CN110882353B - Preparation process of Yizhuangtian wine - Google Patents
Preparation process of Yizhuangtian wine Download PDFInfo
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- CN110882353B CN110882353B CN201911406256.1A CN201911406256A CN110882353B CN 110882353 B CN110882353 B CN 110882353B CN 201911406256 A CN201911406256 A CN 201911406256A CN 110882353 B CN110882353 B CN 110882353B
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- medicinal
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Abstract
The invention discloses a preparation process of a Zhuanditian wine, which comprises the following steps: s1, preparing prescription medicinal materials, and crushing into medicinal powder particles; s2, putting the medicinal powder particles into base wine for wetting and sealing; s3, filling the wet medicinal powder particles into a percolation device, adding base wine, exhausting air, and sealing and soaking; s4, percolating, collecting percolate, completely percolating, completely draining residual liquid in the percolating device by using compressed air, collecting residual liquid, and transferring the residual liquid into the percolate; s5, adding purified water into the percolation device for circulating water for washing, naturally draining the water washing liquid, collecting the water washing liquid, transferring the water washing liquid into the percolation liquid, draining residual liquid by using compressed air, collecting residual liquid, and transferring the residual liquid into the percolation liquid; s6, preparing wine, uniformly mixing the percolate, the sugar-containing solution, the yellow wine, the white spirit and the purified water according to the proportion, standing and filtering. The preparation process of the Yizhuangtian liquor provided by the invention can more effectively extract the effective components in the traditional Chinese medicine formula, and is beneficial to fully exerting the efficacy of the traditional Chinese medicine formula.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a preparation process of a zhuangtian wine.
Background
A ZHULIAN liquor is a Chinese medicinal composition prepared from Bombycis Mori, cornu Cervi Pantotrichum, Ginseng radix, radix Angelicae sinensis, penis et testis Cervi, Scolopendra, and rhizoma Gastrodiae. Has effects of warming and recuperating kidney yang, replenishing essence and replenishing blood, and can be used for treating chronic diseases, such as qi deficiency, listlessness, stomach cold, cold limbs, sexual impotence, spermatorrhea, spontaneous enuresis, soreness of waist and knees, edema of lower limbs, and constipation.
The specific prescription composition comprises 4.8g of silkworm moth (processed), 4.8g of epimedium (processed by mutton fat), 3.6g of morinda officinalis, 4.8g of prepared rehmannia root, 2.4g of Chinese yam, 1.8g of dogwood, 2.4g of wolfberry fruit, 2.4g of dodder (steamed), 2.4g of pilose antler, 2.4g of eucommia bark (charcoal), 1.8g of angelica (fried), 1.2g of cinnamon, 1.2g of monkshood (processed), 0.4g of centipede (processed by wine), 1.2g of gastrodia elata, 1.2g of ginseng and 0.4g of penis cervi.
The currently adopted preparation method mainly adopts a traditional Chinese medicine decoction method, the seventeen medicinal materials are crushed into coarse powder, the coarse powder is decocted for three times by adding water, the first time and the second time are respectively 1 hour and the third time is 0.5 hour, the decoction is combined and filtered, the filtrate is concentrated to a proper amount, 80g of cane sugar is added, the white spirit is added to adjust the specified alcohol content to 1000ml, the refrigeration is carried out for 48 hours, and the filtration and the split charging are carried out, thus obtaining the traditional Chinese medicine.
However, the herbs are decocted repeatedly at high temperature, and the components which are not high in temperature resistance are easily decomposed or volatilized after being concentrated, which has adverse effect on the full exertion of the drug effect of the prescription.
Disclosure of Invention
The invention aims to provide a preparation process of a zhangtian wine, which can more effectively extract effective components in a traditional Chinese medicine formula and is beneficial to fully exerting the efficacy of the traditional Chinese medicine formula.
In order to achieve the above purpose of the present invention, the present invention provides the following technical solutions: a preparation process of Yizhuangtian liquor comprises the following steps:
s1, preparing prescription medicinal materials, and crushing into medicinal powder particles;
s2, putting the medicinal powder particles into base wine for wetting and sealing;
s3, filling the wet medicinal powder particles into a percolation device, adding base wine, exhausting air, and sealing and soaking;
s4, percolating, collecting percolate, completely percolating, completely draining residual liquid in the percolating device by using compressed air, collecting residual liquid, and transferring the residual liquid into the percolate;
s5, adding purified water into the percolation device for circulating water for washing, naturally draining the water washing liquid, collecting the water washing liquid, transferring the water washing liquid into the percolation liquid, draining residual liquid by using compressed air, collecting residual liquid, and transferring the residual liquid into the percolation liquid;
s6, preparing wine, uniformly mixing the percolate, the sugar-containing solution, the yellow wine, the white spirit and the purified water according to the proportion, standing and filtering.
