CN215534464U - Experimental mouse brain electricity acquisition fixer - Google Patents
Experimental mouse brain electricity acquisition fixer Download PDFInfo
- Publication number
- CN215534464U CN215534464U CN202121575516.0U CN202121575516U CN215534464U CN 215534464 U CN215534464 U CN 215534464U CN 202121575516 U CN202121575516 U CN 202121575516U CN 215534464 U CN215534464 U CN 215534464U
- Authority
- CN
- China
- Prior art keywords
- fixed
- laboratory mouse
- base
- head
- fixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The utility model relates to the technical field of biological experiment instruments, in particular to a brain electricity acquisition fixer for an experiment mouse, which comprises a base; first fixed establishment locates on the base for the chest abdomen portion of fixed laboratory mouse still includes: second fixed establishment locates on the base, is located first fixed establishment's the place ahead for the head of fixed laboratory mouse, second fixed establishment includes the centre gripping subassembly that two symmetries set up, and the centre gripping subassembly includes: the fixed seat is arranged on the base, and a mounting hole penetrates through the fixed seat in the horizontal direction; the extension rod is sleeved in the mounting hole, and a plurality of positioning holes are formed in the length direction of the extension rod; the head cover is a hemisphere and is arranged at one end opposite to the extension rod; first holding screw establishes in the vertical direction of fixing base, and first holding screw passes the locating hole and fixes with the extension rod. The utility model has the advantages of simple structure, a mechanism for fixing the body of the laboratory mouse and a mechanism for fixing the head of the laboratory mouse, accurate signal acquisition and improvement of experimental efficiency.
Description
Technical Field
The utility model relates to the technical field of biological experiment instruments, in particular to a brain electricity acquisition fixer for an experiment mouse.
Background
The brain electricity is a bioelectric signal generated when brain nerve cells move, and when the brain is diseased, the corresponding brain signal is also changed. At present, brain signals are often required to be collected when brain diseases are researched, then filtering processing is carried out, and specific wave band parameters are extracted, so that corresponding diseases are researched, for example, experiment of Parkinson rat model evaluation and optogenetic treatment effect based on electroencephalogram signal analysis is carried out.
When implanting electrodes into a laboratory mouse model used for experimental research and collecting brain signals, the brain stereotaxic apparatus used in the market at present for animal surgery implants the electrodes into a specific brain area, then a fixing mechanism is used for fixing the body of the laboratory mouse for collection,
the following problems are often encountered during the acquisition: first, the experimental mouse head that carries out signal acquisition is fixed with the row of gathering the signal female, arranges female less and insert easy swing struggle behind the in-process experimental mouse head atress, leads to external electrode tip difficult to insert or impaired, has reduced experimental efficiency. Secondly, in practical operation, because the laboratory mouse has small volume and flexible and rapid action, and the laboratory mouse also has the possibility of being bitten by the laboratory mouse by accident, a device capable of fixing the laboratory mouse to collect the brain electricity is needed.
SUMMERY OF THE UTILITY MODEL
The utility model aims to overcome the problems in the prior art, and provides a laboratory mouse brain electrical acquisition fixer which can solve the problem that in the prior art, when a laboratory mouse body is fixed to acquire brain electrical signals, the head of the laboratory mouse is easy to swing and struggle, so that the acquired signals are inaccurate, and the experimental efficiency is reduced.
The technical scheme of the utility model is as follows:
the utility model provides a fixer is gathered to laboratory mouse brain electricity, includes base, a fixed establishment locates on the base for the chest abdomen portion of fixed laboratory mouse, its characterized in that still includes:
second fixed establishment locates on the base, be located first fixed establishment's the place ahead for the head of fixed laboratory mouse, second fixed establishment includes the centre gripping subassembly that two symmetries set up, the centre gripping subassembly includes: the fixing seat is arranged on the base, and a mounting hole penetrates through the fixing seat in the horizontal direction; the extension rod is sleeved in the mounting hole, and a plurality of positioning holes are formed in the length direction of the extension rod; the head sleeve is a hemisphere and is arranged at one end opposite to the extension rod; and the first set screw is arranged in the vertical direction of the fixed seat and penetrates through the positioning hole to be fixed with the extension rod.
Preferably, the inner side of the head sleeve is provided with an adjusting mechanism for better fixing the head of the laboratory mouse.
Preferably, the adjustment mechanism comprises:
the second set screws are respectively arranged on the head sleeve;
and the fixed disks are respectively arranged at one end of the second set screw and are positioned in the head sleeve.
