CN110859938A - Traditional Chinese medicine composition for ankylosing spondylitis - Google Patents

Traditional Chinese medicine composition for ankylosing spondylitis Download PDF

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Publication number
CN110859938A
CN110859938A CN201911217353.6A CN201911217353A CN110859938A CN 110859938 A CN110859938 A CN 110859938A CN 201911217353 A CN201911217353 A CN 201911217353A CN 110859938 A CN110859938 A CN 110859938A
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parts
root
decoction
medicated bath
radix
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严明芳
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Individual
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract

The invention provides a traditional Chinese medicine composition for treating ankylosing spondylitis, which comprises a medicated bath agent and a decoction, wherein the medicated bath agent comprises the following components: 30 parts of pseudo-ginseng, 30 parts of ligusticum wallichii, 2 parts of prepared monkshood, 30 parts of cassia twig, 15 parts of frankincense, 15 parts of myrrh, 5 parts of scorpion, 20 parts of angelica, 10 parts of saururus chinensis root, 20 parts of astragalus membranaceus, 10 parts of elecampane, 30 parts of poria cocos, 15 parts of rhizoma atractylodis, 15 parts of rhizoma alismatis, 20 parts of mangnolia officinalis, 15 parts of honeysuckle stem, 15 parts of kadsura pepper stem, 10 parts of red paeony root, 10 parts of rhizoma anemarrhenae, 10 parts of radix rehmanniae, 15 parts of setaria japonica, 5 parts of curcuma longa, 10 parts of saffron crocus, 5 parts of centipede, 5 parts of za; the decoction comprises: 5 parts of pilose antler, 20 parts of eucommia bark, 15 parts of short-pedicel aconite root, 10 parts of dactylicapnos root, 5 parts of small white palm, 20 parts of medicinal cyathula root, 5 parts of pangolin, 15 parts of officinal magnolia bark, 10 parts of honeysuckle stem, 5 parts of turmeric, 5 parts of saffron and 5 parts of bloody scorpion.