In the invention, the medicinal materials of the traditional Chinese medicine prescription are properly crushed into medicinal material particles, and then the medicinal materials are filled into a percolation device to be added with base liquor for immersion, so that the base liquor permeates into the medicinal materials, thereby the effective components in the medicinal materials are dissolved out in the base liquor, and new base liquor is continuously added above the base liquor, when the base liquor moves downwards due to the increase of the specific gravity of the dissolved components in the base liquor, the upper layer of the diluted liquid replaces the position of the base liquor, so that good concentration difference is caused, and the diffusion can be better carried out. The active ingredients of the medicinal materials are leached by utilizing the dynamic extraction process, the decomposition or volatilization of the active ingredients in the high-temperature heating process is avoided, meanwhile, the utilization rate of the solvent is high, the leaching solution can be directly collected, the operation is simple and convenient, and the method is suitable for industrial production. Before the medicinal material particles are subjected to percolation, the medicinal powder particles are placed in base liquor in advance for wetting, so that the situation that the medicinal material particles are wetted and expanded to block pores among the medicinal material particles in the percolation process, so that the transverse diffusion and the vertical flow of the base liquor are hindered, and the effective medicinal material leaching is influenced is avoided. After the alcohol-soluble active ingredients are dissolved out by the base liquor, purified water is continuously added for circular washing, the water-soluble active ingredients in the medicinal materials are further extracted, and the extraction rate of the active ingredients is improved.
Further, before crushing the prescription medicinal materials in the step S1, freezing pretreatment is carried out, wherein the freezing temperature is-20 ℃, the freezing time is 4-5h, and the temperature of the base liquor in the wetting process of the Chinese medicinal powder particles in the step S2 is controlled to be 55-60 ℃.
According to the invention, the medicinal materials are frozen before being crushed, so that the brittleness of the medicinal materials can be increased, the cell walls of the medicinal materials can be damaged in the crushing process, the base wine can permeate into the cells to dissolve out effective components, and the dissolution rate of the effective components is improved; the temperature of the base liquor is controlled to be 55-65 ℃ in the moistening process, the base liquor has good fluidity, and the medicinal materials are moistened to be fully expanded, so that adverse effects caused by expansion in the subsequent percolation process are avoided.
Further, the crushing of the formula medicinal material in the step S1 is separately performed, and includes: s1-1, cutting and roughly crushing prepared rehmannia root, Chinese yam, pilose antler, eucommia bark, Chinese angelica, cinnamon, prepared aconite root, tall gastrodia tuber, ginseng and deer penis in the formula;
s1-2, grinding the rest materials, and pulverizing.
According to the invention, the bulk and sheet medicinal materials in the formula are subjected to shearing and coarse crushing to prepare sheet or block coarse particles, the sheet or block particles have large surface areas relative to polyhedral or approximately spherical particles, and the contact area between base wine and the medicinal particles is increased, so that the effective components in the medicinal particles are promoted to be dissolved out in the base wine; the leaves, threads and particles in the formula are ground and crushed finely, and the particles collide with each other in the grinding process to form fine granular powder, so that the cell walls of the medicinal materials can be promoted to be damaged, and the effective components in the medicinal particles can be quickly dissolved out in the base wine. Meanwhile, by matching the coarse particles and the fine particles, in the powder filling process of the step S3, the flaky or blocky coarse particles are mutually overlapped to play a role of supporting a framework, and sufficient pores are formed in the powder to provide a three-dimensional channel for diffusion and circulation of the base wine, so that the phenomenon that the base wine is difficult to diffuse transversely and flow longitudinally due to blockage caused by over-dense powder filling is avoided. The fluidity of the base wine is ensured by the smoothness of the three-dimensional channel, so that the high-gradient concentration difference is kept in the percolation process, and the effective components can be promoted to be quickly dissolved into the base wine. The pores in the framework formed by overlapping the coarse particles can also contain the fine particles, so that the situation that the base wine flows too fast to cause insufficient dissolution of effective components is prevented. Meanwhile, the specific surface area of the fine particles is large, the fine particles are more fully contacted with the base wine, and the dissolution rate of the effective components is improved. The coarse particles and the fine particles are matched with each other and support each other, so that the flowability of the base wine and the dissolution rate of the effective components in the medicinal materials are ensured.
Further, the crude drug in the step S1-1 is crushed roughly and sieved by a 24-mesh sieve, the drug in the step S1-2 is crushed finely and sieved by a 100-mesh sieve, and the sieved drug particles are mixed uniformly.
The flaky or blocky coarse particles and the fine particles are preferably combined, so that sufficient three-dimensional channels are provided for the circulation of base wine in a formed powder system, the full contact between the drug particles and the base wine is promoted, a high concentration difference can be formed, and the dissolution of active ingredients in medicinal materials is promoted.
