CN107174625B

CN107174625B - Traditional Chinese medicine composition for treating lumbar foreign body sensation after lumbar internal fixation

Info

Publication number: CN107174625B
Application number: CN201710499763.9A
Authority: CN
Inventors: 刘焕发; 李芳�
Original assignee: Weifang Huichu Information Technology Co Ltd
Current assignee: Huichu (Shandong) Intellectual Property Service Co.,Ltd.
Priority date: 2017-06-27
Filing date: 2017-06-27
Publication date: 2020-09-25
Anticipated expiration: 2037-06-27
Also published as: CN107174625A

Abstract

The invention discloses a traditional Chinese medicine composition for treating lumbar foreign body sensation after lumbar internal fixation, which is prepared from the following raw materials in parts by weight: 12 parts of ginseng, 15 parts of epimedium, 10 parts of fructus psoraleae, 10 parts of curculigo orchioides, 10 parts of sambucus chinensis, 30 parts of Chinese herbaceous peony, 12 parts of poria with hostwood, 12 parts of scorpion, 5 parts of prepared kusnezoff monkshood root, 9 parts of rhubarb, 15 parts of yam rhizome, 5 parts of Chinese alangium, 5 parts of argy wormwood fruit, 12 parts of cinnamomum cassia bark, 12 parts of oyster, 6 parts of magnolia officinalis, 20 parts of tuber fleeceflower stem and 12 parts of kadsura pepper stem. The Chinese herbal medicines used by the invention all conform to the regulations of the national drug dictionary of people's republic of China, and according to compatibility of medicines, the Chinese herbal medicine has the effects of tonifying liver and kidney, nourishing heart, soothing nerves, promoting blood circulation, removing blood stasis, clearing and activating the channels and collaterals, and removing arthralgia, and has an obvious effect of treating lumbar foreign body sensation after lumbar internal fixation.

Description

Traditional Chinese medicine composition for treating lumbar foreign body sensation after lumbar internal fixation

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating lumbar foreign body sensation after lumbar internal fixation and a medicament thereof.

Background

The internal lumbar fixing operation is widely suitable for treating diseases such as lumbar fracture, unstable lumbar, lumbar spondylolisthesis, lumbar spinal stenosis and the like, and because the internal fixing object is deeply positioned, the injury caused by operation taking is large, so the internal fixing object is not taken out after the patient is cured. The internal fixed object is placed in the body of a patient for years and decades, no obvious symptoms exist, but some patients always feel foreign body sensation in the body and influence the waist movement, so that the patient is anxious and insomnia, and even cannot normally work and live.

The mechanism of the appearance of the waist foreign body sensation after the internal lumbar fixation is not completely clear at present, and the mechanism can be possibly related to the injury of blood vessels and innervation of tissues such as local muscles, bones, ligaments and the like in the lumbar operation, the local stability is changed, the normal physiological curvature of the lumbar after the internal fixation of the adjacent segments is influenced, and the rejection reaction of internal fixation objects exists in some patients to a greater or lesser extent;

modern medicine cannot find a good treatment method for the phenomenon, only can repeatedly comfort patients, and even if internal fixtures are removed, the symptoms of the patients are not improved and the patients pay the cost of reoperation. The traditional Chinese medicine considers that: patients feel the retention of foreign matters in the waist because the patients suffer from external injury, the blood stasis blocks the channels and collaterals, or the factors of liver and kidney deficiency, muscle and bone deficiency, the blood stasis is retained after the operation, the channels and collaterals are blocked and blocked, and in addition, the patients lie in bed for a long time, the muscles and bones are not nourished, so that the waist is not flexible and the movement is not good.

Disclosure of Invention

The invention aims to solve the technical problem of providing a traditional Chinese medicine composition for treating foreign body sensation at the waist after lumbar internal fixation and a medicament thereof.

In order to solve the technical problems, the technical scheme of the invention is as follows: a traditional Chinese medicine composition for treating waist foreign body sensation after lumbar internal fixation is prepared from the following raw materials in parts by weight: 12 parts of ginseng, 15 parts of epimedium, 10 parts of fructus psoraleae, 10 parts of curculigo orchioides, 10 parts of sambucus chinensis, 30 parts of Chinese herbaceous peony, 12 parts of poria with hostwood, 12 parts of scorpion, 5 parts of prepared kusnezoff monkshood root, 9 parts of rhubarb, 15 parts of yam rhizome, 5 parts of Chinese alangium, 5 parts of argy wormwood fruit, 12 parts of cinnamomum cassia bark, 12 parts of oyster, 6 parts of magnolia officinalis, 20 parts of tuber fleeceflower stem and 12 parts of kadsura pepper stem.

