CN110859635A - Plasma sampling pipeline system and sampling method - Google Patents

Plasma sampling pipeline system and sampling method Download PDF

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Publication number
CN110859635A
CN110859635A CN201910993346.9A CN201910993346A CN110859635A CN 110859635 A CN110859635 A CN 110859635A CN 201910993346 A CN201910993346 A CN 201910993346A CN 110859635 A CN110859635 A CN 110859635A
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China
Prior art keywords
plasma
sampling
tube
pipe
blood
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CN201910993346.9A
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Chinese (zh)
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任滔
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Sichuan Nigale Biomedical Inc
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Sichuan Nigale Biomedical Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A61M1/0023—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention provides a plasma sampling pipeline system and a plasma sampling method, wherein the plasma sampling pipeline system comprises a plasma collecting pipe (14) and a plasma sampling test tube (16), the plasma sampling test tube (16) is connected with the outlet end of the sampling pipe (10) and the inlet end of an exhaust pipe (12), the inlet end of the sampling pipe (10) and the outlet end of the exhaust pipe (12) are respectively in pipeline connection with the plasma collecting pipe (14), and plasma in the plasma collecting pipe (14) flows through the inlet end of the sampling pipe (10) and then flows through the outlet end of the exhaust pipe (12). When the invention is used for plasma sampling operation, plasma can smoothly enter the plasma sampling test tube from the inlet end of the sampling tube, and air in the plasma sampling test tube is discharged from the outlet end of the exhaust tube, so that the traditional vacuum sampler can be cancelled, and an air filter does not need to be specially arranged in the sampling process, thereby effectively reducing the plasma sampling cost.

