CN110917502B

CN110917502B - Oral cavity implanted wireless power supply luminous micro device capable of promoting dental tissue repair

Info

Publication number: CN110917502B
Application number: CN201911132583.2A
Authority: CN
Inventors: 谢曦; 钟璐宇; 张涛; 杭天; 杨成端; 陈惠琄; 胡宁; 何根; 吴倩妮; 黄爽
Original assignee: Sun Yat Sen University
Current assignee: Sun Yat Sen University
Priority date: 2019-11-14
Filing date: 2019-11-14
Publication date: 2021-11-30
Anticipated expiration: 2039-11-14
Also published as: CN110917502A

Abstract

The invention discloses an oral cavity implanted wireless power supply luminous micro device capable of promoting dental tissue repair, which adopts a resonance coil system to supply power, does not have the problems of wire abrasion, bare and poor contact easily caused by the traditional power supply mode adopting wire connection, potential safety hazard or battery size limitation, service life limitation or troublesome replacement and the like existing in the traditional battery power supply mode, is more convenient and safer, can transmit energy under the action of a high-frequency alternating magnetic field through the electromagnetic induction effect of an external transmitting coil and an internal receiving coil, can provide continuous power supply for an LED phototherapy lamp implanted in the oral cavity in the treatment process, and provides a reliable optimal scheme for the long-term power supply of implanted equipment.

Description

Oral cavity implanted wireless power supply luminous micro device capable of promoting dental tissue repair

Technical Field

The invention belongs to the field of dental medicine, and particularly relates to an oral implanted wireless power supply luminous micro device capable of promoting dental tissue repair.

Background

One of the main goals of dental medicine is to restore the oral system, restoring tissue damage, defects or wounds due to trauma, disease, atrophy or surgery. As in oral surgery, the most common post-operative wound is a wound located near the oral mucosa or jaw bone. Tooth extraction is one of the most common surgical procedures (e.g., tooth extraction is required when removing a tumor). Generally, these postoperative wounds require proper care and treatment due to the long healing period of the tissue, or may cause serious complications and great discomfort to the patient. One of the most common complications is a dry socket after tooth extraction, which is exposed due to the dissolution of blood clots, causing severe and persistent pain, halitosis, and localized lymphadenitis. Meanwhile, the implant of the artificial tooth root is generally needed to be implanted at the tooth missing part caused by the tooth extraction operation, namely, the implant is implanted into the upper and lower jawbone of the tooth missing part of the human body in a surgical operation mode, and after the operation wound is healed, the prosthetic tooth is installed at the upper part of the implant. The ultimate goal is to achieve a proper bond between the alveolar bone and the implant in the patient, a process known as osseointegration. Generally speaking, the implantation of the implant needs a relatively healthy and good bone tissue environment, and if the wound tissue of the tooth extraction socket is not healed for a long time or inflammation is frequently generated, the implantation of the artificial titanium implant is not facilitated. After the implant is implanted, the duration of osseointegration should not be too long, and the longer the duration, the more easily some inflammation and diseases around the surface of the implant are caused.

In addition to mechanical therapy, the therapeutic modalities of periodontal phototherapy using lasers and Light Emitting Diodes (LEDs) have also attracted considerable attention in the periodontics world, presenting various beneficial effects in clinical manifestations, treatment procedures and treatment outcomes. Phototherapy is a milder treatment modality than mechanical and chemotherapy, and does not cause mechanical damage or other side effects to the tissues. At present, the combination of mechanical therapy, chemotherapy and phototherapy is becoming increasingly popular.