The invention can be prepared into various preparations acceptable in traditional Chinese pharmacology, preferably decoction, and the preparation method comprises the following steps:

firstly, grinding ginseng and epimedium herb in parts by weight, putting the ground ginseng and epimedium herb into an enzymolysis container, then adding water in an amount which is 5 times the weight of the ginseng and the epimedium herb, adding 1.2% of cellulose hydrolase and pectin hydrolase, hydrolyzing for 12 hours at 30 ℃, and then filtering dregs to obtain enzyme hydrolysate;

grinding dried fructus psoraleae, rhizoma curculiginis, poria with hostwood, prepared kusnezoff monkshood root, rheum officinale, yam rhizome, Chinese alangium root, cinnamomum wilsonii hance, cortex cinnamomi japonici, mangnolia officinalis, tuber fleeceflower stem and kadsura pepper stem by using a grinder, adding crushed oyster in advance, adding distilled water with the total dosage 3 times that of the fructus psoraleae, the rhizoma curculiginis, the poria with hostwood, the prepared kusnezoff monkshood root, rheum officinale, the yam rhizome, the Chinese alangium root, the cinnamomum wilsonii hance, the magnolia officinalis, the tuber fleeceflower stem, the kadsura pepper stem and the oyster, extracting in;

step three, uniformly mixing fresh Chinese forgetmenot root, Chinese herbaceous peony and argy wormwood, then smashing by a beater, mixing with the dregs obtained in the step one and the step two after smashing, adding 75-79% of ethanol for extraction, extracting, decompressing, recovering the solvent, then placing for 120-135 min, placing at the temperature of 8-12 ℃, then filtering to obtain a mixed solvent, and removing precipitates;

step four, mixing the enzyme hydrolysate obtained in the step one, the water bath extracting solution obtained in the step two and the mixed solvent obtained in the step three, firstly concentrating the mixture into liquid medicine with the volume equivalent to 1 to 1.5g of the original medicinal material per milliliter by a water bath method, and then distilling and concentrating the liquid medicine under negative pressure and spray drying the liquid medicine to obtain solid extract powder of the traditional Chinese medicine extract;

step five, weighing 100g of the traditional Chinese medicine extract solid paste powder, and preparing 1000ml of oral medicament with 200ml per bag, wherein the rest is distilled water.

The application method and the dosage are as follows: it is administered orally one bag each time, once a day, in the morning and evening. A treatment course is 10 days.

The medicine mechanism of the invention is as follows:

ginseng: tonify primordial qi, promote the production of body fluid, nourish blood, induce tranquilization and promote intelligence. Can be used for treating asthenia, cold limbs, deficiency of both qi and blood, asthenia due to chronic diseases, palpitation, and insomnia.

Herba epimedii: tonify kidney yang, strengthen tendons and bones, dispel wind-damp. Can be used for treating kidney yang deficiency, sexual impotence, nocturnal emission, tendons and bones flaccidity, rheumatalgia, numbness and contracture.

Psoralea fruit: warming kidney and tonifying yang; can be used for treating kidney yang deficiency, sexual impotence, spermatorrhea, enuresis, frequent micturition, and cold pain of waist and knee.

Rhizoma curculiginis: tonify kidney yang, strengthen tendons and bones, dispel cold-dampness. It can be used for treating atrophy-flaccidity of tendons and bones, and cold pain of waist and knees.

Chinese forgetmenot root: promoting blood circulation and removing blood stasis; relieving swelling and pain. Traumatic injury is mainly caused; and (5) fracture.

Peony: clear heat and cool blood, dissipate blood stasis and alleviate pain. Can be used for treating heat entering nutrient-blood, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain, and traumatic injury.

Poria with hostwood: tranquilize the heart, induce tranquilization and induce diuresis. Can be used for treating palpitation, amnesia, insomnia, and epilepsy due to heart deficiency.

Scorpion: extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation. Can be used for treating stirring of liver wind, spasm, convulsion, hemiplegia, rheumatism, suppurative sore, and lymphoid tuberculosis.

Preparing kusnezoff monkshood root; dispel wind and dampness, warm meridians and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness and arthralgia.

Rhubarb, radix et rhizoma Rhei purges and purges away accumulation, dispels blood stasis and unblocks meridians, and promotes diuresis to alleviate jaundice. Can be used for treating traumatic injury.