Description

Traditional Chinese medicine composition for ankylosing spondylitis
Technical field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating ankylosing spondylitis.
Two background art
Ankylosing spondylitis is generally considered to belong to the category of rheumatism and autoimmune diseases, and the reason for the invention is not yet clear. Ankylosing spondylitis is a rheumatic arthropathy occurring in the spine, is common in young and strong years of 16-40 years old, is common in men, mainly affects sacroiliac joints, causes spinal ankylosis and fibrosis, causes lumbar curvature and limited walking activities, often has lesions of eyes, lungs, muscles and bones and even disorder of autoimmune function in different degrees, has various expression forms, is easy to misdiagnose, and can cause lifelong disability if delayed treatment or improper treatment is performed.
At present, the medicines and methods for treating ankylosing spondylitis in western medicine at home and abroad basically adopt immune preparations, nonsteroidal anti-inflammatory medicines and analgesic medicines to relieve the symptoms of stiffness and delay the development of diseases, but can not prevent or reverse the destruction of synovial membranes, periosteum and bone, and some hormone medicines can even be the cause of femoral head necrosis. The traditional Chinese medicine is commonly used as toxic medicine such as erycibe and the like, and has uncertain curative effect and obvious hepatotoxicity.
Disclosure of the invention
Aiming at the problems, the applicant develops a combination of a traditional Chinese medicine medicated bath agent and an oral medicine on the basis of a home-transmitted prescription for treating the rheumatic ostealgia, and the combination is safe to use, gives consideration to both inside and outside and has a good practical effect.
On one hand, the invention provides a traditional Chinese medicine composition for treating ankylosing spondylitis, which comprises an external preparation and an internal preparation.
Further, the external preparation is a medicated bath preparation which comprises the following raw materials in parts by weight: 20-40 parts of pseudo-ginseng, 20-40 parts of ligusticum wallichii, 1-5 parts of prepared monkshood, 20-40 parts of cassia twig, 10-20 parts of frankincense, 10-20 parts of myrrh, 5-10 parts of scorpion, 20-30 parts of angelica sinensis, 10-20 parts of saururus chinensis root, 20-30 parts of astragalus membranaceus, 5-15 parts of elecampane, 20-30 parts of poria cocos, 10-20 parts of rhizoma atractylodis, 10-20 parts of rhizoma alismatis, 20-30 parts of mangnolia officinalis, 10-20 parts of honeysuckle stem, 10-20 parts of kadsura pepper stem, 5-10 parts of red paeony root, 10-20 parts of rhizoma anemarrhenae, 5-10 parts of radix rehmanniae, 10-20 parts of setose hyphostroma, 5-10 parts of turmeric, 10-20 parts of saffron, 5-10 parts of centipede, 5-10 parts of zaocys dh; the oral preparation is decoction, which comprises 5-10 parts of pilose antler, 20-30 parts of eucommia bark, 10-15 parts of short-pedicel aconite root, 10-30 parts of dactylicapnos root, 5-10 parts of little radix achyranthis bidentatae, 5-10 parts of pangolin, 10-20 parts of officinal magnolia bark, 10-20 parts of honeysuckle stem, 5-10 parts of turmeric, 5-10 parts of saffron crocus and 5-10 parts of bloody scorpion.
Further, the medicated bath agent comprises the following raw materials in parts by weight: 30 parts of pseudo-ginseng, 30 parts of ligusticum wallichii, 2 parts of prepared monkshood, 30 parts of cassia twig, 15 parts of frankincense, 15 parts of myrrh, 5 parts of scorpion, 20 parts of angelica, 10 parts of saururus chinensis root, 20 parts of astragalus membranaceus, 10 parts of elecampane, 30 parts of poria cocos, 15 parts of rhizoma atractylodis, 15 parts of rhizoma alismatis, 20 parts of mangnolia officinalis, 15 parts of honeysuckle stem, 15 parts of kadsura pepper stem, 10 parts of red paeony root, 10 parts of rhizoma anemarrhenae, 10 parts of radix rehmanniae, 15 parts of setaria japonica, 5 parts of curcuma longa, 10 parts of saffron crocus, 5 parts of centipede, 5 parts of za; the decoction comprises: 5 parts of pilose antler, 20 parts of eucommia bark, 15 parts of short-pedicel aconite root, 10 parts of dactylicapnos root, 5 parts of small white palm, 20 parts of medicinal cyathula root, 5 parts of pangolin, 15 parts of officinal magnolia bark, 10 parts of honeysuckle stem, 5 parts of turmeric, 5 parts of saffron and 5 parts of bloody scorpion.
Further, the medicated bath agent is used by adding water 10 times of the total weight of the medicinal materials, boiling for 1 hr, cooling to appropriate temperature, and medicated bath.
