WO2019088939A1 - Dental implant healing cap with integrated led light source for photodynamic therapy - Google Patents

Dental implant healing cap with integrated led light source for photodynamic therapy Download PDF

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Publication number
WO2019088939A1
WO2019088939A1 PCT/TR2017/050533 TR2017050533W WO2019088939A1 WO 2019088939 A1 WO2019088939 A1 WO 2019088939A1 TR 2017050533 W TR2017050533 W TR 2017050533W WO 2019088939 A1 WO2019088939 A1 WO 2019088939A1
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WO
WIPO (PCT)
Prior art keywords
integrated led
led light
light source
dental implant
healing cap
Prior art date
Application number
PCT/TR2017/050533
Other languages
French (fr)
Inventor
Musfik BENLIOGLU
Original Assignee
Benlioglu Musfik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benlioglu Musfik filed Critical Benlioglu Musfik
Priority to PCT/TR2017/050533 priority Critical patent/WO2019088939A1/en
Publication of WO2019088939A1 publication Critical patent/WO2019088939A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/008Healing caps or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • A61N5/0603Apparatus for use inside the body for treatment of body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • A61N5/0603Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606Mouth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0626Monitoring, verifying, controlling systems and methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/065Light sources therefor
    • A61N2005/0651Diodes

Definitions

  • the present invention relates to dental implant healing cap with integrated LED source to promote the osteoblastic development of bone tissue, prevent the infections at soft tissue around the implant and provide the patient easy-handling for usage without need any medical personnel and extra equipment.
  • Photodynamic therapy is a medical treatment that utilizes a photosensitizing molecule (frequently a drug that becomes activated by light exposure) and a light source to activate the administered drug. The procedure is easily performed in a physician's office or outpatient setting. PDT is also referred to as blue light therapy. PDT is currently used in number of medical fields, including oncology (cancer), dermatology (skin), cosmetic surgery, ophthalmology, and oral medicine.
  • PDT in the modern sense is a new, evolving science.
  • Current PDT involves a variety of incubation times for different the light- sensitizing drugs and a variety of light sources depending on the target tissue.
  • the basic premise of PDT is selective tissue destruction.
  • PDT light sources include laser light, intense pulsed light, light-emitting diodes (LEDs), blue light, red light, and many other visible lights (including natural sunlight).
  • Photosensitizer drugs may become activated by one or several types of light. The optimal light source depends on the ideal wavelength for the particular drug used and target tissue.
  • PDT essentially has three steps. First, a light-sensitizing liquid, cream, or intravenous drug (photosensitizer) is applied or administered. Occasionally, a photosensitizing molecule that is already part of the body can be activated. Second, there is an incubation period of minutes to days. Finally, the target tissue is then exposed to a specific wavelength of light that then activates the photosensitizing medication. The mechanism by which tissue is destroyed seems to depend on the presence of activated oxygen molecules.
  • PDT may also be used for local infections as well as in the treatment of dental bacterial disease, such as gum abscesses, gum disease, gingivitis, and removal, deactivation or killing of plaque biofilms, implant infections.
  • the Korean patent document numbered KR20110132688 discloses a movable light therapy device for periodontal disease according to the present invention comprises: a mouthpiece member comprises a light source array for irradiating light to teeth and the gums inside, and is inserted into the mouth of a patient to irradiate light to the teeth and the gums; and a controller supplied with power from the outside for controlling the operation of the light source array, wherein the controller is operated so as to control the wavelength and frequency of the light irradiated from the light source array, thereby enabling treatment of periodontal disease.
  • the movable light therapy device for periodontal disease of the present invention it is possible to control with a wide range, the wavelength and frequency of light, thereby whitening teeth and showing various treatment effects such as periodontal disease treatment, dental implant treatment and the like.
  • photodynamic treatment requires an experienced medical team, high costs and lots of time and being disturbing to patient.
  • the present invention helps to promote the osteoblastic development of bone cells and to treat to infections such as gingivitis, periodontitis at the surrounding soft tissue and the implant surface.
  • This invention provides to remove the requirement of medical personnel, expensive medical equipment and allows the patient for self-administration after the first implementation until final removal.
  • Photodynamic therapy can be applied with a light source that can be integrated with the implant without the need for a light source designed for clinical use.
  • the present invention may be used in the treatment of oral infections caused by microbes and fungi, that cause all kinds of inflammation, gram positive and negative bacteria to the surrounding tissue of the implant by introducing a novel light source technology.
  • Figure 1 shows a perspective view of the dental implant healing cap with integrated LED light source which is the subject matter of the invention.
