CN110934925A - 一种缓解视疲劳眼贴的中药组合物 - Google Patents
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Abstract
一种功效是缓解视疲劳外用眼贴的中药组合物，其特征在于：由以下重量份中药成分组成：桑叶1‑2份、枸杞1‑2份、菊花1‑2份、密蒙花1‑2份、决明子1‑2份、北苍术0.5‑1份、薄荷0.5‑1份。适用于舒缓眼肌，具有改善或缓解视力障碍、眼困倦、畏光、酸痛、流泪、异物感、眼干涩、眼痉挛等视疲劳症状，及对眼部皮肤黑眼圈、鱼尾纹、眼袋、浮肿等症状的缓解和消除。
Description
技术领域
因用眼过度引起的视疲劳随处可见。据国家教育部、卫生部统计，我国小学生近视率占25％，初中生近视率达到70％，每年以8％的速度增长，居世界第一位。用眼过度轻则出现用眼困难，即眼组织功能异常而视物模糊、眼部酸胀、干涩刺痒，重则出现头痛、恶心、精神萎靡、注意力不集中、食欲不振、颈肩酸痛等。长期反复引起近视、远视、高度屈光不正甚至致盲。西医处理的方法是滴各种眼液、佩戴装置。虽可迅速起效，但滴眼刺激或不卫生引起的眼睑、睑缘炎症、泪腺、结膜、角膜炎症、水肿不断上升，其适应性差、有耐药性、易复发、各种装置效难持久易损坏等，人们很难找到一种效果安全迅速、用法简单、副作用少的药物。中医中药的理法方药目前国内各种制剂及市场外用装置已接近30种，共同缺点是只能部分缓解症状、起效慢、刺激性强、适应性差、药理特性不理想。
本发明的目的及要达到的技术效果是：提出一种新的纯中药处方，价格实惠、疗效显著、制备工艺不复杂、使用方便、无毒副作用的中药组合物。
背景技术
中医强调“上工治未病”，其学术体系使中医药在预防优势明显得以关注。对于视疲劳防治，一些药企也有研发(2006.01)I分类号A61K36/815(2006.01)I、A61P27/02(2006.01)I涉及一种缓解视疲劳的中药组合物，成配合穴位按摩，可以达到对视疲劳标本兼治的效果。
又如主分类号A61/K36/534(2006)I分类号A61/K36/534(2006)I、A61/K9/70(2006)I
本发明涉及一种眼部保健用品，即眼贴及制备方法。眼贴包括加入药液的无纺布，每1000ml药液由以下重量，根素0.4-0.6g，野菊花18-25g，薄荷15-18g，麝香0.06-0.08g，冰片0.2-0.6g。经吉林省卫生监督检验中心检验：试验为无刺激；经40例视力易疲劳的自愿受试，本眼帖具有缓解视疲劳作用
发明内容
桑叶1-2份、枸杞1-2份、菊花1-2份、密蒙花1-2份、决明子1-2份、北苍术0.5-1份、薄荷0.5-1份。
制备工艺
如上所述一种用于缓解视疲劳中药贴剂及其制备方法，加水浸泡60min，桑叶、枸杞、菊花、密蒙花、决明子，加成分的10倍量的水煎煮2次，按每隔40min提取一次液体，提取液采用微米膜过滤得滤过液；北苍术、薄荷檬以无水乙醇浸泡后每隔每次40min提取一次，提取浸膏以适量甘油分散制成甘油液；合并滤过液和甘油液，既得产品原液，原液以无纺布浸润，混匀，每消毒眼用膜袋灌装该混合液1.5ml，封口包装。
用途
用于舒缓眼肌，具有改善或缓解视力障碍、眼困倦、畏光、酸痛、流泪、异物感、眼干涩、眼痉挛等视疲劳症状，及对眼部皮肤黑眼圈、鱼尾纹、眼袋、浮肿等症状的缓解和消除。
剂型
贴剂
使用方法
清洁双眼周围，取贴敷于眼部。覆盖攒竹、鱼腰、丝竹空、太阳穴、承泣、睛明、四白。每日1次，1次20分钟。7天为一疗程。
药理作用
桑叶甘、苦、寒，归肺、肝经。疏散风热、清肺润燥、平抑肝阳、清肝明目。主含黄酮类成分、亦含甾体、挥发油、生物碱、萜类，有抑菌、降糖降脂作用；