Description

Plasma sampling pipeline system and sampling method
Technical Field
The invention relates to the field of design of plasma sampling pipelines, in particular to a plasma sampling pipeline system and a sampling method applied to a plasma collector.
Background
Plasma corresponds to the intercellular substance of connective tissue, and is a pale yellow translucent liquid containing, in addition to a large amount of moisture, inorganic salts, fibrinogen, albumin, globulin, enzymes, hormones, various nutrients, metabolites, and the like.
The existing blood plasma collector separates different blood components by high-speed centrifugation according to the specific gravity difference of the blood components. The method comprises the steps of mixing the exported blood with a certain proportion of anticoagulant, inputting the mixture into a separation cup, rotating the separation cup at a high speed under the driving of a plasma collection machine, and layering blood components with different specific gravities, such as red blood cells, plasma, platelets and the like in the blood in the separation cup under the action of centrifugal force, so that the purpose of collecting the plasma is achieved.
However, in the whole collection closed system, a vacuum sampler is mostly adopted for sampling, the cost of the vacuum sampler is high, and the sampling cost is high when a plurality of vacuum samplers are used at one time; in addition, in order to ensure smooth sampling, an air filter must be specially arranged, which obviously further increases the sampling cost. In addition, after the plasma is transfused, blood products still remain in the pipeline consumables, which not only causes waste of blood resources, but also causes environmental pollution.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: aiming at the problems in the prior art, the plasma sampling pipeline system and the sampling method are provided, and the plasma sampling cost is reduced.
The technical problem to be solved by the invention is realized by adopting the following technical scheme: the utility model provides a plasma sampling pipe-line system, includes that plasma gathers pipe and plasma sampling test tube, plasma sampling test tube and plasma gather and pass through the tube coupling between the pipe, plasma sampling test tube and sampling pipe exit end, blast pipe entry end be connected, the entry end of sampling pipe, the exit end of blast pipe form the tube coupling with plasma respectively, and, plasma in the plasma gathering pipe flows through the entry end of sampling pipe earlier, flows through the exit end of blast pipe again.
Preferably, the plasma collecting tube is connected with a saline pipeline in a pipeline way, and the saline pipeline is connected with the bottle stopper puncture device.
Preferably, the saline pipeline is provided with a clamping piece.
Preferably, the plasma collection tube is connected with the outlet end of the separation cup, the inlet end of the separation cup is connected with the blood collection and transportation tube, the blood collection and transportation tube is respectively connected with the inlet end of the sampling tube and the outlet end of the exhaust tube through pipelines, the outlet end of the sampling tube and the inlet end of the exhaust tube are respectively connected with the blood sampling test tube, and blood in the blood collection and transportation tube firstly flows through the inlet end of the sampling tube and then flows through the outlet end of the exhaust tube.
Preferably, the exhaust pipe is provided with a locking roll gap.
Preferably, a blood filter is arranged on the blood collection and transportation pipe.
Preferably, a pipeline connection is formed between the blood filter and the pressure detector.
Preferably, the plasma sampling test tube set up a plurality of, each plasma sampling test tube is connected with the exit end of independent sampling pipe, the entry end of independent blast pipe respectively, the entry end of sampling pipe, the exit end of blast pipe form the tube coupling with plasma collection pipe respectively, plasma in the plasma collection pipe flows through the entry end of sampling pipe earlier, flows through the exit end of blast pipe again.
Preferably, the sampling pipe is provided with a locking roll gap.
A plasma sampling method, which is carried out by adopting the plasma sampling pipeline system.
Compared with the prior art, the invention has the beneficial effects that: when plasma flows along the plasma collection tube, plasma in the plasma collection tube flows through the inlet end of the sampling tube connected with the plasma collection tube firstly and then flows through the outlet end of the exhaust tube connected with the plasma collection tube, therefore, plasma can smoothly enter the plasma sampling test tube from the inlet end of the sampling tube, air in the plasma sampling test tube is discharged from the outlet end of the exhaust tube, a traditional vacuum sampler can be omitted, an air filter does not need to be specially arranged in the sampling process, and the plasma sampling cost is greatly reduced.
Drawings
Fig. 1 is a schematic diagram of a plasma sampling line system according to the present invention.
The labels in the figure are: 1-hemostix, 2-locking notch, 3-tee joint, 4-anticoagulant tube, 5-bottle stopper puncture outfit, 6-blood collection and transportation tube, 7-blood filter, 8-clamping piece, 9-pressure detector, 10-sampling tube, 11-blood sampling tube, 12-exhaust tube, 13-separation cup, 14-plasma collection tube, 15-saline pipeline, 16-plasma sampling tube and 17-plasma collection bag.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The plasma sampling pipeline system shown in fig. 1 mainly comprises a blood collector 1, a bottle stopper puncture outfit 5, a blood filter 7, a pressure detector 9, a blood sampling test tube 11, a separation cup 13, a plasma sampling test tube 16 and a plasma collecting bag 17, wherein the blood collector 1 is respectively connected with an anticoagulant tube 4 and a blood sampling and transporting tube 6 through a tee joint 3 by pipelines, a locking roll-off port 2 is arranged on a connecting pipeline between the tee joint 3 and the blood collector 1, and the anticoagulant tube 4 is connected with the bottle stopper puncture outfit 5 by pipelines. The inlet end of the separating cup 13 is connected with the blood collecting and transporting pipe 6 through a pipeline, the blood collecting and transporting pipe 6 is provided with a blood filter 7, the blood filter 7 is connected with the pressure detector 9 through a pipeline, and a connecting pipeline between the blood filter 7 and the pressure detector 9 is provided with a clamping piece 8; the blood sampling and transporting pipe 6 is respectively connected with the inlet end of the sampling pipe 10 and the outlet end of the exhaust pipe 12 through a tee joint to form a pipeline, the outlet end of the sampling pipe 10 and the inlet end of the exhaust pipe 12 are respectively connected with the blood sampling test tube 11, and blood in the blood sampling and transporting pipe 6 firstly flows through the inlet end of the sampling pipe 10 and then flows through the outlet end of the exhaust pipe 12; the sampling pipe 10 and the exhaust pipe 12 are respectively provided with a locking roll gap 2.
The outlet end of the separation cup 13 is in pipeline connection with the plasma collection pipe 14, the plasma collection pipe 14 is in pipeline connection with the saline pipe 15 through a tee joint, the saline pipe 15 is connected with the bottle stopper puncture device 5, and the saline pipe 15 is provided with a clamping piece 8. The plasma collecting bag 17 and the plasma collecting tube 14 form a pipeline connection, the plasma sampling test tube 16 is respectively connected with the outlet end of the sampling tube 10 and the inlet end of the exhaust tube 12, the inlet end of the sampling tube 10 and the outlet end of the exhaust tube 12 form a pipeline connection with the plasma collecting tube 14 through a tee joint, so that a pipeline connection is formed between the plasma sampling test tube 16 and the plasma collecting tube 14, and plasma in the plasma collecting tube 14 firstly flows through the inlet end of the sampling tube 10 and then flows through the outlet end of the exhaust tube 12.
When the plasma sampling operation is performed by using the plasma sampling line system, as shown in fig. 1, the blood collected by the blood collector 1 enters the separation cup 13 along the blood collection and transportation tube 6, the blood in the separation cup 13 is sufficiently centrifuged by the centrifuge, and then the separated plasma flows out from the plasma collection tube 14.
During the process of flowing the plasma along the plasma collecting tube 14, the plasma in the plasma collecting tube 14 flows through the inlet end of the sampling tube 10 connected to the plasma collecting tube 14 and then flows through the outlet end of the exhaust tube 12 connected to the plasma collecting tube, so the plasma can smoothly enter the plasma sampling test tube 16 from the inlet end of the sampling tube 10, and the air in the plasma sampling test tube 16 is discharged from the outlet end of the exhaust tube 12, enters the plasma collecting bag 17 through the plasma collecting tube 14, and finally is discharged from the plasma collecting bag 17. When the collection amount in the plasma sampling test tube 16 reaches the designated amount, the sampling tube 10, the exhaust tube 12 and the plasma collection tube 14 can be separated in a heat sealing mode, so that the plasma in the plasma sampling test tube 16 is obtained. Therefore, the traditional vacuum sampler can be completely eliminated in the whole plasma sampling operation, and an air filter is not required to be specially arranged in the sampling process, so that the plasma sampling cost is greatly reduced.
Generally, a plurality of plasma sampling test tubes 16 may be provided, each plasma sampling test tube 16 is respectively connected to the outlet end of a separate sampling tube 10 and the inlet end of a separate exhaust tube 12, the inlet end of the sampling tube 10 and the outlet end of the exhaust tube 12 respectively form a pipeline connection with the plasma collecting tube 14, and plasma in the plasma collecting tube 14 firstly flows through the inlet end of the sampling tube 10 and then flows through the outlet end of the exhaust tube 12. Wherein a locking roll 2 can be provided on the sampling tube 10. By adopting the structure design, the plasma in the plasma sampling test tubes 16 can be obtained at one time, so that plasma samples can be well prevented from being left or sampling errors, and the subsequent detection and sampling are more convenient. In addition, through bottle stopper puncture ware 5 and normal saline bag intercommunication, utilize salt solution pipeline 15 to input normal saline in collecting the pipe 14 to plasma, can also reduce the plasma volume of remaining in the pipeline consumptive material, improve the collection utilization ratio of plasma.
It should be noted that, in the above plasma sampling operation, the blood sampling tube 11 may also be used to sample the blood filtered by the blood filter 7, and the sampling method is the same as the above plasma sampling method, which is not described herein again.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, it should be noted that any modifications, equivalents and improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (10)