  • the parts illustrated in the figure are individually numbered where the numbers refer to the following:
  • the dental implant healing cap with integrated LED light source (1) comprises,
  • At least one screw part (2.A) allows screwing into the female screw part within the implant
  • At least one light module (3) for light emission at least one light module (3) for light emission
  • control unit designed to control short circuit, high temperature protection fuse, on/off switch, radiation pattern, radiation wavelength, radiation power and duration,
  • the dental implant healing cap with integrated LED light source (1) has body (2) produced from steel or titanium in different sizes, have empty space for the light module (3) and protects the light module (3) and prevent being crushed against the chewing forces.
  • Body has three parts; screw part (2. A), main case (2.B) and a top cover (2.C).
  • the screw part (2. A) allows screwing into the female screw part within the implant to fix the dental implant healing cap with integrated LED light source (1).
  • the main case (2.B) has holes to provide the LEDs to emit the light outside of the dental implant healing cap (1).
  • the top cover (2.C) is screwed into the body (2). There is a cavity in the middle of it which allows the operator to turn the cover (2.C) with a multi-sided key. At the deepest point of top cover (2.C), there is also another cavity to enable to perform the on / off function of device (1).
  • the light module (3) for light emission is disposable and has three parts; control unit (3.A), battery cell (3.B) and integrated LED source (3.C).
  • the light module (3) is covered with a transparent module shell sealed with medical adhesives or ultrasonic welding, which does not allow penetration of liquid and other substances in the mouth. This case may be fulfilled with an elastomeric material to prevent any kind of short circuit or electrical failure due to air, acid, body liquids or any other penetration as a second protection layer to make a perfectly sealed unit against outer gases or liquids of any kind.
  • the control unit (3. A) comprises means for current and voltage regulation of the LEDs (3.C.) and short circuit protection.
  • the control unit (3. A) may also comprise means for temperature sensing. As the device (1) is used, the circuit means and the LED source (3.C) may be overheated during the operations. When the temperature sensing means detects overheat or overcurrent situation caused from any other reasons, the control unit (3.A) can deactivate the LED source (3.C) for example by a fuse.
  • the dental implant healing cap with integrated LED light source (1) can be used manually and automatically. In automatic operation, the user has the possibility to change the working hours and working patterns of the device (1) with simple commands by using the control unit (3.A). If desired, dental implant healing cap with integrated LED source (1) can be reprogrammed or can be restore the factory settings.
  • the battery cell (3.B) supplies electricity to the LEDs.
  • This type of battery can be a Li- Ion, Alkaline or Cadmium batteries.
  • the dental implant healing cap with integrated LED light source (1) contains at least one LED as light source.
  • These integrated LED sources (3.C) are placed on the lateral sides of the implant facing toward the gingival and angled to the joint part of gingival and implant to emit the light with different wavelengths on a flexible printed circuit.
  • integrated LED sources (3.C) selected due to the wavelength to which the photosensitizer materials in the body of a living organism are susceptible (between 350 nm, ultraviolet and 800 nm, infrared). Radiation pattern, as a pulse or a continuous glow, is adjusted with a determined algorithm during the production of the dental implant healing cap with integrated LED light source (1).
  • the LED sources (3.C), battery cell (3.B), control unit (3.A) and light module (3) are housed in a transparent module shell. Since the light module (3) is disposable, it can be changed by opening the top cover (2.C), if it is necessary to continue the treatment when the battery lifetime is over.
  • the dental implant healing cap with integrated LED light source (1) will be ready to use by screwing it into the implant body. To operate dental implant healing cap with integrated LED light source (1), the mechanical or magnetic key should be applied onto implant and the battery cycle is achieved. Required energy is provided for photodynamic therapy with emitted light with required wavelength.
  • the dental implant healing cap with integrated LED light source (1) will automatically start and stop during the previously programmed time. Radiation algorithm and time is pre-determined according to the therapy applied.
  • the dental implant healing cap with integrated LED light source (1) is mounted on the implant, it can be programmed in automatic mode.
  • the operation time of the dental implant healing cap with integrated LED light source (1) is adjusted according to the photosensitive material application and patient's sleeping time by using the key in the light module (3).
  • the dental implant healing cap with integrated LED light source (1) can be used manually.
  • the magnetic or mechanical key is applied into the screw part (2.A) on the implant to allow operation of the system.
  • the gel or liquid photosensitizing agent is applied to the periphery of the implant and wait for the photosensitizer material loaded into the cells.
  • the present invention may be used in the treatment of oral diseases in the tissue surrounding the implant which is caused by all kinds of inflammation, infections caused by gram positive and negative bacteria, and fungi without the need for a light source designed for clinical use.

