CN110812451B

CN110812451B - Pain arthralgia pill and preparation method and application thereof

Info

Publication number: CN110812451B
Application number: CN201911165217.7A
Authority: CN
Inventors: 陈金玉; 陈从舫
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-25
Filing date: 2019-11-25
Publication date: 2022-01-04
Anticipated expiration: 2039-11-25
Also published as: CN110812451A

Abstract

The invention relates to a pain arthralgia pill, a preparation method and application thereof, wherein the pain arthralgia pill comprises raw material components of red ginseng, tall gastrodia tuber, white pseudo-ginseng, largehead atractylodes rhizome, parietal barberry root, pummelo peel, clematis root, east Asian tree fern rhizome, centipede, scorpion and stiff silkworm. The arthritis pill disclosed by the invention has the effects of tonifying kidney, nourishing blood, regulating collaterals and relieving pain, and has better curative effects on treating cold coagulation type thrombotic closed angiitis, acute and chronic anemofrigid-damp arthralgia, cervical and lumbar intervertebral disc protrusion, acute rheumatic fever and severe swelling pain, multiple neuritis, acroanesthesia pain, qi deficiency and transportation failure, dampness phlegm and blood death, facial nerve paralysis, various headache aeipathia diseases, vascular neurogenic disease, ophthalmically-derived rhinogenous trauma and headache of cerebroma, and particularly has obvious effects on treating rheumatism and lumbar intervertebral disc protrusion.

Description

Pain arthralgia pill and preparation method and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a pain arthralgia pill as well as a preparation method and application thereof.

Background

Arthralgia syndrome is the concept of traditional Chinese medicine, namely arthralgia syndrome, i.e. obstruction of qi by obstruction. Arthralgia syndrome refers to a syndrome of aching pain, numbness, heaviness, difficulty in flexion and extension of the joints and muscles, or even swelling and burning of the joints caused by wind, cold, dampness, heat, etc. on the body's exterior surface and meridians. Clinically, it has progressive or recurrent features. The main pathogenesis is the obstruction of qi and blood and the loss of nourishment of tendons, vessels and joints. The lumbar disc herniation, rheumatic arthritis, rheumatoid arthritis, sciatica, hyperosteogeny diseases and the like in modern medicine belong to the category of the traditional Chinese medicine arthralgia. Compared with western medicines, the traditional Chinese medicine has unique advantages in the aspect of treating arthralgia, but the existing medicines generally have the problems of slow effect, easy relapse and further improvement of treatment effect.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a pain arthralgia pill and a preparation method thereof. The arthritis pill has the effects of tonifying kidney, nourishing blood, regulating collaterals and relieving pain, has better curative effects on treating congealing cold type thrombotic occlusive angiitis, acute and chronic anemofrigid-damp arthralgia, cervical and lumbar intervertebral disc protrusion, acute rheumatic fever swelling and pain, multiple neuritis, acroanesthesia pain, qi deficiency dysfunction, dampness phlegm and blood stasis, facial paralysis, various headache aeipathia diseases, vascular neurogenic trauma, ophthalmically-derived rhinogenous trauma and headache of cerebroma, and particularly has obvious effects on treating rheumatism and lumbar intervertebral disc protrusion.

The technical scheme of the invention is as follows:

a TONGBI pill comprises Ginseng radix Rubri, rhizoma Gastrodiae, radix Notoginseng, rhizoma Polygoni Cuspidati, radix Berberidis kunmingensis, semen Trichosanthis and caulis et folium Gaultheriae Yunnanensis, radix Clematidis, rhizoma Cibotii, Scolopendra, Scorpio, and Bombyx Batryticatus.

Ginseng radix Rubri is dried root and rhizome of Panax ginseng C.A.Mey. Has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating qi, and regulating blood, and can be used for treating asthenia, collapse, cold limbs, slight pulse, qi failing to control blood, metrorrhagia, metrostaxis, etc.

Gastrodia elata (Gastrodia elata) Bl. is dried tuber of Gastrodia elata (Gastrodia elata) belonging to Orchidaceae. Has effects of calming endogenous wind, relieving spasm, suppressing liver yang, dispelling pathogenic wind, and dredging collaterals. It can be used for treating stirring of liver-wind, convulsive epilepsy, convulsion, vertigo, headache, numbness of limbs, hemiplegia, and rheumatalgia.

