CN110934908A - Compound nutritional health product capable of increasing body temperature to prevent diseases - Google Patents

Compound nutritional health product capable of increasing body temperature to prevent diseases Download PDF

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CN110934908A
CN110934908A CN201811108787.8A CN201811108787A CN110934908A CN 110934908 A CN110934908 A CN 110934908A CN 201811108787 A CN201811108787 A CN 201811108787A CN 110934908 A CN110934908 A CN 110934908A
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body temperature
ginsenoside
glycyrrhizic acid
nutraceutical
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邢修宾
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Xing Yating
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Xing Yating
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

The invention discloses a compound nutritional health product capable of raising body temperature to prevent diseases, which comprises ginseng extract, liquorice extract and Chinese date extract as main components.

Description

Compound nutritional health product capable of increasing body temperature to prevent diseases
Technical Field
The invention relates to a compound nutritional health product capable of raising body temperature to prevent diseases, in particular to a compound nutritional health product capable of raising body temperature to prevent diseases, which is prepared from ginseng extract, liquorice extract and Chinese date extract.
Background
Body temperature is an important vital sign of human beings, and modern medical research shows that body temperature is in direct proportion to metabolism, the basal metabolic rate is increased by about 13% when the body temperature is increased by 1 ℃, a plurality of researches show that the body temperature is increased to greatly enhance immunity, and human beings and animals usually adopt a body temperature raising mode to resist a plurality of diseases, and the traditional Chinese medicine also considers that body cold is a source of ten thousands of diseases. In recent years, many books written by doctors of the primary knot of doctor of Japanese medicine doctor indicate that the increase in body temperature can greatly enhance immunity and can prevent and treat many diseases. In 9 months of 2008, a clinic is opened in the fifth major lane of manhattan in new york, and a medical doctor of manhattan famous medical science zitazechu who deeply intersects famous people such as pilgritz, clinton, beckhem, a-Rod, and smallanthus, also indicates in his written book that the body temperature is reduced by 1 ℃, the immunity is reduced by 30%, the hypothermia can also cause acidification in vivo, accelerate aging, and deteriorate healthy cell metabolism. Therefore, the health care product which can increase the body temperature and has no adverse side effect can be taken by people for a long time to maintain the health and prevent and resist diseases.
In the prior art, thyroid hormone (thyroidodhormone) for promoting metabolism can increase thermogenesis to raise body temperature, but if excessive or dosage is increased too fast, adverse side effects such as palpitation, pulse pressure rise, arrhythmia, angina and even heartbeat stop can be caused, and Theophylline (Theophylline) for treating bronchial diseases can also increase thermogenesis to raise body temperature, but adverse side effects such as headache, nausea, insomnia, palpitation and the like can be caused. Some drugs affect the physiological mechanism of central system for regulating heat to raise body temperature, such as monoamine oxidase inhibitor (MAO-I) and Opioids, which may affect the mechanism of body temperature regulation by increasing heat generation to cause fever, and other anticholinergic drugs, tricyclic antidepressants, antihistamines and synthetic alkaloids (such as cocaine) may affect hypothalamic thermoregulatory center and lower peripheral blood temperature, resulting in the symptoms of fever with anticholinergic toxicity. Because the above-mentioned drugs for increasing body temperature in the prior art have many disadvantages of adverse side effects, they are not suitable for human to take for a long time to increase body temperature to maintain health and prevent diseases. Therefore, the invention discloses a health care product which can increase body temperature and has no adverse side effect after long-term use, so that people can maintain health and prevent and resist diseases, and the defects in the prior art can be solved.
Therefore, the inventor is careful to research and explore, and has a mind that is not bound by the inventor to solve the deficiency of the prior art, and finally conceive the 'compound nutritional health care product capable of raising the body temperature to prevent diseases'.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a compound nutritional health-care product which is prepared by taking a ginseng extract, a liquorice extract and a Chinese date extract as raw materials and can raise the body temperature to prevent diseases, in particular to a novel technical scheme which can not only increase the body temperature after being taken, but also has no adverse side effect after being taken for a long time and can be taken by people for a long time to maintain health and prevent and resist diseases.
