CN113949168B - Intracorporal photomedical device and preparation method thereof - Google Patents
Intracorporal photomedical device and preparation method thereof Download PDFInfo
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- CN113949168B CN113949168B CN202111181583.9A CN202111181583A CN113949168B CN 113949168 B CN113949168 B CN 113949168B CN 202111181583 A CN202111181583 A CN 202111181583A CN 113949168 B CN113949168 B CN 113949168B
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- 238000002360 preparation method Methods 0.000 title abstract description 11
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims abstract description 200
- 229910052744 lithium Inorganic materials 0.000 claims abstract description 200
- 230000006698 induction Effects 0.000 claims abstract description 153
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- 238000007600 charging Methods 0.000 claims abstract description 90
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- 238000005538 encapsulation Methods 0.000 claims description 35
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- 238000004519 manufacturing process Methods 0.000 claims description 20
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- 230000015572 biosynthetic process Effects 0.000 claims description 4
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- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 229920001721 polyimide Polymers 0.000 claims description 4
- 239000002274 desiccant Substances 0.000 claims description 3
- 238000003475 lamination Methods 0.000 claims description 3
- -1 polyethylene terephthalate Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 239000005060 rubber Substances 0.000 claims description 3
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- 230000005540 biological transmission Effects 0.000 claims description 2
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- 229910052814 silicon oxide Inorganic materials 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 34
- 230000008569 process Effects 0.000 abstract description 9
- 239000007943 implant Substances 0.000 abstract description 7
- 239000005022 packaging material Substances 0.000 abstract description 5
- 239000010410 layer Substances 0.000 description 149
- 238000001727 in vivo Methods 0.000 description 10
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- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
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- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
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- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
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- 229910052737 gold Inorganic materials 0.000 description 1
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- 230000036541 health Effects 0.000 description 1
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- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
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- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- MHCFAGZWMAWTNR-UHFFFAOYSA-M lithium perchlorate Chemical compound [Li+].[O-]Cl(=O)(=O)=O MHCFAGZWMAWTNR-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
- H02J7/0042—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries characterised by the mechanical construction
- H02J7/0045—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries characterised by the mechanical construction concerning the insertion or the connection of the batteries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
- H02J50/10—Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Power Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Computer Networks & Wireless Communication (AREA)
- Electrotherapy Devices (AREA)
- Secondary Cells (AREA)
Abstract
The embodiment of the invention discloses an implanted biomedical device and a preparation method thereof, wherein the implanted biomedical device comprises: a flexible substrate; the light-emitting structure, the lithium battery and the charging induction structure are arranged on one side of the flexible substrate; the lithium battery is respectively and electrically connected with the light-emitting structure and the charging induction structure; the lithium battery is used for supplying power to the light-emitting structure, and the charging induction structure is used for generating charging current to charge the lithium battery when the excitation current of the external transmitting coil is induced; and the packaging layer is used for packaging the light-emitting structure, the lithium battery and the charging induction structure. According to the technical scheme provided by the embodiment of the invention, the charging induction structure generates the charging current to charge the lithium battery when the exciting current of the external transmitting coil is induced, and the battery is not required to be charged by using a wire harness; the battery is miniaturized, the volume of the device is reduced, and the device is convenient to implant in a body; meanwhile, the light-emitting structure, the lithium battery and the charging induction structure share the packaging material, so that the process cost can be reduced.
Description
Technical Field
The embodiment of the invention relates to the technical field of photomedical devices, in particular to an implant photomedical device and a preparation method thereof.
Background
With the improvement of the living standard of mass substances of people, the demands of people on health are higher and higher, and the illumination technology is loved by consumers as a safe and good way, so that the illumination is widely applied in photomedical treatment.
Problems with current biomedical devices include: the photo-medical device has a relatively large volume, and is flexible and bendable, but is difficult to implant into the human body due to the volume; and the photomedical device is provided with a certain wire harness, the volume of a battery or a power supply for supplying power to the light source is relatively large, the wire harness is relatively long, and the photomedical device cannot be portable, so that great inconvenience is brought to the implantation of the light source into a body.
Disclosure of Invention
The embodiment of the invention provides an implanted biomedical device and a preparation method thereof, which are used for realizing wireless charging of the biomedical device and facilitating implantation in a body.
In a first aspect, embodiments of the present invention provide an implantable photomedical device comprising:
a flexible substrate;
the charging induction structure, the lithium battery and the light-emitting structure are arranged on one side of the flexible substrate in a stacked manner; the lithium battery is respectively and electrically connected with the light-emitting structure and the charging induction structure; the lithium battery is used for supplying power to the light-emitting structure, and the charging induction structure is used for generating charging current to charge the lithium battery when the excitation current of the external transmitting coil is induced;
And the packaging layer is used for packaging the light-emitting structure, the lithium battery and the charging induction structure.
Optionally, the charging induction structure comprises an induction coil and a rectification structure, wherein the induction coil is used for generating induction current when the excitation current of the external transmitting coil is induced;
the rectification structure is respectively and electrically connected with the induction coil and the lithium battery, and is used for rectifying the induction current generated by the induction coil and providing the rectified induction current for the lithium battery;
the rectification structure is arranged on the flexible substrate, and the encapsulation layer covers the rectification structure; alternatively, the encapsulation layer includes a via, and the rectifying structure is located in the via.
Optionally, the lithium battery comprises a positive electrode collector, a positive electrode, an electrolyte layer, a negative electrode and a negative electrode collector which are stacked;
the light-emitting structure comprises an anode, a light-emitting layer and a cathode which are arranged in a stacked manner;
the induction coil and the rectifying structure are arranged on the same layer; the induction coil and the rectifying structure further comprise a first insulating layer at one side far away from the flexible substrate; the first insulating layer includes a first landing hole and a second landing hole;
The lithium battery is positioned on one side of the first insulating layer away from the flexible substrate; the positive electrode collector of the lithium battery is connected with the rectification structure through the first lap joint hole, and the negative electrode collector of the lithium battery is connected with the rectification structure through the second lap joint hole;
the light-emitting structure is positioned on one side of the lithium battery far away from the flexible substrate; the negative electrode collector of the lithium battery is multiplexed to be the cathode of the light-emitting structure; a second insulating layer is further arranged around the side wall of each film layer of the lithium battery, the second insulating layer comprises a third lap joint hole, and the anode of the light-emitting structure is connected with the positive electrode collector of the lithium battery through the third lap joint hole; or the positive collector electrode of the lithium battery is multiplexed to be the anode of the light-emitting structure, and the cathode of the light-emitting structure is connected with the negative collector electrode of the lithium battery through the third lap joint hole.