Bi Xie can promote diuresis, remove turbid pathogen, dispel wind and remove arthralgia. Can be used for treating rheumatic arthralgia, joint discomfort, and pain of waist and knees.

The Chinese alangium root, radix Alangii, has the effects of dispelling pathogenic wind, removing dampness, relaxing muscles and tendons, activating collaterals, dissipating blood stasis and relieving pain. Can be used for treating rheumatalgia, numbness of limbs, and traumatic injury.

Performing moxa cone: warming kidney and strengthening yang. Kidney deficiency with soreness of waist; yang deficiency with internal cold.

Chuan Gui Pi, in order to induce sweat and release muscles, warm and dredge meridians, strengthen yang and regulate qi, and smooth Chong and descend qi. Can be used for treating arthralgia, phlegm retention, edema, palpitation, and galloping.

Oyster shell: calming the liver and suppressing yang; heavy-weight tranquilizing; soften hardness and dissipate nodulation. Palpitation and insomnia; scrofula and goiter; abdominal mass.

Hou Po can dry dampness and resolve phlegm, descend qi and remove fullness. Can be used for treating damp stagnation, abdominal mass, qi stagnation, phlegm retention, asthma and cough.

Caulis Polygoni Multiflori: nourish heart and induce tranquilization, dispel wind and dredge collaterals. Treating insomnia, dreaminess, blood deficiency, body pain, skin numbness, rheumatic arthralgia, and rubella with pruritus.

Caulis Piperis Futokadsurae has effects of dispelling pathogenic wind and removing dampness, dredging channels and collaterals, and relieving arthralgia. Can be used for treating arthralgia due to wind-cold-dampness, pain of limbs and joints, spasm of tendons and vessels, and difficulty in flexion and extension.

The invention uses ginseng, psoralea fruit, epimedium herb, ginseng, scorpion, kadsura pepper stem, rhubarb, rhizoma rhei, cortex cinnamomi, scorpion, caulis piperis futokadsurae, rheum officinale, polygonum multiflorum, oyster, poria cocos, caulis polygoni multiflori, oyster, heart nourishing, nerve soothing, rhizoma dioscoreae, radix aconiti feri, radix paeoniae, blood nourishing, muscle softening and tendon removing arthralgia, and compatibility of magnolia officinalis, rhizoma curculiginis, abrus herb, fructus artemisiae.

The indications and effects of the above herbs are all referred to in the 2010 edition of the Chinese pharmacopoeia.

The following is a summary of clinical trials: 26 cases of clinical experiments for treating foreign body sensation after lumbar internal fixation

Clinical symptoms and physical signs of foreign body sensation after lumbar internal fixation, namely patients feel that foreign bodies remain in the waist and move difficultly after the lumbar internal fixation in the later half year, and daily life is influenced; the lumbar vertebrae of the physical examination patient is not obviously limited in movement, and the fixed object in the imaging examination does not fall off and press adjacent tissues.

The treatment results are as follows: 26 patients with foreign body sensation after lumbar internal fixation are clinically treated, the decoction is orally taken one bag at a time, one time is taken in the morning and at night, and 10 days are a treatment course. After three treatment courses, 19 cases of the traditional Chinese medicine composition have obvious effect, 73 percent of the obvious effect, 5 cases of improvement, 19 percent of the obvious effect, 2 cases of no effect, 8 percent of the ineffective effect and 92 percent of the total effective rate. As shown by treatment, the medicine has no side effect on patients, and no abnormality is found in three routine tests and liver and kidney function detection.

Several typical cases are listed below:

case 1: a patient lies in a certain woman and is 45 years old, 1.5 years after lumbar internal fixation, the patient feels that foreign body sensation at a knife edge is detected for 4 months, the patient has pain in the waist and limited movement after trauma, the local hospital diagnoses that the lumbar is fractured, the vertebral canal decompression internal fixation can participate in physical labor after 1 year, the patient always feels that foreign body is left at the knife edge in nearly 4 months, the internal fixation influences the lumbar movement, the patient goes to an operation hospital to seek treatment, the internal fixation is shown to be not fractured or fallen by shooting, and an operating doctor tells the patient to have no problem in the operation without special treatment. However, patients feel discomfort in the waist and are difficult to bear, so that the patients can see a doctor in our hospital, the foreign body sensation in the waist is relieved after taking the medicine orally for one treatment course, the waist moves better than before, and the symptoms disappear after three treatment courses.