Panax notoginseng (Burk.) F.H.Chen is rhizome of Panax notoginseng (Burk.) F.Chen (Panax pseudo-ginseng var. japonica) of Araliaceae. Has effects in tonifying, strengthening body constitution, relieving pain, stopping bleeding, and dispelling blood stasis. Can be used for treating qi deficiency syndrome, carbuncle, swelling, traumatic injury, traumatic hemorrhage, cough with excessive phlegm, and hematemesis due to overstrain.

Seventhly, learning name: panax bipinnatifidus Seem is a plant of the genus Panax of the family Araliaceae. Has effects in invigorating lung, nourishing yin, activating collaterals, and stopping bleeding, and can be used for treating deficiency of both qi and yin, dysphoria with smothery sensation, thirst, cough due to asthenia, traumatic injury, hematemesis, and traumatic hemorrhage.

Radix Berberidis Amurensis is rhizome of Trillium tschonoskii Maxim of Trillium of Liliaceae and Trillium kamtschaticum pall. Has the functions of tranquilizing, relieving pain, promoting blood circulation and stopping bleeding. Can be used for treating hypertension, neurasthenia, vertigo, headache, lumbago, skelalgia, menoxenia, metrorrhagia, traumatic hemorrhage, and traumatic injury.

Guam and Rice, the whole herb of Amarylris radiata (Liparis fargesii) of Orchidaceae. Has effects in promoting salivation, quenching thirst, moistening lung, and relieving cough. Can be used for treating yin deficiency and dryness heat, dry throat, thirst, lung deficiency and dry cough, pulmonary tuberculosis, infantile hyperpyrexia, etc.

The radix Clematidis is dried root and rhizome of Clematis chinensis Osbeck, Clematis hexapetala pall or Clematis manshurica Rupr of Ranunculaceae. Pungent, salty and warm in nature. Has effects in dispelling pathogenic wind, removing dampness, and dredging channels and collaterals. Can be used for treating rheumatalgia, numbness of limbs, spasm of tendons and vessels, and difficulty in flexion and extension.

Rhizoma Cibotii is dried rhizome of Cibotium barometz (L.) J.Sm. of Unionidae. Bitter and sweet in taste and warm in nature. Dispel wind-damp, tonify liver and kidney, strengthen waist and knees. Can be used for treating rheumatalgia, soreness of waist and knees, and weakness of lower limbs.

Scolopendra is dried product of Scolopendra subspinipes mutilans L.Koch of Scolopendra family. Pungent and warm. Extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation. Can be used for treating liver wind stirring, spasm, convulsion, infantile convulsion, and apoplexy

Hemiplegia, tetanus, stubborn rheumatism, migraine, sore and ulcer, scrofula, snake and insect bite.

The Scorpio is dried body of Buthus martensii Karsch of Buthus martensii of Buthidae. Pungent and even. Extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation.

Bombyx Batryticatus is a dry body of Bombyx mori (Bombyx mori Linnaeus 4-5 instar larva of Bombycidae) killed by Beauveria bassiana (Bals.) Vuillant. Salty and pungent tasteGood sex. Has the effects of calming endogenous wind, relieving spasm, dispelling pathogenic wind, relieving pain, eliminating phlegm and resolving masses. It is commonly used in the mouth of liver wind with phlegm, epilepsy and convulsion, acute infantile convulsions, tetanus and apoplexy

Headache due to wind-heat, conjunctival congestion, pharyngalgia, pruritus due to rubella, and parotitis.

The arthritis-relieving pill comprises the following raw materials in parts by weight: 0.6 to 5 parts of red ginseng, 0.3 to 3 parts of tall gastrodia tuber, 0.3 to 3 parts of white pseudo-ginseng, 0.3 to 3 parts of largehead galingale rhizome, 0.8 to 5 parts of root of Chinese barberry, 0.5 to 3 parts of Guam rice and Huanyang, 0.3 to 3 parts of clematis root, 0.3 to 3 parts of east Asian tree fern rhizome, 0.3 to 3 parts of centipede, 0.3 to 3 parts of scorpion and 0.3 to 3 parts of stiff silkworm.