Optionally, the lithium battery comprises a positive electrode collector, a positive electrode, an electrolyte layer, a negative electrode and a negative electrode collector which are stacked;
the light-emitting structure comprises an anode, a light-emitting layer and a cathode which are arranged in a stacked manner;
the induction coil and the bonding pad structure are arranged on the same layer; the induction coil and the side of the bonding pad structure far away from the flexible substrate further comprise a first insulating layer; the first insulating layer includes a first landing hole and a second landing hole;
The lithium battery is positioned on one side of the first insulating layer away from the flexible substrate; the positive electrode collector of the lithium battery is connected with the bonding pad structure through the first lap joint hole, and the negative electrode collector of the lithium battery is connected with the bonding pad structure through the second lap joint hole;
the light-emitting structure is positioned on one side of the lithium battery far away from the flexible substrate; the negative electrode collector of the lithium battery is multiplexed to be the cathode of the light-emitting structure; a second insulating layer is further arranged around the side wall of each film layer of the lithium battery, the second insulating layer comprises a third lap joint hole, and the anode of the light-emitting structure is connected with the positive electrode collector of the lithium battery through the third lap joint hole; or, the positive collector electrode of the lithium battery is multiplexed to be the anode of the light-emitting structure, and the cathode of the light-emitting structure is connected with the negative collector electrode of the lithium battery through the third lap joint hole;
the rectifying structure is connected with the bonding pad structure through the through hole.
Optionally, the pad structure includes an input pad and an output pad, the rectifying structure is connected with the input pad and the output pad, the induction coil is connected with the input pad, and the lithium battery is connected with the output pad.
Optionally, the number of the light emitting structure, the lithium battery and the charging induction structure is multiple; the lithium battery is connected with the light-emitting structure and the charging induction structure in a one-to-one correspondence manner;
wherein, the maximum size range of the vertical projection of the light-emitting structure on the flexible substrate comprises 10 um-5 mm; the maximum size range of the vertical projection of the lithium battery on the flexible substrate comprises 10 um-5 mm.
Optionally, the material of the flexible substrate includes at least one of polyimide, polyethylene terephthalate, resin, and rubber;
the packaging layer comprises a barrier adhesive, wherein a drying agent is doped in the barrier adhesive; or the material of the encapsulation layer comprises silicon oxide.
In a second aspect, an embodiment of the present invention provides a method for preparing an intracorporal photomedical device, including:
providing a flexible substrate;
forming a light-emitting structure, a lithium battery and a charging induction structure on one side of the flexible substrate; the charging induction structure, the lithium battery and the light-emitting structure are arranged on the flexible substrate in a lamination manner; the lithium battery is respectively and electrically connected with the light-emitting structure and the charging induction structure; the lithium battery is used for supplying power to the light-emitting structure, and the charging induction structure is used for generating charging current to charge the lithium battery when the excitation current of the external transmitting coil is induced;
And forming an encapsulation layer, wherein the encapsulation layer is used for encapsulating the light-emitting structure, the lithium battery and the charging induction structure.
Optionally, the charging induction structure comprises an induction coil and a rectification structure, the induction coil is used for generating induction current when the excitation current of the external transmitting coil is induced, and the rectification structure is used for rectifying the induction current generated by the induction coil; the formation of the light emitting structure, the lithium battery and the charging induction structure on one side of the flexible substrate comprises:
etching an auxiliary electrode layer on the flexible substrate to form the induction coil, and fixing a rectifying structure on the flexible substrate through conductive adhesive; the induction coil is connected with the rectifying structure;
forming a first insulating layer on one side of the induction coil and the rectifying structure away from the flexible substrate;
etching the first insulating layer to form a first lap joint hole and a second lap joint hole; the first and second overlapping holes each expose the rectifying structure;
sequentially forming a positive collector, a positive electrode, an electrolyte layer, a negative electrode and a negative collector of the lithium battery on one side of the first insulating layer far away from the flexible substrate; the positive electrode collector is overlapped with the rectification structure through the first overlap hole; the negative electrode collector is overlapped with the rectification structure through the second overlap hole;
Forming a second insulating layer around the side wall of each film layer of the lithium battery;
etching the second insulating layer to form a third lap joint hole, wherein the third lap joint hole exposes the convex part of the positive collector electrode; the vertical projection of the convex part on the flexible substrate is not overlapped with the vertical projection of the anode, the electrolyte layer, the cathode and the cathode collector on the flexible substrate respectively;
sequentially forming a light-emitting layer and an anode of the light-emitting structure on one side, far away from the flexible substrate, of the lithium battery; wherein the negative electrode collector of the lithium battery is multiplexed as the negative electrode of the light-emitting structure; and the anode of the light-emitting structure is connected with the convex part of the positive electrode collector of the lithium battery through the third lap joint hole.
Optionally, the charging induction structure includes an induction coil and a rectification structure, the induction coil is used for generating induction current when the excitation current of the external transmitting coil is induced, the rectification structure is used for rectifying the induction current generated by the induction coil, and the encapsulation layer includes a through hole; the formation of the light emitting structure, the lithium battery and the charging induction structure on one side of the flexible substrate comprises:
etching the auxiliary electrode layer on the flexible substrate to form the induction coil, and forming an input bonding pad and an output bonding pad on the flexible substrate; the induction coil is connected with the input bonding pad;
Forming a first insulating layer on one side of the induction coil and the bonding pad away from the flexible substrate;
etching the first insulating layer to form a first lap joint hole and a second lap joint hole; the first and second landing holes each expose the output pad;
sequentially forming a positive collector, a positive electrode, an electrolyte layer, a negative electrode and a negative collector of the lithium battery on one side of the first insulating layer far away from the flexible substrate; the positive electrode collector electrode is overlapped with the output bonding pad through the first overlap hole; the negative electrode collector is overlapped with the output bonding pad through the second overlap hole;
forming a second insulating layer around the side wall of each film layer of the lithium battery;
etching the second insulating layer to form a third lap joint hole, wherein the third lap joint hole exposes the convex part of the positive collector electrode; the vertical projection of the convex part on the flexible substrate is not overlapped with the vertical projection of the anode, the electrolyte layer, the cathode and the cathode collector on the flexible substrate respectively;
sequentially forming a light-emitting layer and an anode of the light-emitting structure on one side, far away from the flexible substrate, of the lithium battery; wherein the negative electrode collector of the lithium battery is multiplexed as the negative electrode of the light-emitting structure; the anode of the light-emitting structure is connected with the convex part of the positive electrode collector of the lithium battery through the third lap joint hole;
After the packaging layer is formed, the rectifying structure is attached to the through hole of the packaging layer through a surface mounting technology; the input end of the rectifying structure is connected with the input bonding pad, and the output end of the rectifying structure is connected with the output bonding pad.
