CN104491111A - Application of tradtional Chinese medicine preparation in preparation of external medicament for treating hyperostosis - Google Patents
Application of tradtional Chinese medicine preparation in preparation of external medicament for treating hyperostosis Download PDFInfo
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Abstract
The invention discloses an application of a tradtional Chinese medicine preparation in preparation of an external medicament for treating hyperostosis. The tradtional Chinese medicine preparation is prepared by using 20 gouts of medicinal materials including Szechuan lovage rhizome, myrrh, safflower, tuber fleeceflower stem, clematis root, teasel root, Chinese honeylocust spine, achyranthes root, garden balsam stem, gentiana macrophylla, angelica, epimedium, honeysuckle, poria cocos, Chinese prickly ash, earthworms, pseudostellaria heterophylla, akebiaquinata, borneol and licorice through a modern pharmaceutical technology. The tradtional Chinese medicine preparation not only has the treatment advantages of quick response, good treatment effect, radical treatment, relapse elimination and the like on the aspect of treating hyperostosis, but also has the technical advantages of simplicity in preparation, stable effect, easiness in popularization and application and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation preparing the purposes in curing hyperosteogeny for external application medicine, belonging to the field of Chinese medicines.
Background technology
Bone matrix hyperplasia is also called hyperplastic osteoarthritis, osteoarthritis, degenerative joint disease, senile arthritis, hypertrophiarthritis, soft tissue degeneration, the degeneration such as cartilage, intervertebral disc, ligament owing to forming joint, joint margins forms bony spur, synovial membrane plumpness waits change, and occurs osteoclasia, causes insecondary hyperosteogeny, cause joint deformity, when being subject to abnormal load, cause arthralgia, a kind of disease of the symptoms such as limitation of activity.Hyperostosis constitutional estranged and Secondary cases two kinds.The traditional Chinese medical science thinks that primary disease is relevant with wound, strain, obstruction of collaterals by blood stasis, the damp that is affected by the cold, phlegm resistance, caused by liver and kidney deficiency etc.
Hyperosteogeny is a kind of frequently-occurring disease, commonly encountered diseases.Bone matrix hyperplasia is commonly encountered diseases, the frequently-occurring disease of person in middle and old age, about the name of this disease, and not yet unification both at home and abroad.External main called after osteoarthritis, osteoarthritis, hyperplastic osteoarthritis, degeneration osteoarthritis.The main name of China's medical science has osteoarthritis, intervertebral disc degeneration, proliferative arthritis, osteoarthrosis degenerative disease, bony spur etc., and motherland's medical science then belongs to the scope of arthromyodynia.Regular effective treatment is crucial: the traditional Chinese medical science is thought, hyperosteogeny is the evil knot of the stasis of blood, coagulates and do not fall apart, and treatment hyperosteogeny has channels sootheing and network vessel quickening, and medicine infiltrates sclerotin, effects a radical cure from pathology.Be careful in one's diet equilibrium, and other dry weight is lived, warming.
Bone matrix hyperplasia belongs to the category of " arthromyodynia ", " rheumatism involving the bone " of the traditional Chinese medical science, and this disease blocks with wound, strain, wind-cold damp pathogen, congestion, phlegm resistance, caused by liver and kidney deficiency etc. are relevant.
Caused by liver and kidney deficiency: in other words, deficiency of the liver and kindey, unable protection bone marrow, bone marrow of supplementing nutrition, of long duration, joint, in active procedure repeatedly, gradually suffers damage and occurs too quickly too early degenerating.
Wound and strain: wound and strain causes the most concentrated stressed local joint generation QI and blood disorderly inverse, the serious muscle that causes damages bone injury, and blood flow does not follow Chang Dao and overflows that to form blood stasis outward in arteries and veins sluggish, cause joint skeleton structural damage, lose nourishing, the time one is of a specified duration, and degenerative disease just there will be.
Affection of exogenous wind-cold damp: refer to be affected by the cold, catch a cold or for a long time occupy humidity ground, paddle in spite of the rain.
