CN110914408A - 肝类器官组合物以及其制备和使用方法 - Google Patents

肝类器官组合物以及其制备和使用方法 Download PDF

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CN110914408A
CN110914408A CN201880033510.5A CN201880033510A CN110914408A CN 110914408 A CN110914408 A CN 110914408A CN 201880033510 A CN201880033510 A CN 201880033510A CN 110914408 A CN110914408 A CN 110914408A
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liver
cells
drug
organoids
organoid
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Chinese (zh)
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武部贵则
筱泽忠纮
小池博之
木村昌树
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Japan Science and Technology Agency
Cincinnati Childrens Hospital Medical Center
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Cincinnati Childrens Hospital Medical Center
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CN201880033510.5A 2017-06-09 2018-02-19 肝类器官组合物以及其制备和使用方法 Pending CN110914408A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762517414P 2017-06-09 2017-06-09
US62/517,414 2017-06-09
PCT/US2018/018585 WO2018226267A1 (fr) 2017-06-09 2018-02-19 Compositions d'organoïdes hépatiques et procédés de préparation et d'utilisation correspondants

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CN110914408A true CN110914408A (zh) 2020-03-24

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US (1) US20200199537A1 (fr)
EP (1) EP3635095A4 (fr)
JP (2) JP7148552B2 (fr)
KR (2) KR20240010095A (fr)
CN (1) CN110914408A (fr)
AU (2) AU2018279790B2 (fr)
CA (1) CA3065759A1 (fr)
IL (1) IL270714A (fr)
NZ (1) NZ759164A (fr)
WO (1) WO2018226267A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114317439A (zh) * 2021-12-23 2022-04-12 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN117701492A (zh) * 2023-12-14 2024-03-15 首都医科大学 肝类器官的构建方法及其应用

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JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
WO2018106628A1 (fr) 2016-12-05 2018-06-14 Children's Hospital Medical Center Organoïdes du côlon et leurs procédés de préparation et d'utilisation
JP2022534397A (ja) * 2019-05-31 2022-07-29 チルドレンズ ホスピタル メディカル センター 造血幹細胞の生成および拡大方法
JP2023516484A (ja) 2020-03-11 2023-04-19 ビット バイオ リミテッド 肝細胞作製方法
US20230399623A1 (en) * 2020-11-13 2023-12-14 Oslo Universitetssykehus Hf Artifical liver organoids and methods of their production
CN112553339A (zh) * 2020-12-29 2021-03-26 广东南芯医疗科技有限公司 伊立替康个体化用药基因的指导方法及试剂盒
EP4352206A2 (fr) * 2021-06-11 2024-04-17 Children's Hospital Medical Center Modèle organoïde hépatique pour l'hyperbilirubinémie et ses procédés de fabrication et d'utilisation
JP2023020221A (ja) * 2021-07-30 2023-02-09 ウシオ電機株式会社 薬剤評価方法
CN114891831A (zh) * 2022-01-14 2022-08-12 北京清华长庚医院 过表达wnt2基因的内皮细胞株及其构建方法和应用
CN115386535B (zh) * 2022-10-26 2023-02-03 天津外泌体科技有限公司 多谱系肝类器官模型及基于该模型的药物肝毒评价方法

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WO2015183920A2 (fr) * 2014-05-28 2015-12-03 Children's Hospital Medical Center Procédés et systèmes de conversion de cellules précurseurs en tissus gastriques par différenciation dirigée
CN105209605A (zh) * 2013-03-15 2015-12-30 奥加诺沃公司 工程化肝组织、其阵列及其制备方法
WO2016141137A1 (fr) * 2015-03-03 2016-09-09 President And Fellows Of Harvard College Procédés de génération de tissu humain fonctionnel
CN110381967A (zh) * 2016-11-04 2019-10-25 儿童医院医学中心 肝类器官组合物以及其制备和使用方法

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EP2412800A1 (fr) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Organoïde du foie, ses utilisations et son procédé de culture pour l'obtenir
EP2504424A1 (fr) * 2009-11-25 2012-10-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé de différenciation hépatique de cellules endodermiques définitives
WO2011116930A1 (fr) * 2010-03-22 2011-09-29 Cellartis Ab Différenciation et maturation de cellules pluripotentes en cellules de type hépatocytes par modulation de la voie de signalisation par wnt
TR201104076A1 (tr) * 2011-04-26 2012-11-21 Kordsa Global End�Str�Yel �Pl�K Ve Kord Bez� San. Ve T�C. A.�. Araç lastiği üst kuşak şeridinin üretim yöntemi.
CN107075471A (zh) * 2014-10-08 2017-08-18 新加坡科技研究局 将干细胞分化为肝细胞谱系的方法
US9324528B1 (en) * 2014-11-17 2016-04-26 General Electric Company Magnetic trip mechanism for circuit breaker
WO2017048193A1 (fr) * 2015-09-15 2017-03-23 Agency For Science, Technology And Research (A*Star) Dérivation d'organoïdes hépatiques à partir de cellules souches pluripotentes humaines
CN109153962A (zh) * 2016-03-08 2019-01-04 耶路撒冷希伯来大学的益生研究开发有限公司 连续生物感测的方法及系统

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Publication number Priority date Publication date Assignee Title
CN105209605A (zh) * 2013-03-15 2015-12-30 奥加诺沃公司 工程化肝组织、其阵列及其制备方法
WO2015183920A2 (fr) * 2014-05-28 2015-12-03 Children's Hospital Medical Center Procédés et systèmes de conversion de cellules précurseurs en tissus gastriques par différenciation dirigée
CN106661548A (zh) * 2014-05-28 2017-05-10 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
WO2016141137A1 (fr) * 2015-03-03 2016-09-09 President And Fellows Of Harvard College Procédés de génération de tissu humain fonctionnel
CN110381967A (zh) * 2016-11-04 2019-10-25 儿童医院医学中心 肝类器官组合物以及其制备和使用方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114317439A (zh) * 2021-12-23 2022-04-12 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN114317439B (zh) * 2021-12-23 2024-04-16 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN117701492A (zh) * 2023-12-14 2024-03-15 首都医科大学 肝类器官的构建方法及其应用

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IL270714A (en) 2020-01-30
KR20200015898A (ko) 2020-02-13
AU2022204804A1 (en) 2022-07-28
US20200199537A1 (en) 2020-06-25
AU2018279790A1 (en) 2019-12-05
WO2018226267A1 (fr) 2018-12-13
KR20240010095A (ko) 2024-01-23
JP7148552B2 (ja) 2022-10-05
NZ759164A (en) 2023-02-24
EP3635095A4 (fr) 2021-12-01
JP2022191263A (ja) 2022-12-27
EP3635095A1 (fr) 2020-04-15
JP2020523000A (ja) 2020-08-06
KR102625361B1 (ko) 2024-01-18
AU2018279790B2 (en) 2022-04-07
CA3065759A1 (fr) 2018-12-13

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