CN110927252A - Targeted shear wave elastography detection system and detection method thereof - Google Patents
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- 238000002099 shear wave elastography Methods 0.000 title claims abstract description 27
- 238000012360 testing method Methods 0.000 claims abstract description 36
- 238000003384 imaging method Methods 0.000 claims abstract description 35
- 239000006249 magnetic particle Substances 0.000 claims abstract description 25
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- 238000006073 displacement reaction Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 238000012285 ultrasound imaging Methods 0.000 claims description 4
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- 238000002091 elastography Methods 0.000 description 8
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- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
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Abstract
The invention provides a targeted shear wave elastography detection system and a detection method thereof, wherein magnetic particles are injected into a test body, and the test body is placed between an ultrasonic transducer and an excitation coil; the function generator transmits square waves to the power amplifier, and simultaneously transmits a trigger signal to the ultrasonic imaging system; the power amplifier amplifies the square wave, the exciting coil generates a pulse magnetic field to act on the test body, and the magnetic field drives the magnetic particles in the test body to vibrate; the ultrasonic imaging system triggers an ultrasonic transducer to work, and the ultrasonic transducer receives reflected pulses to form a radio frequency echo signal; the ultrasonic imaging system collects radio frequency echo signals from the ultrasonic transducer, demodulates and images the radio frequency echo signals, and calculates to obtain shear wave velocity c and shear modulus G. The invention uses magnetic particles as probes as markers, can effectively improve the penetrability of excitation signals in complex environments, and has accurate and reliable detection results of shear wave elastography detection.
Description
Technical Field
The invention relates to elastography, and particularly discloses a targeted shear wave elastography detection system and a detection method thereof.
Background
According to different excitation modes, ultrasonic elastography can be divided into quasi-static elastography, low-frequency vibration acoustic elastography, shear wave elastography, acoustic radiation force pulse imaging, rapid shear wave imaging and the like. These imaging methods quantify the shear modulus of tissue primarily by measuring the shear wave velocity in a region of interest. Generally, the greater the hardness of the test body, the greater the shear wave velocity and shear modulus.
Shear wave elastography generally handles the acquisition through ultrasonic imaging system, elastography detecting system among the prior art mainly tests the test body through ultrasonic transducer, rethread ultrasonic imaging system information collection carries out shear wave elastography, because the inside of different test bodies has different structures and components, the transmission of ultrasonic wave may be hindered to different structures and components of the test body inside, thereby influence the sensitivity that shear wave elastography detected, elastography system among the prior art can't obtain accurate reliable shear wave elastography testing result to all test bodies.
Disclosure of Invention
Therefore, it is necessary to provide a targeted shear wave elastography detection system and a detection method thereof, which can effectively improve the reliability of the shear wave elastography detection result, in view of the problems in the prior art.
In order to solve the problems in the prior art, the invention discloses a targeted shear wave elastography detection system which comprises a function generator, wherein the output end of the function generator is respectively connected with a power amplifier and an ultrasonic imaging system, the output end of the power amplifier is connected with an exciting coil, the data acquisition end of the ultrasonic imaging system is connected with an ultrasonic transducer, and a test body containing magnetic particles is arranged between the exciting coil and the ultrasonic transducer.
Further, the ultrasonic imaging system is a Verasonics system.
Further, the ultrasonic transducer is a linear array ultrasonic transducer.
The invention also discloses a targeted shear wave elastography detection method, which comprises the following steps:
step one, injecting magnetic particles into a test body, and placing the test body between an ultrasonic transducer and an exciting coil;
step two, the function generator transmits square waves to the power amplifier, and simultaneously transmits a trigger signal to the ultrasonic imaging system;
amplifying the square wave by a power amplifier to obtain an amplified square wave, generating a pulse magnetic field by an exciting coil under the excitation of the amplified square wave to act on the test body, and driving magnetic particles in the test body to vibrate by the magnetic field;
triggering an ultrasonic transducer to work by an ultrasonic imaging system, emitting a detection pulse by the ultrasonic transducer to act on a test body to form a reflection pulse, and receiving the reflection pulse by the ultrasonic transducer to form a radio frequency echo signal;
and step five, the ultrasonic imaging system acquires a radio frequency echo signal from the ultrasonic transducer, demodulates and images the radio frequency echo signal, and calculates to obtain shear wave velocity c and shear modulus G.