The embodiment of the invention provides an implanted biomedical device and a preparation method thereof, wherein the implanted biomedical device comprises: a flexible substrate; the light-emitting structure, the lithium battery and the charging induction structure are arranged on one side of the flexible substrate; the lithium battery is respectively and electrically connected with the light-emitting structure and the charging induction structure; the lithium battery is used for supplying power to the light-emitting structure, and the charging induction structure is used for generating charging current to charge the lithium battery when the excitation current of the external transmitting coil is induced; and the packaging layer is used for packaging the light-emitting structure, the lithium battery and the charging induction structure. According to the technical scheme provided by the embodiment of the invention, the charging induction structure generates the charging current to charge the lithium battery when the exciting current of the external transmitting coil is induced, and the battery is not required to be charged by using a wire harness; the battery is miniaturized, the volume of the device is reduced, and the device is convenient to implant in a body; meanwhile, the light-emitting structure, the lithium battery and the charging induction structure share the packaging material, so that the process cost can be reduced.
Drawings
FIG. 1 is a cross-sectional view of an embodiment of an implantable photomedical device according to the present invention;
FIG. 2 is a top view of an implantable photomedical device according to an embodiment of the present invention;
FIG. 3 is a charging circuit diagram according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a mobile phone for wirelessly charging a biomedical device implanted in a body according to an embodiment of the present invention;
FIG. 5 is a cross-sectional view of another embodiment of an implantable photomedical device according to the present invention;
FIG. 6 is a flowchart of a method for manufacturing an implantable photomedical device according to an embodiment of the present invention;
FIG. 7 is a flowchart of another method for manufacturing an implantable photomedical device according to an embodiment of the present invention;
fig. 8 is a top view of step S210 in a method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention;
FIG. 9 is a cross-sectional view taken along line AA' of FIG. 8;
fig. 10 is a top view of step S230 in a method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention;
FIG. 11 is a cross-sectional view taken along line AA' of FIG. 10;
fig. 12 is a top view of step S240 in a method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention;
FIG. 13 is a cross-sectional view taken along line AA' of FIG. 12;
fig. 14 is a structural cross-sectional view of step S260 in the method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention;
fig. 15 is a top view of step S270 in a method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention;
FIG. 16 is a cross-sectional view taken along line AA' of FIG. 15;
fig. 17 is a top view of step S280 in a method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention;
FIG. 18 is a flowchart of another method for manufacturing an implantable photomedical device according to an embodiment of the present invention;
fig. 19 is a structural cross-sectional view of step S380 in a method for manufacturing an implanted biomedical device according to an embodiment of the present invention.
Detailed Description
The invention is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting thereof. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present invention are shown in the drawings.
An embodiment of the present invention provides an intracorporal photomedical device, and fig. 1 is a structural cross-sectional view of the intracorporal photomedical device provided by the embodiment of the present invention, and referring to fig. 1, the intracorporal photomedical device includes:
A flexible substrate 10;
a charge induction structure, a lithium battery 30, and a light emitting structure 40, which are stacked on one side of the flexible substrate 10; the lithium battery 30 is electrically connected with the light emitting structure 40 and the charging sensing structure 20, respectively; the lithium battery 30 is used for supplying power to the light emitting structure 40, and the charging induction structure 20 is used for generating charging current to charge the lithium battery 30 when the excitation current of the external transmitting coil is induced;
the encapsulation layer 70, the encapsulation layer 70 is used for encapsulating the light emitting structure 40, the lithium battery 30 and the charge sensing structure 20.
Specifically, the flexible substrate 10 may be used to carry the light emitting structure 40, the lithium battery 30, and the charge sensing structure 20, and the material of the flexible substrate 10 is a polymer, such as Polyimide (PI), polyethylene terephthalate (PET), or a resin, and may include a copolymer, an embedded polymer, or the like. The implanted photomedical device may be a stretchable structure, in which case the material of the flexible substrate may be a rubber elastomer. The lithium battery 30 is a secondary battery in which lithium ions are reciprocally intercalated and deintercalated between the positive electrode and the negative electrode and undergo oxidation-reduction reaction, and chemical energy is converted into electric energy during discharging of the battery, so that the electric energy can be converted into chemical energy by charging the battery, thereby realizing energy storage and conversion. The charging induction structure 20 generates a charging current to charge the lithium battery 30 when sensing an exciting current of the external transmitting coil, and does not need to charge the battery using a wire harness, thereby realizing wireless charging of the lithium battery 30. The light emitting structure 40, the lithium battery 30 and the charging sensing structure 20 are sealed by a sealing material, the material of the packaging layer 70 comprises a barrier adhesive, a layer of barrier adhesive is coated on the device, and a drying agent can be doped in the barrier adhesive, so that the damage of moisture to the internal device can be prevented. The encapsulation layer 70 may also be a silicon film formed on the surfaces of the light emitting unit, the lithium battery 30, the charge induction structure 20, and the like by physical vapor deposition (Physical Vapor Deposition, PVD) or plasma enhanced chemical vapor deposition (Plasma Enhanced Chemical Vapor Deposition, PECVD). The light emitting structure 40, the lithium battery 30 and the charging sensing structure 20 are packaged by the same packaging layer 70, so that the process cost can be reduced. Optionally, a protective layer may also be provided on the side of the encapsulation layer 70 remote from the flexible substrate 10, and the material of the protective layer may be the same as that of the flexible substrate 10.
According to the technical scheme provided by the embodiment of the invention, the charging induction structure generates the charging current to charge the lithium battery when the exciting current of the external transmitting coil is induced, and the battery is not required to be charged by using a wire harness, so that the lithium battery is convenient to implant in a body; meanwhile, the light-emitting structure, the lithium battery and the charging induction structure share the packaging material, so that the process cost can be reduced. The miniature photo-medical device can be realized to cope with smaller windows, such as application in early focus or convenient implantation in vivo for photo-therapy.