Phototherapy technology has developed to date, its concept and application has extended to many aspects of the dental field and in some aspects has formed a complete and mature medical system. However, the physiological environment of the oral cavity is complex, the diseases are various, and even though the development is rapid, the existing phototherapy technical means are not suitable for all other pathological scenes. For different tissue sites and conditions, different instruments, devices and methods need to be selected for different diagnostic purposes. The application of phototherapy in some scenes is yet to be further researched and optimized. The limitations and drawbacks of the existing phototherapy techniques mainly include:

the oral cavity tissue structure is complex, and partial tissues are not easy to carry out light therapy from the outside. Most of the existing dental phototherapy devices are external light sources, such as external probes connected with a laser or external diodes connected with a power supply, and the light emitted by the existing dental phototherapy devices easily irradiates some superficial or shallow tissues to generate photochemical reaction, so that the treatment effect is achieved. However, for some deep or more closely structured tissues, it is difficult to directly illuminate them with an external light source. For example, after a general tooth extraction, it is necessary to wrap the damaged part and cover the wound with gauze in order to prevent infection of the wound, and at this time, it is difficult to perform phototherapy on the tissue by using an external light source again due to problems such as light transmittance of the gauze. Furthermore, if the implant and the alveolar bone are not properly bonded, the inflammation caused by the implant is difficult to treat by means of light, such as after the artificial tooth root is implanted. This is also one of the reasons why peri-implant inflammation is currently clinically incurable.

② the operation is complicated and the treatment is inconvenient. Low power laser phototherapy is currently one of the most widely used phototherapy methods in clinical practice. However, even if the laser power is low, since the energy range is concentrated, a small amount of thermal effect is generated, and therefore, water cooling treatment is required while the laser is used, which makes the operation complicated. For most of the existing phototherapy methods, no matter laser phototherapy or LED phototherapy is adopted, the upper jaw and the lower jaw of a patient need to be separated to a certain degree constantly in the treatment process due to illumination treatment from the outside of the oral cavity, so that light can enter the oral cavity. This also causes a certain degree of inconvenience to the patient.

And thirdly, the light source is difficult to regulate and control as required. Tissue healing is a relatively long-term process requiring low-power light on a timely basis throughout the treatment cycle. However, during this period, the patient often cannot adjust the parameters such as illumination time, illumination intensity, light source wavelength, etc. according to the self-treatment requirement due to practical factors (such as high treatment cost and limited number of instruments); some implanted or wearable LED phototherapy devices are driven by batteries, and it is difficult to ensure flexibility and convenience of application.

And fourthly, limiting the wavelength. The photostimulating effect of tissue cells is related to the wavelength of the light. In the case of a laser, the output wavelength corresponds to the output frequency, and in practical applications, the laser can output a single mode with a single frequency or a multi-mode with multiple frequencies. However, the characteristics of the laser determine which output mode is, the wavelength of the light that can be output is relatively fixed, and cannot cover all the visible and near infrared bands that can be used for biomedical treatment. This also limits the use of lasers in certain aspects of oral phototherapy.

Safety problem. Due to cost, most laser systems are not designed for medical use at the outset, but for scientific research and other non-medical applications, and therefore are prone to safety concerns when re-used as a medical aid. The traditional gas laser needs high-pressure supply when working, and meanwhile, a complex gas-liquid cooling system is needed for cooling, so that certain potential safety hazards are easily formed.

Disclosure of Invention

In order to overcome the technical defects, the invention provides the oral cavity implanted wireless power supply luminous micro-device capable of promoting dental tissue repair, which does not need to make a wound on the body surface of a patient, avoids wound inflammation and secondary damage of exudate to the patient, simultaneously improves the efficiency of intestinal tract nutrition supply and the nutrition absorption degree of the intestinal tract, and prevents the intestinal tract from being damaged by intestinal fluid accumulation in the intestinal tract of the patient.

In order to solve the problems, the invention is realized according to the following technical scheme:

an oral cavity implanted wireless power supply luminous micro device capable of promoting dental tissue repair comprises a power supply module and a phototherapy module; the power supply module is arranged outside the oral cavity of the human body and comprises a power supply and a transmitting coil, wherein the power supply is used for supplying power; the power supply is connected to the transmitting coil through a transmitting resonant circuit so that the transmitting coil transmits an alternating magnetic field; the phototherapy module is arranged in the oral cavity of a human body and comprises a receiving coil and a Micro LED lamp; the receiving coil is connected to the Micro LED lamp through a receiving resonant circuit; the receiving coil is used for generating current in the alternating magnetic field emitted by the transmitting coil so as to supply power to the Micro LED lamp; the Micro LED lamp is arranged in a filling material of oral tooth tissue and used for emitting light to stimulate the restoration of the tooth tissue through photochemical effect.