Preferably, the arthritis-relieving pill comprises the following raw material components:

1 to 2 parts of red ginseng, 0.5 to 1.5 parts of tall gastrodia tuber, 0.5 to 1.5 parts of white pseudo-ginseng, 0.5 to 1.5 parts of largehead galingale rhizome, 1.5 to 3 parts of root of Chinese barberry, 1 to 2 parts of garden balsam stem and rice, 0.5 to 1.5 parts of clematis root, 0.5 to 1.5 parts of east Asian tree fern rhizome, 0.5 to 1.5 parts of centipede, 0.5 to 1.5 parts of scorpion and 0.5 to 1.5 parts of stiff silkworm.

1.5 parts of red ginseng, 1 part of gastrodia elata, 1 part of white pseudo-ginseng, 1 part of rhizoma polygoni multiflori, 2 parts of root of common barberry, 1.5 parts of fortune's-drynaria rhizome, 1 part of clematis root, 1 part of east Asian tree fern rhizome, 1 part of centipede, 1 part of scorpion and 1 part of stiff silkworm.

The preparation method of the arthritis pain pill comprises the following steps:

(1) mixing and crushing the panax notoginseng, the root of Chinese paris, the root of common cephalanoplos and the root of common nightshade herb, then adding ethanol for reflux extraction to obtain an extracting solution, and filtering and concentrating under reduced pressure to obtain an extract;

(2) weighing red ginseng, gastrodia elata, clematis chinensis, rhizoma cibotii, centipede, scorpio and stiff silkworm respectively, drying respectively, crushing to obtain raw material powder, and mixing the raw material powder to obtain mixed medicinal powder;

(3) and (3) adding the mixed medicinal powder in the step (2) into the extract in the step (1), uniformly mixing, and then preparing a pill, namely the arthritis-pain pill.

Preferably, in the step (1), the crushing is carried out until the particle size is 20-60 meshes; the concentration of the ethanol is 80-90 wt%, the volume ratio of the mass of the crushed mixture to the ethanol is 1g:10-20ml, and the extraction time is 1-2 h; the concentration is carried out until the relative density is 1.02-1.05.

Preferably, in step (1), the extraction is performed twice, the first extraction is performed for 1.5h, and the second extraction is performed for 0.5 h.

Preferably, in the step (2), the drying is performed until the water content is 6 to 8%.

Preferably, in the step (2), the particle size of each raw material powder is 40 to 100 mesh.

The pain bi pills are applied to the preparation of medicines for treating cold-coagulation type thrombotic closed-cold vasculitis, acute and chronic wind-cold-dampness arthralgia, cervical and lumbar intervertebral disc protrusion, acute rheumatic fever and severe swelling and pain, polyneuritis acroanesthesia and pain, qi deficiency and transportation failure with damp phlegm and blood death, facial nerve paralysis, various headache aeipathia diseases, vascular neurogenic disease, eye-borne rhinogenic trauma and headache caused by brain tumor.

The invention has the beneficial effects that:

the invention relates to a Tongbi pill, which takes radix notoginseng and rhizoma polygoni multiflori as monarch drugs, red ginseng and berberis capitata as minister drugs, the radix notoginseng and the rhizoma polygoni capitata are vital drugs for tonifying qi, can dilate blood vessels and improve blood circulation, and the red ginseng is used as adjuvant drugs for enhancing drug effect, the radix berberis capitata is has the functions of reducing blood fat, reducing blood pressure, dissolving thrombus and promoting angiogenesis, and has better capacity of promoting angiogenesis, the semen trichosanthis, the radix clematidis, the rhizoma cibotii, the rhizoma gastrodiae have the functions of clearing and activating the channels and collaterals and removing dampness, and the centipedes, the scorpios and the batryticated silkworm have the functions of dredging meridians and clearing blood vessel garbage. The medicines have the effects of nourishing blood and dredging collaterals, and the medicines are combined to tonify the kidney and nourish the blood, and coordinate collaterals to relieve pain. The traditional Chinese medicine composition has good curative effects on treating cold-coagulation type thrombotic closed-cold vasculitis, acute and chronic anemofrigid-damp arthralgia, cervical and lumbar disc herniation, acute rheumatic fever and severe swelling and pain, multiple neuritis acroanesthesia pain, qi deficiency and transportation failure with damp phlegm and blood death, facial nerve paralysis, various headache and pertinence diseases, vascular neurogenic disease, ophthalmic rhinogenic traumatic injury and headache of cerebroma, and particularly has remarkable effects on treating rheumatism and lumbar disc herniation.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.