Preferably, the first fixing mechanism includes:
two fixed subassemblies, the symmetry sets up on the base, fixed subassembly includes: the pressing plate is an arc-shaped plate and is arranged on the base; and the torsional spring is arranged between the pressing plate and the base, one end of the torsional spring is fixed with the pressing plate, and the other end of the torsional spring is fixed with the base.
Preferably, a layer of silica gel pad is arranged on one side of the pressing plate, which is in contact with the chest and abdomen of the laboratory mouse.
Preferably, the method further comprises the following steps: the pipe wrench is arranged at the clamping end of the brain stereotaxic apparatus and used for fixing the electrode tip for collecting signals.
Preferably, the pipe wrench comprises:
one end of the first screw is in threaded connection with the clamping end of the brain stereotaxic apparatus;
one end of the jaw is fixed at the other end of the first screw rod, a gap is formed in the middle of the jaw, a connector is arranged at one end of the gap, and the connector is clamped with an electrode tip for collecting signals;
one end of the second screw rod is provided with a clamping block and is arranged at the other end of the notch;
and the deflector rod is arranged at the other end of the second screw rod and used for adjusting the position of the clamping block.
Preferably, the method further comprises the following steps: the buckle structure, quantity are two sets of, set up respectively in the both sides of the electrode tip of gathering the signal for the connection of firm electrode tip.
Preferably, the snap structure includes:
the sub-buckles are arranged on two sides of the electrode tip on the joint;
the female button is arranged on two sides of the electrode tip at the head of the laboratory mouse and correspondingly buckled with the male button.
Compared with the prior art, the experimental mouse brain electricity acquisition fixator provided by the utility model has the beneficial effects that:
the mechanism that has the fixed laboratory mouse health and the mechanism of fixed laboratory mouse head, the collection signal that can be accurate has improved experimental efficiency, and simple structure, and each fixed knot constructs can be according to the nimble adjustment of size of laboratory mouse, can one-man operation to reduce manpower resources's waste. The headgear of the head of fixed laboratory mouse is ventilative all around, inside is with silica gel, the material is soft, can adjust according to the size of laboratory mouse head, and can not produce the influence because the dead time is too long to the laboratory mouse, this just can be on the basis of not injuring the laboratory mouse, fixed laboratory mouse, can not cause the influence to the experimental result again, the inboard silica gel pad of clamp plate can adjust according to the physique of laboratory mouse, the torsion spring of junction can make the laboratory mouse obtain abundant fixed, silica gel is soft, do not harm the laboratory mouse, contrast other fixers more friendly to living body animals such as laboratory mouse. The buckle structure that adds on the electrode head lets the laboratory mouse can keep the activity under the natural state, can stably gather the EEG signal again.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic structural diagram of a first fixing mechanism according to the present invention;
FIG. 3 is a schematic structural view of a second fixing mechanism according to the present invention;
FIG. 4 is a schematic structural view of a pipe wrench according to the present invention;
fig. 5 is a schematic structural view of the buckle structure of the present invention.
Detailed Description
The utility model provides a laboratory mouse brain electricity collecting fixer, which is described below by combining the structural schematic diagrams of fig. 1 to 5, but it should be understood that the protection scope of the utility model is not limited by the specific embodiment.
Examples
As shown in fig. 1, the experimental mouse brain electricity collecting fixer provided by the utility model comprises a base 2 serving as a platform for fixing an experimental mouse and a structure for supporting and fixing the experimental mouse; first fixed establishment 1 locates on the base 2 for the chest abdomen portion of fixed laboratory mouse, its characterized in that still includes: second fixed establishment 3 locates on base 2, be located the place ahead of first fixed establishment 1 for the head of fixed laboratory mouse, second fixed establishment 3 includes the centre gripping subassembly that two symmetries set up, as shown in fig. 3, the centre gripping subassembly includes: the fixed seat 31 is arranged on the base 2, and a mounting hole penetrates through the fixed seat 31 in the horizontal direction; the extension rod 32 is sleeved in the mounting hole, and a plurality of positioning holes are formed in the extension rod 32 in the length direction; the head sleeve 33 is a hemisphere and is arranged at one end opposite to the extension rod 32, and a leaked electroencephalogram signal acquisition part is arranged on the head sleeve 33; the first set screw 34 is disposed in the vertical direction of the fixing seat 31, and the first set screw 34 passes through the positioning hole to be fixed with the extension rod 32. When the head of the mouse is fixed, the two head caps 33 are used to hold the head of the mouse for signal acquisition. Wherein, the second fixed establishment 3 of fixed laboratory mouse's head and the first fixed establishment 1 of fixed laboratory mouse's chest belly, the position of two fixed establishment accords with the position of laboratory mouse's health and head.