Optionally, fig. 2 is a top view of an intracorporal photomedical device according to an embodiment of the present invention, and referring to fig. 1-2, the number of the light emitting structure 40, the lithium battery 30, and the charging sensing structure 20 is multiple; the lithium battery 30 is connected with the light-emitting structure 40 and the charging induction structure 20 in a one-to-one correspondence manner;
wherein, the maximum size range of the vertical projection of the light emitting structure 40 on the flexible substrate 10 comprises 10 um-5 mm; the maximum size range of the perpendicular projection of the lithium battery 30 on the flexible substrate 10 includes 10um to 5mm.
Specifically, the biomedical device implanted in the body includes a plurality of light emitting structures 40, a plurality of lithium batteries 30, and a plurality of charging sensing structures 20; the lithium battery 30, the light emitting structure 40 and the charging sensing structure 20, which are connected in one-to-one correspondence, may constitute one light emitting unit, that is, the photomedical device implanted in the body is formed of a plurality of light emitting units, which may be arranged on the flexible substrate 10 in an array form. The light emitting structure 40 may be circular, rectangular or elliptical, and the specific shape of the light emitting structure 40 may be set according to actual needs. The lithium battery 30 may be circular, rectangular or oval, and the specific shape of the lithium battery 30 may be set according to actual needs. The maximum size range of the vertical projection of the lithium battery 30 on the flexible substrate 10 is set to be 10 um-5 mm, a large-volume battery or power supply for supplying power to a light source in the prior art is miniaturized into a plurality of lithium batteries 30 with smaller volumes, the lithium batteries 30 are in one-to-one correspondence with the light emitting structures 40 and are packaged together, and packaging materials are fully utilized, so that the volume of a photo-medical device implanted into a body can be reduced, and the photo-medical device is convenient to implant into the body.
Optionally, the charging induction structure comprises an induction coil and a rectification structure, wherein the induction coil is used for generating induction current when the excitation current of the external transmitting coil is sensed;
the rectification structure is respectively and electrically connected with the induction coil and the lithium battery, and is used for rectifying the induction current generated by the induction coil and providing the rectified induction current for the lithium battery;
the rectification structure is arranged on the flexible substrate, and the encapsulation layer covers the rectification structure; alternatively, the encapsulation layer includes a via in which the rectifying structure is located.
Specifically, fig. 3 is a charging circuit diagram provided by the embodiment of the present invention, and fig. 4 is a schematic structural diagram of a wireless charging of a mobile phone to an implanted photomedical device provided by the embodiment of the present invention, referring to fig. 3-4, by providing a corresponding current excitation I to an internal induction coil 21 through an external coil or the mobile phone 1, the lithium battery 30 may be charged according to a near field communication (Near Field Communication, NFC) technology or an electromagnetic induction principle. The induction coil 21 may generate an induction current when sensing an excitation current I of the external transmission coil, thereby realizing the charging of the lithium battery 30. Since the lithium battery 30 requires constant current charging, the induced current generated by the induction coil 21 needs to be rectified by the rectifying structure 22, and the rectifying structure 22 includes, but is not limited to, schottky diode, inductance, and capacitance.
Referring to fig. 1, the rectifying structure 22 may be disposed directly on the flexible substrate 10, and the encapsulation layer 70 covers the rectifying structure 22. Alternatively, fig. 5 is a cross-sectional view of another embodiment of an implantable biomedical device according to the present invention, and referring to fig. 5, the rectifying structure 22 may be mounted by surface mounting technology (Surface Mount Technology, SMT) after the packaging layer 70 is formed, and a through hole may be reserved in the packaging layer 70 during the preparation process, and the rectifying structure 22 is mounted in the through hole. The rectifying structure is electrically connected with the induction coil and the lithium battery respectively, and the connection mode can be realized through a connection lead wire, a contact or a bonding pad, and can also be connected through other modes. In the case where the rectifying structure 22 is mounted in the through hole, connection by the pad 23 is exemplarily shown in fig. 5.
Alternatively, referring to fig. 1, the lithium battery 30 includes a positive collector 31, a positive electrode 32, an electrolyte layer 33, a negative electrode 34, and a negative collector 35, which are stacked;
the light emitting structure 40 includes an anode 43, a light emitting layer 42, and a cathode 41 which are stacked;
the induction coil 21 and the rectifying structure 22 are arranged on the same layer; the side of the induction coil 21 and the rectifying structure 22 remote from the flexible substrate further comprises a first insulating layer 50; the first insulating layer 50 includes a first landing hole 51 and a second landing hole 52;
The lithium battery 30 is located on the side of the first insulating layer 50 remote from the flexible substrate 10; the positive collector 31 of the lithium battery 30 is connected with the rectifying structure 22 through a first lap joint hole 51, and the negative collector 35 of the lithium battery 30 is connected with the rectifying structure 22 through a second lap joint hole 52;
the light emitting structure 40 is located at a side of the lithium battery 30 away from the flexible substrate 10; the negative collector electrode 35 of the lithium battery 30 is multiplexed as the cathode 41 of the light emitting structure 40; a second insulating layer 60 is further disposed around the sidewalls of the respective film layers of the lithium battery 30, the second insulating layer 60 including a third overlap hole 61, and the anode 43 of the light emitting structure 40 and the positive collector 31 of the lithium battery 30 are connected through the third overlap hole 61.
