry is provided with two ear clamping component 2 on the brain locater body 100, is provided with the supersound imaging unit 24 that is used for brain formation of image on the ear clamping component 2. Through set up supersound imaging unit 24 on ear centre gripping subassembly 2, through imaging behind the brain district degree of depth or the position of ultrasonic detection experimental animal, reduced the error that different experimenters judge the brain district through experience and produce, can obtain more accurate experimental result.

Specifically, the ultrasound imaging unit 24 includes a fixing sleeve 242 and two ultrasound imaging components 241, the fixing sleeve 242 is sleeved on the ear clamping assembly 2, and the two ultrasound imaging components 241 are symmetrically disposed on the upper and lower sides of the fixing sleeve 242 and form a semicircle. All be provided with ultrasonic imaging unit 24 on two ear's centre gripping subassemblies 2, two ultrasonic imaging units 24 mutually support and form the detection chamber.

During the use, adjust four supersound formation of image pieces 241 to experimental animal brain surface, form a detection ring to experimental animal's brain, can carry out omnidirectional detection to animal's brain, promote positioning accuracy, help the user correctly to find the information such as the degree of depth and the size of each brain district and different brain districts, reduce experimenter's subjective error.

In addition, the ultrasound imaging device 241 needs to be connected to an imaging system, and the specific structure is as follows:

the ultrasonic imaging part 241 comprises an arc-shaped support 2411, an ultrasonic probe 2412 and a signal processing module 2413, wherein the ultrasonic probe 2412 is installed on the arc-shaped support 2411 and is electrically connected with the signal processing module 2413, the signal processing module 2413 is in communication connection with an imaging system, and the imaging system is used for converting an ultrasonic signal fed back by the ultrasonic probe 2412 into an image. The signal processing module 2413 receives the electrical signal that the host computer gave and transmits to ultrasonic transducer 2412, makes it send the ultrasonic wave, also receives the ultrasonic signal of ultrasonic transducer 2412 feedback simultaneously to convert it into the electrical signal and feed back to imaging system and handle, form the image after the processing is accomplished, the experimenter can judge the brain area distribution of experimental animal through observing the image, makes whole experiment more accurate.

To further adjust the ultrasound imaging device 241 to accommodate a variety of different animals, the arcuate support 2411 is preferably a universal tube, which not only increases the directionality of the ultrasound probe 2412, but also allows the neural circuit tracking brain stereotaxic apparatus to accommodate different types of animal brains, increasing the range of applicability and the utility of the neural circuit tracking brain stereotaxic apparatus.

In the actual use process, the ear holding assembly 2 can hold the test animal well in the waking state of the test animal, but due to the suturing operation and other operations in the operation, the test animal frequently struggles due to pain. To address this problem, the neural circuit tracking stereotaxic apparatus of the present embodiment performs certain structural optimization on the ear grip assembly 2.

Specifically, the ear holding assembly 2 comprises a holding seat 21 and an ear rod 22 held on the holding seat 21, and a first horizontal adjusting mechanism and a first longitudinal adjusting mechanism for adjusting the ear rod 22 are arranged on the holding seat 21. First horizontal adjustment structure can carry out the adjustment of relative position according to experimental animal's volume size, and first vertical adjustment mechanism can carry out the ascending adjustment of vertical direction according to experimental animal's head size, can adapt to the not animal of equidimension. The tip cover 23 of the ear rod 22 is provided with a tip cover 23 for protecting the ear canal, and a buffer layer 231 is provided at the end of the tip cover 23.

After the tip of ear stick 22 inserted the duct of animal, with the fragile skin contact of duct be soft tip cover 23 to and set up the anti-skidding line on tip cover 23, both can effectively protect the duct, have and can prevent to struggle the in-process damage duct after experimental animal is sobried, cause follow-up test result to appear error etc. or confuse the test result, lead to the unable accurate analysis result of experimenter.

In addition to the above-described structure, the adjustment of each holder and the working assembly 4 in the brain positioning test needs to be relatively precise:

specifically, the neural circuit tracking stereotaxic apparatus comprises a tooth clamping assembly 3, wherein the tooth clamping assembly 3 comprises a base 31 and a tooth fixing member 32, and further comprises a second horizontal adjusting mechanism and a second longitudinal adjusting mechanism which are arranged on the base 31 and used for adjusting the tooth fixing member 32.