Phlegm resistance: general yang deficiency excessive phlegm, easily suffers from hyperosteogeny.And fat people has also increased the weight of the burden in joint, more easily cause local joint blood to transport not smooth, muscles and bones mistake has been supported, and then becomes numbness for a long time.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine preparation and is preparing the purposes in curing hyperosteogeny for external application medicine, develop a kind of Chinese medicine of curing hyperosteogeny for external application, and utilize modern pharmaceutical technology to be processed into preparation easy to use, require that preparation technology is easy, efficacy stability, general applicability are good.
In order to solve the problems of the technologies described above, the solution that inventor provides is Chinese prescription as follows and preferred prescription (with parts by weight):
Rhizoma Chuanxiong 16-32 part, Myrrha 18-34 part, Flos Carthami 16-34 part, Caulis Polygoni Multiflori 13-27 part, Radix Clematidis 19-41 part, Radix Dipsaci 8-22 part, Spina Gleditsiae 9-25 part, Radix Achyranthis Bidentatae 7-20 part, Herba speranskiae tuberculatae 9-27 part, Radix Gentianae Macrophyllae 5-17 part, Radix Angelicae Sinensis 7-21 part, Herba Epimedii 5-16 part, Flos Lonicerae 5-15 part, Poria 6-19 part, Pericarpium Zanthoxyli 5-14 part, Pheretima 5-14 part, Radix Pseudostellariae 8-22 part, Caulis Akebiae 7-17 part, Borneolum Syntheticum 4-14 part, Radix Glycyrrhizae 5-14 part.
Preferred prescription 1: Rhizoma Chuanxiong 25 parts, Myrrha 26 parts, 25 parts, Flos Carthami, Caulis Polygoni Multiflori 20 parts, Radix Clematidis 30 parts, Radix Dipsaci 15 parts, Spina Gleditsiae 17 parts, Radix Achyranthis Bidentatae 14 parts, Herba speranskiae tuberculatae 18 parts, Radix Gentianae Macrophyllae 11 parts, Radix Angelicae Sinensis 14 parts, Herba Epimedii 11 parts, Flos Lonicerae 10 parts, 12 parts, Poria, 10 parts, Pericarpium Zanthoxyli, Pheretima 10 parts, Radix Pseudostellariae 15 parts, Caulis Akebiae 12 parts, Borneolum Syntheticum 9 parts, 10 parts, Radix Glycyrrhizae.
Preferred prescription 2: Rhizoma Chuanxiong 23 parts, Myrrha 29 parts, 26 parts, Flos Carthami, Caulis Polygoni Multiflori 21 parts, Radix Clematidis 28 parts, Radix Dipsaci 17 parts, Spina Gleditsiae 15 parts, Radix Achyranthis Bidentatae 15 parts, Herba speranskiae tuberculatae 17 parts, Radix Gentianae Macrophyllae 11 parts, Radix Angelicae Sinensis 15 parts, Herba Epimedii 10 parts, Flos Lonicerae 11 parts, 13 parts, Poria, 12 parts, Pericarpium Zanthoxyli, Pheretima 9 parts, Radix Pseudostellariae 14 parts, Caulis Akebiae 11 parts, Borneolum Syntheticum 10 parts, 11 parts, Radix Glycyrrhizae.
Preferred prescription 3: Rhizoma Chuanxiong 24 parts, Myrrha 27 parts, 23 parts, Flos Carthami, Caulis Polygoni Multiflori 22 parts, Radix Clematidis 32 parts, Radix Dipsaci 14 parts, Spina Gleditsiae 16 parts, Radix Achyranthis Bidentatae 12 parts, Herba speranskiae tuberculatae 16 parts, Radix Gentianae Macrophyllae 13 parts, Radix Angelicae Sinensis 15 parts, Herba Epimedii 12 parts, Flos Lonicerae 11 parts, 12 parts, Poria, 9 parts, Pericarpium Zanthoxyli, Pheretima 12 parts, Radix Pseudostellariae 14 parts, Caulis Akebiae 13 parts, Borneolum Syntheticum 8 parts, 11 parts, Radix Glycyrrhizae.