Specifically, the structure of the lithium battery 30 includes a positive electrode collector 31, a positive electrode 32, an electrolyte layer 33, a negative electrode 34, and a negative electrode collector 35, which are stacked; the positive and negative electrode collector materials can be aluminum, copper, gold, nickel, platinum and other metals, or can be transparent conductive oxide such as ITO (indium tin oxide). The positive and negative electrodes are composed of cobalt oxide composed of lithium, acetylene black, polyvinylidene fluoride and N-methyl-2-pyrrolidone solvent, and can be formed by transfer printing technology. The gel electrolyte of the dielectric layer is composed of a mixture of lithium perchlorate, ethylene carbonate, dimethyl carbonate, and polyethylene oxide. The light emitting structure 40 may be an organic light emitting diode (Organic Light Emitting Diodes, OLED). The light emitting structure 40 includes an anode 43, a light emitting layer 42, and a cathode 41, which are stacked. An OLED anode 43 is prepared on the flexible substrate 10, a light emitting material may be printed on the anode 43 by means of inkjet printing to form a light emitting layer 42, and a cathode 41 is formed on the light emitting layer 42. At least one functional layer among a Hole Injection Layer (HIL), a Hole Transport Layer (HTL), an Electron Transport Layer (ETL), and an Electron Injection Layer (EIL) may be further included in the light emitting structure 40. The positive collector 31 of the lithium battery 30 is electrically connected to the anode 43 of the light emitting structure 40, and the negative collector 35 of the lithium battery 30 is electrically connected to the negative electrode of the light emitting structure 40. When a voltage is applied between the anode 43 and the cathode 41, the light emitting layer 42 emits visible light.
The induction coil 21 and the rectifying structure 22 constituting the charging induction structure 20 are provided in the same layer. The auxiliary electrode layer on the flexible substrate 10 is etched to form an induction coil 21, and the rectifying structure 22 is fixed on the flexible substrate 10 through conductive glue, or the rectifying structure 22 can be fixed on the flexible substrate 10 through conductive silver or carbon paste. The material of the first insulating layer 50 includes photoresist, and the photoresist may be coated on a side of the induction coil 21 and the rectifying structure 22 away from the flexible substrate to form the first insulating layer 50, and the first insulating layer 50 is etched through a photolithography process to form the first landing hole 51 and the second landing hole 52, and the first landing hole 51 and the second landing hole 52 expose the rectifying structure 22.
The lithium battery 30 is located on the side of the first insulating layer 50 remote from the flexible substrate 10; positive collector 31, positive electrode 32, electrolyte layer 33, negative electrode 34, and negative collector 35 of lithium battery 30 are sequentially formed on the side of first insulating layer 50 remote from flexible substrate 10. The negative collector 35 of the lithium battery 30 can be multiplexed into the cathode 41 of the light-emitting structure 40, that is, the negative collector 35 and the cathode 41 of the light-emitting structure 40 adopt the same aluminum layer, so that the total thickness of the film layer can be reduced and the cost can be reduced. The material of the second insulating layer 60 may be photoresist, and the second insulating layer 60 is etched to form the third landing hole 61. The third overlap hole 61 exposes the protruding portion of the positive collector electrode 31; the perpendicular projections of the protrusions on the flexible substrate 10 are not overlapped with the perpendicular projections of the positive electrode 32, the electrolyte layer 33, the negative electrode 34, and the negative electrode collector 35 on the flexible substrate 10, respectively, and the anode 43 of the light emitting structure 40 is connected with the positive electrode collector 31 of the lithium battery 30 through the third overlap hole 61. The light emitting structure 40, the lithium battery 30 and the charging induction structure 20 are stacked on the flexible substrate 10 in the in-vivo photo-medical device provided by the embodiment of the invention, so that the density of light emitting points of the in-vivo photo-medical device can be improved, and the light emitting quantity of the in-vivo photo-medical device can be ensured when the area of the in-vivo photo-medical device is reduced. In an embodiment, the lithium battery 30 may also be prepared by sequentially forming the negative collector electrode 35, the negative electrode 34, the electrolyte layer 33, the positive electrode 32 and the positive collector electrode 31, where the positive collector electrode 31 of the lithium battery 30 may be multiplexed into the anode 43 of the light emitting structure 40, and the cathode 41 of the light emitting structure 40 is connected to the negative collector electrode 35 of the lithium battery 30 through the third lap hole 61.
Referring to fig. 5, for the biomedical device implanted in the body in which the light emitting structure 40, the lithium battery 30, and the charge inducing structure 20 are stacked on the flexible substrate 10, a rectifying structure may be further provided after the encapsulation layer is formed. After the encapsulation layer 70 is completed, the rectifying structure 22 is attached by a surface mounting technology, and the bonding pads 23 are disposed on the flexible substrate. The pads 23 include input pads and output pads. The input pads include first and second input pads, and the output pads include first and second output pads. The two ends of the induction coil are connected with the first input bonding pad and the second input bonding pad in a one-to-one correspondence mode. A first insulating layer 50 is provided on the side of the induction coil 21 and the bonding pad 23 remote from the flexible substrate, the positive collector 31 of the lithium battery 30 is connected to the first output bonding pad through a first landing hole 51, and the negative collector 35 of the lithium battery 30 is connected to the second output bonding pad through a second landing hole 52. The packaging layer 70 may be reserved with a through hole in the preparation process, and the rectifying structure 22 is mounted in the through hole and connected with the input pad and the output pad on the flexible substrate 10, so that the rectifying structure 22 rectifies the induced current generated by the induction coil 21 and provides the rectified induced current for the lithium battery 30 to charge. Similarly, the lithium battery 30 may be prepared by sequentially forming the negative collector electrode 35, the negative electrode 34, the electrolyte layer 33, the positive electrode 32 and the positive collector electrode 31, and in this case, the positive collector electrode 31 of the lithium battery 30 may be multiplexed as the anode 43 of the light emitting structure 40, and the cathode 41 of the light emitting structure 40 and the negative collector electrode 35 of the lithium battery 30 may be connected through the third overlap hole 61.
The embodiment of the invention also provides a preparation method of the in-vivo photomedical device, which is used for forming the in-vivo photomedical device according to any embodiment, and fig. 6 is a flowchart of the preparation method of the in-vivo photomedical device provided by the embodiment of the invention, and referring to fig. 6, the method includes:
s110, providing a flexible substrate.
S120, sequentially forming a charging induction structure, a lithium battery and a light-emitting structure on one side of the flexible substrate; the charging induction structure, the lithium battery and the light-emitting structure are arranged on the flexible substrate in a lamination manner; the lithium battery is respectively and electrically connected with the light-emitting structure and the charging induction structure; the lithium battery is used for supplying power to the light-emitting structure, and the charging induction structure is used for generating charging current to charge the lithium battery when the excitation current of the external transmitting coil is induced.
S130, forming an encapsulation layer, wherein the encapsulation layer is used for encapsulating the light-emitting structure, the lithium battery and the charging induction structure.