Further, the decoction is prepared by adding water 5 times of the total weight of the medicinal materials, heating with slow fire and then strong fire for 2 hours, filtering the decoction, pouring out, adding water 5 times of the total weight of the medicinal materials, decocting, heating according to the same steps to obtain decoction, and combining the decoction obtained in two times to obtain the decoction.
Furthermore, the medicated bath is taken once a day, and the decoction is taken once every 400 ml.
Application of cornu Cervi Pantotrichum, Eucommiae cortex, radix Aconiti Brachypodi radix Aconiti Szechenyian, radix Dactylicapni, radix Seu caulis Parthenocissi Tricuspidatae, radix Cyathulae, squama Manis, cortex Magnolia officinalis, caulis Lonicerae, Curcuma rhizome, stigma croci Sativi, and sanguis Draxonis in preparing medicine for treating ankylosing spondylitis is provided.
The medicinal materials in the invention can be selected from products of various producing areas and grades according to corresponding quality standards.
The ankylosing spondylitis referred to in the present invention includes hereditary, infectious, toxic and other causes of ankylosing spondylitis.
Detailed description of the invention
EXAMPLE 1 preparation of the Chinese medicinal composition of the present invention
Medicated bath agent:
weighing 30 parts of pseudo-ginseng, 30 parts of ligusticum wallichii, 2 parts of prepared monkshood, 30 parts of cassia twig, 15 parts of frankincense, 15 parts of myrrh, 5 parts of scorpion, 20 parts of angelica, 10 parts of saururus chinensis root, 20 parts of astragalus membranaceus, 10 parts of elecampane, 30 parts of poria cocos, 15 parts of rhizoma atractylodis, 15 parts of rhizoma alismatis, 20 parts of mangnolia officinalis, 15 parts of honeysuckle stem, 15 parts of kadsura pepper stem, 10 parts of red paeony root, 10 parts of rhizoma anemarrhenae, 10 parts of radix rehmanniae, 15 parts of setaria japonica, 5 parts of curcuma longa, 10 parts of saffron crocus, 5 parts of centipede, 5 parts of za;
adding water 10 times of the total weight of the medicinal materials, boiling for 1 hr, cooling to appropriate temperature, and bathing.
Decoction:
weighing 5 parts of pilose antler, 20 parts of eucommia bark, 15 parts of short-pedicel aconite root, 10 parts of dactylicapnos root, 5 parts of small white palm, 20 parts of medicinal cyathula root, 5 parts of pangolin, 15 parts of officinal magnolia bark, 10 parts of honeysuckle stem, 5 parts of turmeric, 5 parts of saffron and 5 parts of bloody scorpion;
adding water 5 times the total weight of the medicinal materials, heating with slow fire and then strong fire for 2 hr, filtering, pouring out the medicinal liquid, adding water 5 times the total weight of the medicinal materials, decocting, heating according to the same steps to obtain medicinal liquid, and mixing the medicinal liquids obtained at two times to obtain decoction.
The medicated bath is taken once a day for about 30 minutes each time; the decoction is administered once per day at a dose of 400 ml.
Example 2 model experiment of arthritis
Animal experiment center of Zhejiang university of traditional Chinese medicine entrusted with medicinal bath for treating rat inflammation model experiment
SD rat is taken and injected with pentobarbital sodium solution in abdominal cavity, and 200 mug (emulsion, about 0.1mL) of collagen is injected subcutaneously at tail root; rats were injected subcutaneously with 100 μ g (emulsion, approximately 0.05mL) on both sides of the hip and back on day 7 after primary immunization.
30 model rats were treated with 10 of the medicated bath of example 1 daily for 20 minutes (40 degrees) and 2mL of the decoction of the Chinese medicine of example 1 were gavaged, 10 of the rats were treated with the medicated bath of example 1 daily for 20 minutes (40 degrees), and 10 of the rats were treated with 40-degree warm water for 20 minutes in a simulated manner. After 2 consecutive weeks, the degree of arthritis and the degree of swelling of the ankle joint of the right lower limb of the rat were evaluated by a scoring method.
The results are as follows:
mean score Swelling degree of ankle joint
Medicated bath and decoction 2.5 0.77
Medicated bath 2.7 0.89
Warm water simulation therapy 4.0 1.15
The results show that the treatment effect of the medicated bath and the decoction is obvious no matter the medicated bath is used alone or the medicated bath and the decoction are used together, and the therapeutic effect of the medicated bath and the decoction is better. The curative effect on the rheumatic arthritis can be used as a basis for embodying the curative effect of the ankylosing spondylitis.
By the time the present text was written, the applicant used the decoction + medicated bath method of example 1 to treat 29 total cases of ankylosing spondylitis, of which 19 cases of mild patients within half a year of the disease course had an efficacy number of 17, of which 9 cases were essentially cured, and of which 10 cases of moderately severe patients over half a year of the disease course had an efficacy number of 8.