Abstract

In the present invention, the gingival infections like gingivitis, periodontitis and bone support lost around a dental implant to be treated by photodynamic therapy and photo osteoblastic therapy can be performed by a dental implant healing cap with an integrated LED light source (1) that can be able to produce in a present lite paradigm at different wavelength lights to activate the already placed photosensitive materials around the implants to treat the infections at soft tissue cells and at the surrounding bone cells and also activate the bone cell regeneration by applying the specific wavelength of light.

Description

DENTAL IMPLANT HEALING CAP WITH INTEGRATED LED LIGHT SOURCE FOR PHOTODYNAMIC THERAPY
Field of the invention
The present invention relates to dental implant healing cap with integrated LED source to promote the osteoblastic development of bone tissue, prevent the infections at soft tissue around the implant and provide the patient easy-handling for usage without need any medical personnel and extra equipment.
Background of the invention Photodynamic therapy (PDT) is a medical treatment that utilizes a photosensitizing molecule (frequently a drug that becomes activated by light exposure) and a light source to activate the administered drug. The procedure is easily performed in a physician's office or outpatient setting. PDT is also referred to as blue light therapy. PDT is currently used in number of medical fields, including oncology (cancer), dermatology (skin), cosmetic surgery, ophthalmology, and oral medicine.
Although first used in the early 1900s, PDT in the modern sense is a new, evolving science. Current PDT involves a variety of incubation times for different the light- sensitizing drugs and a variety of light sources depending on the target tissue. The basic premise of PDT is selective tissue destruction.
The generation of singlet oxygen species by type II photochemical reactions is believed to be the predominant reaction in PDT. At low levels of PDT, biological systems may be positively stimulated by low enhancement of ROS levels.
PDT light sources include laser light, intense pulsed light, light-emitting diodes (LEDs), blue light, red light, and many other visible lights (including natural sunlight). Photosensitizer drugs may become activated by one or several types of light. The optimal light source depends on the ideal wavelength for the particular drug used and target tissue. PDT essentially has three steps. First, a light-sensitizing liquid, cream, or intravenous drug (photosensitizer) is applied or administered. Occasionally, a photosensitizing molecule that is already part of the body can be activated. Second, there is an incubation period of minutes to days. Finally, the target tissue is then exposed to a specific wavelength of light that then activates the photosensitizing medication. The mechanism by which tissue is destroyed seems to depend on the presence of activated oxygen molecules.
One of the usage are is about dental therapies. PDT may also be used for local infections as well as in the treatment of dental bacterial disease, such as gum abscesses, gum disease, gingivitis, and removal, deactivation or killing of plaque biofilms, implant infections.
The Korean patent document numbered KR20110132688 discloses a movable light therapy device for periodontal disease according to the present invention comprises: a mouthpiece member comprises a light source array for irradiating light to teeth and the gums inside, and is inserted into the mouth of a patient to irradiate light to the teeth and the gums; and a controller supplied with power from the outside for controlling the operation of the light source array, wherein the controller is operated so as to control the wavelength and frequency of the light irradiated from the light source array, thereby enabling treatment of periodontal disease. According to the movable light therapy device for periodontal disease of the present invention, it is possible to control with a wide range, the wavelength and frequency of light, thereby whitening teeth and showing various treatment effects such as periodontal disease treatment, dental implant treatment and the like. In addition, it is possible to conveniently move the device according to the location of a patient by separating and storing a separate mouthpiece-type of equipment, and it is possible to conveniently sterilize the mouthpiece-type equipment by forming sterilization equipment. In the state of the art, photodynamic treatment requires an experienced medical team, high costs and lots of time and being disturbing to patient.