Further, 60vol% edible alcohol is adopted as base liquor, the percolation temperature is 35-40 ℃, the percolation speed is 25-27.5L/hr, the relative balance between the base liquor and the percolation liquid is controlled, and continuous percolation is kept.
The alcohol concentration in the base wine is too high, the fluidity is poor, the liquid flow is not facilitated, and the concentration is too low, the dissolution of the alcohol-soluble effective components is not facilitated. The temperature of the base liquor determines the solubility of the active ingredients in the base liquor. The extraction is insufficient when the percolation speed is too fast, and the concentration gradient in the fluid is reduced when the percolation speed is too slow, so that the leaching of effective components is not facilitated. By controlling proper concentration of base liquor, percolation temperature and percolation speed, high-gradient concentration difference is always formed between the base liquor and the medicine particles in the percolation process, the relative balance of the addition of the base liquor and the outflow speed of the percolation liquid is controlled, continuous percolation is kept, and the extraction rate of effective components is improved.
Further comprising S7, freezing, filtering, temperature returning, checking, filling, capping and outer packaging.
By adopting the scheme, the Chinese medicinal preparation produced in batches is concentrated and filtered, the purity of the medicinal liquor is improved, the phenomenon that the product phase is influenced by precipitation in the long-term placing process is prevented, the product is inspected, and the qualified product is packaged according to the specification, so that the market demand is met.
Further, the percolation in the step S4 adopts multi-stage counter-current percolation.
By adopting multi-stage countercurrent percolation, the trend of the fresh solvent is opposite to that of the solid medicinal material, the contact time of the base wine and the medicinal particles is prolonged through the flow with a plurality of cylinder heights, the leaching rate is improved, and meanwhile, the solvent and the energy are saved.
In conclusion, the invention has the following beneficial effects:
1. the invention provides a preparation process of a zhuangtian liquor, which adopts a percolation method to extract effective components of medicinal materials of a preparation, utilizes the dynamic extraction process to leach the effective components of the medicinal materials, avoids the decomposition or volatilization of the effective components in the high-temperature heating process, has high solvent utilization rate, can directly collect leachate, utilizes purified water to further extract water-soluble effective components after the alcohol-soluble effective components are extracted from base liquor, improves the extraction rate, has simple and convenient operation and is suitable for industrial production.
2. The invention improves the brittleness of the drug particles by freezing before crushing, destroys the tissue cell walls in the crushing process, controls the temperature of the base wine in the crushing and wetting process to be 55-60 ℃, ensures that the drug tissues are fully expanded, and promotes the base wine to permeate into the drug particles.
3. According to the invention, different medicinal materials are crushed in different ways to form a medicinal particle system with high loading rate, and the medicinal particle system is overlapped to form a three-dimensional channel, so that base liquor is fully contacted with medicinal particles, and the diffusion and outflow of the base liquor are promoted, thereby ensuring high gradient concentration difference and improving the extraction rate of medicinal active ingredients.
Detailed Description
The present invention will be described in further detail with reference to examples. The prescription and standard batch size (in 5000 times the prescription) of the present invention are shown in table 1, the prescription is based on: tenth volume WS of Chinese materia medica prescription preparation from drug Standard of ministry of health of China3-B-1871-95, page 1, approval accession number: the national standard of medicine Z37021384. The medicinal materials adopted by the invention are purchased from a pharmacy of Chinese medicine, the arrangement and the processing of the raw medicinal materials are based on pharmacopoeia of the people's republic of China (2015 edition) and processing specifications of traditional Chinese medicine decoction pieces in Shandong province (2012 edition), 95vol% of food-grade alcohol is purchased from Jinan Tianyou chemical Co., Ltd, purified water is obtained from EDI ultrapure water, white spirit (60 vol%) is obtained from Shandong Fushan wine factory, and yellow wine is obtained from Shaoxing wine jar food Co., Ltd.
TABLE 1 recipe and Standard batch quantities (5000 times the recipe quantity)
| Name of raw materials | Amount of prescription | Standard batch size |
| Silkworm moth (preparation) | 4.8g | 24.0kg |
| Herba Epimedii (mutton fat) | 4.8g | 24.0kg |
| Morinda officinalis | 3.6g | 18.0kg |
| Prepared rehmannia root | 4.8g | 24.0kg |
| Chinese yam | 2.4g | 12.0kg |
| Fructus Corni | 1.8g | 9.0kg |
| Chinese wolfberry fruit | 2.4g | 12.0kg |
| Semen Cuscutae (steamed) | 2.4g | 12.0kg |
| Cornu Cervi Pantotrichum | 2.4g | 12.0kg |
| Eucommia ulmoides (charcoal) | 2.4g | 12.0kg |
| Radix Angelicae sinensis (parched) | 1.8g | 9.0kg |
| Cortex Cinnamomi | 1.2g | 6.0kg |
| Radix Aconiti lateralis Preparata | 1.2g | 6.0kg |
| Centipede (wine) | 0.4g | 2.0kg |
| Gastrodia tuber | 1.2g | 6.0kg |
| Ginseng radix | 1.2g | 6.0kg |
| Penis et testis Cervi | 0.4g | 2.0kg |
| Sucrose | 80g | 400.0kg |
| White spirit (60 vol%) | 120ml | 600.0L |
| Food grade alcohol (95 vol%) | Proper amount of | Proper amount of |
| Yellow wine (15 vol%) | 80ml | 400.0L |
| Purified water | Proper amount of | Proper amount of |
| Is made into | 1000ml | 5000L |
The main equipment used in the process is shown in table 2.