枸杞子甘、平，归肝、肾经。滋补肝肾，益精明目。含多糖(提高巨噬细胞，T细胞活力，从而提高免疫力)，甜菜碱(药理不明)，色素类(生物功能，胡罗卜素，叶黄素等，有利于眼部健康)，有抗氧化、抗衰老、降血脂、降血糖、降血脂、抗肿瘤、抗诱变、较强的抑菌作用；
菊花甘、苦、微寒，归肺、肝经。疏散风热、平抑肝阳，清肝明目，清热解毒。其水浸剂或煎剂对金黄色葡萄球菌、多种致病杆菌及皮肤真菌均有一定的抗菌作用，对流感病毒PR3和钩端螺旋体也有抑制作用，具有解热、抗炎镇静、降压、缩短凝血时间作用。菊花含挥发油龙脑、桉叶素等，可醒脑、提神、明目。密蒙花甘、微寒，归肝经。清热泻火、养肝明目，退翳。其提取物体外金黄色葡萄球菌、乙型溶血性链球菌有抑菌作用。此外，有抗血管增生、抑制泪腺细胞凋亡、解痉、利胆、利尿作用；
决明子甘、苦、寒。归肝胆经。清肝泻火，明目，散结消肿。决明子主含大黄酚、大黄素、大黄素甲醚、芦荟大黄素、决明素等恩醌类化合物，并含决明苷、甾醇类及硬脂酸、棕榈酸、油酸、亚油酸等。决明子水浸出液有降压作用。决明子粉、煎剂及流浸膏均有泻下和抗菌作用。决明子醇提取物具有保肝、降转氨酶等作用；
苍术辛、苦、温。归脾、胃、肝经，燥湿健脾，祛风散寒，明目。主要含挥发油，油中含苍术醇、少量苍术酮、维生素A样物质、维生素B及菊糖。其挥发油有明显的抗副交感神经介质乙酰胆碱引起的肠痉挛，能促进肾上腺抑制作用的振幅恢复，苍术挥发油对中枢神经系统小剂量治疗夜盲和角膜软化症；
薄荷辛、凉，归肺、肝经，疏散风热、清利头目，利咽透诊，疏肝行气，主含薄荷脑、薄荷酮、异薄荷酮、柠檬烯。外用时能刺激神经末梢的冷感受器而产生冷感，并反射性地造成深部组织血管的变化而起到消炎、止痛、止痒、局部麻醉和抗刺激作用。
综上7味，有疏风清热、养肝明目，安神舒适作用。
功效：疏风清肝、凉血明目、安神宁心。
原理
眼与五脏六腑有着不可分割的联系，并赖经络为之贯通。肾为藏精之所，肝开窍于目，心之血脉传输，肺司制节，脾上输五脏六腑精气。眼病的发生，亦是感受六淫，加饮食、七情、劳倦所伤而致。视疲劳虽属眼科轻症，但受众广泛。在上述配方中，桑叶、薄荷归肺、肝经，枸杞子归肝、肾经，菊花归肺、肝，密蒙花只属肝经，决明子善入肝、肾、大肠经，清肝明目、润肠通便，早在《神农本草经》就列为上品，苍术归脾、胃、肝经，燥湿健脾、祛风散寒，明目。薄荷清新，营养视神经。加起来滋养肝肾、清心降火、益肺健脾。
临床试验
1.一般资料：成年男性26例，女性24例。轻度视疲劳39例、7例结膜炎、4例睑缘炎。
2.治疗方法：取贴，清洗双侧眼部，闭目，卧位，一次20分钟。连续7日。
3.疗效评定
4.治疗结果：95％.
5.典型病历
叶XX，女，30岁。IT工程师。视疲劳明显，眼晕、头昏2天。经用帖后1周，症状消失，恢复正常工作。
Claims (1)
1.一种功效是疏肝清热、凉血明目、安神宁心作用的外用缓解视疲劳眼贴的中药组合物，其特征在于：由以下重量份中药成分组成：桑叶1-2份、枸杞1-2份、菊花1-2份、密蒙花1-2份、决明子1-2份、苍术0.5-1份薄荷0.5-1份。
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| CN113133957A (zh) * | 2021-04-25 | 2021-07-20 | 广东舒畅日用品有限公司 | 一种植物发酵提拉紧致抗氧化抗疲劳眼贴膜及其制备方法 |
| CN114010724A (zh) * | 2021-12-24 | 2022-02-08 | 李艳红 | 一种治疗眼部疾病的眼膏及其制备方法 |
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