To overcome these problems and able to apply photodynamic therapy, patients need a simple yet efficient and cheaper method of treatment applied by a Dental professional but can be performed outside of dental clinic throughout the treatment period.
Objectives of the invention The present invention helps to promote the osteoblastic development of bone cells and to treat to infections such as gingivitis, periodontitis at the surrounding soft tissue and the implant surface.
This invention provides to remove the requirement of medical personnel, expensive medical equipment and allows the patient for self-administration after the first implementation until final removal.
Photodynamic therapy can be applied with a light source that can be integrated with the implant without the need for a light source designed for clinical use.
The present invention may be used in the treatment of oral infections caused by microbes and fungi, that cause all kinds of inflammation, gram positive and negative bacteria to the surrounding tissue of the implant by introducing a novel light source technology.
Detailed description of the invention
A realisation to fulfil the objective of the present invention is illustrated in the accompanying figures, in which:
Figure 1. shows a perspective view of the dental implant healing cap with integrated LED light source which is the subject matter of the invention. The parts illustrated in the figure are individually numbered where the numbers refer to the following:
1. Dental implant healing cap with integrated LED light source
2. Body
2.A. Screw part
2.B. Main case
2. C. Top cover
3. Light module
3. A. Control unit
3. B. Battery cell
3.C. Integrated LED source
The dental implant healing cap with integrated LED light source (1) comprises,
- at least one body (2) produced from steel or titanium in different sizes,
at least one screw part (2.A) allows screwing into the female screw part within the implant,
at least one main case (2.B) which has holes,
at least one top cover (2.C) which is screwed onto the body (2), has a cavity in the center to allows the operator to open or close the cover with a multi- sided key,
at least one light module (3) for light emission,
at least one control unit (3.A) designed to control short circuit, high temperature protection fuse, on/off switch, radiation pattern, radiation wavelength, radiation power and duration,
at least one battery cell (3.B) which is Li-Ion, Alkaline or Cadmium batteries, at least one integrated LED source on a flexible printed circuit. (3.C), angulated to the joining of gingival and implant surface. The dental implant healing cap with integrated LED light source (1) has body (2) produced from steel or titanium in different sizes, have empty space for the light module (3) and protects the light module (3) and prevent being crushed against the chewing forces. Body has three parts; screw part (2. A), main case (2.B) and a top cover (2.C).
The screw part (2. A) allows screwing into the female screw part within the implant to fix the dental implant healing cap with integrated LED light source (1). The main case (2.B) has holes to provide the LEDs to emit the light outside of the dental implant healing cap (1).
The top cover (2.C) is screwed into the body (2). There is a cavity in the middle of it which allows the operator to turn the cover (2.C) with a multi-sided key. At the deepest point of top cover (2.C), there is also another cavity to enable to perform the on / off function of device (1).
The light module (3) for light emission is disposable and has three parts; control unit (3.A), battery cell (3.B) and integrated LED source (3.C). The light module (3) is covered with a transparent module shell sealed with medical adhesives or ultrasonic welding, which does not allow penetration of liquid and other substances in the mouth. This case may be fulfilled with an elastomeric material to prevent any kind of short circuit or electrical failure due to air, acid, body liquids or any other penetration as a second protection layer to make a perfectly sealed unit against outer gases or liquids of any kind.