Table 2 main equipment used in the process flow
| Device | Model/parameter | Manufacturer of the product |
| Percolation cylinder | 1000ml | Huayu glass fiber |
| Shearing type coarse material crusher | 400 type | Jiangyin excellence machinery |
| Grinding crusher | 40B | Changzhou Wanyu drying engineering |
| Powder mixer | V-750 | Jiangsu Obo machine |
| Extracting pot | TQ-1000 | Wenzhou remote machinery |
Preparation example 1
Preparation example 1 provides a percolation method of a shoutian liquor, comprising the following preparation steps:
s1, preparing prescription medicinal materials, crushing into medicinal powder particles:
the medicinal materials are mixed according to the prescription amount shown in the table 1, the mixed amount is 39.2g, the medicinal materials are mixed and put into a grinding crusher to be crushed, the crushed medicinal powder particles pass through a 24-mesh sieve, and oversize materials are crushed again, so that the medicinal powder particles can pass through the 24-mesh sieve.
S2, putting the medicinal powder particles into base wine for wetting and sealing:
placing the medicinal powder particles in a beaker, adding 95vol% food grade alcohol and water to prepare 500ml base wine with alcohol content of 50vol%, adding 36ml base wine into a glass beaker, stirring, sealing, and moistening at room temperature of 25 deg.C for 1 hr.
S3, filling the wet medicinal powder particles into a percolation cylinder, adding base wine, exhausting, sealing and soaking:
stirring and dispersing the wet medicinal powder particles, uniformly loading into a percolation barrel, slowly adding 100ml of base wine, opening a discharge valve of the percolation barrel, discharging air among the medicinal powder particles, closing the discharge valve after 4ml of percolate flows out, sealing the percolation barrel, and soaking for 24 h.
S4, percolation:
opening the material valve to percolate, placing a beaker below the percolation barrel to collect, controlling the percolation speed to be 1ml/min, continuously supplementing base liquor above the percolation barrel, keeping the base liquor higher than the medicine particles all the time, controlling the relative balance between the added base liquor and the percolation liquid outflow speed, and continuously percolating until the base liquor is completely added.
After the percolates had been naturally drained, the percolates in the beaker were stirred well, the resulting percolates were dried in an oven at 100 ℃ to constant weight and the weight was recorded, the dry extract of this fraction was obtained and recorded in table 3.
Preparation example 2
Preparation example 2 provides a percolation method of a shoutian liquor, which is different from preparation example 1 in that the alcohol concentration of the prepared base liquor is 60 vol%.
Preparation example 3
Preparation example 3 provides a percolation method of a shoutian liquor, which is different from preparation example 1 in that the alcohol concentration of the prepared base liquor is 70 vol%.
Preparation example 4
Preparation example 4 provides a percolation method of a Yizhuang liquor, which is different from preparation example 1 in that the step S1 of crushing the medicinal material comprises a freezing pretreatment at-20 ℃ for 4 hours, the wetting process in step S2 is to place a beaker containing the medicinal powder particles in a water bath, and the temperature of the base liquor is controlled to be 55 ℃.
Preparation example 5
Preparation example 5 provides a percolation method of a Yizhuang liquor, which is different from preparation example 1 in that the step S1 of crushing the medicinal materials comprises a freezing pretreatment before crushing, the freezing temperature is-20 ℃, the freezing time is 5 hours, the wetting process in the step S2 is to place a beaker containing the medicinal powder particles in a water bath, and the temperature of the base liquor is controlled to be 60 ℃.
Preparation example 6
Preparation example 6 provides a percolation method of a shoutian liquor, which is different from preparation example 1 in that the crushing of the formula medicinal material in step S1 is separately performed, comprising: s1-1, putting prepared rehmannia root, Chinese yam, pilose antler, eucommia bark, Chinese angelica, cinnamon, monkshood, gastrodia elata, ginseng and deer penis in the formula into a shearing type coarse material crusher for shearing and coarse crushing, sieving the crushed medicinal powder particles with a 24-mesh sieve, and crushing oversize materials again to ensure that the medicinal powder particles can pass through the 24-mesh sieve; s1-2, the other medicinal materials in the prescription are put into a grinding crusher to be ground and crushed finely, the crushed medicinal powder particles pass through a 100-mesh sieve, and the oversize products are crushed again, so that the medicinal powder particles can pass through the 100-mesh sieve.