Example 1

The embodiment provides a pain arthralgia pill which comprises the following raw material components:

0.6 part of red ginseng, 0.3 part of gastrodia elata, 0.3 part of white pseudo-ginseng, 0.3 part of rhizoma polygoni multiflori, 0.8 part of cacumen platycladi, 0.5 part of semen trichosanthis, 0.3 part of radix clematidis, 0.3 part of rhizoma cibotii, 0.3 part of centipede, 0.3 part of scorpion and 0.3 part of stiff silkworm.

Further, a method for preparing the arthritis pain pill is provided, which comprises the following steps:

(1) mixing radix et rhizoma Rhei Lijiangensis, rhizoma Polygoni Cuspidati, herba Berberidis Amurensis and semen Trichosanthis Cucumeroidis, pulverizing to particle size of 20 mesh, adding 80 wt% ethanol (the pulverized mixture: ethanol 1g:10ml), reflux extracting for 1h to obtain extractive solution, filtering, and concentrating under reduced pressure to relative density of 1.02 to obtain extract;

(2) weighing red ginseng, gastrodia elata, radix clematidis, rhizoma cibotii, centipede, scorpio and stiff silkworm respectively, drying until the water content is 6%, crushing to obtain raw material powder with the particle size of 40 meshes, and mixing the raw material powder to obtain mixed medicinal powder;

(3) and (3) adding the mixed medicinal powder in the step (2) into the extract in the step (1), uniformly mixing, and then preparing pills (5 g per 65 pills), namely the arthritis-pain pills.

Example 2

5 parts of red ginseng, 3 parts of gastrodia elata, 3 parts of white pseudo-ginseng, 3 parts of rhizoma polygoni multiflori, 5 parts of root of common cephalanoplos, 3 parts of semen trichosanthis, 3 parts of radix clematidis, 3 parts of rhizoma cibotii, 3 parts of centipede, 3 parts of scorpio and 3 parts of stiff silkworm.

(1) mixing radix et rhizoma Rhei Lijiangensis, rhizoma Polygoni Cuspidati, herba Berberidis Amurensis and semen Trichosanthis, pulverizing to 60 mesh, adding 90 wt% ethanol (the pulverized mixture: ethanol 1g:20ml), reflux extracting for 2h to obtain extractive solution, filtering, and concentrating under reduced pressure to relative density of 1.05 to obtain extract;

(2) weighing red ginseng, gastrodia elata, radix clematidis, rhizoma cibotii, centipede, scorpio and stiff silkworm respectively, drying until the water content is 8%, crushing to obtain raw material powder with the particle size of 100 meshes, and mixing the raw material powder to obtain mixed medicinal powder;

Example 3

1 part of red ginseng, 0.5 part of gastrodia elata, 0.5 part of panax notoginseng, 0.5 part of rhizoma polygoni multiflori, 1.5 parts of berberis pubescens, 1 part of semen trichosanthis, 0.5 part of radix clematidis, 0.5 part of rhizoma cibotii, 0.5 part of centipede, 0.5 part of scorpion and 0.5 part of stiff silkworm.

(1) mixing radix et rhizoma Rhei Lijiangensis, rhizoma Polygoni Cuspidati, herba Berberidis Amurensis and semen Trichosanthis Cucumeroidis, pulverizing to particle size of 40 mesh, adding 80 wt% ethanol (the pulverized mixture: ethanol 1g:12ml), reflux extracting for 1.5h to obtain extractive solution, filtering, and concentrating under reduced pressure to relative density of 1.03 to obtain extract;

(2) weighing red ginseng, gastrodia elata, radix clematidis, rhizoma cibotii, centipede, scorpio and stiff silkworm respectively, drying until the water content is 8%, crushing to obtain raw material powder with the particle size of 80 meshes, and mixing the raw material powder to obtain mixed medicinal powder;

Example 4

2 parts of red ginseng, 1.5 parts of gastrodia elata, 1.5 parts of white pseudo-ginseng, 1.5 parts of rhizoma polygoni multiflori, 3 parts of parietal barberry, 2 parts of semen trichosanthis, 1.5 parts of radix clematidis, 1.5 parts of rhizoma cibotii, 1.5 parts of centipede, 1.5 parts of scorpion and 1.5 parts of stiff silkworm.