The invention further improves the technical scheme that the lighting control system further comprises a control module connected to the power supply module, and the control module is used for sending a control command to the power supply module to control the current or voltage of the power supply module, so that the lighting time and the lighting intensity of the Micro LED lamp are controlled.

The invention is further improved in that an inverter circuit is arranged between the power supply and the transmitting resonant circuit.

A further improvement of the present invention is that the inverter circuit is a high frequency inverter circuit including a class D power amplifier.

The invention is further improved in that the transmitting resonant circuit is a primary side series resonant circuit and comprises a primary side compensation capacitor connected with the transmitting coil in series.

A further development of the invention is that the transmission coil is a coil of a multiple array overlap design.

A further development of the invention is that the receiving coil is a cylindrical coil.

The receiving resonant circuit is a secondary parallel resonant circuit and comprises a secondary compensation capacitor connected with the receiving coil in parallel.

The invention is further improved in that the Micro LED lamp is a green LED lamp with the wavelength of 520nm or a blue LED lamp with the wavelength of 405 nm.

The phototherapy module is further improved in that a receiving coil, a receiving resonant circuit and Micro LED lamps of the phototherapy module are integrated on a flexible substrate, the flexible substrate is implanted into the oral cavity of a human body, and an anti-adhesion coating is arranged on the surface of the flexible substrate.

A further improvement of the invention is that the anti-adhesion coating is prepared by steps comprising:

coating a layer of silicone resin on the surface of the flexible substrate base plate, and curing at a high temperature;

plating a layer of N-type parylene material on the surface of the flexible substrate;

in an oxygen environment, carrying out plasma cleaning on the surface of the flexible substrate base plate to link hydroxyl on the surface;

suspending the flexible substrate above silicon oil to perform a sealing gas phase reaction under a high temperature condition;

compared with the prior art, the method has the beneficial effects that the flexible substrate base plate is taken out, the surface of the flexible substrate base plate is cleaned by ethanol and dried:

Drawings

Fig. 1 is a schematic structural diagram of an oral implantable wirelessly powered light-emitting microdevice for promoting dental tissue repair, according to an embodiment of the present invention.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.

Fig. 1 shows an embodiment of the invention, disclosing an oral implantation type wireless power supply luminous microdevice capable of promoting dental tissue repair, which is composed of two parts: an implantable portion inside the body and a wearable portion outside the body. Wherein external wearable part is including the direct current power supply DC who connects in order, inverter circuit, resonant circuit and transmitting coil.

Specifically, the dc power supply in the external wearable part is used to supply power to the external device circuit, limited by the requirements of the wearable device, and generally powered by a miniaturized lithium battery or a flexible battery. The power required by the implanted device is about mW magnitude, the maximum transmission efficiency of the magnetic resonance coil is about 40% to 50%, and even if the loss of the circuit and the loss of the internal resistance of the power supply are added, the lithium battery which is commonly used in the market can sufficiently meet the requirement of output power.

Specifically, the dc power supply is connected to the resonant circuit through an inverter circuit, and the inverter circuit currently applied to the magnetic coupling resonant coil system mainly includes a half-bridge inverter circuit, a full-bridge inverter circuit, an E-class power amplifier, a D-class power amplifier, and the like. The full-bridge inverter circuit and the half-bridge inverter circuit are generally only suitable for systems with smaller working frequency, and the system of the class-E power amplifier needs to design the size of a parallel capacitor on a switch tube while tuning, so that the tuning difficulty of the system is increased, the flexibility of the system is reduced, and the debugging of an experimental circuit is not facilitated. Therefore, the class D power amplifier with relatively low system tuning difficulty is used as the high-frequency inverter circuit of the system in the present embodiment.

Specifically, the resonant circuit adopts primary side series resonance, and the transmitting coil and the compensation capacitor are directly connected in series. The primary side compensation capacitor is independent of the coupling strength of the magnetic field and the load of the secondary side, so that the tuning of the system is more flexible; and the frequency range and the voltage of the normal operation of the phototherapy device are higher than those of a system adopting primary side parallel resonance, so that the phototherapy device is suitable for an implanted phototherapy device with relatively high power requirement.