Preparation example 7
Preparation example 7 provides a percolation method of a one column day wine, which is different from preparation example 6 in that the medicinal powder particles after being crushed in S1-1 are sieved by a 35-mesh sieve, and the oversize products are crushed again, so that the medicinal powder particles can pass through the 35-mesh sieve.
Preparation example 8
Preparation example 8 provides a percolation method of a one column wine, which is different from preparation example 6 in that the medicinal powder particles after being crushed in S1-1 are sieved by a 65-mesh sieve, and the oversize products are crushed again, so that the medicinal powder particles can pass through the 65-mesh sieve.
Comparative example 1
Comparative example 1 provides a percolation method of a shoutian liquor, which is different from preparation example 1 in that a base liquor having an alcohol concentration of 40vol% was prepared.
Comparative example 2
Comparative example 2 provides a percolation method of a shoutian liquor, which is different from preparation example 1 in that the alcohol concentration of the prepared base liquor is 80 vol%.
Comparative example 3
Comparative example 3 provides a percolation method of the one column spirit, which is different from the preparation example 1 in that the powder particles crushed in the step S1 are sieved through a 10-mesh sieve, and the oversize product is crushed again so that the powder particles can pass through the 10-mesh sieve.
Comparative example 4
Comparative example 4 provides a percolation method of the one column spirit, which is different from the preparation example 1 in that the granules of the medicinal powder crushed in the step S1 are sieved with a 65 mesh sieve, and the oversize product is crushed again so that the granules of the medicinal powder can pass through the 65 mesh sieve.
Comparative example 5
Comparative example 5 provides a percolation method of a one-column Tian wine, which is different from preparation example 6 in that prescription medicinal materials are crushed and not classified, the prescription medicinal materials are divided into two equal parts by mass, S1-1, one part of the medicinal materials is put into a shearing type coarse material crusher to be sheared and coarsely crushed, crushed medicinal powder particles pass through a 24-mesh sieve, and oversize products are crushed again, so that medicinal powder particles can pass through the 24-mesh sieve; s1-2, the other medicinal materials are put into a grinding crusher to be ground and crushed finely, the crushed medicinal powder particles pass through a 100-mesh sieve, and the oversize products are crushed again, so that the medicinal powder particles can pass through the 100-mesh sieve.
Comparative example 6
According to the existing decocting method, the ingredient medicinal materials are put into a grinding crusher to be crushed, the crushed medicinal powder particles are sieved by a 24-mesh sieve, water is added for decocting for three times, the first time and the second time are respectively 1 hour, the third time is 0.5 hour, the decoction is combined and filtered, the filtrate is placed into an oven to be dried at 100 ℃ until the weight is constant, the weight is weighed and recorded, and the part of dry extract is obtained and recorded in the table 3.
TABLE 3 Dry extracts of preparation examples 1-8 and comparative examples 1-6
| Dry extract (g/L) | |
| Example 1 | 7.08 |
| Example 2 | 7.74 |
| Example 3 | 7.26 |
| Example 4 | 7.89 |
| Example 5 | 8.04 |
| Example 6 | 10.68 |
| Example 7 | 8.91 |
| Example 8 | 8.58 |
| Comparative example 1 | 6.33 |
| Comparative example 2 | 5.85 |
| Comparative example 3 | 5.31 |
| Comparative example 4 | 4.68 |
| Comparative example 5 | 4.89 |
| Comparative example 6 | 6.47 |
The influence of the concentration of base liquor, freezing pretreatment, wetting temperature and crushing of medicinal materials on the extraction rate of the medicinal materials is mainly considered through preparation examples 1-8 and comparative examples 1-5, and comparative example 6 is to adopt the existing decocting method as a reference.
The alcohol concentrations of the base liquors were compared in preparation examples 1 to 3. As a result, it was found that in preparation example 1, the elution amount of the crude drug was small and the obtained dry extract was low because the alcohol concentration was relatively low; in preparation example 3, the alcohol concentration is high, the viscosity is high, and the diffusion and the flowing of alcohol are not facilitated, so that the leaching rate of the effective components in the medicinal materials is reduced. Preparation example 2 is relatively preferred.
In addition, in the present application, the influence of the freezing pretreatment and the wetting temperature before crushing was examined in preparation examples 4 and 5, with preparation example 1 as a control. The results show that the brittleness of the medicinal materials is increased after the freezing pretreatment, the destructive effect on cell walls is enhanced in the crushing process, and the dissolution amount of the medicinal materials is increased; the water bath heating during the wetting process promoted the base liquor to permeate into the drug particles, and reduced the adverse effect of drug particle expansion during the permeation process, and it can be seen that the dry extracts obtained in preparation examples 4 and 5 were increased.