The control unit (3. A) comprises means for current and voltage regulation of the LEDs (3.C.) and short circuit protection.
The control unit (3. A) may also comprise means for temperature sensing. As the device (1) is used, the circuit means and the LED source (3.C) may be overheated during the operations. When the temperature sensing means detects overheat or overcurrent situation caused from any other reasons, the control unit (3.A) can deactivate the LED source (3.C) for example by a fuse.
The dental implant healing cap with integrated LED light source (1) can be used manually and automatically. In automatic operation, the user has the possibility to change the working hours and working patterns of the device (1) with simple commands by using the control unit (3.A). If desired, dental implant healing cap with integrated LED source (1) can be reprogrammed or can be restore the factory settings.
The battery cell (3.B) supplies electricity to the LEDs. This type of battery can be a Li- Ion, Alkaline or Cadmium batteries.
The dental implant healing cap with integrated LED light source (1) contains at least one LED as light source. These integrated LED sources (3.C) are placed on the lateral sides of the implant facing toward the gingival and angled to the joint part of gingival and implant to emit the light with different wavelengths on a flexible printed circuit.
As a general working principle, integrated LED sources (3.C) selected due to the wavelength to which the photosensitizer materials in the body of a living organism are susceptible (between 350 nm, ultraviolet and 800 nm, infrared). Radiation pattern, as a pulse or a continuous glow, is adjusted with a determined algorithm during the production of the dental implant healing cap with integrated LED light source (1). The LED sources (3.C), battery cell (3.B), control unit (3.A) and light module (3) are housed in a transparent module shell. Since the light module (3) is disposable, it can be changed by opening the top cover (2.C), if it is necessary to continue the treatment when the battery lifetime is over. The dental implant healing cap with integrated LED light source (1) will be ready to use by screwing it into the implant body. To operate dental implant healing cap with integrated LED light source (1), the mechanical or magnetic key should be applied onto implant and the battery cycle is achieved. Required energy is provided for photodynamic therapy with emitted light with required wavelength.
The dental implant healing cap with integrated LED light source (1) will automatically start and stop during the previously programmed time. Radiation algorithm and time is pre-determined according to the therapy applied.
During the dental implant healing cap with integrated LED light source (1) is mounted on the implant, it can be programmed in automatic mode. The operation time of the dental implant healing cap with integrated LED light source (1) is adjusted according to the photosensitive material application and patient's sleeping time by using the key in the light module (3). First the patient needs to apply the supplied photosensitive material around the implant to be treated. After an upload of photosensitive material to the cells. It starts emitting the light with required wavelength for photodynamic therapy at the specified time. After light emitting with an interval pattern as specified before, an infra-red radiation starts and continues at certain intervals to improve the osteoblastic activity for a specified time.
In a preferred embodiment of the invention, the dental implant healing cap with integrated LED light source (1) can be used manually. In manual operation, the magnetic or mechanical key is applied into the screw part (2.A) on the implant to allow operation of the system. In both case (either automatic or manual), before the procedure is started, the gel or liquid photosensitizing agent is applied to the periphery of the implant and wait for the photosensitizer material loaded into the cells.
The present invention may be used in the treatment of oral diseases in the tissue surrounding the implant which is caused by all kinds of inflammation, infections caused by gram positive and negative bacteria, and fungi without the need for a light source designed for clinical use.

