CN110898136A - 一种治疗玻璃体的中药组合物及其制备方法 - Google Patents
一种治疗玻璃体的中药组合物及其制备方法 Download PDFInfo
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- CN110898136A CN110898136A CN201911130487.4A CN201911130487A CN110898136A CN 110898136 A CN110898136 A CN 110898136A CN 201911130487 A CN201911130487 A CN 201911130487A CN 110898136 A CN110898136 A CN 110898136A
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Abstract
本发明公开了一种治疗玻璃体的中药组合物，其原料包括：桃仁、红花、当归、川芎、白芍、熟地、枸杞子、茯苓、泽泻、车前子。本发明公开了上述治疗玻璃体的中药组合物的制备方法，包括如下步骤：将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取，过滤后再加入浓度为50％乙醇水溶液中回流提取，过滤，合并滤液，回收乙醇，一次浓缩得到第一稠膏；将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮，过滤，再加入固体物料总质量8倍的水，进行二次煎煮，过滤，合并滤液，二次浓缩得到第二稠膏；将第一稠膏和第二稠膏混合后，加入辅料，制粒，干燥。
Description
技术领域
本发明涉及中药技术领域，尤其涉及一种治疗玻璃体的中药组合物及其制备方法。
背景技术
玻璃体混浊属于中医“云雾移睛”“视瞻昏渺”的范畴，乃为瞳神疾患。本病中医病因病机主要是由痰湿上泛，瘀血停滞或肝肾亏损，精血不足所致。玻璃体混浊在临床上表现为是指玻璃体呈尘状，丝状，絮状，条索状，云片状混浊，患者可见眼前形态不一的黑影飘移。患者往往自觉视力有不同程度的妨碍和不适感，严重者可致失明。
因玻璃体混浊临床上常常分为炎性、出血性、退化性三类，多发于中老年人及屈光不正患者，可以采用滋补阴虚，活血化瘀治疗。
发明内容
本发明的目的是为了解决现有技术中存在的缺点，而提出的一种治疗玻璃体的中药组合物及其制备方法。
一种治疗玻璃体的中药组合物，其原料包括：桃仁、红花、当归、川芎、白芍、熟地、枸杞子、茯苓、泽泻、车前子。
桃仁，蔷薇科植物桃或山桃的干燥成熟种子。果实成熟后采收，除去果肉及核壳，取出种子，晒干。味苦、甘，性平。归心、肝、大肠经。具有活血祛瘀，润肠通便，止咳平喘之功效。用于经闭，痛经，癓瘕痞块，跌扑损伤，肠燥便秘。
红花，菊科植物红花的干燥花。花多聚集成不规则的团块。红色或红黄色。味辛、性温，归心、肝经。气香行散，入血分具有活血通经，祛瘀止痛的功效。主治痛经，经闭，产后血晕，瘀滞腹痛，胸痹心痛，血积，跌打瘀肿，关节疼痛，中风瘫痪，斑疹紫暗。
当归，伞形科植物当归的根。含基本内酯、正丁烯酰内酯、阿魏酸、烟酸、蔗糖和多种氨基酸，以及倍半萜类化合物等。性温，味甘、辛。归肝、心、脾经。具有补血活血，调经止痛，润肠通便的功效。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。
川芎，伞形科植物川芎的干燥根茎。夏季当茎上的节盘显著突出，并略带紫色时采挖，除去泥沙，晒后炕干，再去须根。味辛，性温。归肝、胆、心包经。具有活血行气，祛风止痛的功效。用于安抚神经，正头风头痛，症瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
白芍，毛茛科植物芍药除去外皮的根。味苦、酸，性微寒。入肝经。具有养血敛阴，柔肝止痛，平肝阳之功效。用于月经不调，经行腹痛，崩漏，以及自汗、盗汗等症，肝气不和所致的胁痛、腹痛，以及手足拘挛疼痛等症，以及肝阳亢盛所引起的头痛、眩晕。
熟地，玄参科植物地黄的块根经加工炮制而成。味甘，性温。归肝、肾经。具有补血滋润；益精填髓的功效。用于血虚萎黄；眩晕心悸；月经不调；崩不止；肝肾阴亏；潮热盗汗；遗精阳痿；不育不孕；月经不调；崩漏下血；腰膝酸软；耳鸣耳聋；头目昏花；须发早白；消渴；便秘；肾虚喘促。
枸杞子，茄科植物宁夏枸杞的干燥成熟果实。夏、秋二季果实呈红色时采收，热风烘干，除去果梗。或晾至皮皱后，晒干，除去果梗。味甘，性平。归肝、肾经。具有滋补肝肾，益精明目之功效。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。
茯苓，俗称云苓、松苓、茯灵，为寄生在松树根上的菌类植物，形状像甘薯，外皮黑褐色，里面白色或粉红色。其原生物为多孔菌科真菌茯苓的干燥菌核，多寄生于马尾松或赤松的根部。味甘、淡，性平。具有渗湿利水；健脾和胃；宁心安神的功效。主治小便不利；水肿胀满；痰饮咳逆；呕吐；脾虚食少；泄泻；心悸不安；失眠健忘；遗精白浊。
泽泻，泽泻科植物泽泻的块茎。味甘、淡，性寒。归肾、膀胱经。具有利水渗湿；泄热通淋的功效。主治小便不利；热淋涩痛；水肿胀满；泄泻；痰饮眩晕；遗精。
车前子，车前科植物车前的干燥成熟种子。均系野生。夏、秋二季种子成熟时采收果穗，晒干，搓出种子，除去杂质。味甘，性微寒。归肝、肾、肺、小肠经。具有清热利尿，渗湿通淋，明目祛痰的功效。用于水肿胀满，热淋涩痛，暑湿泄泻，目赤肿痛，痰热咳嗽。
优选地，桃仁、红花、当归、川芎、白芍、熟地、枸杞子、茯苓、泽泻、车前子的质量比为7-11：7-11：5-7：5-7：2-4：2-4：2-4：2-4：1-3：1-3。
优选地，桃仁、红花的质量之和为a，当归、川芎的质量之和为b，a、b之比为18-20：11-13。
优选地，桃仁、当归、川芎、白芍、熟地、泽泻的质量之和为c，红花、枸杞子、茯苓、车前子的质量之和为d，c、d之比为25.5-32.5：14.5-19.5。
优选地，其原料按质量份包括：桃仁8-10份，红花8-10份，当归5.5-6.5份，川芎5.5-6.5份，白芍2.5-3.5份，熟地2.5-3.5份，枸杞子2.5-3.5份，茯苓2.5-3.5份，泽泻1.5-2.5份，车前子1.5-2.5份。
上述治疗玻璃体的中药组合物的制备方法，包括如下步骤：
S1、将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取，过滤后再加入浓度为50％乙醇水溶液中回流提取，过滤，合并滤液，回收乙醇，一次浓缩得到第一稠膏；
S2、将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮，过滤，再加入固体物料总质量8倍的水，进行二次煎煮，过滤，合并滤液，二次浓缩得到第二稠膏；
S3、将第一稠膏和第二稠膏混合后，加入辅料，制粒，干燥。
优选地，S1中，加入浓度为70％的乙醇水溶液中回流提取1.5-2.5h；加入浓度为50％乙醇水溶液中回流提取1.5-2.5h。
优选地，S2中，一次煎煮时间为1.5-2.5h；二次煎煮时间为1-2h。
优选地，第一稠膏和第二稠膏的相对密度均为1.30，一次浓缩和二次浓缩的温度均为55-65℃。
优选地，S3中，辅料包括：糊精和白砂糖，干燥温度小于等于80℃。
仁宇著有《审视瑶函》(又名《眼科大全》)一书(1644年刊行)，其认为：目之诸病，皆由其阴虚火旺，火热炎上，导致气血不循经络，郁滞而不通畅，故应用开滞导郁之法，以泄其疲，使道路通畅。因单独应用开导法，有损人体正气，眼具有视觉功能，生理上依赖气、血、律液的滋润和濡养，若伤及人体气血津液，则其功能难以恢复，所以“开导补益”法应运而生。
本发明以活血化瘀桃仁、红花为君药；臣药当归养血活血，川芎活血行气，使活血祛瘀之力倍增；其余各药有滋肝肾，补阴血，清虚热之功效，使祛瘀而不伤正；同时川芎，红花兼能引药上行，全方共奏活血化瘀，滋补肝肾，通络明目之功效。
本发明针对玻璃体混浊的病因病机，采用活血化瘀治疗为主，辅以滋补阴虚、通络明目，祛瘀而不伤正，疗效明显。
具体实施方式
下面结合具体实施例对本发明作进一步解说。
实施例1
一种治疗玻璃体的中药组合物，其原料包括：桃仁7g，红花11g，当归5g，川芎7g，白芍2g，熟地4g，枸杞子2g，茯苓4g，泽泻1g，车前子3g。
上述治疗玻璃体的中药组合物的制备方法，包括如下步骤：
S1、将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取1.5h，过滤后再加入浓度为50％乙醇水溶液中回流提取2.5h，过滤，合并滤液，回收乙醇，55℃一次浓缩得到相对密度均为1.30的第一稠膏；
S2、将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮2.5h，过滤，再加入固体物料总质量8倍的水，进行二次煎煮1h，过滤，合并滤液，65℃二次浓缩得到相对密度均为1.30的第二稠膏；
S3、将第一稠膏和第二稠膏混合后，加入糊精和白砂糖，制粒，76℃干燥。
实施例2
一种治疗玻璃体的中药组合物，其原料包括：桃仁11g，红花7g，当归7g，川芎5g，白芍4g，熟地2g，枸杞子4g，茯苓2g，泽泻3g，车前子1g。
上述治疗玻璃体的中药组合物的制备方法，包括如下步骤：
S1、将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取2.5h，过滤后再加入浓度为50％乙醇水溶液中回流提取1.5h，过滤，合并滤液，回收乙醇，65℃一次浓缩得到相对密度均为1.30的第一稠膏；
S2、将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮1.5h，过滤，再加入固体物料总质量8倍的水，进行二次煎煮2h，过滤，合并滤液，55℃二次浓缩得到相对密度均为1.30的第二稠膏；
S3、将第一稠膏和第二稠膏混合后，加入糊精和白砂糖，制粒，80℃干燥。
实施例3
一种治疗玻璃体的中药组合物，其原料包括：桃仁8g，红花10g，当归5.5g，川芎6.5g，白芍2.5g，熟地3.5g，枸杞子2.5g，茯苓3.5g，泽泻1.5g，车前子2.5g。
上述治疗玻璃体的中药组合物的制备方法，包括如下步骤：
S1、将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取1.8h，过滤后再加入浓度为50％乙醇水溶液中回流提取2.2h，过滤，合并滤液，回收乙醇，58℃一次浓缩得到相对密度均为1.30的第一稠膏；
S2、将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮2.2h，过滤，再加入固体物料总质量8倍的水，进行二次煎煮1.2h，过滤，合并滤液，62℃二次浓缩得到相对密度均为1.30的第二稠膏；
S3、将第一稠膏和第二稠膏混合后，加入糊精和白砂糖，制粒，70℃干燥。
实施例4
一种治疗玻璃体的中药组合物，其原料包括：桃仁10g，红花8g，当归6.5g，川芎5.5g，白芍3.5g，熟地2.5g，枸杞子3.5g，茯苓2.5g，泽泻2.5g，车前子1.5g。
上述治疗玻璃体的中药组合物的制备方法，包括如下步骤：
S1、将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取2.2h，过滤后再加入浓度为50％乙醇水溶液中回流提取1.8h，过滤，合并滤液，回收乙醇，62℃一次浓缩得到相对密度均为1.30的第一稠膏；
S2、将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮1.8h，过滤，再加入固体物料总质量8倍的水，进行二次煎煮1.8h，过滤，合并滤液，58℃二次浓缩得到相对密度均为1.30的第二稠膏；
S3、将第一稠膏和第二稠膏混合后，加入糊精和白砂糖，制粒，75℃干燥。
实施例5
一种治疗玻璃体的中药组合物，其原料包括：桃仁9g，红花9g，当归6g，川芎6g，白芍3g，熟地3g，枸杞子3g，茯苓3g，泽泻2g，车前子2g。
上述治疗玻璃体的中药组合物的制备方法，包括如下步骤：
S1、将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取2h，过滤后再加入浓度为50％乙醇水溶液中回流提取2h，过滤，合并滤液，回收乙醇，60℃一次浓缩得到相对密度均为1.30的第一稠膏；
S2、将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮2h，过滤，再加入固体物料总质量8倍的水，进行二次煎煮1.5h，过滤，合并滤液，60℃二次浓缩得到相对密度均为1.30的第二稠膏；
S3、将第一稠膏和第二稠膏混合后，加入糊精和白砂糖，制粒，72℃干燥。
选取门诊确诊玻璃体混浊的患者550例，其中男女比例为1.2：1，41-50岁占34.9％，51-60岁占32％，61-70岁占22％。门诊确诊玻璃体混浊标准(根据《实用眼科学》诊断标准)如下：全部病例治疗前均进行视力，眼底镜裂隙灯检查。眼部主要改变见玻璃体内有黑色或黄褐色不透明点片状、圆形等形态不同，大小不一之混浊。临床症状患者自觉眼前有黑影飘动，或伴有视力下降等。
采用实施例5所得治疗玻璃体的中药组合物颗粒对上述550例患者进行口服治疗，治疗期间忌辛辣、忌酒，治疗时间为4周，其疗效如下：
| 治愈，例 | 264 |
| 有效，例 | 259 |
| 无效，例 | 27 |
换算后：
| 治愈率，％ | 48.0 |
| 有效率，％ | 47.1 |
| 无效率，％ | 4.9 |
上述疗效具体如下：
治愈：治疗后眼前黑影消失，视力恢复至发病前水平，检眼镜及裂隙灯检查玻璃体内无异常；
有效：治疗后眼前黑影变小、减少，视力较发病前稍有提高，检眼镜及裂隙灯检查玻璃体内混浊变小减少；
无效：治疗后以上情况无变化。
由上述结果可知：本发明针对玻璃体混浊的病因病机，采用活血化瘀治疗为主，辅以滋补阴虚、通络明目，祛瘀而不伤正，疗效明显，95％的患者发生好转。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (10)
1.一种治疗玻璃体的中药组合物，其特征在于，其原料包括：桃仁、红花、当归、川芎、白芍、熟地、枸杞子、茯苓、泽泻、车前子。
2.根据权利要求1所述治疗玻璃体的中药组合物，其特征在于，桃仁、红花、当归、川芎、白芍、熟地、枸杞子、茯苓、泽泻、车前子的质量比为7-11：7-11：5-7：5-7：2-4：2-4：2-4：2-4：1-3：1-3。
3.根据权利要求1所述治疗玻璃体的中药组合物，其特征在于，桃仁、红花的质量之和为a，当归、川芎的质量之和为b，a、b之比为18-20：11-13。
4.根据权利要求1所述治疗玻璃体的中药组合物，其特征在于，桃仁、当归、川芎、白芍、熟地、泽泻的质量之和为c，红花、枸杞子、茯苓、车前子的质量之和为d，c、d之比为25.5-32.5：14.5-19.5。
5.根据权利要求1所述治疗玻璃体的中药组合物，其特征在于，其原料按质量份包括：桃仁8-10份，红花8-10份，当归5.5-6.5份，川芎5.5-6.5份，白芍2.5-3.5份，熟地2.5-3.5份，枸杞子2.5-3.5份，茯苓2.5-3.5份，泽泻1.5-2.5份，车前子1.5-2.5份。
6.一种如权利要求1-5任一项所述治疗玻璃体的中药组合物的制备方法，其特征在于，包括如下步骤：
S1、将桃仁、当归、川芎、白芍、熟地、泽泻加入浓度为70％的乙醇水溶液中回流提取，过滤后再加入浓度为50％乙醇水溶液中回流提取，过滤，合并滤液，回收乙醇，一次浓缩得到第一稠膏；
S2、将S1所得滤饼与红花、枸杞子、茯苓、车前子混合，加入固体物料总质量10倍的水，进行一次煎煮，过滤，再加入固体物料总质量8倍的水，进行二次煎煮，过滤，合并滤液，二次浓缩得到第二稠膏；
S3、将第一稠膏和第二稠膏混合后，加入辅料，制粒，干燥。
7.根据权利要求6所述治疗玻璃体的中药组合物的制备方法，其特征在于，S1中，加入浓度为70％的乙醇水溶液中回流提取1.5-2.5h；加入浓度为50％乙醇水溶液中回流提取1.5-2.5h。
8.根据权利要求6所述治疗玻璃体的中药组合物的制备方法，其特征在于，S2中，一次煎煮时间为1.5-2.5h；二次煎煮时间为1-2h。
9.根据权利要求6所述治疗玻璃体的中药组合物的制备方法，其特征在于，第一稠膏和第二稠膏的相对密度均为1.30，一次浓缩和二次浓缩的温度均为55-65℃。
10.根据权利要求6所述治疗玻璃体的中药组合物的制备方法，其特征在于，S3中，辅料包括：糊精和白砂糖，干燥温度小于等于80℃。
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