The invention relates to a solution of a compound nutritious health product for raising body temperature to prevent diseases, which is the result of intensive research and research by the inventor and experiments by adopting examples, because the medicines capable of raising body temperature in the prior art have a plurality of defects of adverse side effects and are not suitable for long-term taking of human beings for raising body temperature to maintain health and prevent diseases, the inventor adopts the components in the plants such as ginseng, liquorice, Chinese date and the like which are eaten by human beings daily since ancient times as raw materials to prepare the compound nutritious health product which can not only raise body temperature but also has no adverse side effects after long-term taking, and can be taken by human beings for long term to maintain health and prevent and resist diseases.
The compound nutritional health product comprises the following raw materials: ginseng extract, licorice extract and jujube extract, and the index components of each extract include ginsenoside Rg1 and Rb1, glycyrrhizic acid and glycyrrhetinic acid, and jujube cyclic adenosine monophosphate.
Because the ginsenoside Re can be metabolized into the ginsenoside Rg1 in a human body, the ginsenoside Re can be used for replacing the ginsenoside Rg1 when the compound nutritional health-care product is prepared, and the ginsenoside Rd can be metabolized into the ginsenoside Rb1 in the human body, so the ginsenoside Rd can be used for replacing the ginsenoside Rb1 when the compound nutritional health-care product is prepared. After taking the embodiment of the invention, many people can not only raise the body temperature, but also can not catch a cold for a long time, and has no adverse side effect.
The technology disclosed by the invention can be applied to prepare special medical food, health-care food, nutrition auxiliary food and medicines which are suitable for human beings to take for a long time to raise the body temperature so as to promote metabolism and enhance immunity, has the advantage of high safety after long-term taking, and further overcomes the defects of a plurality of adverse side effects in the prior art.
The invention discloses a compound nutritional health product capable of raising body temperature to prevent diseases, which comprises the following raw materials: ginseng extract, licorice extract and jujube extract.
Preferably, the index components of the raw materials of the compound nutritional health product comprise: the ginseng extract comprises 2-27 parts by weight of ginsenoside (Rg1+ Rb 1); and the licorice extract contains 3-49 parts by weight of glycyrrhizic acid, and the glycyrrhizic acid is selected from one of glycyrrhizic acid, glycyrrhetinic acid and a combination thereof; and the jujube extract contains 0.002-0.6 weight part of jujube cyclic adenosine monophosphate.
Preferably, the compound nutritional health product comprises one selected from food nutrition and pharmaceutically acceptable carriers, additives and combinations thereof.
Preferably, the compound nutritional health product is prepared into a dosage form, and the dosage form is one of lozenge, capsule, powder, tablet, powder, solution, microcapsule, suspension, emulsion, granule, dripping pill, pill and pharmaceutical oral dosage forms.
Preferably, the compound nutritional health product comprises special medical food, health food, nutritional auxiliary food and medicines which can be prepared into special medical food, health food, nutritional auxiliary food and medicines for raising body temperature to promote metabolism and enhance immunity.
According to another aspect of the present invention, there is disclosed a compound nutraceutical for increasing body temperature to prevent diseases, comprising: a first main component comprising 2-27 parts by weight of ginsenoside (Rg1+ Rb 1); and a second main component comprising 3 to 49 parts by weight of a glycyrrhizic acid selected from the group consisting of glycyrrhizic acid, glycyrrhetinic acid, and combinations thereof; and the third main component, which contains 0.002-0.6 weight part of jujube cyclic adenosine monophosphate.
Preferably, the compound nutritional health product of the invention comprises one selected from a food nutrition and pharmaceutically acceptable carrier, an additive and a combination thereof.
Preferably, the compound nutritional health product comprises a preparation form, wherein the preparation form is one selected from lozenge, capsule, powder, tablet, powder, solution, microcapsule, suspension, emulsion, granule, dripping pill, pill and pharmaceutical oral preparation forms.
Preferably, the compound nutritional health product comprises special medical food, health food, nutritional auxiliary food and medicines which can be prepared into special medical food, health food, nutritional auxiliary food and medicines for raising body temperature to promote metabolism and enhance immunity.
According to another aspect of the present invention, a compound nutraceutical for elevating body temperature to prevent diseases, comprises: a first main component comprising a first ginsenoside (selected from ginsenoside Rg1, ginsenoside Re, and combinations thereof) and a second ginsenoside (selected from ginsenoside Rb1, ginsenoside Rd, and combinations thereof); and a second main component comprising glycyrrhizic acid (selected from glycyrrhizic acid, glycyrrhetinic acid, and combinations thereof); and the third main component is prepared with date cyclic adenosine monophosphate.