Furthermore, the inner side of the head cover 33 is provided with an adjusting mechanism for better fixing the head of the laboratory mouse, so that the head covers 33 at two sides are attached to two sides of the skull of the laboratory mouse as much as possible.
Further, the adjustment mechanism includes: a second set screw 331, and a fixed disk 332. A plurality of second set screws 331 are respectively provided on the head cover 33; the fixing disks 332 are respectively disposed at one end of the second set screw 331 and located in the head housing 33. Wherein, fixed disk 332 is the flexible disk that silica gel material made, and the laboratory mouse can be comfortable some relatively, according to the concrete head size of laboratory mouse, tightens up or second holding screw 331, fixes the head of laboratory mouse.
Further, as shown in fig. 2, the first fixing mechanism 1 includes: two fixed subassemblies, the symmetry sets up on base 2, fixed subassembly includes: a pressure plate 11 and a torsion spring 12. The pressing plate 11 is an arc-shaped plate and is arranged on the base 2 so as to accord with the body radian of the experimental mouse; the torsion spring 12 is arranged between the pressing plate 11 and the base 2, one end of the torsion spring is fixed with the pressing plate 11, the other end of the torsion spring is fixed with the base 2, and the torsion spring 12 can fully fix the body of the laboratory mouse. When fixing the chest and abdomen of the laboratory mouse, the two pressing plates 11 are firstly opened outwards from the middle, the pressing plates 11 at the two sides are loosened after the trunk part of the laboratory mouse is put in, and the laboratory mouse is pressed by the torsion spring 12 to finish the fixation.
Furthermore, a layer of silica gel pad 23 is arranged on one side of the pressing plate 11, which is in contact with the chest and abdomen of the laboratory mouse. The silica gel pad 13 is arranged, so that the silica gel is soft, the influence on the experimental mouse due to too long fixing time can not be generated, and the experimental mouse can be fixed on the basis of not damaging the experimental mouse.
Further, the method also comprises the following steps: the pipe wrench 4 is arranged at the clamping end of the brain stereotaxic apparatus 5 and is used for fixing the electrode tip for collecting signals.
Further, as shown in fig. 4, the pipe wrench 4 includes: a first screw 41, a jaw 42, a second screw 43 and a shift lever 44. One end of the first screw rod 41 is in threaded connection with the clamping end of the brain stereotaxic apparatus 5, and when the pipe wrench is used, the whole pipe wrench 4 can be screwed at the clamping end of the brain stereotaxic apparatus 5; one end of the jaw 42 is fixed at the other end of the first screw rod 41, a gap 421 is arranged in the middle of the jaw 42, a joint 422 is arranged at one end of the gap 421, and the joint 422 is clamped with the electrode head for collecting signals; one end of the second screw 43 is provided with a clamping block 431 arranged at the other end of the notch 421; the shift lever 44 is provided at the other end of the second screw 43 for adjusting the position of the clamping block 431. Wherein, the electrode tip is put in the middle of breach 421, and the one end of electrode tip and joint 422 joint have the bayonet socket with the electrode tip joint on the joint 422, and rotatory driving lever 44 makes grip block 431 press from both sides the other end of tight electrode tip, fixes the electrode tip with joint 422 and grip block 431 together.
Further, the method also comprises the following steps: the buckle structure, quantity are two sets of, set up respectively in the both sides of the electrode tip of gathering the signal for the connection of firm electrode tip. For the experiment of electrode brain electrical signal collection under the natural state of living animal, the insertion of the channel interface is difficult to implement due to the movement and struggle of the animal, and the interface is difficult to maintain to be stably contacted well for a long time under the natural state of the animal. Therefore, the clamping structure is designed, and the electrode tips can be kept fully and stably connected when the laboratory mouse moves freely.
Further, as shown in fig. 5, the snap structure includes: a male button 6 and a female button 7. The subspans 6 are arranged at two sides of the electrode head on the joint 422; the female button 7 is arranged on two sides of the electrode tip at the head of the laboratory mouse, and the female button 7 and the male button 6 are correspondingly buckled. The son is detained 6, the box 7 is overlapped respectively on two electrode tips that are connected, connects when two electrode tips, detains 6 locks with the box 7 with son again, and two electrode tips just can not break away from easily, lets the laboratory mouse can keep the activity under the natural state, can stably gather brain electrical signal again.