In preparation examples 6 to 8, the present application examined the influence of the crushing mode of the medicinal materials. The results show that the extraction rate of the active ingredients of the medicinal materials can be improved by classifying and classifying the medicinal materials and carrying out coarse crushing and fine crushing. The preparation example 6 is the best, and the 24-mesh sieve and the 100-mesh sieve are matched, so that an effective channel can be provided for diffusion and circulation of the base wine, the base wine is more fully contacted with the medicine particles, and the dissolution rate of the effective components is improved. The improvement effect is gradually weakened as the difference between the particle sizes of the coarse and fine particles is reduced.
In contrast to preparation example 1, the alcohol concentration of comparative example 1 was too low and the dry extract was reduced. In comparison with preparation example 3, the alcohol concentration of comparative example 2 was too high, the flowability of the base wine was deteriorated, and the dry extract was also reduced.
Compared with preparation example 1, the particle size of the particles of comparative example 3 is too large, the base liquor permeability is poor in the percolation process, the effective components are difficult to be fully dissolved in the base liquor, and the dry extract is reduced as well. Comparative example 4 the particle size was too small, the porosity was low, the base wine could not achieve good diffusion and flow, and the dry extract was small.
Compared with the preparation example 6, the comparative example 5 does not classify the medicinal materials, the leaf-shaped and filiform medicinal materials have small hardness after being coarsely crushed, the skeleton supporting effect cannot be realized, the porosity is reduced, meanwhile, the fine particles are filled in the pores of the coarse particles, the porosity is further reduced, the base wine has poor permeability in the percolation process, the effective components are difficult to fully dissolve in the base wine, and the dry extract is less.
Example 1
Embodiment 1 provides a process for preparing a zhangtian wine, comprising the following steps:
s1, preparing the prescription medicinal materials, crushing into medicinal powder particles:
the medicinal materials are mixed according to the standard batch mixing amount shown in the table 1, the mixing amount is 196.0kg, the medicinal materials are mixed and put into a grinding crusher to be crushed, the crushed medicinal powder particles pass through a 24-mesh sieve, and oversize materials are crushed again, so that the medicinal powder particles can pass through the 24-mesh sieve.
S2, putting the medicinal powder particles into base wine for moistening and sealing:
placing the medicinal powder particles in a storage tank, adding 95vol% food grade alcohol and water to obtain 2400 + -50L base liquor of 60vol% food grade alcohol, adding 180L base liquor into the storage tank, stirring, sealing, and moistening at room temperature of 25 deg.C for 1 hr.
S3, filling the wet medicinal powder particles into an extraction tank, adding base wine, exhausting, sealing and soaking:
stirring and dispersing the wet medicinal powder particles, uniformly filling into an extraction tank, uniformly pressing with a T-shaped rod every 10 cm thick, filling layer by layer according to the above operation, properly pressurizing, filling the medicinal powder particles at a height not exceeding 2/3 of the extraction tank, covering the upper surface of the medicinal powder particles with a pore plate, pressing firmly, and slowly adding 500L of base wine. Opening the discharge valve of the extraction tank to discharge air between the medicinal powder particles, and allowing percolate to flow out for 20L, closing the discharge valve, sealing the extraction tank, and soaking for 24 hr.
S4, percolation:
heating to 35 deg.C, opening the material valve for percolating at 25L/hr, transferring the percolate into a storage tank, continuously supplementing base liquor above the extraction tank, keeping the base liquor higher than the medicinal materials, controlling the relative balance between the base liquor and the leachate, and continuously percolating until the base liquor is completely added.
S5, completely percolating in each tank, exhausting liquid in the tank by using compressed air, collecting residual liquid, and transferring the residual liquid into percolate in a storage tank; adding 500L purified water, washing with 35 deg.C circulating water for 3.0 + -0.1 hr, naturally draining water eluate, collecting water eluate, and transferring into percolate; exhausting the liquid in the tank with compressed air, collecting the residual liquid, transferring into the percolate, and mixing circularly. Opening the bottom cover of the percolation tank to remove the residue. And (5) testing alcohol content and microorganism indexes.
Optionally, multi-stage countercurrent percolation is adopted for extracting the effective components of the medicinal materials.
S6, wine blending:
transferring sucrose and appropriate amount of purified water in the ingredients into a sugar melting tank, heating and stirring until boiling, then stirring while maintaining slightly boiling state until sugar is completely dissolved, and closing steam. Opening the condensed water, cooling the syrup to room temperature, closing the condensed water, and then pumping all the condensed water into a wine blending tank;
adding 60vol% Chinese liquor and yellow wine in percolate, sugar-containing solution, adjuvants into compounding tank, calculating the shortage of edible alcohol according to ethanol content 32.5 (+ -1.5)% adding food grade alcohol for supplement, supplementing to limited volume with purified water, stirring and circulating to mix thoroughly, checking ethanol content, standing for 24 hr, and filtering.