Claims (7)

1. A Chinese medicinal composition for treating ankylosing spondylitis comprises topical preparation and oral preparation.
2. The Chinese medicinal composition according to claim 1, wherein the external preparation is a medicated bath preparation comprising the following raw materials in parts by weight: 20-40 parts of pseudo-ginseng, 20-40 parts of ligusticum wallichii, 1-5 parts of prepared monkshood, 20-40 parts of cassia twig, 10-20 parts of frankincense, 10-20 parts of myrrh, 5-10 parts of scorpion, 20-30 parts of angelica sinensis, 10-20 parts of saururus chinensis root, 20-30 parts of astragalus membranaceus, 5-15 parts of elecampane, 20-30 parts of poria cocos, 10-20 parts of rhizoma atractylodis, 10-20 parts of rhizoma alismatis, 20-30 parts of mangnolia officinalis, 10-20 parts of honeysuckle stem, 10-20 parts of kadsura pepper stem, 5-10 parts of red paeony root, 10-20 parts of rhizoma anemarrhenae, 5-10 parts of radix rehmanniae, 10-20 parts of setose hyphostroma, 5-10 parts of turmeric, 10-20 parts of saffron, 5-10 parts of centipede, 5-10 parts of zaocys dh; the oral preparation is decoction, which comprises 5-10 parts of pilose antler, 20-30 parts of eucommia bark, 10-15 parts of short-pedicel aconite root, 10-30 parts of dactylicapnos root, 5-10 parts of little radix achyranthis bidentatae, 5-10 parts of pangolin, 10-20 parts of officinal magnolia bark, 10-20 parts of honeysuckle stem, 5-10 parts of turmeric, 5-10 parts of saffron crocus and 5-10 parts of bloody scorpion.
3. The traditional Chinese medicine composition according to claim 2, wherein the medicated bath agent comprises the following raw materials in parts by weight: 30 parts of pseudo-ginseng, 30 parts of ligusticum wallichii, 2 parts of prepared monkshood, 30 parts of cassia twig, 15 parts of frankincense, 15 parts of myrrh, 5 parts of scorpion, 20 parts of angelica, 10 parts of saururus chinensis root, 20 parts of astragalus membranaceus, 10 parts of elecampane, 30 parts of poria cocos, 15 parts of rhizoma atractylodis, 15 parts of rhizoma alismatis, 20 parts of mangnolia officinalis, 15 parts of honeysuckle stem, 15 parts of kadsura pepper stem, 10 parts of red paeony root, 10 parts of rhizoma anemarrhenae, 10 parts of radix rehmanniae, 15 parts of setaria japonica, 5 parts of curcuma longa, 10 parts of saffron crocus, 5 parts of centipede, 5 parts of za; the decoction comprises: 5 parts of pilose antler, 20 parts of eucommia bark, 15 parts of short-pedicel aconite root, 10 parts of dactylicapnos root, 5 parts of small white palm, 20 parts of medicinal cyathula root, 5 parts of pangolin, 15 parts of officinal magnolia bark, 10 parts of honeysuckle stem, 5 parts of turmeric, 5 parts of saffron and 5 parts of bloody scorpion.
4. The Chinese medicinal composition according to claim 2 or 3, wherein the medicated bath agent is prepared by adding water 10 times of the total weight of the medicinal materials, boiling for 1 hr, cooling to a suitable temperature, and taking medicated bath.
5. The Chinese medicinal composition according to any one of claims 2 to 4, wherein the decoction is prepared by adding water 5 times the total weight of the herbs, heating with slow fire and then with strong fire for 2 hours, filtering the decoction, pouring out the filtrate, adding water 5 times the total weight of the herbs, decocting the filtrate, heating the same procedure to obtain the decoction, and combining the two decoctions to obtain the decoction.
6. The Chinese medicinal composition according to claim 5, when in use, the medicated bath is taken once a day, and the decoction is taken once every 400 ml.
7. Application of cornu Cervi Pantotrichum, Eucommiae cortex, radix Aconiti Brachypodi radix Aconiti Szechenyian, radix Dactylicapni, radix Seu caulis Parthenocissi Tricuspidatae, radix Cyathulae, squama Manis, cortex Magnolia officinalis, caulis Lonicerae, Curcuma rhizome, stigma croci Sativi, and sanguis Draxonis in preparing medicine for treating ankylosing spondylitis is provided.
CN201911217353.6A 2019-12-03 2019-12-03 Traditional Chinese medicine composition for ankylosing spondylitis Pending CN110859938A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1433787A (en) * 2002-01-19 2003-08-06 马献山 Oral taken and external use medicine for antirheumatism and stopping numbness pain
CN104225103A (en) * 2014-08-29 2014-12-24 韩世昌 Plaster for treating ankylosing spondylitis and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1433787A (en) * 2002-01-19 2003-08-06 马献山 Oral taken and external use medicine for antirheumatism and stopping numbness pain
CN104225103A (en) * 2014-08-29 2014-12-24 韩世昌 Plaster for treating ankylosing spondylitis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨向炎: "中药内服加熏蒸治疗强直性脊柱炎29例", 《浙江中医杂志》 *

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Application publication date: 20200306