The technical scheme that above-mentioned prescription is made preparation by inventor is following steps:
(1), each taste Chinese crude drug is taken by proportioning;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 6-10 times of weight, soak 10-20 hour, backflow decocts 2-4 hour, filters; Filtering residue is added again the purified water of 3-5 times of weight, backflow decocts 1-3 hour, filters; Merge twice filtrate, being evaporated to relative density is 1.05-1.15(60-70 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of the 60-80% of 4-8 times of weight, backflow decocts 2-4 hour, filters; Filtering residue is added again the ethanol of the 60-80% of 3-6 times of weight, backflow decocts 1-3 hour, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make finished product preparation, as dosage forms such as ointment, plaster, tincture, suppositorys.
The source of the present invention's Chinese crude drug used, meridian distribution of property and flavor and function:
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong.Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
Myrrha: the oleo-gum-resin that Burseraceae bdellium plant myrrh and the trunk skin zone belonging to his kind of plant together ooze out.Bitter in the mouth, property is put down; Enter Liver Channel; Eliminating stasis to stop pain, externally used detumescence granulation promoting.
Flos Carthami: call red indigo plant flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium.Acrid in the mouth, warm in nature; Enter the heart, Liver Channel; Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.
Caulis Polygoni Multiflori: this product is the rattan of dicotyledon medicine polygonum multiflorum thunb.Sweet micro-hardship, flat.Control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.
Radix Clematidis: this product is the dry root and rhizome of ranunculaceae plant Radix Clematidis, Clematis hexapetala (mountain knotweed) or northeast clematis (black common vetch).Acrid in the mouth, salty, warm in nature; Return urinary bladder channel; Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
Radix Dipsaci: this product is the dry root of Dipsacaceae plant Radix Dipsaci.Bitter in the mouth, pungent, slightly warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.
Spina Gleditsiae: this product is the dry Spina jujubae of leguminous plant Fructus Gleditsia.Acrid in the mouth, warm in nature; Return liver, stomach warp; Detumescence poison holding, evacuation of pus, parasite killing.
Radix Achyranthis Bidentatae: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Bitter in the mouth, acid, property is put down; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Herba speranskiae tuberculatae: the herb of Euphorbiaceae Speranskia plant speranskia tuberculata, Balsaminaceae herbaceous plant Flos Impatientis, Bignoniaceae Incarvillea AJuss plant Herba Incarvilleae sinensis, pulse family Vetch plant Herba Viciae Amoenae and the Herb of Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis.Acrid in the mouth, hardship, warm in nature; Return liver, kidney channel; Expelling wind and removing dampness, removing toxic substances pain relieving.
Radix Gentianae Macrophyllae: this product is the dry root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana straminea maxim, gentiana crassicaulis Duthie or Gentiana dahurica.Acrid in the mouth, hardship, property is put down; Return stomach, liver, gallbladder meridian; Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Herba Epimedii: this product is the dry aerial parts of Berberidaceae plant Herba Epimedii, Epimedium sagittatum, E. Pubescens, Epimedium wushanense or Herba Epimedii.Acrid in the mouth, sweet, warm in nature; Return liver, kidney channel; Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Flos Lonicerae: this product is caprifoliaceae plant Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae (hair calyx Radix Ophiopogonis) or the dry flower of hair style Radix Ophiopogonis.Sweet in the mouth, cold in nature; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, wind-heat dissipating.
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
Pericarpium Zanthoxyli: this product is that the dry mature skin (Pericarpium Zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)) and seed (Semen zanthoxyli) are used as medicine.Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Warming middle-JIAO to relieve pain, killing parasites for relieving itching.
Pheretima: this product is the dry body of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or the blind Pheretimatschiliensis of comb.Salty in the mouth, cold in nature; Return liver, spleen, urinary bladder channel; Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.
Radix Pseudostellariae: this product is Caryophyllaceae Radix Pseudostellariae platymiscium, sweet in the mouth, micro-hardship is flat.Return spleen, lung meridian.Body lubricant nature and, tonifying QI to produce body fluid.