Case 2: a patient is cured of a certain patient, male or 62 years old, is diagnosed with a foreign body sensation at a knife edge for 5 months after 1 year, and is diagnosed with spinal stenosis and spinal canal decompression internal fixation in a local hospital for more than 1 year due to weakness and lameness of two lower limbs after lumbar internal fixation, so that the postoperative numbness of the lower limbs is relieved, and the lameness disappears. In the last 5 months, the doctor always feels that foreign matters exist at the knife edge, the internal fixing objects influence the lumbar movement, the doctor asks for treatment in multiple hospitals, the doctor considers that the internal fixing objects are not obviously related to the feeling of the lumbar foreign matters, but the patient always feels that the lumbar foreign matters exist and are hard to endure, so that the patient is difficult to sleep at night, and the internal fixing objects are strongly required to be taken out.

Case 3: a patient is in Song Dynasty, male and 31 years old, the patient is diagnosed with the foreign body sensation at the knife edge for 6 months after 2 years of lumbar internal fixation, the waist of the patient is painful, the activity of the patient is limited, the left lower limb is numb and powerless for 3 years, the lumbar intervertebral disc protrusion occurs in a local hospital, the nucleus pulposus is extirpated and the internal fixation is performed, the physical labor can be performed after 1 year, the patient always feels that the foreign body is remained at the knife edge to obstruct the waist activity in about 6 months, the internal fixation is found to be broken after the examination is performed in an operation hospital, but the internal fixation is not separated, and an operator thinks that the self sensation of the waist is not greatly related. However, patients feel discomfort in the waist and are difficult to bear, so that the patients can see a doctor in our hospital, the foreign body sensation in the waist is relieved after taking the medicine orally for one treatment course, the waist moves better than before, and the symptoms disappear after two treatment courses.

The invention has the following advantages:

(1) the Chinese herbal medicines used by the invention all conform to the regulations of the national drug dictionary of the people's republic of China, and the invention has the functions of tonifying liver and kidney, nourishing heart, soothing nerves, promoting blood circulation, removing blood stasis, clearing and activating the channels and collaterals, and removing paralysis according to compatibility.

(2) The invention not only has good treatment effect on foreign body sensation after lumbar internal fixation, but also has the effects of promoting the repair of surgical wounds, improving the blood circulation of tissues in the wounds and preventing osteoporosis.

(3) The invention adheres to a big method of treatment based on syndrome differentiation of traditional Chinese medicine, has strict and high-efficiency formula, is non-toxic and harmless, has quick effect on treating the foreign body sensation at the waist after the lumbar internal fixation, short treatment course, safety and convenience, and does not find the occurrence of complications after long-term administration.

(4) The medicinal materials are classified, so that effective components in the medicine are fully extracted, the effective components of the medicinal materials are prevented from being damaged, and the utilization rate of the medicinal materials is higher than that of the traditional fire decoction mode by more than 20%.

Detailed Description

Example 1

A traditional Chinese medicine composition for treating waist foreign body sensation after lumbar internal fixation is prepared from the following raw materials in parts by weight: 12 parts of ginseng, 15 parts of epimedium, 10 parts of fructus psoraleae, 10 parts of curculigo orchioides, 10 parts of sambucus chinensis, 30 parts of Chinese herbaceous peony, 12 parts of poria with hostwood, 12 parts of scorpion, 5 parts of prepared kusnezoff monkshood root, 9 parts of rhubarb, 15 parts of yam rhizome, 5 parts of Chinese alangium, 5 parts of argy wormwood fruit, 12 parts of cinnamomum cassia bark, 12 parts of oyster, 6 parts of magnolia officinalis, 20 parts of tuber fleeceflower stem and 12 parts of kadsura pepper stem.

A medicament of a traditional Chinese medicine composition for treating waist foreign body sensation after lumbar internal fixation operation is prepared by the following steps: firstly, grinding ginseng and epimedium herb in parts by weight, putting the ground ginseng and epimedium herb into an enzymolysis container, then adding water in an amount which is 5 times the weight of the ginseng and the epimedium herb, adding 1.2% of cellulose hydrolase and pectin hydrolase, hydrolyzing for 12 hours at 30 ℃, and then filtering dregs to obtain enzyme hydrolysate;

step four, mixing the enzyme hydrolysate obtained in the step one, the water bath extracting solution obtained in the step two and the mixed solvent obtained in the step three, firstly concentrating the mixture into liquid medicine with the volume equivalent to 1-1.5 g of the raw medicinal materials per milliliter by a water bath method, and then distilling and concentrating the liquid medicine under negative pressure and spray drying the liquid medicine to obtain solid extract powder of the Chinese medicinal extract;