When the fixing device is used, the trunk part of the laboratory mouse is fixed by the first fixing mechanism 1, the laboratory mouse is firstly broken off from the middle of the two pressing plates 11, and the laboratory mouse is pressed by the action of the torsion spring 12, so that the first step of fixing is completed; fixing the head of the laboratory mouse by using the second fixing mechanism 3, pushing the extension rod 32 to enable the two head sleeves 33 to clamp the head of the laboratory mouse, then screwing the first set screw 34 arranged on the fixed seat 31, enabling the first set screw 34 to penetrate through the positioning hole to be fixed with the extension rod 32, adjusting through the adjusting mechanism according to the size of the head of the laboratory mouse, rotating the set screw 331 to enable the fixed disk 332 to be attached to the two sides of the skull of the laboratory mouse as much as possible, and finishing the fixing of the second step; the pipe wrench 4 is screwed at the clamping end of the brain stereotaxic apparatus 5, one of the electrode tips is clamped on the joint 422, the deflector rod 44 is rotated to enable the clamping block 431 to clamp the other end of the electrode tip, the other electrode tip is inserted into the head of a laboratory mouse to enable the two electrode tips to be connected, and finally the female buckle 7 and the male buckle 6 are buckled to finish the fixation of the last step; and collecting the electroencephalogram signals of the experimental mice. The utility model has the advantages that the device has a mechanism for fixing the body of the laboratory mouse and a mechanism for fixing the head of the laboratory mouse, can accurately acquire signals, improves the experimental efficiency, has simple structure, can be flexibly adjusted according to the size of the laboratory mouse, can be operated by one person, and further reduces the waste of human resources. The headgear of the head of fixed laboratory mouse is ventilative all around, inside is with silica gel, the material is soft, can adjust according to the size of laboratory mouse head, and can not produce the influence because the dead time is too long to the laboratory mouse, this just can be on the basis of not injuring the laboratory mouse, fixed laboratory mouse, can not cause the influence to the experimental result again, the inboard silica gel pad of clamp plate can adjust according to the physique of laboratory mouse, the torsion spring of junction can make the laboratory mouse obtain abundant fixed, silica gel is soft, do not harm the laboratory mouse, contrast other fixers more friendly to living body animals such as laboratory mouse. The buckle structure that adds on the electrode head lets the laboratory mouse can keep the activity under the natural state, can stably gather the EEG signal again.
The above disclosure is only for a few specific embodiments of the present invention, however, the present invention is not limited to the above embodiments, and any variations that can be made by those skilled in the art are intended to fall within the scope of the present invention.
Claims (9)
1. The utility model provides a fixer is gathered to laboratory mouse brain electricity, includes base (2), first fixed establishment (1), and first fixed establishment (1) is located on base (2) for the chest abdomen portion of fixed laboratory mouse, its characterized in that still includes:
second fixed establishment (3) locates on base (2), be located the place ahead of first fixed establishment (1) for the head of fixed laboratory mouse, second fixed establishment (3) include the centre gripping subassembly that two symmetries set up, the centre gripping subassembly includes: the fixing seat (31) is arranged on the base (2), and a mounting hole penetrates through the fixing seat (31) in the horizontal direction; the extension rod (32) is sleeved in the mounting hole, and a plurality of positioning holes are formed in the extension rod (32) in the length direction; the head cover (33) is a hemisphere and is arranged at one end opposite to the extension rod (32); the first set screw (34) is arranged in the vertical direction of the fixed seat (31), and the first set screw (34) penetrates through the positioning hole to be fixed with the extension rod (32).
2. The experimental mouse brain electricity collection fixer according to claim 1, wherein the inner side of the head cover (33) is provided with an adjusting mechanism for better fixing the head of the experimental mouse.
3. The laboratory mouse brain electricity collection fixture according to claim 2, wherein the adjusting mechanism comprises:
a plurality of second set screws (331) respectively provided on the head cover (33);
and a plurality of fixed disks (332) which are respectively arranged at one end of the second set screw (331) and are positioned in the head cover (33).
4. The laboratory mouse brain electrical collection fixer according to claim 1, wherein the first fixing mechanism (1) comprises:
two fixed subassemblies, the symmetry sets up on base (2), fixed subassembly includes: the pressing plate (11) is an arc-shaped plate and is arranged on the base (2); and the torsion spring (12) is arranged between the pressing plate (11) and the base (2), one end of the torsion spring is fixed with the pressing plate (11), and the other end of the torsion spring is fixed with the base (2).
5. The laboratory mouse brain electricity collection fixer according to claim 4, characterized in that a layer of silica gel pad (13) is arranged on the side of the pressing plate (11) contacting with the chest and abdomen of the laboratory mouse.
6. The laboratory mouse brain electricity collection fixer according to claim 1, further comprising: and the pipe tongs (4) are arranged at the clamping end of the brain stereotaxic apparatus (5) and are used for fixing the electrode tip for collecting signals.