Caulis Akebiae: be the woody stems of plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, Caulis Akebiae.Bitter in the mouth, cool in nature; Enter the heart, small intestinal, urinary bladder channel; Pathogenic fire purging row water, promoting blood circulation.
Borneolum Syntheticum: point BORNEOLUM SYNTHETICUM and Blumeae preparatum Tabellae two class.BORNEOLUM SYNTHETICUM is the Borneolum Syntheticum that raw material synthesizes through chemical method with Oleum Terebinthinae, Camphora etc.; Blumeae preparatum Tabellae is the crystallization of fresh leaf through steam distillation, cooling gained of Compositae Herba Blumeae Balsamiferae platymiscium Balsamiferou Blumea Herb, also known as " Chinese mugwort powder " or " sheeting ".Acrid in the mouth, hardship, cold nature; GUIXIN, spleen, lung meridian; To have one's ideas straightened out refreshment, clearing away heat to alleviate pain.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is on the basis of traditional proved recipe, follow drug matching principle, according to inventor to the dialectical cognition of hyperosteogeny, in conjunction with inventor's tcm clinical practice experience for many years and the ill feature of modern, through clinical repeated examinations adjustment, science is arranged in pairs or groups and obtains.This prescription is with Rhizoma Chuanxiong, Myrrha, Flos Carthami, Caulis Polygoni Multiflori, Radix Clematidis, Herba speranskiae tuberculatae for monarch drug, blood-activating and qi-promoting, detumescence and promoting granulation, nourishing blood for regulating menstruation, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain; With Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Pseudostellariae, Pericarpium Zanthoxyli for ministerial drug, the continuous wound of bone strengthening, detumescence detoxification, eliminating blood stasis and inducing menstruation, damp eliminating the kidney invigorating; With Radix Gentianae Macrophyllae, Herba Epimedii, Poria, Flos Lonicerae for adjuvant drug, clear wet only numbness, the kidney invigorating bone strengthening, eliminating dampness and diuresis, heat-clearing and toxic substances removing; With Pheretima, Radix Angelicae Sinensis, Caulis Akebiae, Borneolum Syntheticum for making medicine, dredging collateral is invigorated blood circulation, pathogenic fire purging row water, clearing away heat to alleviate pain; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, make all medicine coordinated, complement each other, the effect such as reach expelling wind and removing dampness, detumescence detoxification, clear wet only numbness, dredging collateral are invigorated blood circulation, have very significant therapeutic effect to hyperosteogeny.
Compared with prior art, Chinese medicine preparation of the present invention has instant effect, good effect, easily digs up the roots, the not easily treatment advantage such as recurrence, and has that processing technology is easy, efficacy stability, is easy to technical advantages such as applying.
Detailed description of the invention
Embodiment 1, embodiment 2 and embodiment 3 carry out actual production by three optimum ratios respectively, and embodiment 4, embodiment 5 are respectively the minimum of prescription proportioning and maximum magnitude, and embodiment 6 is any proportioning in prescription ratio range.Embodiment 7 is clinical trial.
Embodiment 1,
(1), each taste Chinese crude drug is taken by proportioning: Rhizoma Chuanxiong 25kg, Myrrha 26kg, Flos Carthami 25kg, Caulis Polygoni Multiflori 20kg, Radix Clematidis 30kg, Radix Dipsaci 15kg, Spina Gleditsiae 17kg, Radix Achyranthis Bidentatae 14kg, Herba speranskiae tuberculatae 18kg, Radix Gentianae Macrophyllae 11kg, Radix Angelicae Sinensis 14kg, Herba Epimedii 11kg, Flos Lonicerae 10kg, Poria 12kg, Pericarpium Zanthoxyli 10kg, Pheretima 10kg, Radix Pseudostellariae 15kg, Caulis Akebiae 12kg, Borneolum Syntheticum 9kg, Radix Glycyrrhizae 10kg;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 8 times of weight, soak 15 hours, backflow decoction 3 hours, filters; Filtering residue is added again the purified water of 4 times of weight, backflow decoction 2 hours, filters; Merge twice filtrate, being evaporated to relative density is 1.10(65 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of 70% of 6 times of weight, backflow decoction 3 hours, filters; Filtering residue is added again the ethanol of 70% of 4 times of weight, backflow decoction 2 hours, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make ointment, amount to crude drug content and be about 0.3g crude drug/g ointment.