Specifically in this embodiment, dc power supply makes transmitting coil transmit alternating magnetic field, in order to guarantee receiving coil's easy implantation nature and external equipment's easy dress nature, receiving coil and transmitting coil's alignment is lower, and this requires that the alternating magnetic field that transmitting coil produced can have higher homogeneity, therefore transmitting coil adopts the array design that the multicoil overlaps, has improved the scope and the degree of consistency in magnetic field, has reduced the requirement of wireless transmission to coil alignment, has guaranteed higher transmission efficiency.

In terms of the transmitting coil, the existing wireless power supply system for biomedical use generally adopts a multi-layer large-area coil, such as a classical helmholtz coil, or a multi-layer segmented coil, so as to meet the power requirement of the implantable device and improve the uniformity of the magnetic field. However, such coils are often cumbersome and not suitable for powering orally implantable devices. High-power transmitting coils are generally used for implantable devices (such as cardiac pacemakers) with the coil spacing larger than 10cm, and the implantation depth of the oral cavity part is shallow, so that energy input with too high power is easy to cause overload, and the normal work of the device is influenced. The embodiment designs a transmitting coil array formed by intersecting and overlapping a plurality of single-layer coils, which can generate an alternating magnetic field with high uniformity and high transmission efficiency in a small range so as to drive the load of a receiving coil to work normally. The array has individual coils within 5cm in diameter and the entire array area is no more than 10cm by 10 cm. External circuit and coil can be integrated to wearable equipment on, adopt battery powered, can further improve the convenience that equipment used, realize the wireless power supply formula oral cavity phototherapy in the real meaning.

Specifically, the circuit and the coil of the extracorporeal wearable part in this embodiment are integrally packaged by using a flexible substrate, so as to improve the wearability of the device.

Specifically, the implantable part in the body is arranged in the oral cavity of the human body and comprises a receiving coil, a resonant circuit and a Micro LED lamp used as a therapeutic light source, wherein the receiving coil is used for generating current in an alternating magnetic field emitted by the emitting coil so as to supply power to the Micro LED lamp; the Micro LED lamp is arranged in a filling material of oral tooth tissue and used for emitting light to stimulate the restoration of the tooth tissue through photochemical effect.

The size of the resonant circuit and the size of the light emitting diode are both in the order of mum, the size and the shape of the whole implanted device are mainly determined by the design of the coil, and the receiving coil in the embodiment adopts the columnar coil design, so that the implanted type device meets the implanted requirement on one hand, and the number of turns is increased as much as possible in the vertical direction on the other hand, thereby greatly improving the quality factor of the coil.

Meanwhile, the resonance circuit of the implantable part in the body in the embodiment adopts secondary side parallel resonance, and the transmitting coil and the compensation capacitor are connected in parallel and then connected with the load. Compared with series resonance, the secondary side parallel resonance is more suitable for constant voltage occasions. Considering the working property of the LED, practical tests show that the parallel connection of the secondary sides is more beneficial to the stable operation of the LED.

The implantable part in the body in the embodiment adopts a Micro LED lamp for illumination treatment. The working current of the LED is generally in mA magnitude, the output power is in mW magnitude, and the magnetic coupling resonance system can provide enough power output. The emitting angle of the LED lamp can be adjusted according to the area size of the wound and the power requirement of phototherapy, and under the condition that the effect of obviously promoting tissue healing of illumination is guaranteed, the illumination covers more wound areas as far as possible.