Example 2
Embodiment 2 provides a preparation technology of a zhangtian wine, comprising the following preparation steps:
s1, preparing the prescription medicinal materials, crushing into medicinal powder particles:
the medicinal materials are mixed according to the standard batch mixing amount shown in the table 1, the mixing amount is 196.0kg, the medicinal materials are mixed and put into a grinding crusher to be crushed, the crushed medicinal powder particles pass through a 24-mesh sieve, and oversize materials are crushed again, so that the medicinal powder particles can pass through the 24-mesh sieve.
S2, putting the medicinal powder particles into base wine for moistening and sealing:
placing the medicinal powder particles in a storage tank, adding 95vol% food grade alcohol and water to obtain 2400 + -50L base liquor of 60vol% food grade alcohol, adding 180L base liquor into the storage tank, stirring, sealing, and moistening at room temperature of 25 deg.C for 1 hr.
S3, filling the wet medicinal powder particles into an extraction tank, adding base wine, exhausting, sealing and soaking:
stirring and dispersing the wet medicinal powder particles, uniformly filling into an extraction tank, uniformly pressing with a T-shaped rod every 10 cm thick, filling layer by layer according to the above operation, properly pressurizing, filling the medicinal powder particles at a height not exceeding 2/3 of the extraction tank, covering the upper surface of the medicinal powder particles with a pore plate, pressing firmly, and slowly adding 500L of base wine. Opening the discharge valve of the extraction tank to discharge air between the medicinal powder particles, and allowing percolate to flow out for 20L, closing the discharge valve, sealing the extraction tank, and soaking for 24 hr.
S4, percolation:
heating to 40 deg.C, opening the material valve for percolating at a speed of 27.5L/hr, transferring the percolate into a storage tank, continuously supplementing base liquor above the extraction tank, keeping the base liquor higher than the medicinal materials, controlling the relative balance between the base liquor and the leachate, and continuously percolating until the base liquor is completely added.
S5, completely percolating in each tank, exhausting liquid in the tank by using compressed air, collecting residual liquid, and transferring the residual liquid into percolate in a storage tank; adding 500L purified water, circularly washing at 40 deg.C for 3.0 + -0.1 hr, naturally draining water eluate, collecting water eluate, and transferring into percolate; exhausting the liquid in the tank with compressed air, collecting the residual liquid, transferring into the percolate, and mixing circularly. Opening the bottom cover of the percolation tank to remove the residue. And (5) testing alcohol content and microorganism indexes.
Optionally, multi-stage countercurrent percolation is adopted for extracting the effective components of the medicinal materials.
S6, wine blending:
transferring sucrose and appropriate amount of purified water in the ingredients into a sugar melting tank, heating and stirring until boiling, then stirring while maintaining slightly boiling state until sugar is completely dissolved, and closing steam. Opening the condensed water, cooling the syrup to room temperature, closing the condensed water, and then pumping all the condensed water into a wine blending tank;
adding 60vol% Chinese liquor and yellow wine in percolate, sugar-containing solution, adjuvants into compounding tank, calculating the shortage of edible alcohol according to ethanol content 32.5 (+ -1.5)% adding food grade alcohol for supplement, supplementing to limited volume with purified water, stirring and circulating to mix thoroughly, checking ethanol content, standing for 24 hr, and filtering.
S7, freezing, filtering, returning to the temperature, inspecting, filling, sealing and externally packaging:
directly pumping the filtered liquor to a freezing tank, starting to freeze, starting to time when the freezing temperature reaches-9 ℃, and freezing for 72 hours at-9-10 ℃. The wine is mixed evenly while freezing. Then filtered while cold. Pumping the filtrate into a liquid storage tank, fully mixing uniformly, returning the temperature to normal temperature, and returning the temperature to the ambient temperature. And (5) after the inspection is qualified, transferring the filling process to fill, cover and outer package.
Clinical curative effect
Selecting clinical patients with symptoms of chronic diseases, such as qi deficiency, fatigue, cold stomach, cold limbs, impotence, spermatorrhea, spontaneous enuresis, soreness and weakness of waist and knees, edema of lower limbs, and constipation. 107 of the patients were male and 97 of the patients were female, with the youngest age being 17 years old and the oldest being 73 years old. The medicinal liquor prepared in the embodiment 1 is taken in the first group, and the medicinal liquor prepared in the embodiment 2 is taken in the second group, wherein the medicinal liquor is taken once a day in the morning and at night, and is taken 20-40 ml each time half an hour after meals according to the serious conditions and the length of the disease course of patients. 15 days is a course of treatment.
The curative effect standard is as follows:
and (3) curing: the symptoms completely disappear, and the disease does not relapse within 3 months after the treatment is stopped.