1. A plasma sampling pipe system, comprising a plasma collecting pipe (14) and a plasma sampling test tube (16), wherein the plasma sampling test tube (16) is connected with the plasma collecting pipe (14) through a pipeline, characterized in that: the plasma sampling test tube (16) is connected with the outlet end of the sampling tube (10) and the inlet end of the exhaust tube (12), the inlet end of the sampling tube (10) and the outlet end of the exhaust tube (12) are respectively connected with the plasma sampling tube (14) through pipelines, and plasma in the plasma sampling tube (14) firstly flows through the inlet end of the sampling tube (10) and then flows through the outlet end of the exhaust tube (12).
2. The plasma sampling tubing set of claim 1, wherein: the blood plasma collecting tube (14) is in tube connection with the saline tube (15), and the saline tube (15) is connected with the bottle stopper puncture device (5).
3. The plasma sampling tubing set of claim 2, wherein: the saline pipe (15) is provided with a clamping piece (8).
4. The plasma sampling tubing set of claim 1, wherein: plasma collection tube (14) be connected with separation cup (13) exit end, the entry end and the blood of separation cup (13) are adopted defeated tub (6) and are connected, blood adopt defeated tub (6) form the tube coupling with the entry end of sampling pipe (10), the exit end of blast pipe (12) respectively, the exit end of sampling pipe (10), the entry end of blast pipe (12) are connected with blood sampling test tube (11) respectively, and, blood in the blood collection and transportation pipe (6) flows through the entry end of sampling pipe (10) earlier, flows through the exit end of blast pipe (12) again.
5. The plasma sampling tubing set of claim 4, wherein: the exhaust pipe (12) is provided with a locking roll gap (2).
6. The plasma sampling tubing set of claim 4, wherein: the blood collecting and transporting pipe (6) is provided with a blood filter (7).
7. The plasma sampling tubing set of claim 6, wherein: the blood filter (7) and the pressure detector (9) form a pipeline connection.
8. The plasma sampling line system according to any one of claims 1-7, wherein: plasma sampling test tube (16) set up a plurality of, each plasma sampling test tube (16) is connected with the exit end of independent sampling pipe (10), the entry end of independent blast pipe (12) respectively, the entry end of sampling pipe (10), the exit end of blast pipe (12) form tube coupling with plasma collection pipe (14) respectively, plasma in plasma collection pipe (14) flows through the entry end of sampling pipe (10) earlier, flows through the exit end of blast pipe (12) again.
9. The plasma sampling tubing set of claim 8, wherein: the sampling pipe (10) is provided with a locking roll opening (2).
10. A method of sampling plasma, comprising: using the plasma sampling line system of any of claims 1-9.
CN201910993346.9A 2019-10-18 2019-10-18 Plasma sampling pipeline system and sampling method Withdrawn CN110859635A (en)