7. The laboratory mouse brain electrical collection fixer according to claim 6, wherein the pipe wrench (4) comprises:
a first screw rod (41), one end of which is in threaded connection with the clamping end of the brain stereotaxic apparatus (5);
the clamp comprises a jaw (42), one end of the jaw (42) is fixed at the other end of a first screw rod (41), a gap (421) is formed in the middle of the jaw (42), a joint (422) is arranged at one end of the gap (421), and the joint (422) is clamped with an electrode head for collecting signals;
a second screw (43) with one end provided with a clamping block (431) arranged at the other end of the gap (421);
and the shift lever (44) is arranged at the other end of the second screw rod (43) and is used for adjusting the position of the clamping block (431).
8. The laboratory mouse brain electricity collection fixer according to claim 1, further comprising: the buckle structure, quantity are two sets of, set up respectively in the both sides of the electrode tip of gathering the signal for the connection of firm electrode tip.
9. The experimental rat brain electrical collection fixer according to claim 8, wherein the snap structure comprises:
the subsidiary buttons (6) are arranged on two sides of the electrode head on the joint (422);
the female button (7) is arranged on two sides of the electrode tip at the head of the laboratory mouse, and the female button (7) and the male button (6) are correspondingly buckled.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121575516.0U CN215534464U (en) | 2021-07-12 | 2021-07-12 | Experimental mouse brain electricity acquisition fixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121575516.0U CN215534464U (en) | 2021-07-12 | 2021-07-12 | Experimental mouse brain electricity acquisition fixer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215534464U true CN215534464U (en) | 2022-01-18 |
Family
ID=79825019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121575516.0U Active CN215534464U (en) | 2021-07-12 | 2021-07-12 | Experimental mouse brain electricity acquisition fixer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215534464U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114748645A (en) * | 2022-03-25 | 2022-07-15 | 江苏中慧元通生物科技股份有限公司 | Ferritin-based universal influenza vaccine development system |
-
2021
- 2021-07-12 CN CN202121575516.0U patent/CN215534464U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114748645A (en) * | 2022-03-25 | 2022-07-15 | 江苏中慧元通生物科技股份有限公司 | Ferritin-based universal influenza vaccine development system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bartol et al. | Auditory evoked potentials of the loggerhead sea turtle (Caretta caretta) | |
| US20130274583A1 (en) | Electrodes Adapted for Transmitting or Measuring Voltages Through Hair | |
| CN215534464U (en) | Experimental mouse brain electricity acquisition fixer | |
| CN205251540U (en) | Ultrasound stimulation and EEG signal collection probe of integration | |
| Kraus et al. | Cortical mapping of the auditory middle latency response in the unanesthetized guinea pig | |
| Mayhew et al. | A method of assessing auditory and brainstem function in horses | |
| CN213883250U (en) | Adjustable electroencephalogram electrode fixing assembly convenient to position | |
| CN102784010A (en) | Rat primary auditory cortex microelectrode array implantation fixation operation method | |
| CA2959855A1 (en) | Multichannel clip device and methods of use | |
| CN110226929A (en) | A kind of electro physiology test method automating auditory brainstem implant | |
| KR101967867B1 (en) | Apparatus for acquiring bio-signal of laboratory animal and system for measuring bio-signal having the same | |
| CN105852855A (en) | Implantable cerebral electrode for measuring cerebral primary visual electrocorticograms in rodents | |
| CN101904776B (en) | Method and device for pressure regulation and fixation of epidural microstimulation (EMS) visual cortex neural prosthesis | |
| Mahmud et al. | An automated method to remove artifacts induced by microstimulation in local field potentials recorded from rat somatosensory cortex | |
| CN204394730U (en) | A kind of novel rat fixing device | |
| CN210056005U (en) | Safety protection needle electrode | |
| CN209884216U (en) | Tissue biopsy pen for grabbing type stomatology department | |
| CN104287959B (en) | Optical fiber acupunction needle diagnosis and treatment and detection imaging system | |
| CN107028608B (en) | Brain wave signal acquisition device and preprocessing method | |
| CN113648541A (en) | Magnetic stimulation and brain signal acquisition combined synchronous integrated device | |
| CN105944244B (en) | Ultrasound stimulation system | |
| CN205031384U (en) | Frame -type mouse cranium face vertically leads tension loading device | |
| CN205586001U (en) | Be used for electrometric implanted brain electrode of muroid brain primary vision cortex brain | |
| CN116849684B (en) | Signal source space positioning method of multichannel sEMG based on independent component analysis | |
| Sherk et al. | A novel system for recording from single neurons in unrestrained animals |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |