CN110891584B - 用于使肿瘤细胞对自然杀伤细胞的杀灭敏感的新型溶瘤病毒 - Google Patents

用于使肿瘤细胞对自然杀伤细胞的杀灭敏感的新型溶瘤病毒 Download PDF

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CN110891584B
CN110891584B CN201880047292.0A CN201880047292A CN110891584B CN 110891584 B CN110891584 B CN 110891584B CN 201880047292 A CN201880047292 A CN 201880047292A CN 110891584 B CN110891584 B CN 110891584B
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CN110891584A (zh
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格里夫·帕克
艾丽嘉·柯皮克
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CN201880047292.0A 2017-05-25 2018-05-25 用于使肿瘤细胞对自然杀伤细胞的杀灭敏感的新型溶瘤病毒 Active CN110891584B (zh)

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US201762511010P 2017-05-25 2017-05-25
US62/511,010 2017-05-25
PCT/US2018/034655 WO2018218151A1 (en) 2017-05-25 2018-05-25 Novel oncolytic viruses for sensitizing tumor cells to killing by natural killer cells

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CN110891584B true CN110891584B (zh) 2024-02-13

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EP (1) EP3630144A4 (https=)
JP (2) JP7522426B2 (https=)
KR (2) KR102700175B1 (https=)
CN (1) CN110891584B (https=)
AU (1) AU2018273963B2 (https=)
BR (1) BR112019024656A2 (https=)
CA (1) CA3064897A1 (https=)
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
WO2019032628A1 (en) 2017-08-07 2019-02-14 The Regents Of The University Of California GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS
WO2020037215A1 (en) 2018-08-17 2020-02-20 Icahn School Of Medicine At Mount Sinai Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease
WO2020154640A1 (en) * 2019-01-24 2020-07-30 University Of Central Florida Research Foundation, Inc. Compositions and methods for stimulating natural killer cells
US20230330140A1 (en) * 2019-11-25 2023-10-19 Ansun Biopharma, Inc. Immune cell delivery of sialidase cancer cells, immune cells and the tumor microenvironment
CN111676245B (zh) * 2020-06-24 2022-09-13 武汉波睿达生物科技有限公司 一种含有HSV-1型溶瘤病毒的NFAT-Cre-CAR-T细胞及其应用
KR20230048046A (ko) * 2020-08-12 2023-04-10 유니버시티 오브 센트럴 플로리다 리서치 파운데이션, 인코포레이티드 감마 델타 t 세포를 자극하기 위한 방법 및 조성물
CN112852757A (zh) * 2021-02-01 2021-05-28 南京大学 一种制备新型溶瘤病毒EM/VSV-G Ad5sPVRCD137L的方法
CA3215085A1 (en) * 2021-04-08 2022-10-13 Immvira Biopharmaceuticals Co., Limited Genetically modified oncolytic herpes simplex virus delivering chemokine and tumor associated/specific antigen
CN115678854A (zh) * 2021-07-29 2023-02-03 上海中医药大学 一种基因工程细胞及其制备方法和应用
CN116875547A (zh) * 2023-09-04 2023-10-13 山东德升细胞治疗工程技术有限公司 一种利用细胞外泌体激活nk细胞的体外扩增培养方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2670790A1 (en) * 2006-11-28 2008-06-05 Ghc Research Development Corporation Polypeptides comprising fas activation and nkg2d-ligand domains
WO2008140621A2 (en) * 2006-12-21 2008-11-20 Mount Sinai School Of Medicine Of New York University Transgenic oncolytic viruses and uses thereof
WO2014037124A1 (en) * 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
WO2014041119A1 (en) * 2012-09-14 2014-03-20 Deutsches Krebsforschungszentrum Oncolytic viruses expressing immuno-nucleases
CN104093422A (zh) * 2012-01-24 2014-10-08 乔治亚大学研究基金公司 基于副流感病毒5的疫苗
WO2016069607A1 (en) * 2014-10-27 2016-05-06 University Of Central Florida Research Foundation, Inc. Methods and compositions for natural killer cells
WO2016109668A1 (en) * 2014-12-31 2016-07-07 Anthrogenesis Corporation Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1601438A (https=) 1968-10-17 1970-08-24
US20020187543A1 (en) * 2001-04-05 2002-12-12 Curiel David T. Enhanced dispersion of adenoviral vectors by fusogenic membrane glycoproteins
US20090214590A1 (en) * 2005-07-08 2009-08-27 Wayne State University Virus Vaccines Comprising Envelope-Bound Immunomodulatory Proteins and Methods of Use Thereof
US20080299137A1 (en) 2005-10-28 2008-12-04 Novo Nordisk A/S Fusion Proteins That Bind Effector Lymphocytes And Target Cells
US8652466B2 (en) * 2006-12-08 2014-02-18 Macrogenics, Inc. Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting
FR2938840B1 (fr) * 2008-11-21 2010-12-17 Centre Nat Rech Scient Proteines mutantes de la proteine f de piv-5 et de piv-2
AU2009332883B2 (en) 2008-12-22 2015-05-21 Oncos Therapeutics Oy Oncolytic adenoviral vectors and methods and uses related thereto
US9592287B2 (en) * 2009-10-09 2017-03-14 New York Blood Center, Inc. Immunopotentiator-linked oligomeric influenza immunogenic compositions
LT3578201T (lt) * 2012-06-28 2023-05-25 University Of Central Florida Research Foundation Incorporated Nk ląstelių metodai ir kompozicijos
EP2968525A4 (en) 2013-03-14 2016-10-26 Icahn School Med Mount Sinai MORBUS NEWCASTLE VIRUSES AND USES THEREOF
WO2015069745A2 (en) * 2013-11-05 2015-05-14 The Board Of Regents Of The University Of Texas System Tumors expressing igg1 fc induce robust cd8 cell responses
US10238700B2 (en) * 2014-01-02 2019-03-26 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
JP2017530114A (ja) 2014-09-26 2017-10-12 バヴァリアン・ノルディック・アクティーゼルスカブ フラジェリンをコードする組み換えｍｖａによる鼻腔内免疫のための方法と組成物
JP6961490B2 (ja) 2015-04-08 2021-11-05 ノバルティス アーゲー Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
HRP20200439T1 (hr) * 2015-04-30 2020-06-12 Psioxus Therapeutics Limited Onkolitički adenovirus koji kodira protein b7
WO2018083259A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2670790A1 (en) * 2006-11-28 2008-06-05 Ghc Research Development Corporation Polypeptides comprising fas activation and nkg2d-ligand domains
WO2008140621A2 (en) * 2006-12-21 2008-11-20 Mount Sinai School Of Medicine Of New York University Transgenic oncolytic viruses and uses thereof
CN104093422A (zh) * 2012-01-24 2014-10-08 乔治亚大学研究基金公司 基于副流感病毒5的疫苗
WO2014037124A1 (en) * 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
WO2014041119A1 (en) * 2012-09-14 2014-03-20 Deutsches Krebsforschungszentrum Oncolytic viruses expressing immuno-nucleases
WO2016069607A1 (en) * 2014-10-27 2016-05-06 University Of Central Florida Research Foundation, Inc. Methods and compositions for natural killer cells
WO2016109668A1 (en) * 2014-12-31 2016-07-07 Anthrogenesis Corporation Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

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EP3630144A4 (en) 2021-03-31
US20240000842A1 (en) 2024-01-04
AU2018273963A1 (en) 2020-01-23
KR102700175B1 (ko) 2024-08-30
US11684637B2 (en) 2023-06-27
KR20240132124A (ko) 2024-09-02
KR20200010405A (ko) 2020-01-30
BR112019024656A2 (pt) 2020-06-09
IL270876A (en) 2020-01-30
IL270876B2 (en) 2024-06-01
IL270876B1 (en) 2024-02-01
JP2020521447A (ja) 2020-07-27
EP3630144A1 (en) 2020-04-08
CN110891584A (zh) 2020-03-17
US12312393B2 (en) 2025-05-27
AU2018273963B2 (en) 2023-07-20
JP7522426B2 (ja) 2024-07-25
WO2018218151A1 (en) 2018-11-29
US20210145876A1 (en) 2021-05-20
JP2024133640A (ja) 2024-10-02
CA3064897A1 (en) 2018-11-29

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