One of the main application scenarios of the present embodiment is to promote the regeneration and healing of the injured tissue in the period after the wound is created by the surgical operation and before the artificial tooth root is implanted, so as to provide a healthy bone tissue environment for the implantation of the implant. Generally, after the tooth is removed or the diseased tissue is removed, the alveolus needs to be filled with some biocompatible materials such as bone powder or collagen membrane for supporting the tissue, such as Bio-Os and Bio-Gide, and covered with gauze to ensure that the tissue of the edentulous part does not grow abnormally. At this time, it is clinically difficult to treat the wound with the conventional external laser therapy. The implanted LED light source of the present embodiment is well suited for use in the treatment of this procedure. The implanted device consists of three parts, namely a light emitting diode, a resonance compensation circuit and a receiving coil, the whole size of the implanted device is slightly smaller than that of a titanium implant, the implanted device can be implanted into the wound environment of a tooth socket along with a filling material, and the implanted device can be taken out after basic repair and molding of tissues, so that burden on a patient is avoided. Bio-Os is a porous material with internal gaps, and a light source can penetrate through the material to act on tissues, stimulate the tissue repair through photochemical effect, and improve the healing efficiency and the treatment effect of wounds.

The implanted design and the use of LED light sources employed in this embodiment solve most of the problems of conventional oral phototherapy systems and exhibit their favorable properties in biomedical applications: because the LED chip is very small and a large number of LEDs are not needed in medical treatment, the implanted LED light source can be directly inserted into a body to irradiate the deep target tissue without transmitting by using optical fibers; the LED light source has a relatively large action range and relatively dispersed energy, a thermal effect is not easy to form, the irradiation range of the light source can be changed by changing the packaging mode of the LED through design, and uniform light receiving of a large-area wound can be realized; and the wavelength coverage range of the LED is wide. As a large number of new optoelectronic semiconductor materials are continuously researched and developed, the LED wavelength also continuously breaks through the original wavelength range. At present, the wavelength of the LED almost covers all the wave bands of visible light and near infrared light, and more choices are provided for the medical use of the LED; and on the aspect of safety, the power of the LED light source is generally lower, high-voltage driving is not needed, and the safety of the solid-state LED is higher than that of the traditional gas laser. In addition, the implanted LED phototherapy device has the following advantages: semiconductor materials commonly used in the manufacture of LEDs have high photoelectric conversion efficiency, such as GaAlAs; in some medical aspects, the action effect of the LED and the laser is not greatly different, but the cost of the LED and the laser is much lower; due to the low manufacturing cost, when the device is designed, the LED can be directly designed into a medical device according with a specific scene according to the requirement of medical treatment on one aspect. These superior properties determine the wide application of led light source therapy in clinical treatment.

The power supply mode of the implantable device designed in this embodiment is the power supply mode of the magnetic coupling-based resonance coil system. The traditional power supply mode adopting wire connection is easy to cause abrasion and exposure of wires and poor contact of equipment after long-time use, and has great potential safety hazard; the non-toxic battery powered mode also has the defects that the size of the battery can hinder the miniaturization development of the implant device, the service life of the battery is limited, and the battery replacement operation is required. In contrast, the wireless charging method based on magnetic coupling between coils is more convenient and safer. Energy transmission is carried out under the action of a high-frequency alternating magnetic field through the electromagnetic induction effect of the in-vitro transmitting coil and the in-vivo receiving coil, continuous power supply can be provided for the implanted device in the treatment process, and parameters such as power, wavelength and the like of the light source can be adjusted according to the treatment requirement. The basic power supply system consists of a direct current power supply, an inverter circuit, a transmitting coil, a receiving coil and a load. On the basis, the resonant circuit is designed to compensate the topological structure of the primary and secondary coils, so that the transmission efficiency and the stability of output power of the system are greatly improved, the transmission distance is increased, the requirement on the alignment degree of the coils is reduced, and a reliable optimal scheme is provided for the long-term electric energy supply of the implanted device.

The power requirements of phototherapy are difficult to meet with the commonly used planar single layer coil designs. In consideration of the applicability of the dental alveolus, which is an implantation part, and the requirement of illumination power, the receiving coil is designed to be the columnar coil similar to the implant, so that the receiving coil is easy to implant, the number of turns of the receiving coil is increased in the longitudinal direction, and the power of the light source is increased. Meanwhile, the working frequency of the system is in the MHz magnitude and high-frequency alternating current can be used as electric energy supply of the diode in medical treatment, so that a load part does not need a rectifying circuit, redundant space can be used for transversely increasing the number of turns of the receiving coil, the quality factor is improved, and miniaturization of implanted equipment is facilitated.