Further, in the second step, the square wave pulse width emitted by the function generator is 1 ms.
Further, in the third step, the power amplifier amplifies the square wave by 20dB to obtain an amplified square wave.
Furthermore, in the fourth step, the central frequency of the detection pulse emitted by the ultrasonic transducer is 5MHz, the repetition frequency is 10kHz, the number of composite angles is 5, and the effective detection frequency is 2 kHz.
Further, in the fifth step, the calculation methods for obtaining the shear wave velocity c and the shear modulus G by the ultrasonic imaging system respectively include:
wherein ,
is the average displacement within a given axial range, M is the number of samples in the vertical direction, N is the number of samples in the time direction, fcThe center frequency of the radio frequency signal is shown, I and Q are in-phase and quadrature components of the radio frequency echo signal after demodulation respectively, and rho is the density of the test body.
The invention has the beneficial effects that: the invention discloses a targeted shear wave elastography detection system and a detection method thereof.A magnetic particle is used as a probe to serve as a mark, and under the action of a magnetic field emitted by an excitation coil, the magnetic particle can vibrate to further cause shear wave propagation of a surrounding structure of the magnetic particle, so that the penetrability of an excitation signal in a complex environment can be effectively improved, vibration and shear wave propagation information of the magnetic particle can be accurately and reliably obtained through an ultrasonic transducer, the overall sensitivity of the system is effectively improved, an ultrasonic imaging system can obtain the distribution of the magnetic particle and the elasticity information of the surrounding structure of the magnetic particle, and the detection result of shear wave elastography detection is accurate and reliable.
Drawings
FIG. 1 is a schematic structural diagram of a targeted shear wave elastography detection system of the present invention.
Fig. 2 is a schematic flow chart of demodulation imaging of the ultrasonic imaging system in the invention.
FIG. 3 is an image of a conventional method of inspection and the inspection of the present invention.
FIG. 4 is a graph showing the vibration displacement at different detection points during the detection of the present invention.
The reference signs are: function generator 10, power amplifier 20, ultrasonic imaging system 30, exciting coil 40, ultrasonic transducer 50, test body 60.
Detailed Description
For further understanding of the features and technical means of the present invention, as well as the specific objects and functions attained by the present invention, the present invention will be described in further detail with reference to the accompanying drawings and detailed description.
Refer to fig. 1 to 4.
The embodiment of the invention discloses a targeted shear wave elastography detection system, which comprises a function generator 10, wherein the output end of the function generator 10 is respectively connected with a power amplifier 20 and an ultrasonic imaging system 30, the output end of the power amplifier 20 is connected with an exciting coil 40, the data acquisition end of the ultrasonic imaging system 30 is connected with an ultrasonic transducer 50, and a test body 60 containing magnetic particles is arranged between the exciting coil 40 and the ultrasonic transducer 50.
In this embodiment, the ultrasound imaging system 30 is a Verasonics system in the united states, and through a friendly and powerful MATLAB compiling environment, researchers can customize any one component function of the whole ultrasound system, and can perform rapid data acquisition based on plane wave pulse emission.
In the present embodiment, the ultrasonic transducer 50 is a linear array ultrasonic transducer 50 of type L7-4.
The embodiment of the invention also discloses a targeted shear wave elastography detection method, which sequentially comprises the following steps:
step one, injecting magnetic particles into a test body 60, wherein the magnetic particles are equivalent to an image probe and used for improving the sensitivity and accuracy of elastography, and placing the test body 60 between an ultrasonic transducer 50 and an exciting coil 40;
step two, the function generator 10 transmits square waves to the power amplifier 20, and the function generator 10 simultaneously transmits a trigger signal to the ultrasonic imaging system 30;
step three, the power amplifier 20 amplifies the square wave to obtain an amplified square wave, the exciting coil 40 generates a pulse magnetic field under the excitation of the amplified square wave to act on the test body 60, and the magnetic field drives the magnetic particles in the test body 60 to vibrate;
step four, the ultrasonic imaging system 30 triggers the ultrasonic transducer 50 to work, the ultrasonic transducer 50 emits detection pulses to act on the test body 60 under the action of the pulse magnetic field to form reflection pulses, and the ultrasonic transducer 50 receives the reflection pulses to form radio frequency echo signals;
and step five, the ultrasonic imaging system 30 acquires the radio frequency echo signal from the ultrasonic transducer 50, demodulates and images the radio frequency echo signal, and calculates to obtain the shear wave velocity c and the shear modulus G of the test body 60.