After the present invention is disclosed, the ordinary addition and subtraction cutting of the nutrition health care product by the technicians in the field is all the ordinary technical activities of the technicians in the field, so the compound nutrition health care product capable of raising the body temperature to prevent the diseases is the core content for realizing the purpose of the present invention, and the compound nutrition health care product is all within the protection scope of the present invention.
In order to make the invention more comprehensible, the following detailed description is given with reference to the accompanying drawings.
Drawings
FIG. 1 is a schematic flow chart of a method for preparing a nutraceutical according to an embodiment of the present invention.
Fig. 2 is a schematic flow chart of a method for preparing the five-component nutritional health product of the invention.
Detailed Description
The invention will be further explained with reference to the drawings and examples. The compound nutritional health-care product is prepared by combining the characteristics of the invention by adopting a method known by persons skilled in the art. The following examples are for illustrative purposes only and are not intended to limit the present invention.
In order to achieve the purpose of the invention, the invention particularly proposes the following technical solutions.
The invention discloses a compound nutritional health product capable of raising body temperature to prevent diseases, which is prepared from raw materials including ginseng extract, licorice extract, Chinese date extract and the like.
The first scheme is as follows:
the compound nutritional health product capable of raising body temperature to prevent diseases is prepared by processing raw materials containing ginseng extract, liquorice extract and Chinese date extract.
Scheme II:
the compound nutritional health product is prepared by processing raw materials of ginseng extract containing 2-27 parts by weight of ginsenoside (Rg1+ Rb1), liquorice extract containing 3-49 parts by weight of glycyrrhizic acid (one of glycyrrhizic acid, glycyrrhetinic acid and a combination thereof), and Chinese date extract containing 0.002-0.6 part by weight of Chinese date cyclic adenosine monophosphate.
The third scheme is as follows:
the compound nutritional health product of the invention can contain carriers or additives acceptable in food nutrition and pharmacy, and can be prepared into any pharmaceutically known oral pharmaceutical dosage forms such as troches, capsules, powder and the like.
And the scheme is as follows:
the nutrient health-care product of the invention can be prepared into special medical food, health-care food, nutrient auxiliary food and medicines which can raise body temperature to promote metabolism and enhance immunity.
And a fifth scheme:
the compound nutrient health-care product capable of raising body temperature and preventing diseases is prepared by processing raw materials of a first main component containing 2-27 parts by weight of ginsenoside (Rg1+ Rb1), a second main component containing 3-49 parts by weight of glycyrrhizic acid (one selected from glycyrrhizic acid, glycyrrhetinic acid and a combination thereof), and a third main component containing 0.002-0.6 part by weight of jujube cyclic adenosine monophosphate.
Scheme six:
the compound nutrient health-care product capable of raising body temperature and preventing diseases is prepared by processing raw materials of a first main component containing first ginsenoside (selected from ginsenoside Rg1, ginsenoside Re and one of the combination thereof) and second ginsenoside (selected from ginsenoside Rb1, ginsenoside Rd and one of the combination thereof), a second main component containing glycyrrhizic acid (selected from glycyrrhizic acid, glycyrrhetinic acid and one of the combination thereof) and a third main component containing jujube cyclic adenosine monophosphate.
In order to achieve the purpose of the invention, the preparation method of the compound nutritional health product is particularly provided.
The method comprises the following steps:
the raw materials containing ginseng extract, licorice extract and Chinese date extract are processed into the compound nutritional health-care product capable of raising body temperature to prevent diseases.
The second method comprises the following steps:
processing raw materials of a ginseng extract containing 2-27 parts by weight of ginsenoside (Rg1+ Rb1), a liquorice extract containing 3-49 parts by weight of glycyrrhizic acid (selected from glycyrrhizic acid, glycyrrhetinic acid and one of the combination thereof), and a Chinese date extract containing 0.002-0.6 part by weight of Chinese date cyclic adenosine monophosphate to prepare the compound nutritional health product.
The third method comprises the following steps:
the compound nutritional health product of the invention is added with carriers or additives which contain food nutrition and are acceptable in pharmacy to be prepared into any pharmaceutical dosage forms known in pharmacy, such as troches, capsules, powder and the like.