Further, the wearable type external wearable type Micro LED lamp further comprises a control module, wherein the control module is used for sending a control instruction to control the current or the voltage of a circuit of the wearable type external wearable part, so that the illumination time and the illumination intensity of the Micro LED lamp are controlled. Specifically, a sensor can be added to the implantable device to continuously detect the healing degree of the wound in real time, collect information of the internal environment of the alveolus while phototherapeutic tissue, and feed back the information to a chip or a processor of the external device. The external equipment can automatically plan a phototherapy period according to the detected information, and regulate and control the wavelength, intensity, time and irradiation range of the internal illumination so as to achieve the optimal treatment effect; meanwhile, the best time for taking out the device in the secondary operation can be judged, and the real intelligent diagnosis and treatment integration is realized.

Further, the packaging of the device may be further optimized. In the early stage of treatment, blood seeps out of the alveolus due to the loss of bone tissue to fill the alveolus and eventually form blood clots. When the implantable phototherapy device enters the oral cavity and is exposed in blood, the implantable phototherapy device is easily adhered by proteins, cells and even bacteria in the liquid environment, causing unnecessary biological pollution, further causing inflammation and thrombosis, and even possibly causing persistent infection of patients. The surface modification of the flexible substrate of the device is required on this basis: a liquid-like high-molecular polymer with low surface energy is bonded to the surface of the flexible substrate of the device through a chemical reaction, so that an anti-adhesion coating with the liquid characteristic can be formed. The liquid layer can convert a solid-liquid interface between the device and biological liquid into a liquid-liquid interface, so that liquid and biological macromolecules in contact with the device can easily slide off the surface of the device without adhesion, the biological pollution problem caused by non-specific adhesion is reduced, and the implanted device has good anti-adhesion and self-cleaning performances. Therefore, the in-vivo circuit and the coil are packaged by adopting the flexible substrate and subjected to surface modification, and the biocompatibility of the device is ensured.

Specifically, the method for preparing the high molecular polymer in this embodiment is as follows:

coating a layer of silicone resin (SYLGARD) on the whole surface of the substrate device^TM184Silicone Elastomer Base) cured at 80 ℃;

secondly, evaporating a layer of N-type parylene N on the surface;

thirdly, in an oxygen environment, carrying out plasma (plasma) cleaning on the surface of the coating to link hydroxyl (-OH) on the surface of the coating;

suspending the device in a proper amount of silicon oil (ALDRICH) at the temperature of about 100 DEG C^TMSilicone Oil), and carrying out sealed gas phase reaction deposition for 48 hours;

taking out the substrate device after the reaction is finished, cleaning the surface of the device by using ethanol, and drying.

Furthermore, in this embodiment, two different Micro LEDs are used for tissue illumination therapy, namely, a green LED with a wavelength of 520nm and a blue LED with a wavelength of 405 nm. The green light and the blue light can inhibit the inflammation and the bacterial infection of the wound, simultaneously accelerate the proliferation of fibroblasts and osteoblasts, promote the wound healing and the tissue regeneration, and create good conditions for the planting of the artificial tooth root.

Meanwhile, the following specific test modes are also carried out on the oral cavity implanted wireless power supply luminous micro-device disclosed in the embodiment to verify the efficacy of the oral cavity implanted wireless power supply luminous micro-device, and beneficial technical effects are obtained:

1. the performance of the implantable devices was tested in vitro. The signal generator replaces a transmitting coil to generate square waves with peak voltage Vpp being 20V and duty ratio being 50%, so that the transmitting frequency is convenient to adjust, and the device is adjusted to the optimal coupling state. The variation of the optical power generated by devices with different parameters (coil wire diameter, compensation capacitor, etc.) in a certain frequency range is tested, and the optimal energy transmission frequency is obtained through analysis and summary.

2. The device is implanted into a rat with damaged tooth root tissues, and corresponding wearable equipment suitable for animals is designed, or a large-area coil with equivalent transmission power is directly adopted as a transmitting coil to carry out animal experiments. Different rats are subjected to different illumination schemes, and the influence of the wavelength, time, intensity and illumination area of illumination on the healing of rat tissues is observed. After the treatment period is finished, the implanted part is subjected to tissue slicing, and whether the tissue has any adverse reaction or not is observed. And subsequently, rabbits or dogs can be selected to continue relevant animal experiments, and the action effect of the device in different animal bodies is observed.