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CN201910993346.9A CN110859635A (en) 2019-10-18 2019-10-18 Plasma sampling pipeline system and sampling method

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
CN104225698A (en) * 2014-09-03 2014-12-24 西安交通大学 Hepatocyte microsphere bioartificial liver supporting system
CN104474600A (en) * 2015-01-07 2015-04-01 成都市佳颖医用制品有限公司 Plasma sampling separating device
CN104491945A (en) * 2014-12-31 2015-04-08 成都市佳颖医用制品有限公司 Blood plasma collecting device
CN204352269U (en) * 2014-12-31 2015-05-27 成都市佳颖医用制品有限公司 A kind of sampled plasma device
CN204543022U (en) * 2015-03-17 2015-08-12 四川南格尔生物科技有限公司 A kind of collection stem cell blood bagging apparatus
CN105854104A (en) * 2016-04-22 2016-08-17 四川南格尔生物科技有限公司 Annular separator applied to continuous blood plasma collection device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
CN104225698A (en) * 2014-09-03 2014-12-24 西安交通大学 Hepatocyte microsphere bioartificial liver supporting system
CN104491945A (en) * 2014-12-31 2015-04-08 成都市佳颖医用制品有限公司 Blood plasma collecting device
CN204352269U (en) * 2014-12-31 2015-05-27 成都市佳颖医用制品有限公司 A kind of sampled plasma device
CN104474600A (en) * 2015-01-07 2015-04-01 成都市佳颖医用制品有限公司 Plasma sampling separating device
CN204543022U (en) * 2015-03-17 2015-08-12 四川南格尔生物科技有限公司 A kind of collection stem cell blood bagging apparatus
CN105854104A (en) * 2016-04-22 2016-08-17 四川南格尔生物科技有限公司 Annular separator applied to continuous blood plasma collection device

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Application publication date: 20200306