The embodiment of the invention provides a preparation method of an in-vivo implanted photomedical device, which comprises the following steps: providing a flexible substrate; forming a light-emitting structure, a lithium battery and a charging induction structure which are stacked on a flexible substrate; and forming an encapsulation layer, wherein the encapsulation layer is used for encapsulating the light-emitting structure, the lithium battery and the charging induction structure. When the excitation current of the external transmitting coil is sensed through the charging induction structure, charging current is generated to charge the lithium battery, and the battery is not required to be charged by using a wire harness; the battery is miniaturized, and the battery and the light-emitting unit are packaged on the flexible substrate together, so that the wireless charging of the photo-medical device is realized, the volume of the device is reduced, and the device is convenient to implant in vivo; meanwhile, the light-emitting structure, the lithium battery and the charging induction structure share packaging materials, and the process cost can be reduced.
Fig. 7 is a flowchart of another method for preparing an implantable biomedical device according to an embodiment of the present invention, where the method for preparing an implantable biomedical device according to the embodiment of the present invention is used to form an implantable biomedical device in which a light emitting structure, a lithium battery, and an induction coil are stacked on a flexible substrate, and a rectifying structure in a charging induction structure is directly disposed on the flexible substrate, and the method includes:
s210, etching an auxiliary electrode layer on the flexible substrate to form an induction coil, fixing the rectifying structure on the flexible substrate through conductive adhesive, and connecting the induction coil with the rectifying structure.
Specifically, fig. 8 is a top view of step S210 in the method for manufacturing an implanted biomedical device according to the embodiment of the present invention, fig. 9 is a cross-sectional view along line AA' of fig. 8, and referring to fig. 8-9, an auxiliary electrode layer on a flexible substrate is etched to form an induction coil 21, and a rectifying structure 22 is fixed on the flexible substrate by conductive adhesive, and it should be noted that the auxiliary electrode layer and an auxiliary lead on an anode are formed by the same process.
And S220, forming a first insulating layer on one side of the induction coil and the rectifying structure away from the flexible substrate.
S230, etching the first insulating layer to form a first lap joint hole and a second lap joint hole; the first and second lap holes each expose the rectifying structure.
Specifically, fig. 10 is a top view of step S230 in the method for manufacturing an implanted biomedical device according to the embodiment of the present invention, fig. 11 is a cross-sectional view along line AA' of fig. 10, and referring to fig. 10-11, after forming the first insulating layer 50 on the side of the induction coil 21 and the rectifying structure 22 away from the flexible substrate 10, the first insulating layer 50 is etched to form the first lap hole 51 and the second lap hole 52; the first and second landing holes 51 and 52 each expose the rectifying structure 22.
S240, forming a positive collector, a positive electrode, an electrolyte layer, a negative electrode and a negative collector of the lithium battery on one side of the first insulating layer far away from the flexible substrate in sequence; the positive collector electrode is lapped with the rectifying structure through a first lapping hole; the negative electrode collector is lapped with the rectifying structure through a second lapping hole.
Specifically, fig. 12 is a top view of step S240 in the method for manufacturing an intracorporal photomedical device according to the embodiment of the invention, fig. 13 is a cross-sectional view taken along line AA' of fig. 12, and referring to fig. 12-13, a positive collector 31, a positive electrode 32, an electrolyte layer 33, a negative electrode 34, and a negative collector 35 of a lithium battery are sequentially formed on a side of the first insulating layer 50 away from the flexible substrate 10; the positive collector 31 is overlapped with the rectifying structure 22 through the first overlap hole 51; negative collector 35 is lapped over rectifying structure 22 through second lap hole 52.
S250, forming a second insulating layer around the side wall of each film layer of the lithium battery.
S260, etching the second insulating layer to form a third lap joint hole, wherein the third lap joint hole exposes the convex part of the positive collector electrode; the perpendicular projections of the projections on the flexible substrate do not overlap with the perpendicular projections of the positive electrode, the electrolyte layer, the negative electrode, and the negative electrode collector, respectively, on the flexible substrate.
Specifically, fig. 14 is a cross-sectional view of a structure of step S260 in a method for manufacturing an implanted biomedical device according to an embodiment of the present invention, referring to fig. 14, a second insulating layer 60 is formed around the sidewall of each film layer of a lithium battery, a third overlap hole 61 is formed by etching the second insulating layer 60, and the third overlap hole 61 exposes a protruding portion of the positive collector 31.
S270, sequentially forming a light-emitting layer and an anode of a light-emitting structure on one side of the lithium battery far away from the flexible substrate; wherein the negative electrode collector of the lithium battery is multiplexed into a negative electrode of the light-emitting structure; the anode of the light-emitting structure is connected with the convex part of the positive electrode collector of the lithium battery through a third lap joint hole.
Specifically, fig. 15 is a top view of step S270 in the method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention, fig. 16 is a cross-sectional view taken along line AA' of fig. 15, and referring to fig. 15-16, a light-emitting layer 42 and an anode 43 of a light-emitting structure are sequentially formed on a side of a lithium battery remote from the flexible substrate 10; wherein the negative collector 35 of the lithium battery is multiplexed as the negative electrode 41 of the light emitting structure; the anode 43 of the light emitting structure is connected to the protruding portion of the positive collector electrode 31 of the lithium battery through the third overlap hole 61.
S280, forming an encapsulation layer, wherein the encapsulation layer is used for encapsulating the light-emitting structure, the lithium battery and the charging induction structure.
Specifically, fig. 17 is a top view of step S280 in the method for manufacturing an intracorporal photomedical device according to an embodiment of the present invention, and referring to fig. 17 and fig. 1, an encapsulation layer 70 is formed, and the encapsulation layer 70 encapsulates the light emitting structure 40, the lithium battery 30, and the charge induction structure.
Fig. 18 is a flowchart of another method for preparing an implantable biomedical device according to an embodiment of the present invention, and referring to fig. 18, the embodiment of the present invention further provides a method for preparing an implantable biomedical device, where a light emitting structure, a lithium battery, and an induction coil are stacked on a flexible substrate in the above embodiment, and a rectifying structure in a charging induction structure is disposed in a through hole of a packaging layer, and the method includes:
s310, etching an auxiliary electrode layer on the flexible substrate to form an induction coil, and forming an input pad and an output pad on the flexible substrate; the induction coil is connected with the input pad.
And S320, forming a first insulating layer on one side of the induction coil and the bonding pad away from the flexible substrate.
S330, etching the first insulating layer to form a first lap joint hole and a second lap joint hole; the first and second landing holes each expose an output pad.