In this embodiment, in step five, as shown in fig. 2, the ultrasonic imaging system 30, that is, the method for demodulating and imaging the radio frequency echo signal, specifically includes:
A. IQ demodulation is carried out on the radio frequency echo signal to obtain a demodulation signal;
B. envelope and autocorrelation of the demodulated signal;
C. carrying out normalization, logarithmic compression and structural imaging on the signal subjected to envelope finding in sequence;
D. sequentially carrying out centroid positioning, median filtering and magnetic imaging on the autocorrelation signals;
E. and obtaining the mass point vibration speed from the self-correlated signal, and sequentially performing direction filtering, speed fitting and elastography on the mass point vibration speed.
In this embodiment, in step two, the pulse width of the square wave emitted by the function generator 10 is 1 ms.
In the present embodiment, in step three, the power amplifier 20 amplifies the square wave by 20dB to obtain an amplified square wave.
In the fourth step of the present embodiment, the ultrasonic transducer 50 emits detection pulses with a center frequency of 5MHz, a repetition frequency of 10kHz, a number of composite angles of 5, and an effective detection frequency of 2 kHz.
In this embodiment, in step five, the calculation methods for obtaining the shear wave velocity c and the shear modulus G by the ultrasound imaging system 30 are respectively as follows:
wherein ,
is the average displacement in a given axial range, M is the number of samples in the vertical direction, i.e. in the depth direction, N is the number of samples in the time direction, i.e. the number of frames, fcFor the central frequency of the radio frequency signal, I and Q are respectively the in-phase and quadrature components of the radio frequency echo signal after IQ demodulation, the same excitation method is repeated for each phantom for a plurality of times, and the obtained data are superposed to improve the signal-to-noise ratio of the vibration displacement detection signal, where ρ is the density of the test body 60.
Detection was performed using both the traditional method and the inventive method:
preparing a simulated body, namely mixing pigskin powder, corn powder and deionized water according to the mass ratio of 5: 5: 100, microwave heating to dissolve pigskin powder and corn powder, placing in a dummy mold, and cooling to obtain hollow gel. Taking part of the imitation solution after being heated and dissolved and magnetic particles gamma-Fe respectively2O3And nonmagnetic particles α -Fe2O3The mixture was mixed, the particle diameters of the magnetic particles and the non-magnetic particles were each 10nm, and the prepared particles were concentrated at 10mg/ml, which were then separately poured into gels having a hollow region with a diameter of 3mm to obtain a phantom, which was used as the test body 60.
The region with large acoustic impedance difference is first scanned by a conventional B-mode ultrasound imaging system to obtain the cross-sectional area of the particle marker. As shown in fig. 3 a1-a3, both the areas marked with magnetic particles and non-magnetic particles show a strong acoustic reflection signal. The results also indicate that single structure imaging in the conventional method is susceptible to interference from other occupancy information.