(1) mixing radix et rhizoma Rhei Lijiangensis, rhizoma Polygoni Cuspidati, herba Berberidis Amurensis and semen Trichosanthis Cucumeroidis, pulverizing to particle size of 40 mesh, adding 85 wt% ethanol (the pulverized mixture: ethanol 1g:12ml), reflux extracting for 1.8h to obtain extractive solution, filtering, and concentrating under reduced pressure to relative density of 1.03 to obtain extract;

(2) weighing red ginseng, gastrodia elata, radix clematidis, rhizoma cibotii, centipede, scorpio and stiff silkworm respectively, drying until the water content is 8%, crushing to obtain raw material powder with the particle size of 60 meshes, and mixing the raw material powder to obtain mixed medicinal powder;

Example 5

(1) mixing radix et rhizoma Rhei Lijiangensis, rhizoma Polygoni Cuspidati, herba Berberidis Amurensis and semen Trichosanthis Cucumeroidis, pulverizing to particle size of 40 mesh, adding 85 wt% ethanol (the pulverized mixture: ethanol 1g:10ml), reflux-extracting for two times, extracting for the first time for 1.5 hr and extracting for the second time for 0.5 hr to obtain extractive solution, filtering, and concentrating under reduced pressure to relative density of 1.03 to obtain extract;

Comparative example 1

The comparative example provides a pain arthralgia pill which comprises the following raw materials:

1.5 parts of red ginseng, 1 part of gastrodia elata, 1 part of white pseudo-ginseng, 1 part of rhizoma polygoni multiflori, 2 parts of safflower, 1.5 parts of salvia miltiorrhiza, 1 part of clematis chinensis, 1 part of rhizoma cibotii, 1 part of centipede, 1 part of scorpion and 1 part of stiff silkworm.

The preparation method of the arthritis-pain pill comprises the following steps:

(1) mixing radix et rhizoma Gynurae Divaricatae, rhizoma Polygoni Cuspidati, Carthami flos and Saviae Miltiorrhizae radix, pulverizing to particle size of 40 mesh, adding 85 wt% ethanol (the pulverized mixture: ethanol 1g:10ml), reflux-extracting for two times, the first time for 1.5 hr, and the second time for 0.5 hr to obtain extractive solution, filtering, and concentrating under reduced pressure to relative density of 1.03 to obtain extract;

(3) and (3) adding the mixed medicinal powder in the step (2) into the extract in the step (1), uniformly mixing, and then preparing pills (5 g per 65 pills), namely the arthritis-pain pills. The comparative example differs from example 5 in that safflower is used instead of the first pearl and salvia is used instead of the melon and rice but also yang.

Comparative example 2

1.5 parts of red ginseng, 1 part of gastrodia elata, 1 part of white pseudo-ginseng, 1 part of rhizoma polygoni multiflori, 0.5 part of cacumen platycladi, 4 parts of fortune windmillpalm herb, 1 part of radix clematidis, 1 part of rhizoma cibotii, 1 part of centipede, 0.5 part of scorpion and 0.5 part of stiff silkworm.

(3) and (3) adding the mixed medicinal powder in the step (2) into the extract in the step (1), uniformly mixing, and then preparing pills (5 g per 65 pills), namely the arthritis-pain pills. The total amount of the raw materials of the comparative example is the same as that of the example 5, and the difference is that the mixture ratio of the raw materials is different.

Test examples

1. Test of influence of the drug of the invention on the level of the peripheral blood cytokines of rats with wind-cold-dampness arthralgia syndrome

1.1 test animals and groups: healthy Lewis rats, females, weighing 180-. All rats were randomly divided into 5 groups of 6 rats each.

1.2 test molding: each group of rats was made inflammatory by injecting 0.1ml of complete Freund's adjuvant into the right hind plantar skin, and then the rats were placed in cold water at 5-7 ℃ and 2cm deep and allowed to stand for 20min while being given wind power at a wind speed of 6m/s 1 time a day for 10 consecutive days. Then, the rats in each group have obvious swelling on the right foot, the joints are not flexible, the appetite is reduced, and the wind-cold-dampness arthralgia syndrome modeling is successful.