Embodiment 2
(1), each taste Chinese crude drug is taken by proportioning: Rhizoma Chuanxiong 23kg, Myrrha 29kg, Flos Carthami 26kg, Caulis Polygoni Multiflori 21kg, Radix Clematidis 28kg, Radix Dipsaci 17kg, Spina Gleditsiae 15kg, Radix Achyranthis Bidentatae 15kg, Herba speranskiae tuberculatae 17kg, Radix Gentianae Macrophyllae 11kg, Radix Angelicae Sinensis 15kg, Herba Epimedii 10kg, Flos Lonicerae 11kg, Poria 13kg, Pericarpium Zanthoxyli 12kg, Pheretima 9kg, Radix Pseudostellariae 14kg, Caulis Akebiae 11kg, Borneolum Syntheticum 10kg, Radix Glycyrrhizae 11kg;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 8 times of weight, soak 15 hours, backflow decoction 3 hours, filters; Filtering residue is added again the purified water of 4 times of weight, backflow decoction 2 hours, filters; Merge twice filtrate, being evaporated to relative density is 1.10(65 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of 70% of 6 times of weight, backflow decoction 3 hours, filters; Filtering residue is added again the ethanol of 70% of 4 times of weight, backflow decoction 2 hours, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make ointment, amount to crude drug content and be about 0.3g crude drug/g ointment.
Embodiment 3
(1), each taste Chinese crude drug is taken by proportioning: Rhizoma Chuanxiong 24kg, Myrrha 27kg, Flos Carthami 23kg, Caulis Polygoni Multiflori 22kg, Radix Clematidis 32kg, Radix Dipsaci 14kg, Spina Gleditsiae 16kg, Radix Achyranthis Bidentatae 12kg, Herba speranskiae tuberculatae 16kg, Radix Gentianae Macrophyllae 13kg, Radix Angelicae Sinensis 15kg, Herba Epimedii 12kg, Flos Lonicerae 11kg, Poria 12kg, Pericarpium Zanthoxyli 9kg, Pheretima 12kg, Radix Pseudostellariae 14kg, Caulis Akebiae 13kg, Borneolum Syntheticum 8kg, Radix Glycyrrhizae 11kg;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 8 times of weight, soak 15 hours, backflow decoction 3 hours, filters; Filtering residue is added again the purified water of 4 times of weight, backflow decoction 2 hours, filters; Merge twice filtrate, being evaporated to relative density is 1.10(65 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of 70% of 6 times of weight, backflow decoction 3 hours, filters; Filtering residue is added again the ethanol of 70% of 4 times of weight, backflow decoction 2 hours, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make ointment, amount to crude drug content and be about 0.3g crude drug/g ointment.
Embodiment 4
(1), each taste Chinese crude drug is taken by proportioning: Rhizoma Chuanxiong 16 parts, Myrrha 18 parts, 16 parts, Flos Carthami, Caulis Polygoni Multiflori 13 parts, Radix Clematidis 19 parts, Radix Dipsaci 8 parts, Spina Gleditsiae 9 parts, Radix Achyranthis Bidentatae 7 parts, Herba speranskiae tuberculatae 9 parts, Radix Gentianae Macrophyllae 5 parts, Radix Angelicae Sinensis 7 parts, Herba Epimedii 5 parts, Flos Lonicerae 5 parts, 6 parts, Poria, 5 parts, Pericarpium Zanthoxyli, Pheretima 5 parts, Radix Pseudostellariae 8 parts, Caulis Akebiae 7 parts, Borneolum Syntheticum 4 parts, 5 parts, Radix Glycyrrhizae;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 8 times of weight, soak 15 hours, backflow decoction 3 hours, filters; Filtering residue is added again the purified water of 4 times of weight, backflow decoction 2 hours, filters; Merge twice filtrate, being evaporated to relative density is 1.10(65 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of 70% of 6 times of weight, backflow decoction 3 hours, filters; Filtering residue is added again the ethanol of 70% of 4 times of weight, backflow decoction 2 hours, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make ointment, amount to crude drug content and be about 0.3g crude drug/g ointment.