By detecting with the method of the invention, through excitation of the pulsed magnetic field and acquisition and processing of vibration signals, we can obtain the vibration distribution of magnetic particles with good signal-to-noise ratio, as shown in b in fig. 3. Comparing a1, a2, a3 and b in fig. 3, the position of the vibration source can be clearly located, as shown in c in fig. 3. The vibration information of the surrounding tissues is collected and analyzed while the position of the vibration source is obtained, and the time intervals of the parts b and c in fig. 3 from the excitation signal are respectively 0.5ms, 1.5ms, 2.5ms and 3.5 ms. The results show more pronounced shear wave propagation. Subsequently, the variation curves of the vibration displacement with time are respectively calculated for three different positions in the shear wave propagation process, and as a result, as shown in fig. 4, the distance between two adjacent points is 0.308mm, and in the shear wave propagation process, the displacement curve of a farther mass point and the displacement curve of a closer mass point have a certain time delay in phase, and the displacement amplitude value shows a decreasing trend. Based on the above, by analyzing the vibration phase diagrams at different positions on the vibration source line, the time difference of each point reaching the peak displacement is respectively calculated, and then linear fitting is carried out, so that the shear wave speed of the dummy is 3.669m/s, the density of the dummy is about 1.3Kg/L, and the shear modulus of the dummy is about 17.5 Kpa. The hardness of the test body 60 is reflected in terms of shear wave velocity and shear modulus.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. The targeted shear wave elastography detection system is characterized by comprising a function generator (10), wherein the output end of the function generator (10) is respectively connected with a power amplifier (20) and an ultrasonic imaging system (30), the output end of the power amplifier (20) is connected with an exciting coil (40), the data acquisition end of the ultrasonic imaging system (30) is connected with an ultrasonic transducer (50), and a test body (60) containing magnetic particles is arranged between the exciting coil (40) and the ultrasonic transducer (50).
2. A targeted shear wave elastography detection system as claimed in claim 1, wherein the ultrasound imaging system (30) is a Verasonics system.
3. A targeted shear wave elastography detection system as claimed in claim 1, wherein said ultrasound transducer (50) is a linear array ultrasound transducer (50).
4. A method of testing a targeted shear wave elastography detection system as claimed in any of claims 1 to 3, comprising the steps of:
step one, injecting magnetic particles into a test body (60), and placing the test body (60) between an ultrasonic transducer (50) and an exciting coil (40);
step two, the function generator (10) transmits square waves to the power amplifier (20), and the function generator (10) simultaneously transmits a trigger signal to the ultrasonic imaging system (30);
amplifying the square wave by the power amplifier (20) to obtain an amplified square wave, wherein the exciting coil (40) generates a pulse magnetic field under the excitation of the amplified square wave to act on the test body (60), and the magnetic field drives the magnetic particles in the test body (60) to vibrate;
step four, the ultrasonic imaging system (30) triggers the ultrasonic transducer (50) to work, the ultrasonic transducer (50) emits detection pulses to act on the test body (60) to form reflection pulses, and the ultrasonic transducer (50) receives the reflection pulses to form radio frequency echo signals;
and fifthly, the ultrasonic imaging system (30) acquires the radio frequency echo signal from the ultrasonic transducer (50), demodulates and images the radio frequency echo signal, and calculates to obtain the shear wave velocity c and the shear modulus G.
5. The targeted shear wave elastography detection method of claim 4, wherein in step two, the square wave pulse width emitted by the function generator (10) is 1 ms.
6. The targeted shear wave elastography detection method of claim 5, wherein in step three, the power amplifier (20) amplifies the square wave by 20dB to obtain an amplified square wave.
7. The targeted shear wave elastography detection method of claim 6, wherein in step four, the ultrasonic transducer (50) emits detection pulses with a center frequency of 5MHz, a repetition frequency of 10kHz, a composite angle number of 5 and an effective detection frequency of 2 kHz.
8. The targeted shear wave elastography detection method of claim 4, wherein in step five, the computation methods for the ultrasonic imaging system (30) to obtain the shear wave velocity c and the shear modulus G are respectively as follows:
wherein ,
is the average displacement within a given axial range, M is the number of samples in the vertical direction, N is the number of samples in the time direction, fcI and Q are the in-phase and quadrature components of the demodulated radio frequency echo signal, respectively, at the center frequency of the radio frequency signal, and ρ is the density of the test volume (60).
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| CN113768543A (en) * | 2021-09-15 | 2021-12-10 | 南京超维景生物科技有限公司 | Ultrasound contrast imaging method and system |
| GB2616515A (en) * | 2022-01-27 | 2023-09-13 | Darkvision Tech Inc | Efficient storage of high-resolution industrial ultrasonic data |
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| GB2616515A (en) * | 2022-01-27 | 2023-09-13 | Darkvision Tech Inc | Efficient storage of high-resolution industrial ultrasonic data |
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