1.3 administration method: the molding was successful and then administration was started, (1) example 5 drug group: the drug prepared in example 5 was administered; (2) comparative example 1 drug group: the drug prepared in comparative example 1 was administered; (3) comparative example 2 drug group: the drug prepared in comparative example 2 was administered; (4) positive control group: the rheumatism pill is given. Grinding the above materials into powder, adding normal saline, mixing to obtain 1mg/mL medicinal liquid, and intragastrically administering at a dose of 10 mL/kg; (5) negative control group: an equal volume of saline was administered. Each group was administered 1 time daily for 20 consecutive days, all rats were fed under the same conditions, and each group of rats was decapitated and bled for cytokine detection on day 21 after administration.

1.4 test results, see Table 1.

TABLE 1 cytokine assay results for each group

Group of	Number of examples	IL-4	IL-6	IL-10
					Negative control group	6	7.55±1.52	11.73±1.66	54.62±4.12
Positive control group	6	36.97±2.96	15.35±2.02	100.21±7.11
					EXAMPLE 5 drug group	6	43.52±4.02^**#	17.54±2.38^*#	136.73±7.31^**#
Comparative example 1 drug group	6	36.74±3.21^**	14.26±1.95	97.48±5.04^*
					Comparative example 2 drug group	6	40.33±3.78^**	15.59±1.97	123.56±6.86^**

Compared with the negative control group, the ratio of the positive control group,^*p<0.05，^**p<0.01; compared with the positive control group, the ratio of the positive control group,^#p<0.05。

2. clinical test of the treatment effect of the medicine on rheumatism

2.1 general data 96 patients with rheumatism were selected, and all subjects met the diagnosis standards of the American society for rheumatism: firstly, morning stiffness symptoms appear for more than 6 weeks, and the time of each attack is not shorter than 1 h; ② swelling of at least 3 joints; ③ symmetric joint swelling, and the time is more than 6 weeks; fourthly, subcutaneous nodules; swelling of the wrist, palm or proximal interphalangeal joints for more than 6 weeks; sixthly, the rheumatoid factor is positive; and the X-ray inspection result shows osteoporosis. The diagnosis can be confirmed by the agreement of 4 of the above 7 items. All subjects were randomized into 2 groups of 48 patients each, and the patients in each group were comparable in sex, age, and stage of joint X-ray.

2.2 methods of treatment the invention (example 5) and the rheumatism pills were administered separately in the following groups: the medicine is orally taken 5g (65 pills) each time after breakfast and supper every day, and the rheumatism pill is taken 6g (1 pill) each time after breakfast and supper every day for 3 months.

2.3 the curative effect standard is cured: the clinical symptoms completely disappear, and no recurrence occurs; the effect is shown: the clinical symptoms are obviously relieved, and the symptoms are that the morning stiffness attack frequency is reduced by more than half within 2 consecutive weeks, the attack time is obviously shortened, the joint swelling disappears, the pain is not obvious, and the joint movement is basically recovered to be normal; the method has the following advantages: the clinical symptoms are reduced, which is characterized in that the morning stiffness attack frequency is reduced 1/3-1/2 within 2 consecutive weeks, the attack time is shortened, the joint swelling is relieved, and the joint still has active pain; and (4) invalidation: the effect is the same as before treatment. Effective rate is (curative case + significant case + effective case)/number of cases.

2.4 therapeutic effects the overall therapeutic effect is shown in Table 2.

TABLE 2 Overall therapeutic Effect of the groups

Group of	Number of examples	Cure of disease	Show effect	Is effective	Invalidation	High efficiency
							EXAMPLE 5 drug group	48	8(16.67)	21(43.75)	15(31.25)	4(8.33)	91.67％
Commercially available drug group	48	5(10.42)	17(35.42)	15(31.25)	11(22.92)	77.08％

The results show that the total effective rate of the medicine for treating rheumatism reaches 91.67 percent, which is obviously superior to the commercially available medicine, and the curative effect of the medicine for treating rheumatism is obvious.

3. Typical cases of treatment effect of the medicine on lumbar disc herniation

Patient 1: when a certain Chinese fiddle is in the age of 63 years and suffers from lumbar disc herniation, the doctor is seeking to seek no effect in four places, the Chinese fiddle starts to be taken 5 months in 1996, the Chinese fiddle is healed after being taken for 3 months, and the Chinese fiddle does not relapse after being taken for 10 years.