Claims

The dental implant healing cap with integrated LED light source (1) comprising,
- at least one body (2) produced from steel or titanium in different sizes, have empty spaces,
- at least one screw part (2.A) allows screwing into the female screw part within the implant,
- at least one main case (2.B) which has holes,
- at least one top cover (2.C) which is screwed onto the body (2), has a recess in the middle of the it to allows the operator to turn the cover with a multi-sided key,
- at least one light module (3) for light emission,
- at least one control unit (3. A) adapted to control short circuit, high temperature circuit break, on/off switch, radiation pattern, radiation wavelength, radiation power and duration,
- at least one battery cell (3.B) which is Li-Ion, Alkaline or Cadmium batteries and
- at least one integrated LED source (3.C), which is placed on the lateral sides of the implant facing toward the gingival and angled to the joining of gingival and implant surface.
The dental implant healing cap with integrated LED light source (1) according to claim 1, wherein the cap is programmed to operate in automatic mode.
The dental implant healing cap with integrated LED light source (1) according to claim 1, wherein the cap is programmed to operate in manual mode.
The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising a magnetic key to apply into the screw part (2. A) on the implant to operate the system.
5. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising a mechanical key to apply into the screw part (2. A) on the implant to operate the system.
6. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising a battery cell (3.B) which is Li-Ion, Alkaline or Cadmium batteries.
7. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising a top cover (2.C), which has a cavity at the deepest point to enable to fulfill the on / off function.
8. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising a light module (3) which is covered with a transparent module shell, seaLED with medical adhesives.
9. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising a light module (3) which is covered with a transparent module shell, seaLED by ultrasonic welding.
10. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising the control unit (3.A) comprises means for current and voltage regulation of the LED sources (3.C.).
11. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising the control unit (3. A) which may work manually or automatically.
12. The dental implant healing cap with integrated LED light source (1) according to claim 1, comprising the integrated LED sources (3.C) to emits the light with different wavelengths on a flexible printed circuit.
13. Integrated LED light sources (3.C), according to claim 12, emitting the light in the wavelength which is between 350 nm, ultraviolet and 800 nm, infrared.
14. Integrated LED light sources (3.C), according to claim 12, selected due to the wavelength to which the photosensitizer materials are susceptible.
15. Integrated LED light sources (3.C), according to claim 12, comprising a radiation pattern, as a pulse or a continuous glow, which is adjusted with a determined algorithm.
PCT/TR2017/050533 2017-10-31 2017-10-31 Dental implant healing cap with integrated led light source for photodynamic therapy WO2019088939A1 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10933252B2 (en) * 2018-07-03 2021-03-02 Chang H. Huh Medical light diffusion implant
CN113101536A (en) * 2021-05-21 2021-07-13 中国科学院半导体研究所 Phototherapy device and assembling method thereof
CN113209491A (en) * 2021-05-21 2021-08-06 中国科学院半导体研究所 Phototherapy device and assembling method thereof
US20220176153A1 (en) * 2018-08-20 2022-06-09 The General Hospital Corporation ANTI-MICROBIAL IRRADIATION FOR PERCUTANEOUS OSSEOINTEGRATED PROSTHESES (POPs)
WO2024012961A1 (en) 2022-07-12 2024-01-18 Danmarks Tekniske Universitet Disinfection system for patients

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0865260B1 (en) * 1995-12-04 1999-08-04 Institut Straumann AG Healing cap for dental implants
WO2011152585A1 (en) * 2010-06-03 2011-12-08 메디럭스(주) Movable light therapy device for periodontal disease
US20130266909A1 (en) * 2010-09-10 2013-10-10 Daniel Delfosse Implant for use in a photodynamic treatment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0865260B1 (en) * 1995-12-04 1999-08-04 Institut Straumann AG Healing cap for dental implants
WO2011152585A1 (en) * 2010-06-03 2011-12-08 메디럭스(주) Movable light therapy device for periodontal disease
US20130266909A1 (en) * 2010-09-10 2013-10-10 Daniel Delfosse Implant for use in a photodynamic treatment

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10933252B2 (en) * 2018-07-03 2021-03-02 Chang H. Huh Medical light diffusion implant
US20220176153A1 (en) * 2018-08-20 2022-06-09 The General Hospital Corporation ANTI-MICROBIAL IRRADIATION FOR PERCUTANEOUS OSSEOINTEGRATED PROSTHESES (POPs)
CN113101536A (en) * 2021-05-21 2021-07-13 中国科学院半导体研究所 Phototherapy device and assembling method thereof
CN113209491A (en) * 2021-05-21 2021-08-06 中国科学院半导体研究所 Phototherapy device and assembling method thereof
WO2024012961A1 (en) 2022-07-12 2024-01-18 Danmarks Tekniske Universitet Disinfection system for patients

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