Embodiment 5
(1), each taste Chinese crude drug is taken by proportioning: Rhizoma Chuanxiong 32 parts, Myrrha 34 parts, 34 parts, Flos Carthami, Caulis Polygoni Multiflori 27 parts, Radix Clematidis 41 parts, Radix Dipsaci 22 parts, Spina Gleditsiae 25 parts, Radix Achyranthis Bidentatae 20 parts, Herba speranskiae tuberculatae 27 parts, Radix Gentianae Macrophyllae 17 parts, Radix Angelicae Sinensis 21 parts, Herba Epimedii 16 parts, Flos Lonicerae 15 parts, 19 parts, Poria, 14 parts, Pericarpium Zanthoxyli, Pheretima 14 parts, Radix Pseudostellariae 22 parts, Caulis Akebiae 17 parts, Borneolum Syntheticum 14 parts, 14 parts, Radix Glycyrrhizae;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 8 times of weight, soak 15 hours, backflow decoction 3 hours, filters; Filtering residue is added again the purified water of 4 times of weight, backflow decoction 2 hours, filters; Merge twice filtrate, being evaporated to relative density is 1.10(65 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of 70% of 6 times of weight, backflow decoction 3 hours, filters; Filtering residue is added again the ethanol of 70% of 4 times of weight, backflow decoction 2 hours, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make ointment, amount to crude drug content and be about 0.3g crude drug/g ointment.
Embodiment 6
(1), each taste Chinese crude drug is taken by proportioning: Rhizoma Chuanxiong 32kg, Myrrha 19kg, Flos Carthami 33kg, Caulis Polygoni Multiflori 26kg, Radix Clematidis 20kg, Radix Dipsaci 9kg, Spina Gleditsiae 24kg, Radix Achyranthis Bidentatae 18kg, Herba speranskiae tuberculatae 11kg, Radix Gentianae Macrophyllae 16kg, Radix Angelicae Sinensis 8kg, Herba Epimedii 15kg, Flos Lonicerae 6kg, Poria 18kg, Pericarpium Zanthoxyli 6kg, Pheretima 13kg, Radix Pseudostellariae 9kg, Caulis Akebiae 16kg, Borneolum Syntheticum 5kg, Radix Glycyrrhizae 13kg;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 8 times of weight, soak 15 hours, backflow decoction 3 hours, filters; Filtering residue is added again the purified water of 4 times of weight, backflow decoction 2 hours, filters; Merge twice filtrate, being evaporated to relative density is 1.10(65 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of 70% of 6 times of weight, backflow decoction 3 hours, filters; Filtering residue is added again the ethanol of 70% of 4 times of weight, backflow decoction 2 hours, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make ointment, amount to crude drug content and be about 0.3g crude drug/g ointment.
Embodiment 7
The clinical effectiveness test of traditional Chinese herb medicine of the present invention
1, experimenter's data
All experimenters, all from certain city's urgent disorder in orthopaedics hospital, from the hyperosteogeny patient that this institute accepts for medical treatment year February in June, 2011 to 2014, filter out the patient 160 of applicable clinical trial, wherein man 88, age 45-71 year, female 72, age 47-68 year.Experimenter is divided into 4 groups, each group 40, man 22, female 18.Each group is numbered matched group, test 1, test 2 respectively, tests 3 groups.
2, test medicine
Contrast medicine: Chinese pill for curing hyperosteogeny, the accurate word Z14021334 of traditional Chinese medicines, Xi'an new city company of Chinese medicine group.
By reagent: the ointment obtained by embodiment of the present invention 1-3.
3, test method
The oral Chinese pill for curing hyperosteogeny of matched group, every day 2 times, each 0.3g.
The ointment that test 1-3 group uses embodiment of the present invention 1-3 to produce respectively, is evenly applied to affected part, every day three times.