Patient 2: when a certain plum is aged 55 years old and male, the male suffers from lumbar disc herniation, the pain is difficult to describe, the physical activity cannot be performed, the drug is taken at 9 months in 2009, the patient is healed after taking the drug for 3 months, and the disease does not recur in 6 years of follow-up visit.

Patient 3: in a certain grandson, male, age 46, suffering from lumbar disc herniation, difficulty in standing and walking, the medicine is taken in 2016 for 1 month, symptoms are obviously relieved after the medicine is taken for 1 month, and then the medicine is continuously taken until the disease is healed, and no relapse occurs in 6 years after follow-up.

Patient 4: when a male is 30 years old, the male suffers from lumbar disc herniation, the back of the male has pain, the pain is aggravated under the action of gravity, mild disc herniation is detected by a hospital, the drug is taken in 3 months in 2018, the male heals after taking the drug for 1 month, and the male does not relapse in 6 years of follow-up visit.

Patient 5: when a certain Zhao is a woman in age of 54, the lumbar disc herniation is suffered, the medicine is taken at 9 months in 2003, the symptoms are obviously relieved after the medicine is taken for 2 months, the medicine is continuously taken until the disease is cured, and the disease does not relapse in 6 years of follow-up visit.

Patient 6: when a certain grandson is aged 76 years old, the male suffers from lumbar disc herniation, can not walk and can not stand, the medicine is taken in 1 month in 2017, the symptoms are obviously relieved after the medicine is continuously taken for 3 months, and the male is healed after the medicine is continuously taken.

Patient 7: one of grandsons, male, 57 years old, suffered from lumbar disc herniation, was treated by doctors in many hospitals in Hubei and Hunan provinces and folk doctors in self-statement, but the effect is not obvious, the medicine is taken in 5 months in 2001, the medicine is obviously relieved after being continuously taken for 3 months, the medicine is continuously taken until the disease is cured, and the follow-up visit is not recurrent.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The arthritis-relieving pill is characterized by being prepared from the following raw materials:

0.6 to 5 parts of red ginseng, 0.3 to 3 parts of tall gastrodia tuber, 0.3 to 3 parts of white pseudo-ginseng, 0.3 to 3 parts of largehead atractylodes rhizome, 0.8 to 5 parts of root of Chinese barberry, 0.5 to 3 parts of Guam rice, 0.3 to 3 parts of clematis root, 0.3 to 3 parts of east Asian tree fern rhizome, 0.3 to 3 parts of centipede, 0.3 to 3 parts of scorpion and 0.3 to 3 parts of stiff silkworm;

2. The gout flaccid pill of claim 1 wherein the raw materials comprise:

3. The gout flaccid pill of claim 1 wherein the raw materials comprise:

4. The gout flaccid pill of claim 1 wherein in step (1), the pulverization is to a particle size of 20-60 mesh.

5. The gout flaccid arthralgia pill according to claim 1, wherein in the step (1), the concentration of ethanol is 80-90 wt%, the volume ratio of the mass of the crushed mixture to the volume of the ethanol is 1 g/10-20 ml, and the extraction time is 1-2 hours; the concentration is carried out until the relative density is 1.02-1.05.

6. The gout flaccid pill of claim 1 wherein in step (1), the extraction is performed twice, the first extraction being performed for 1.5 hours and the second extraction being performed for 0.5 hours.

7. The gout flaccid pill of claim 1 wherein in step (2), the pill is dried to a moisture content of 6-8%.

8. The gout flaccid pill of claim 1, wherein in step (2), the particle size of each raw material powder is 40-100 mesh.

9. The use of the TONGBI pill of any one of claims 1-3 in the preparation of a medicament for treating congealing cold type thromboangiitis obliterans, acute and chronic anemofrigid-damp arthralgia, cervical and lumbar disc herniation, acute rheumatic fever with swelling and pain, multiple neuritis, acroanesthesia and pain, qi deficiency with transportation and blood stasis due to damp phlegm, facial paralysis, various types of headache aeipathia, vascular neurogenic disease, oculogenic rhinogenic traumatic injury, and headache due to cerebroma.