Specifically, the output pads include a first output pad and a second output pad, the first landing hole exposing the first output pad, and the second landing hole exposing the second output pad.
S340, sequentially forming a positive collector, a positive electrode, an electrolyte layer, a negative electrode and a negative collector of the lithium battery on one side of the first insulating layer away from the flexible substrate; the positive collector electrode is lapped with the output bonding pad through the first lapping hole; the negative collector electrode is lapped with the output bonding pad through the second lapping hole.
Specifically, the positive collector electrode is lapped with the first output bonding pad through the first lapping hole; the negative collector electrode is overlapped with the second output bonding pad through the second overlap hole.
S350, forming a second insulating layer around the side wall of each film layer of the lithium battery.
S360, etching the second insulating layer to form a third lap joint hole, wherein the third lap joint hole exposes the protruding part of the positive collector electrode; the perpendicular projections of the projections on the flexible substrate do not overlap with the perpendicular projections of the positive electrode, the electrolyte layer, the negative electrode, and the negative electrode collector, respectively, on the flexible substrate.
S370, sequentially forming a light-emitting layer and an anode of a light-emitting structure on one side of the lithium battery far away from the flexible substrate; wherein the negative electrode collector of the lithium battery is multiplexed into a negative electrode of the light-emitting structure; the anode of the light-emitting structure is connected with the convex part of the positive electrode collector of the lithium battery through a third lap joint hole.
S380, forming an encapsulation layer, wherein the encapsulation layer is used for encapsulating the light-emitting structure, the lithium battery and the induction coil; the encapsulation layer includes a via.
Specifically, fig. 19 is a cross-sectional view of a structure of step S380 in a method for manufacturing an implanted biomedical device according to an embodiment of the present invention, referring to fig. 19, an encapsulation layer 70 is formed, a through hole 71 is reserved in the process of forming the encapsulation layer 70, and the through hole is reserved in the process of forming the first insulating layer and the second insulating layer, so that the through hole 71 of the encapsulation layer 70 in combination with the through holes of the first insulating layer and the second insulating layer may expose a bonding pad 23 (an input bonding pad and an output bonding pad).
S390, mounting the rectifying structure in the through hole of the packaging layer through a surface mounting technology; the input end of the rectifying structure is connected with the input bonding pad, and the output end of the rectifying structure is connected with the output bonding pad.
Specifically, referring to fig. 5, the rectifying structure 22 is mounted in the through-hole by a surface mount technology such that the rectifying structure 22 is connected to the input pad and the output pad.
Note that the above is only a preferred embodiment of the present invention and the technical principle applied. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, while the invention has been described in connection with the above embodiments, the invention is not limited to the embodiments, but may be embodied in many other equivalent forms without departing from the spirit or scope of the invention, which is set forth in the following claims.
Claims (10)
1. An implantable photomedical device, comprising:
a flexible substrate;
the charging induction structure, the lithium battery and the light-emitting structure are arranged on one side of the flexible substrate in a stacked manner; the lithium battery is respectively and electrically connected with the light-emitting structure and the charging induction structure; the lithium battery is used for supplying power to the light-emitting structure, and the charging induction structure is used for generating charging current to charge the lithium battery when the excitation current of the external transmitting coil is induced;
the packaging layer is used for packaging the light-emitting structure, the lithium battery and the charging induction structure;
the lithium battery comprises a positive electrode collector, a positive electrode, an electrolyte layer, a negative electrode and a negative electrode collector which are arranged in a stacked manner; a first insulating layer is further included on a side of the induction coil and the rectifying structure away from the flexible substrate or on a side of the induction coil and the pad structure away from the flexible substrate; the first insulating layer includes a first landing hole and a second landing hole; the positive electrode collector of the lithium battery is connected with the rectifying structure or the bonding pad structure through the first lap joint hole, and the negative electrode collector of the lithium battery is connected with the rectifying structure or the bonding pad structure through the second lap joint hole.
2. The implantable photomedical device of claim 1, wherein the induction coil is configured to generate an induced current when an excitation current of the external transmitting coil is induced;
the rectification structure is respectively and electrically connected with the induction coil and the lithium battery, and is used for rectifying the induction current generated by the induction coil and providing the rectified induction current for the lithium battery;
the rectification structure is arranged on the flexible substrate, and the encapsulation layer covers the rectification structure; alternatively, the encapsulation layer includes a via, and the rectifying structure is located in the via.
3. An implantable photomedical device as defined in claim 2, wherein,
the light-emitting structure comprises an anode, a light-emitting layer and a cathode which are arranged in a stacked manner;
the induction coil and the rectifying structure are arranged on the same layer; the induction coil and the rectifying structure further comprise a first insulating layer at one side far away from the flexible substrate;
the lithium battery is positioned on one side of the first insulating layer away from the flexible substrate; the positive electrode collector of the lithium battery is connected with the rectification structure through the first lap joint hole, and the negative electrode collector of the lithium battery is connected with the rectification structure through the second lap joint hole;
The light-emitting structure is positioned on one side of the lithium battery far away from the flexible substrate; the negative electrode collector of the lithium battery is multiplexed to be the cathode of the light-emitting structure; a second insulating layer is further arranged around the side wall of each film layer of the lithium battery, the second insulating layer comprises a third lap joint hole, and the anode of the light-emitting structure is connected with the positive electrode collector of the lithium battery through the third lap joint hole; or the positive collector electrode of the lithium battery is multiplexed to be the anode of the light-emitting structure, and the cathode of the light-emitting structure is connected with the negative collector electrode of the lithium battery through the third lap joint hole.
4. An implantable photomedical device as defined in claim 2, wherein,
the light-emitting structure comprises an anode, a light-emitting layer and a cathode which are arranged in a stacked manner;
the induction coil and the bonding pad structure are arranged on the same layer; the induction coil and the side of the pad structure away from the flexible substrate further comprise a first insulating layer;
the lithium battery is positioned on one side of the first insulating layer away from the flexible substrate; the positive electrode collector of the lithium battery is connected with the bonding pad structure through the first lap joint hole, and the negative electrode collector of the lithium battery is connected with the bonding pad structure through the second lap joint hole;
The light-emitting structure is positioned on one side of the lithium battery far away from the flexible substrate; the negative electrode collector of the lithium battery is multiplexed to be the cathode of the light-emitting structure; a second insulating layer is further arranged around the side wall of each film layer of the lithium battery, the second insulating layer comprises a third lap joint hole, and the anode of the light-emitting structure is connected with the positive electrode collector of the lithium battery through the third lap joint hole; or, the positive collector electrode of the lithium battery is multiplexed to be the anode of the light-emitting structure, and the cathode of the light-emitting structure is connected with the negative collector electrode of the lithium battery through the third lap joint hole;
the rectifying structure is connected with the bonding pad structure through the through hole.