The method four comprises the following steps:
the nutritional health-care product of the invention is prepared into special medical food, health-care food, nutritional auxiliary food and medicine which can increase the body temperature to promote metabolism and enhance immunity.
The method five comprises the following steps:
the compound nutritional health product capable of raising body temperature and preventing diseases is prepared by processing raw materials of a first main component containing 2-27 parts by weight of ginsenoside (Rg1+ Rb1), a second main component containing 3-49 parts by weight of glycyrrhizic acid (one selected from glycyrrhizic acid, glycyrrhetinic acid and a combination thereof), and a third main component containing 0.002-0.6 part by weight of jujube cyclic adenosine monophosphate.
The method six:
the compound nutrient health-care product capable of raising body temperature and preventing diseases is prepared by processing raw materials of a first main component containing first ginsenoside (selected from ginsenoside Rg1, ginsenoside Re and one of the combination thereof) and second ginsenoside (selected from ginsenoside Rb1, ginsenoside Rd and one of the combination thereof), a second main component containing glycyrrhizic acid (selected from glycyrrhizic acid, glycyrrhetinic acid and one of the combination thereof) and a third main component containing jujube cyclic adenosine monophosphate.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The invention will be further explained with reference to the drawings and the specific embodiments.
Example one
Please refer to fig. 1, which is a schematic flow chart of a method for preparing a compound nutritional health product according to an embodiment of the present invention. In figure 1, 30kg of ginseng is crushed, then is heated and extracted by 70% ethanol solution, and is separated, purified and dried by column chromatography to obtain 1.1kg of ginseng extract containing 143g of ginsenoside Rg1+ Rb 1; crushing 10kg of liquorice, heating and extracting by using 70% ethanol solution, concentrating and drying to obtain 1.9kg of liquorice extract containing 196g of glycyrrhizic acid; crushing 20kg of Chinese dates, adding water, soaking at normal temperature, filtering the soaking solution to obtain a Chinese date extract, adsorbing, separating, purifying and drying by using a macroporous resin column to obtain 66.3g of a Chinese date extract containing cAMP1.113g of the Chinese dates as a raw material for preparing the compound nutritional health-care product; then, 100g of the ginseng extract, 200g of the licorice extract and 9.2g of the Chinese date extract obtained by the method are crushed and mixed uniformly to obtain 309.2g of the compound nutritional health-care product according to the first scheme of the invention.
Example two
Please refer to fig. 2, which is a flow chart of a method for preparing a compound nutritional health product according to the second embodiment of the present invention. In the figure 2, after 120g of the ginseng extract and 2g of the jujube extract obtained in the first embodiment are added with 24g of commercially available glycyrrhetinic acid with the purity of 96 percent, and the mixture is crushed and uniformly mixed, 146g of the compound nutritional health product of the fifth embodiment of the invention is obtained.
The first experimental example: example one test for raising body temperature
1. The number of the tested persons is as follows:
16 adults, gender and age distribution are shown in Table 1.
Table 1: experimental example a sex and age distribution of the test subjects
Age (age) 41~50 51~60 61~70 71~80 81~90 Total up to
For male 0 3 4 1 0 8
Woman 2 2 1 1 2 8
2. The test mode is as follows:
the capsule prepared as the nutrition supplementary food in the first embodiment is provided for a tester to take, the average body temperature of the tester is measured before the tester takes the first embodiment, and the average body temperature of the tester is measured after the tester takes 800 mg of the first embodiment every day for 7 days.
3. And (3) test results:
the average body temperature of 13 of the testers is increased by more than 0.4 ℃, and no adverse side effect exists.
Experiment example two: EXAMPLE one Cold prevention test
1. The number of the tested persons is as follows:
6 adults, sex and age distribution are shown in Table 2.
Table 2: experimental example two sex and age distribution of the test subjects
Age (age) 51~60 61~70 71~80 Total up to
For male 2 1 1 4
Woman 2 0 0 2
2. The test mode is as follows:
the first example was prepared as a nutraceutical capsule and provided to the experimenter for administration, who took 800 mg of the first example per day for 6 consecutive months.
3. And (3) test results:
in the test process, 5 people have no cold phenomenon, 1 person has throat discomfort phenomenon for two days, and no adverse side effect exists.