Example 2

The components of the medicine and the processing method of the solid extract powder of the traditional Chinese medicine are the same, but the difference lies in the composition and the preparation method of the medicine,

a medicament of a traditional Chinese medicine composition for treating waist foreign body sensation after lumbar internal fixation is prepared from the following raw materials by weight: 100g of Chinese medicinal extract solid paste powder, 50g of honey, 50g of sesame oil with the purity of more than 95%, 10g of sodium citrate, 0.1g of sodium benzoate, 3g of glycerin fatty acid ester, 1g of dextrin and 2g of Arabic gum, and the balance of distilled water, and the Chinese medicinal extract solid paste powder is prepared into 1000ml of oral preparation, and each bag is 200 ml.

A Chinese medicinal composition for treating lumbar foreign body sensation after lumbar internal fixation is prepared by the following steps:

weighing the raw materials according to the weight part ratio, then adding the traditional Chinese medicine extract solid paste powder, honey, sesame oil with the purity of more than 95%, sodium citrate, sodium benzoate, glycerin fatty acid ester, dextrin and Arabic gum into distilled water, stirring the mixed solution, stirring for 15min at 2500r/min, heating the mixed solution in the stirring process at the temperature of 60-80 ℃, finally standing, cooling and filtering to prepare the oral preparation, wherein each bag contains 200ml of the oral preparation.

The treatment results are as follows: 26 patients with foreign body sensation after lumbar internal fixation are clinically treated and are divided into two groups, 13 patients in each group take the medicament of the embodiment 1 and the embodiment 2 of the invention by equal amount, one bag is taken once, one time is taken in the morning and evening, and 10 days is a treatment course. After three treatment periods, the results are given in the following table:

therapeutic effects	Example 1	Example 2
			Show effect	9	10
Improvement of life	2	3
			Invalidation	2	0

As can be seen from the above table, when the medicament of example 1 of the present invention is taken, 9 cases of significant effect, 69% of significant efficiency, 2 cases of improvement, 15% of ineffective 2 cases, 15% of total effective rate, 84% of total effective rate, and when the medicament of example 2 of the present invention is taken, 10 cases of significant effect, 77% of significant efficiency, 2 cases of improvement, 15% of ineffective 0 cases, and 100% of total effective rate are obtained. The treatment shows that the honey has no side effect on patients, no abnormality is found in three routine tests and liver and kidney function detection, the treatment effect of the scheme adopted in the embodiment 2 is better, and the honey has a regulating effect on gastrointestinal functions and can ensure that gastric acid is normally secreted. The honey also has effects of dilating coronary artery, nourishing myocardium, improving myocardium function, and regulating blood pressure; sesame oil has good effects of softening blood vessels and keeping the elasticity of the blood vessels, is rich in vitamin E, is beneficial to maintaining the integrity and normal functions of cell membranes, and can also reduce the accumulation of lipid in vivo, and the sesame oil contains about 40 percent of linoleic acid unsaturated fatty acid which is easily decomposed, absorbed and utilized by human bodies to promote the metabolism of cholesterol and help to eliminate deposits on arterial vessel walls.

The preparation of example 2 further contains sodium citrate, sodium benzoate, glycerin fatty acid ester, dextrin, and gum arabic, and the preparation process includes high-speed stirring and heating to fully emulsify the sesame oil, so that the sesame oil is uniformly dispersed in the preparation and is not easy to delaminate even after long-term standing, thereby ensuring good uniformity of the preparation and more stable drug effect.

The above description is only an exemplary embodiment of the present invention, and is not intended to limit the scope of the present invention. Any equivalent changes and modifications that can be made by one skilled in the art without departing from the spirit and principles of the invention should fall within the protection scope of the invention.

Claims

1. A traditional Chinese medicine composition for treating lumbar foreign body sensation after lumbar internal fixation is characterized by comprising the following raw materials in parts by weight: 12 parts of ginseng, 15 parts of epimedium, 10 parts of fructus psoraleae, 10 parts of curculigo orchioides, 10 parts of sambucus chinensis, 30 parts of Chinese herbaceous peony, 12 parts of poria with hostwood, 12 parts of scorpion, 5 parts of prepared kusnezoff monkshood root, 9 parts of rhubarb, 15 parts of yam rhizome, 5 parts of Chinese alangium, 5 parts of argy wormwood fruit, 12 parts of cinnamomum cassia bark, 12 parts of oyster, 6 parts of magnolia officinalis, 20 parts of tuber fleeceflower stem and 12 parts of kadsura pepper stem.