Within 3 weeks, be a course for the treatment of, continuously 3 courses for the treatment of of treatment, treatments period cured person can stopped treatment, and treatment end, after 6 months, is paid a return visit healing person, record recurrent cases.
4, evaluation criterion
Cure: the symptoms such as pain disappear completely, make a definite diagnosis fully recover through doctor.
Effective: the symptom partial disappearance such as pain, still need further treatment.
Invalid: the symptoms such as pain are without any improvement, even more serious.
Recurrence: cure in latter 6 months, suffer from same disease at identical position.
5, result of the test statistical analysis
(1), phenomenon contrast is characterized: the main distinction is, compared with contrast medicine, ointment instant effect of the present invention, the overwhelming majority just takes effect after 5 hours in medication, and contrast medicine takes two days and just takes effect later; In addition for healing patient, the Ointment in Treatment cycle of the present invention is obviously short, average out to 12.4 days, and contrast medicine cures cycle average out to 24.6 days.
(2), therapeutic outcome statistical table
After whole treatment cycle being terminated by test method, statistical analysis test data is in table 1.
Table 1 test data statistical analysis table
| Group | Case load | Cure (rate) | Effective | Invalid | Total effective rate | Recurrence (rate) |
| Matched group | 40 | 8（20.0%） | 14 | 18 | 55.0% | 3（37.5%） |
| Test 1 | 40 | 25（62.5%） | 15 | 0 | 100% | 1（4.0%） |
| Test 2 | 40 | 23（57.5%） | 16 | 1 | 97.5% | 2（8.7%） |
| Test 3 | 40 | 21（52.5%） | 18 | 1 | 97.5% | 2（9.5%） |
6, conclusion (of pressure testing)
As can be seen from the test results, compared with contrast medicine, traditional Chinese herb medicine of the present invention takes effect faster, and the course for the treatment of is shorter.And the average cure rate of test group is 57.5%, be 2.9 times of contrast medicine; The average total effective rate of test group is 98.3%, higher 43.3 percentage points than contrast medicine; And average relapse rate is 7.4%, be only about 1/5 of contrast medicine.Therefore Chinese medicine preparation of the present invention has very significant treatment technology advantage relative to prior art, achieves beyond thought technique effect.
Claims (6)
1. Chinese medicine preparation is preparing the purposes in curing hyperosteogeny for external application medicine, it is characterized in that, described Chinese medicine preparation has the Chinese crude drug of following weight portion to process:
Rhizoma Chuanxiong 16-32 part, Myrrha 18-34 part, Flos Carthami 16-34 part, Caulis Polygoni Multiflori 13-27 part, Radix Clematidis 19-41 part, Radix Dipsaci 8-22 part, Spina Gleditsiae 9-25 part, Radix Achyranthis Bidentatae 7-20 part, Herba speranskiae tuberculatae 9-27 part, Radix Gentianae Macrophyllae 5-17 part, Radix Angelicae Sinensis 7-21 part, Herba Epimedii 5-16 part, Flos Lonicerae 5-15 part, Poria 6-19 part, Pericarpium Zanthoxyli 5-14 part, Pheretima 5-14 part, Radix Pseudostellariae 8-22 part, Caulis Akebiae 7-17 part, Borneolum Syntheticum 4-14 part, Radix Glycyrrhizae 5-14 part.
2. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation has the Chinese crude drug of following weight portion to process:
Rhizoma Chuanxiong 25 parts, Myrrha 26 parts, 25 parts, Flos Carthami, Caulis Polygoni Multiflori 20 parts, Radix Clematidis 30 parts, Radix Dipsaci 15 parts, Spina Gleditsiae 17 parts, Radix Achyranthis Bidentatae 14 parts, Herba speranskiae tuberculatae 18 parts, Radix Gentianae Macrophyllae 11 parts, Radix Angelicae Sinensis 14 parts, Herba Epimedii 11 parts, Flos Lonicerae 10 parts, 12 parts, Poria, 10 parts, Pericarpium Zanthoxyli, Pheretima 10 parts, Radix Pseudostellariae 15 parts, Caulis Akebiae 12 parts, Borneolum Syntheticum 9 parts, 10 parts, Radix Glycyrrhizae.
3. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation has the Chinese crude drug of following weight portion to process:
Rhizoma Chuanxiong 23 parts, Myrrha 29 parts, 26 parts, Flos Carthami, Caulis Polygoni Multiflori 21 parts, Radix Clematidis 28 parts, Radix Dipsaci 17 parts, Spina Gleditsiae 15 parts, Radix Achyranthis Bidentatae 15 parts, Herba speranskiae tuberculatae 17 parts, Radix Gentianae Macrophyllae 11 parts, Radix Angelicae Sinensis 15 parts, Herba Epimedii 10 parts, Flos Lonicerae 11 parts, 13 parts, Poria, 12 parts, Pericarpium Zanthoxyli, Pheretima 9 parts, Radix Pseudostellariae 14 parts, Caulis Akebiae 11 parts, Borneolum Syntheticum 10 parts, 11 parts, Radix Glycyrrhizae.
4. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation has the Chinese crude drug of following weight portion to process:
Rhizoma Chuanxiong 24 parts, Myrrha 27 parts, 23 parts, Flos Carthami, Caulis Polygoni Multiflori 22 parts, Radix Clematidis 32 parts, Radix Dipsaci 14 parts, Spina Gleditsiae 16 parts, Radix Achyranthis Bidentatae 12 parts, Herba speranskiae tuberculatae 16 parts, Radix Gentianae Macrophyllae 13 parts, Radix Angelicae Sinensis 15 parts, Herba Epimedii 12 parts, Flos Lonicerae 11 parts, 12 parts, Poria, 9 parts, Pericarpium Zanthoxyli, Pheretima 12 parts, Radix Pseudostellariae 14 parts, Caulis Akebiae 13 parts, Borneolum Syntheticum 8 parts, 11 parts, Radix Glycyrrhizae.
5. the purposes as described in as arbitrary in claim 1-4, it is characterized in that, the processing technique of described Chinese medicine preparation is following steps:
(1), each taste Chinese crude drug is taken by proportioning;
(2), Rhizoma Chuanxiong, Caulis Polygoni Multiflori, Radix Clematidis, Radix Dipsaci, Spina Gleditsiae, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, Herba Epimedii, Flos Lonicerae, Poria, Pheretima, Radix Pseudostellariae, Caulis Akebiae, Radix Glycyrrhizae are pulverized respectively, add the purified water of 6-10 times of weight, soak 10-20 hour, backflow decocts 2-4 hour, filters; Filtering residue is added again the purified water of 3-5 times of weight, backflow decocts 1-3 hour, filters; Merge twice filtrate, being evaporated to relative density is 1.05-1.15(60-70 DEG C of survey), be water extracting liquid, for subsequent use;
(3), the medicinal residues of step (2) are added the ethanol of the 60-80% of 4-8 times of weight, backflow decocts 2-4 hour, filters; Filtering residue is added again the ethanol of the 60-80% of 3-6 times of weight, backflow decocts 1-3 hour, filters, merging filtrate, and distilling under reduced pressure removing ethanol, is alcohol extraction concentrated solution, for subsequent use;
(4), by water extracting liquid and the mixing of alcohol extraction concentrated solution, concentrating under reduced pressure, dry and obtain dry extract, ground 120 mesh sieves are fine powder A, for subsequent use;
(5), by Myrrha, Flos Carthami, Herba speranskiae tuberculatae, Pericarpium Zanthoxyli clean, dry, pulverize, levigate mistake 200 mesh sieve is fine powder B, for subsequent use;
(6), by levigate for Borneolum Syntheticum mistake 120 mesh sieve, be fine powder C, for subsequent use;
(7), by fine powder A, fine powder B and fine powder C mix homogeneously, add adjuvant and make finished product preparation.
6. the purposes as described in as arbitrary in claim 1-4, it is characterized in that, described Chinese medicine preparation can make ointment, plaster, tincture and suppository.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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