3. Implantable devices of different sizes can be designed according to the size difference of tooth sockets at different parts of the human oral cavity, and the devices and filling materials are implanted into the oral cavity of a patient with an extracted tooth or an excised tooth root. In a treatment period of 2-3 months, the patient is regularly checked: the assessment was made by VAS (visual analogue scale), asking the patient whether the implantation of the device would bring any discomfort; judging the condition of tissue healing and whether the device has position deviation or not by a medical imaging technology; check for any inflammatory response near the gingiva.

4. The optimal time to remove the device was analyzed by clinical studies. After the second operation is taken out, the alveolar tissues are directly observed and physiologically checked, the promotion effect of illumination on the healing of the alveolar tissues is comprehensively analyzed, and the optimal implantation time and the optimal taking-out time are summarized. Follow up and know the follow-up implantation operation of patient and the integration condition of implant and bone tissue, perfect the phototherapy effect analysis of this implanted device and relevant pathological analysis, further improve the design and the application method of device.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.

Claims

1. An oral cavity implanted wireless power supply luminous micro device capable of promoting dental tissue repair is characterized by comprising a power supply module and a phototherapy module;

the power supply module is arranged outside the oral cavity of the human body and comprises a power supply and a transmitting coil, wherein the power supply is used for supplying power; the power supply is connected to the transmitting coil through a transmitting resonant circuit so that the transmitting coil transmits an alternating magnetic field;

the phototherapy module is arranged in the oral cavity of a human body and comprises a receiving coil and a Micro LED lamp; the receiving coil is connected to the Micro LED lamp through a receiving resonant circuit; the receiving coil is used for generating current in the alternating magnetic field emitted by the transmitting coil so as to supply power to the Micro LED lamp;

the Micro LED lamp is arranged in a filling material of oral tooth tissue and used for emitting light to stimulate the restoration of the tooth tissue through photochemical effect;

the receiving coil, the receiving resonant circuit and the Micro LED lamp of the phototherapy module are integrated on a flexible substrate, the flexible substrate is implanted into the oral cavity of a human body, and an anti-adhesion coating is arranged on the surface of the flexible substrate;

the preparation steps of the anti-adhesion coating comprise:

coating a layer of silicone resin on the surface of the flexible substrate base plate, and curing at 80 ℃;

suspending the flexible substrate above silicon oil at 100 ℃ to perform a sealing gas phase reaction;

and taking the flexible substrate out, cleaning the surface with ethanol and drying.

2. The orally-implantable wirelessly-powered light-emitting microdevice that facilitates dental tissue repair of claim 1, further comprising a control module coupled to the power module, the control module configured to send control commands to the power module to control a current or a voltage of the power module, thereby controlling an illumination time and an illumination intensity of the Micro LED light.

3. The orally-implantable, wirelessly-powered, light-emitting microdevice for promoting dental tissue repair of claim 1, wherein an inverter circuit is further disposed between the power source and the transmitting resonant circuit.

4. The orally-implantable, wirelessly-powered, light-emitting microdevice that facilitates dental tissue repair of claim 3, wherein the inverter circuit is a high frequency inverter circuit that includes a class D power amplifier.

5. The orally-implantable, wirelessly-powered, light-emitting microdevice of claim 1, wherein the transmitting resonant circuit is a primary side series resonant circuit including a primary side compensation capacitor connected in series with the transmitting coil.

6. The orally-implantable, wirelessly-powered, light-emitting microdevice that facilitates dental tissue repair of claim 1, wherein the transmitter coil is a plurality of coils in an array overlapping design.

7. The orally-implantable, wirelessly-powered, light-emitting microdevice that facilitates dental tissue repair of claim 1, wherein the receiving coil is a cylindrical coil.

8. The orally-implantable, wirelessly-powered, light-emitting microdevice of claim 1, wherein the receive resonant circuit is a secondary parallel resonant circuit including a secondary compensation capacitor connected in parallel with the receive coil.