5. The implantable photomedical device of claim 4, wherein the pad structure comprises an input pad and an output pad, the rectifying structure is coupled to the input pad and the output pad, the induction coil is coupled to the input pad, and the lithium battery is coupled to the output pad.
6. An implantable photomedical device as defined in claim 1, wherein,
the number of the light-emitting structures, the lithium batteries and the charging induction structures is multiple; the lithium battery is connected with the light-emitting structure and the charging induction structure in a one-to-one correspondence manner;
Wherein, the maximum size range of the vertical projection of the light-emitting structure on the flexible substrate comprises 10 um-5 mm; the maximum size range of the vertical projection of the lithium battery on the flexible substrate comprises 10 um-5 mm.
7. An implantable photomedical device as defined in claim 1, wherein,
the material of the flexible substrate comprises at least one of polyimide, polyethylene terephthalate, resin and rubber;
the packaging layer comprises a barrier adhesive, wherein a drying agent is doped in the barrier adhesive; or the material of the encapsulation layer comprises silicon oxide.
8. A method of making an implantable photomedical device comprising:
providing a flexible substrate;
forming a light-emitting structure, a lithium battery and a charging induction structure on one side of the flexible substrate; the charging induction structure, the lithium battery and the light-emitting structure are arranged on the flexible substrate in a lamination manner; the lithium battery is respectively and electrically connected with the light-emitting structure and the charging induction structure; the lithium battery is used for supplying power to the light-emitting structure, and the charging induction structure is used for generating charging current to charge the lithium battery when the excitation current of the external transmitting coil is induced;
Forming an encapsulation layer, wherein the encapsulation layer is used for encapsulating the light-emitting structure, the lithium battery and the charging induction structure;
the charging induction structure comprises an induction coil and a rectifying structure, a first insulating layer is formed on one side of the induction coil and the rectifying structure away from the flexible substrate or one side of the induction coil and the bonding pad structure away from the flexible substrate, and the first insulating layer is etched to form a first lap joint hole and a second lap joint hole; the first and second landing holes each expose the rectifying structure or pad; sequentially forming a positive collector, a positive electrode, an electrolyte layer, a negative electrode and a negative collector of the lithium battery on one side of the first insulating layer far away from the flexible substrate; the positive electrode collector is overlapped with the rectifying structure or the bonding pad through the first overlap hole; and the negative electrode collector is lapped with the rectifying structure or the bonding pad through the second lapping hole.
9. The method of manufacturing an implantable photomedical device according to claim 8, wherein the induction coil is configured to generate an induction current when an excitation current of an external transmission coil is induced, and the rectifying structure is configured to rectify the induction current generated by the induction coil; the formation of the light emitting structure, the lithium battery and the charging induction structure on one side of the flexible substrate comprises:
Etching an auxiliary electrode layer on the flexible substrate to form the induction coil, and fixing a rectifying structure on the flexible substrate through conductive adhesive; the induction coil is connected with the rectifying structure;
forming a first insulating layer on one side of the induction coil and the rectifying structure away from the flexible substrate;
the first and second overlapping holes each expose the rectifying structure; the positive electrode collector is overlapped with the rectification structure through the first overlap hole; the negative electrode collector is overlapped with the rectification structure through the second overlap hole;
forming a second insulating layer around the side wall of each film layer of the lithium battery;
etching the second insulating layer to form a third lap joint hole, wherein the third lap joint hole exposes the convex part of the positive collector electrode; the vertical projection of the convex part on the flexible substrate is not overlapped with the vertical projection of the anode, the electrolyte layer, the cathode and the cathode collector on the flexible substrate respectively;
sequentially forming a light-emitting layer and an anode of the light-emitting structure on one side, far away from the flexible substrate, of the lithium battery; wherein the negative electrode collector of the lithium battery is multiplexed as the negative electrode of the light-emitting structure; and the anode of the light-emitting structure is connected with the convex part of the positive electrode collector of the lithium battery through the third lap joint hole.
10. The method of manufacturing an implantable photomedical device according to claim 8, wherein the induction coil is configured to generate an induction current when an excitation current of an external transmitting coil is induced, the rectifying structure is configured to rectify the induction current generated by the induction coil, and the encapsulation layer includes a through hole; the formation of the light emitting structure, the lithium battery and the charging induction structure on one side of the flexible substrate comprises:
etching the auxiliary electrode layer on the flexible substrate to form the induction coil, and forming an input bonding pad and an output bonding pad on the flexible substrate; the induction coil is connected with the input bonding pad;
forming a first insulating layer on one side of the induction coil and the bonding pad away from the flexible substrate;
the first and second landing holes each expose the output pad;
the positive electrode collector electrode is overlapped with the output bonding pad through the first overlap hole; the negative electrode collector is overlapped with the output bonding pad through the second overlap hole;
forming a second insulating layer around the side wall of each film layer of the lithium battery;
etching the second insulating layer to form a third lap joint hole, wherein the third lap joint hole exposes the convex part of the positive collector electrode; the vertical projection of the convex part on the flexible substrate is not overlapped with the vertical projection of the anode, the electrolyte layer, the cathode and the cathode collector on the flexible substrate respectively;
Sequentially forming a light-emitting layer and an anode of the light-emitting structure on one side, far away from the flexible substrate, of the lithium battery; wherein the negative electrode collector of the lithium battery is multiplexed as the negative electrode of the light-emitting structure; the anode of the light-emitting structure is connected with the convex part of the positive electrode collector of the lithium battery through the third lap joint hole;
after the packaging layer is formed, the rectifying structure is attached to the through hole of the packaging layer through a surface mounting technology; the input end of the rectifying structure is connected with the input bonding pad, and the output end of the rectifying structure is connected with the output bonding pad.
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| CN202111181583.9A CN113949168B (en) | 2021-10-11 | 2021-10-11 | Intracorporal photomedical device and preparation method thereof |
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