The brain positioning instrument body 100 is provided with the working component 4, any one of an electrode, a craniotomy component and a sample adding component is arranged on the working component 4, and the electrode, the craniotomy component, the sample adding component and the like can be detachably connected with the working component 4, so that the brain positioning instrument can adapt to various neurobiology experiments, the test requirements of different testers are met, and the application range and the practicability of the brain stereotaxic instrument for tracking the neural loop are increased.

Meanwhile, the working assembly 4 further comprises a third horizontal adjusting mechanism and a third longitudinal adjusting mechanism so as to adjust the positions of the electrode, the craniotomy assembly, the sample adding assembly and the like relative to the test animal according to the test animal and the test requirement.

The first horizontal adjusting mechanism, the first longitudinal adjusting mechanism, the second horizontal adjusting mechanism, the second longitudinal adjusting mechanism, the third horizontal adjusting mechanism and the third longitudinal adjusting mechanism all need to adjust three-dimensional coordinates of the movable ear rod 22, the tooth fixing part 32, the electrode, the craniotomy assembly, the sample adding assembly and the like through a lead screw with higher precision, namely, the position of the movable ear rod, the tooth fixing part 32, the electrode, the craniotomy assembly, the sample adding assembly and the like relative to a test animal, so that the optimal test effect is achieved, and the main pipe error is further reduced.

To sum up, the utility model provides a pair of brain stereotaxic instrument is used to neural loop spike has following advantage:

effect one, the utility model provides a neural loop is brain stereotaxic appearance for spike through setting up brain supersound imaging unit 24 at ear's centre gripping subassembly 2 to show brain information on imaging system, can effectively assist the user and correctly look for the brain district, reduce experimental error, raise the efficiency.

Effect two, through set up tip cover 23 on ear stick 22, avoided ear stick 22 and the fragile skin direct contact of ear, set up anti-skidding line on the tip cover 23 simultaneously, damage the duct when preventing experimental animal from struggling, still set up buffer layer 231 at the point portion of tip cover 23 in addition, further avoid the damage of the most advanced inner ear of ear stick 22.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The utility model provides a brain stereotaxic apparatus for neural loop tracer, a serial communication port, includes the brain locater body, the symmetry is provided with two ear's centre gripping subassemblies on the brain locater body, be provided with the supersound imaging unit that is used for the brain formation of image on the ear's centre gripping subassembly.

2. The neural circuit tracking stereotaxic apparatus according to claim 1, wherein the ear holding assembly includes a holder and an ear bar held on the holder, and a first horizontal adjusting mechanism and a first vertical adjusting mechanism for adjusting the ear bar are disposed on the holder.

3. The neural circuit tracking brain stereotaxic apparatus according to claim 2, wherein the tip of the ear rod is sleeved with a tip sleeve for protecting the ear canal.

4. The neural circuit tracking brain stereotaxic apparatus according to claim 3, wherein a buffer layer is provided on an end portion of the tip sleeve.

5. The neural circuit tracking brain stereotaxic apparatus according to claim 1, wherein ultrasonic imaging units are disposed on both of the ear holding assemblies, and the two ultrasonic imaging units cooperate with each other to form a detection chamber.

6. The neural circuit tracking brain stereotaxic apparatus according to claim 1, wherein the ultrasound imaging unit includes a fixing sleeve and two ultrasound imaging members, the fixing sleeve is sleeved on the ear clamping assembly, and the two ultrasound imaging members are symmetrically disposed on upper and lower sides of the fixing sleeve and form a semicircle.

7. The neural circuit tracking brain stereotaxic apparatus according to claim 1, further comprising a toothed clamping assembly, the toothed clamping assembly including a base and a toothed fixture, and further comprising a second horizontal adjustment mechanism and a second vertical adjustment mechanism disposed on the base for adjusting the toothed fixture.

8. The neural circuit tracking brain stereotaxic apparatus according to claim 1, wherein the brain stereotaxic apparatus body is further provided with a working assembly, and any one of the electrode, the craniotomy assembly and the sample adding assembly is detachably arranged on the working assembly.

9. The neural-loop tracking brain stereotaxic apparatus according to claim 1, further comprising an imaging system, wherein the ultrasound imaging component includes an arc-shaped support, an ultrasound probe mounted on the arc-shaped support and electrically connected to the signal processing module, and a signal processing module communicatively connected to the imaging system, and the imaging system is configured to convert an ultrasound signal fed back from the ultrasound probe into an image.

10. The neural circuit tracking brain stereotaxic apparatus according to claim 9, wherein the arcuate frame is a gimbaled tube.