Remarkably: the symptoms are obviously improved and basically recovered to be normal, but relapse occasionally or relapse after stopping the medicine for 3 months.
The method has the following advantages: the symptoms are reduced, and the symptoms are not completely improved after 3 treatment courses.
And (4) invalidation: after the symptoms are taken, the symptoms are not obviously changed or the symptoms are aggravated.
The results of the first group of clinical trials are shown in table 4 and the results of the second group of clinical trials are shown in table 5.
TABLE 4 results of the first group of clinical trials
| Cases of disease | Cure of disease | Is remarkable in that | Is effective | Invalidation | High efficiency | |
| Aversion to qi, mental fatigue, cold stomach and cold limbs | 32 | 20 | 4 | 4 | 4 | 87.5% |
| Impotence, spermatorrhea and urinationSelf-lost article | 15 | 13 | 0 | 1 | 1 | 93.3% |
| Soreness and weakness of the waist and knees, edema of lower limbs | 30 | 24 | 1 | 2 | 3 | 90.0% |
| Weak stool | 25 | 23 | 2 | 0 | 0 | 100% |
TABLE 5 results of the second group of clinical trials
| Cases of disease | Cure of disease | Is remarkable in that | Is effective | Invalidation | High efficiency | |
| Aversion to qi, mental fatigue, cold stomach and cold limbs | 32 | 20 | 5 | 4 | 3 | 90.6% |
| Impotence, spermatorrhea and spontaneous urination | 15 | 11 | 0 | 2 | 2 | 86.7% |
| Soreness and weakness of the waist and knees, edema of lower limbs | 30 | 26 | 2 | 0 | 2 | 93.3% |
| Weak stool | 25 | 21 | 2 | 2 | 0 | 100% |
As can be seen from tables 4 and 5, the effective rate of the treatment for various clinical symptoms is not less than 86.7%. The traditional Chinese medicine formula prepared by the invention has the effects of warming and invigorating kidney yang, replenishing essence and enriching blood, and can achieve the treatment effect after patients are treated by the medicinal liquor.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (6)
1. A preparation process of Yizhuangtian liquor is characterized by comprising the following steps:
s1, preparing prescription medicinal materials, and crushing into medicinal powder particles;
s2, putting the medicinal powder particles into base wine for wetting and sealing;
s3, filling the wet medicinal powder particles into a percolation device, adding base wine, exhausting air, and sealing and soaking;
s4, percolating, collecting percolate, completely percolating, completely draining residual liquid in the percolating device by using compressed air, collecting residual liquid, and transferring the residual liquid into the percolate;
s5, adding purified water into the percolation device for circulating water for washing, naturally draining the water washing liquid, collecting the water washing liquid, transferring the water washing liquid into the percolation liquid, draining residual liquid by using compressed air, collecting residual liquid, and transferring the residual liquid into the percolation liquid;
s6, preparing wine, uniformly mixing the percolate, the sugar-containing solution, the yellow wine, the white spirit and the purified water according to the proportion, standing and filtering; freezing pretreatment is carried out before the prescription medicinal materials in the step S1 are crushed, the freezing temperature is-20 ℃, the freezing time is 4-5h, and the temperature of the base liquor is controlled to be 55-60 ℃ in the wetting process of the Chinese medicinal powder particles in the step S2.
2. The process of claim 1, wherein the step S1 of crushing the herbs is performed separately, comprising:
s1-1, cutting and roughly crushing prepared rehmannia root, Chinese yam, pilose antler, eucommia bark, Chinese angelica, cinnamon, prepared aconite root, tall gastrodia tuber, ginseng and deer penis in the formula;
s1-2, grinding the rest materials, and pulverizing.
3. The process for preparing Yizhuangtian liquor as claimed in claim 2, wherein the crude herb in step S1-1 is crushed roughly and sieved by 24 mesh sieve, the fine herb in step S1-2 is crushed finely and sieved by 100 mesh sieve, and the sieved herb particles are mixed uniformly.
4. The process for preparing a zhangtian wine as claimed in any one of claims 1-3, wherein the base wine is 60vol% edible alcohol, the percolation temperature is 35-40 ℃, the percolation speed is 25-27.5L/hr, the relative balance between the base wine and the percolation liquid is controlled, and the continuous percolation is maintained.
5. The process for preparing the Yizhuangtian wine according to claim 4, further comprising S7. freezing, filtering, warming, inspecting, filling, capping and outer packaging.
6. The process of claim 4, wherein the percolation in step S4 is performed by multi-stage counter-current percolation.
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Address after: 264000 No.1 Airport Road, Zhifu District, Yantai City, Shandong Province Patentee after: Yantai Zhongya Zhibao Pharmaceutical Co.,Ltd. Address before: 264000 No.1 Airport Road, Zhifu District, Yantai City, Shandong Province Patentee before: Yantai Central Asia Healthcare Wine Co.,Ltd. |