The application range of the compound nutritional health product capable of increasing body temperature to prevent diseases is as follows:
1. the compound nutritional health product capable of raising body temperature to prevent diseases can contain food nutritionally and pharmaceutically acceptable additives;
2. the compound nutritional health product capable of raising body temperature to prevent diseases can be processed into various known formulations such as powder, capsules, tablets and the like; and
3. the compound nutritional health-care product capable of increasing body temperature to prevent diseases can be prepared into special medical food, health-care food, nutritional auxiliary food and medicines capable of increasing body temperature to promote metabolism and enhance immunity.
The invention is subject to various modifications as will be obvious to those skilled in the art, without however departing from the scope of the appended claims.

Claims (10)

1. A compound nutritional health product capable of raising body temperature to prevent diseases is characterized in that the compound nutritional health product comprises the following raw materials: ginseng extract, licorice extract and jujube extract.
2. The compound nutritional health product of claim 1, wherein the raw materials of the nutritional health product comprise index components of:
the ginseng extract comprises 2-27 parts by weight of ginsenoside Rg1+ Rb 1;
the licorice extract comprises 3-49 parts by weight of glycyrrhizic acid, and the glycyrrhizic acid is one selected from glycyrrhizic acid, glycyrrhetinic acid and a combination thereof; and
the jujube extract contains 0.002-0.6 weight part of jujube cyclic adenosine monophosphate.
3. The combination nutritional supplement of claim 1, wherein said combination nutritional supplement comprises a composition comprising one selected from the group consisting of a dietetic and a pharmaceutically acceptable carrier, an additive, and combinations thereof.
4. The compound nutraceutical of claim 1, wherein said compound nutraceutical is in a dosage form selected from the group consisting of a lozenge, a capsule, a powder, a tablet, a powder, a solution, a microcapsule, a suspension, an emulsion, a granule, a drop pill, a pill, and a pharmaceutical oral dosage form.
5. The compound nutraceutical of claim 1, wherein the compound nutraceutical comprises a specialized medical food, a health food, a nutritional supplement, and a pharmaceutical product that can be prepared to increase body temperature to promote metabolism and enhance immunity.
6. A compound nutritional health product capable of raising body temperature to prevent diseases, which is characterized by comprising:
the first main component: comprises 2-27 parts by weight of ginsenoside Rg1+ Rb 1;
the second main component: contains 3 to 49 parts by weight of glycyrrhizic acid, wherein the glycyrrhizic acid is one selected from glycyrrhizic acid, glycyrrhetinic acid and a combination thereof; and
the third main component: contains 0.002-0.6 weight part of jujube cyclic adenosine monophosphate.
7. The combination nutritional supplement of claim 6, wherein said combination nutritional supplement comprises a composition comprising one selected from the group consisting of a dietetic and a pharmaceutically acceptable carrier, an additive, and combinations thereof.
8. The compound nutraceutical of claim 6, wherein said compound nutraceutical is in a dosage form selected from the group consisting of a lozenge, a capsule, a powder, a tablet, a powder, a solution, a microcapsule, a suspension, an emulsion, a granule, a drop pill, a pill, and a pharmaceutical oral dosage form.
9. The compound nutraceutical of claim 6, wherein the compound nutraceutical comprises a special medical food, a health food, a nutritional supplement, and a pharmaceutical product that can be prepared to increase body temperature to promote metabolism and enhance immunity.
10. A compound nutritional health product capable of raising body temperature to prevent diseases, which is characterized by comprising:
the first main component: comprises a first ginsenoside selected from the group consisting of ginsenoside Rg1, ginsenoside Re, and combinations thereof, and a second ginsenoside selected from the group consisting of ginsenoside Rb1, ginsenoside Rd, and combinations thereof;
the second main component: comprises glycyrrhizic acid selected from glycyrrhizic acid, glycyrrhetinic acid and combinations thereof; and
the third main component: comprises annular adenosine monophosphate of Chinese date.
CN201811108787.8A 2018-09-21 2018-09-21 Compound nutritional health product capable of increasing body temperature to prevent diseases Pending CN110934908A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN115300547A (en) * 2021-05-06 2022-11-08 邢禹贤 Application of pharmaceutical composition in preparation of medicines and health-care products for treating halitosis, hemorrhoid, leucorrhea and fishy smell and one of combination thereof

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Application publication date: 20200331